79results about How to "Less prone to side effects" patented technology

The invention discloses a method for modifying a nano metal oxide by coupling graft, and belongs to the technical field of nano granule surface modification. The nano metal oxide is used as a raw material, N,N'-carbonyl diimidazole (CDI) is used as an activating agent, and a finished product is obtained by simple processes of drying treatment, coupling reaction, separation and purification, coupling graft, re-separation and re-purification. The method has the advantages of simplicity, mild reaction conditions, high grafting efficiency which reaches 87 percent, energy conservation, emission reduction, low cost and suitability for large-scale industrial production. The nano metal oxide prepared by using the method can be widely applied in the fields of rubber, coating, ink, dye, glass, piezoelectric ceramics, photoelectrons, medicament and the like.

The invention provides a preparation method of erlotinib hydrochloride. The method comprises the following steps: taking 6,7-dimethoxy-3,4-dihydro-quinazoline as an initial raw material, chlorinating directly, then reacting with 3-aminophenylacetylene, afterwards removing methyl on the positions of 6 and 7 and finally introducing a methoxyethyl side chain to generate the erlotinib hydrochloride. The invention has the technological lines of mild reaction condition, no need of high temperature, deep cooling, energy saving and environment friendliness; the whole line has better yield and quality; and the reaction steps are little, the reaction is stable and controllable, the postprocessing is very simple and convenient, and the industrialized production is easy.

The invention provides an isothermal fixed bed reactor loading a catalyst among heat exchange tubes, and the isothermal fixed bed reactor comprises a pressure-bearingg casing, the plurality of heat exchange tubes installed in the pressure-bearing casing, and the catalyst; gaps among the plurality of heat exchange tubes form a catalyst filling zone, and a gas inlet, the gaps among the plurality of heat exchange tubes and a gas outlet form a gas channel. The isothermal fixed bed reactor loads the catalyst among the plurality of heat exchange tubes, the catalyst loading quantity is large; the heat exchange tubes can quickly remove the reaction heat, the whole bed basically reaches the even temperature effect and is free of excess temperature and occurrence of side reactions, and the isothermal fixed bed reactor enables a reaction gas to axially radially flow in the bed, can maximize the use of the and can use a more active small particle catalyst.

The invention provides a pregnant sow traditional Chinese medicine health feed and a preparation method thereof, and belongs to the technical field of feeds. The pregnant sow traditional Chinese medicine health feed is suitable for Xiangxi black pigs. The pregnant sow traditional Chinese medicine health feed includes, by weight: corn, soybean meal, wheat bran, folium eucommiae, a pregnant sow compound premix, compound probiotics, yeast cell walls and compound traditional Chinese medicine additives. The compound Chinese medicine additives include radix astragali, radix codonopsis, radix angelicae sinensis, radix achyranthis bidentatae, rhizoma atractylodis macrocephalae, liquorice root, poria cocos and fructus amomi. The preparation method is as below: smashing the corn, the soybean meal, the folium eucommiae, the wheat bran, and the compound traditional Chinese medicine additives to obtain mixed powder, mixing the mixed powder with the pregnant sow compound premix, the compound probiotics and the yeast cell walls, and conducting granulating. The pregnant sow traditional Chinese medicine health feed prepared through the preparation method has the effects of tranquilizing mind, preventing miscarriage, regulating spleen and stomach functions, activating intestinal flora, and reducing constipation. The pregnant sow traditional Chinese medicine health feed tends not to exhibit residuals, or cause drug resistance and toxic side effects, and is safe and reliable.

The present invention relates to a preparation method of natural vitamin E succinic acid monoester, and is characterized by that it used natural vitamin E and succinic anhydride according to a certain proportion and dissolves them in reaction medium petroleum ether, uses tertiary amine as catalyst, its reaction temp. is 30-70 deg.C, and its reaction time is 2-6 hr., after reaction it uses dilute acid and distilled water to wash it to neutrality, them makes it stand still and laminate, removes its lower layer and makes it recrystallize, its recrystallization temp. is -5-10 deg.c, them adopts the processes of suction filtering and drying so as to obtain the invented product natural vitamin E succinic acid monoester, its content is greater than 95.0%. It is simple in synthesis process, and is suitable for industrial production.

