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Process for preparing natural vitamin E monomester succinate

A natural vitamin and succinic acid monoester technology, which is applied in the field of chemical engineering, can solve the problems of low application efficiency and long time consumption, and achieve the effects of low production cost, less side reactions, and low reaction temperature

Inactive Publication Date: 2002-01-30
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method is carried out at normal temperature, it takes too long, 24 hours, and the practical application efficiency is too low
In addition, none of the above methods involve natural vitamin E mainly in gamma type

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0009] Weigh 220 grams of natural vitamin E with a content of 90.0%, 100 grams of succinic anhydride, 10ml of triethylamine, and 300ml of petroleum ether, put them into a three-necked flask, stir and react at 60°C for 4 hours. After the reaction is complete, add dilute hydrochloric acid , Wash with distilled water, stand for layering, crystallize the organic layer at 0°C, filter with suction, and dry to obtain 190 grams of natural vitamin E succinate monoester with a purity of 95.0% and a melting point of 72-74°C.

Embodiment 2

[0010] Example 2: Weigh 220 grams of natural vitamin E with a content of 90.0%, 100 grams of succinic anhydride, 10ml of triethylamine, and 300ml of petroleum ether, put them into a three-necked flask, and stir and react at 70°C for 3 hours. After the reaction is complete , Washing with dilute hydrochloric acid and distilled water, standing for layering, crystallization of the organic layer at 0°C, suction filtration, and drying to obtain 196 g of natural vitamin E succinate monoester with a purity of 94.2% and a melting point of 72-74°C.

Embodiment 3

[0011] Example 3: Weigh 220 grams of natural vitamin E with a content of 90.0%, 100 grams of succinic anhydride, 10ml of triethylamine, and 300ml of petroleum ether, put them into a three-necked flask, and stir and react at 30°C for 6 hours. After the reaction is complete , Washing with dilute hydrochloric acid and distilled water, standing for layering, crystallization of the organic layer at 0°C, suction