The invention provides milking sow traditional Chinese medicine healthcare feed and a preparation method thereof, and belongs to the technical field of feed. The milking sow traditional Chinese medicine healthcare feed is suitable for black pigs in western Hunan; the milking sow traditional Chinese medicine healthcare feed is prepared from the following raw materials in parts by weight: corns, soybean meal, folium eucommiae, milking sow compound premix, compound probiotics, oil meal and a composite traditional Chinese medicine additive, wherein the composite traditional Chinese medicine additive is prepared from herba taraxaci, semen vaccariae, rhizoma chuanxiong, bighead atractylodes rhizome, rhizoma dioscoreae and cortex magnoliae officinalis. The preparation method of the milking sow traditional Chinese medicine healthcare feed comprises the following steps: smashing the corns, the soybean meal, the folium eucommiae and the composite traditional Chinese medicine additive, thus obtaining mixed powder; mixing the mixed powder with the milking sow compound premix, the compound probiotics and the oil meal, and pelletizing. The milking sow traditional Chinese medicine healthcare feed prepared through the preparation method has the functions of increasing the feed intake and the lactation yield of a milking sow, reducing the occurrence of postnatal diseases of the milking sow and increasing the survival rate of piglets, residue, drug resistance and toxicity and side effects are not easy to generate, and safety and reliability are achieved.

The invention provides a fusible non-curing rubber asphalt waterproof coating. The waterproof coating comprises asphalt, oil-filled styrene-butadiene rubber, a low-molecular-weight polymer modifier and oil-filled block copolymer styrene butadiene rubber. The fusible non-curing rubber asphalt waterproof coating has the advantages that on the basis of having various excellent performances of a non-curing rubber asphalt waterproof coating, like persistent viscosity state, good high-and-low-temperature resistance, caking property, creep property and self-heating property, the excellent use performance of the non-curing rubber asphalt waterproof coating in the production process at a low temperature within a short time and in the construction process is realized, for example, fast heating and melting can be performed; the heating is uniform, and the probability of side reaction is low, so that the material stability is improved.

The invention provides a traditional Chinese medicine health-care feed for middle and big pigs and a preparation method of the traditional Chinese medicine health-care feed, and belongs to the technical field of feed. The traditional Chinese medicine health-care feed for middle and big pigs comprises the following raw materials in parts by weight: corn, bean pulp, folium cortex eucommiae, compound premix for middle and big pigs, compound probiotic, coated allicin and a compound traditional Chinese medicine additive. The composite traditional Chinese medicine additive comprises dandelion, radix achyranthis bidentatae, bighead atractylodes rhizome, uncaria rhynchophylla, rhizoma zingiberis and hawthorn. The preparation method comprises the following steps: pulverizing the corn, the bean pulp, the folium cortex eucommiae and the compound traditional Chinese medicine additive to obtain mixed powder; and mixing the mixed powder with the compound premix for middle and big pigs, the compound probiotic and the coated allicin and granulating. The traditional Chinese medicine health-care feed for middle and big pigs, which is prepared by the preparation method, can improve the immunity of the middle and big pigs, the morbidity is reduced, the functions of the spleen and stomach are regulated, the feed intake is increased, digestive absorption abilities are improved, growth is promoted, flavor of pork is improved, residues, resistance to drugs and toxic and side effects cannot be caused easily, and the traditional Chinese medicine health-care feed for middle and big pigs has safety and reliability.

The invention is to provide a wearable phototherapy system, which comprises a light source assembly, a light guide assembly and a wearable phototherapy assembly. The light source assembly can emit oneor more kinds of light in specific wavelength and is used for carrying out illumination during phototherapy. The light source can be an LED light source. The light guide assembly is arranged betweenthe light source assembly and the wearable phototherapy assembly and is used for conducting light energy generated by the light source assembly to the wearable phototherapy assembly. By separating a generation portion and an application portion of the light source, safety and usability of the product are improved, and a solution scheme is provided for unified treatment of a plurality of human bodyparts; the wearable phototherapy system can treat a plurality of diseases, such as skin diseases and rheumatism and the like, or has the characteristic of health care by using the light; light in specific spectrum is uniformly irradiated on a treated surface through a side-glowing optical fiber module, so that a better curative effect can be obtained; and the system has a good market popularization value.

The invention discloses a butylene glycol-based polyester elastomer and a preparation method thereof. The structure of the butenediol-based polyester elastomer is shown as follows: 1, 4-butenediol containing high-stability double bonds is selected to replace itaconic acid, a series of high-molecular-weight narrow-distribution butenediol-based polyester elastomers are synthesized, and the high-molecular-weight narrow-distribution butenediol-based polyester elastomers have high relative molecular mass and narrow relative molecular mass distribution; and the crosslinking in the subsequent processing process is more controllable, and the dosage of the vulcanizing agent is equivalent to that of the traditional rubber.

The invention discloses a hair nourishing conditioner, which is prepared from the following raw materials in parts by weight: 3-5 parts of apple cider vinegar, 5-10 parts of jojoba oil, 5-10 parts of aloe gel, and 10-15 parts of coconut oil , olive oil 10‑20 parts, black sesame oil 10‑15 parts, Polygonum multiflorum 5‑10 parts, safflower oil 10‑15 parts, garlic 3‑5 parts, rice wine 1‑2 parts, mung beans 3‑7 parts, soybeans 3‑ 7 parts, ginger 3‑7 parts, rice water 20‑50 parts, rose 10‑15 parts. The hair nourishing conditioner of the present invention adds pure natural ingredients, can moisturize the scalp, improve hair quality, remove dandruff and relieve itching, and make the hair soft and smooth.

The invention discloses a method for preparing N,N-dimethyl cyclohexylamine. The method comprises the following steps: (1) adding cyclohexylamine, a solvent and a supported palladium-based catalyst into a reaction kettle, slowly adding a formaldehyde aqueous solution into the reaction kettle, and carrying out a reaction at a certain reaction temperature under a certain hydrogen pressure; (2) afterthe formaldehyde is dropwise added, raising the reaction temperature to continue the reaction to obtain a N,N-dimethyl cyclohexylamine reaction liquid; and (3) carrying out high-temperature phase splitting on the reaction liquid to obtain an oil-phase crude product, and dehydrating and rectifying the oil-phase crude product to obtain the N,N-dimethylcyclohexylamine product. The method has the advantages of cheap and easily available raw materials, high product yield, high product purity, simple process and low production cost, and is suitable for industrial mass production.

The invention relates to the technical field of synthesis methods of organic compounds, in particular to a preparation method of 2-fluoro-1, 3-propanesulfonic acid lactone, which comprises the following steps of: sulphonation reaction: carrying out substitution reaction on a sulfite water solution and a reactant (I) under a phase catalyst to obtain a compound (II), or acidifying with strong acid to obtain a compound (III), (1) cyclization reaction: reacting the compound (II) or compound (III) obtained in step (1) with a dehydrating agent, removing the dehydrating agent after the reaction is finished, washing, extracting, removing the solvent, vacuum-distilling and recrystallizing to obtain a product (IV), namely the 2-fluoro-1, 3-propanesulfonic acid lactone. The preparation method has theadvantages of cheap and easily obtained raw materials, simple operation, mild reaction conditions, good intermediate stability, difficult side reaction, and simple product separation and purification.

The invention provides traditional Chinese medicine health fodder for piglets and a preparation method of the fodder and belongs to the technical field of fodder. The traditional Chinese medicine health fodder for the piglets is applicable to black pigs in western Hunan and is prepared from corn, soybean meal, eucommia ulmoides leaves, compound premix for piglets, compound probiotics, montmorillonite and a compound traditional Chinese medicine additive, wherein the compound traditional Chinese medicine additive is prepared from Chinese yams, radix achyranthis bidentatae, rhizoma atractylodis macrocephalae, cinnamon, poria cocos and hawthorn fruits. According to the preparation method of the traditional Chinese medicine health fodder, the corn, the soybean meal, the eucommia ulmoides leaves and the compound traditional Chinese medicine additive are crushed, mixed powder is obtained and mixed with the compound premix for the piglets, the compound probiotics and montmorillonite, and the mixture is granulated. The traditional Chinese medicine health fodder prepared with the preparation method can promote development of immune organs of the piglets, improve the functions of the liver and the kidney, regulate the functions of the spleen and the stomach, promote establishment of intestinal flora, improve the immunity of the piglets and reduce the morbidity and the death rate of the piglets, has low probability of residues, drug resistance and toxic and side effects and is safe and reliable.

The invention discloses a preparation method of waterborne polyaniline modified epoxy cationic emulsion and belongs to the technical field of anticorrosive coating. The preparation method is characterized by comprising the following steps: firstly, raising the temperature of epoxy resin and part of a solvent and activating; adding primary secondary amine and carrying out ring opening and chain expansion; then adding aromatic organic acid containing -NH2 and acetic acid and neutralizing; finally, adding aniline and an oil-soluble initiator, and initiating polymerization at 65 to 75 DEG C; thendecompressing and removing the solvent; adding de-ionized water and stirring and emulsifying at a high speed to obtain the waterborne polyaniline modified epoxy cationic emulsion. According to the preparation method disclosed by the invention, a chemical modification method is adopted, and polyaniline and the epoxy resin are connected through a covalent bond to synthesize waterborne polyaniline modified epoxy resin, so that the problems of dispersity and compatibility of the conducting polyaniline in an epoxy resin matrix are solved, and the metal anticorrosion performance and the environment-friendly performance of polyaniline coating are greatly improved.

The invention discloses a preparation method of high-performance suspension PTFE. The method comprises the following steps of polymerizer leak finding, polymerizer vacuumizing, testing of water passing flow of a TOC processor, polymerizer water adding, polymerizer additive adding, polymerizer temperature raising, polymerizer deoxidizing, feeding preparation and PTFE preparation. Vacuumizing is conducted on polymerizer, water is added into the polymerizer after vacuumizing is conducted, various additives are added into the polymerizer, the temperature is raised to the reaction temperature through hot water, and when the oxygen content in the polymerizer is controlled to be qualified, a tetrafluoroethylene monomer is added for a reaction. A reaction system is a thermal decomposition system, operation is simple, time and labor are saved, the yield of the PTFE is generally high, and a side reaction is not prone to occur in the reaction. Meanwhile, the performance of all aspects of the product PTFE is promoted by adopting a high-temperature polymerization method.

The invention discloses a Chinese herbal medicinal immunopotentiator for enhancing the immunity of salmons, and a use thereof. The Chinese herbal medicinal immunopotentiator comprises, by weight, 15-18 parts of isatis root, 17-20 parts of Artemisia carvifolia, 16-20 parts of Radix Astragali, 6-8 parts of Chinese angelica root, 17-21 parts of Weeping Forsythia, 7-10 parts of Radix Hedysari, 5-10 parts of Manyprickle Acathopanax Root, 13-17 parts of Chinese gall, 1-2 parts of garlic, 3-5 parts of dried orange peel, 1-2 parts of ginger and 2-3 parts of Poria cocos. The Chinese herbal medicinal immunopotentiator has he advantages of wide sources of raw materials, low drug resistance after long-term use, improbable residual, drug resistance and toxic and side effects, good safety and reliability, high content of effective components of Chinese herbal medicines, enhancement of the immunity and the disease resistance of bodies, good antibacterial and antiviral effects, obviousness in killing and inhibiting of pathogen microorganisms, reduction of the illness probability of the salmons, and increase of the survival rate.

The invention discloses a Chinese medicinal composition for treatment of broiler breeder diarrhea. The Chinese medicinal composition comprises the following raw materials by weight part: 8-10 of hippophae rhamnoides, 3-5 of Gynostemma pentaphyllum, 2-4 of prepared rhizome of rehmannia, 10-15 of scorched Cape Jasmine Fruit, 10-12 of pomegranate rind, 2-4 of Ipomoea aquatica Forsk, 6-8 of Rosa roxburghii root, 1-3 of garden burnet leaf, 2-3 of stir-fried Semen Raphani, 10-15 of lonicera japonica, 4-5 of Alisma plantago-aquatica, 2-4 of Acorus tatarinowii, 4-5 of rhubarb, 1-2 of jasminum sambac, 6-10 of Lagedium sibiricum, 4-5 of Citrus aurantium L., 2-4 of cortex moutan, 1-3 of wrightia pubescens root or stem, 3-5 of soybean seed slurry, and 2-3 of Cortex Juglandis Mandshuricae. The Chinese medicinal composition provided by the invention has very good curative effect on broiler breeder diarrhea, and has the characteristics of no side effect, simple medication and difficult relapse, not only ensures the safety of broiler breeders, but also has the effects of clearing heat and removing toxicity, removing dampness and stopping diarrhea and relieving pain, and can promote the growth and development of chicken.

The invention discloses a water treatment agent for improving an ammonia nitrogen removal ability of a biochemical system. The water treatment agent is prepared from the following components in parts by weight: 75 to 100 parts of filler, 22 to 35 parts of bio-enzyme, 33 to 40 parts of microorganism and 80 to 100 parts of nutrient substances, wherein the nutrient substances comprise vitamin, amino acid, cane sugar and whey. Hazardous substances such as ammonia nitrogen in waste water are decomposed by utilizing biological bacteria, so that the biochemical ability of the waste water is improved.

The invention provides a feed additive for poultry and a preparation method of the feed additive. The feed additive comprises the following traditional Chinese medicine components of echinacea purpurea, poria cocos, radix codonopsis, angelica dahurica, dandelions, dried orange peel, cloves, licorice roots and cinnamon, wherein the echinacea purpurea, the poria cocos and the radix codonopsis are sovereign drugs; the angelica dahurica and the dandelions are minister drugs; the dried orange peel and the cloves are assistant drugs; the licorice roots and the cinnamon are envoy drugs. The feed additive prepared by the preparation method disclosed by the invention has the effects of regulating the physiological functions of poultry organisms, improving the production properties of the poultry organisms and strengthening the immunity and the disease resistance of the poultry organisms.

The present invention discloses a trimethoxybenzoic acid preparation method, which comprises: A, adding 100 parts of Galla chinensis powder, 48-58 parts of water, 80-100 parts of Dimethylsulfate, and 130-140 parts of an alkali liquid to a reaction kettle, carrying out steam heating, controlling the temperature of 75-90 DEG C, stirring, and controlling the PH value of 9.4-10.3; B, after carrying out the reaction for 4-5 h, heating to the temperature of 90-100 DEG C, and adding 11-19 parts of sulfuric acid to carry out acidification; C, carrying out cooling crystallization to obtain a trimethoxybenzoic acid crude product; D, adding 85-110 parts of the trimethoxybenzoic acid crude product obtained in the step C, 900-970 parts of water, 25-40 parts of active carbon and 1-3 parts of EDTA to the reaction kettle to carry out a reaction for 2 h, and controlling the temperature of 100-105 DEG C and the pressure of 0.7-0.9 MPa; and E, adding the mixed liquid obtained in the step D to a centrifuge to carry out solid-liquid separation, and carrying out cooling crystallization on the obtained liquid to obtain the trimethoxybenzoic acid solid. According to the present invention, the purity of the trimethoxybenzoic acid prepared through the method is high, the cost and the production period are less, and the whole production efficiency is improved.

The invention relates to a wastewater degradation device, which belongs to the technical field of water treatment. The wastewater degradation device comprises a shell in which a reaction chamber is formed, wherein two electrodes are arranged in the reaction chamber; one electrode consists of an electrode shaft which is arranged in the middle of the reaction chamber and can rotate and a sedimentation cylinder which is sleeved on the electrode shaft; the sedimentation cylinder is electrically communicated with the electrode shaft; and the other electrode is circumferentially arranged in the reaction chamber around the sedimentation cylinder. In the wastewater degradation device, a central rotating electrode structure is adopted, so side reaction is difficulty produced during degradation of wastewater, and the device has the advantage of high electrolysis efficiency.

The invention discloses a preparation method of teriparatide. The preparation method comprises steps as follows: 2-CTC resin is taken as a resin carrier and is coupled with Fmoc-Phe-OH under the action of an activator and a coupling reagent, and Fmoc-Phe-resin is obtained, an Fmoc deprotection reagent is added to the Fmoc-Phe-resin, after a reaction ends, washing is performed with N,N-DMF, Phe-resin is obtained, one-by-one extension coupling is performed on amino acid under the action of a condensation reagent and an activating reagent, and teriparatide-resin is obtained; a lysate containing PhSMe / PhOH / EDT system is added to the teriparatide-resin, and a crude product of teriparatide is obtained; the crude product of teriparatide is separated, purified and freeze-dried by use of a C18 column, and high-purity teriparatide is obtained. The preparation method of teriparatide is low in cost and adopts a simple process. The total yield of teriparatide is increased, and no harm is caused toany environment. The preparation method is suitable for large-scale production.

The invention discloses a compound red yeast capsule. 30% to 85% of red yeast, 1% to 12% of ginkgo biloba extract and 3% to 69% of eucommia leaf extract by mass percent form a composition and are filled in an empty capsule, wherein the red yeast is prepared by natural fermentation and the mass percent of lovastatin in the red yeast is 0.5% to 4%. The mass percent of the lovastatin in the raw material of the red yeast in each capsule can meet effective dosage and ensure the safety of the product. The raw material of the red yeast of contents is a naturally fermented product. The acid proportion is more than 70%. Relative to some products having the raw material of chemically synthesized lovastatin in the market, the capsule has the advantages of direct absorption by human bodies and difficult generation of side effects. Proved by a test, relative to a single red yeast product, the compound red yeast capsule of the invention has better lipid lowering effect and can ensure the safety of eaters.

The present invention discloses a Chinese medicine for curing AIDS. Said Chinese medicine can be made up by using the Chinese medicinal materials of licorice, scutellaria root, ginseng, dried ginger, coptis root, jujube and pinellia tuber according to the mixing ratio of 10-15:3-6:5-8:2-5:1-3:3-4:1-2 through conventional preparation process.

The invention relates to the technical field of aptamers, and discloses a connecting arm of an immobilized nucleic acid aptamer as well as a preparation method and application of the connecting arm. The connecting arm has a structure as shown in a formula 1 shown in the specification, wherein R1 and R2 are independently selected from straight-chain or branched-chain C1-C10 alkyl groups, R is an amino protection group, and n is an integer from 2 to 6. Compared with the prior art, the connecting arm has the following beneficial effects: 1) the connecting arm of the immobilized nucleic acid aptamer provided by the invention has high selectivity when CPG is excised by using concentrated ammonia water in the last step of synthesizing the aptamer, and only one product can be obtained; 2) only one secondary alcohol is left on the connecting arm of the nucleic acid aptamer, and side reaction is not liable to occur, and 3) the raw material for preparing the connecting arm of the immobilized nucleic acid aptamer is solketal and is easy to obtain.

The invention provides feed for enhancing the immunity of piglets. The feed comprises raw materials such as corn, soybean meal, salt, fish meal, soybean oil, methionine, lysine, tryptophan, vitamin A, vitamin E, vitamin C and medical feed additives for helping the piglets to enhance the immunity. With the adoption of the feed, the immunity of the piglets can be significantly enhanced, the feed is good in effect, becomes effective quickly, can decrease the incidence and the death rate of the piglets and is safe and reliable, residues, the drug resistance and toxic and side effects do not appear easily, and the raised piglets are healthy green food.

The invention belongs to the fields of biological catalysis and bio-manufacturing, and discloses a preparation method of furfuryl alcohol. Immobilizedmeyerozymaguilliermondii SC1103 is used for catalyzing reduction of furfuraldehyde to prepare the furfuryl alcohol. The preparation method of the furfuryl alcohol has the advantages of high selectivity, mild reaction condition, environmental friendliness, high reaction speed, high spatiotemporal yield of a target product, easy recovery of a catalyst, and the like.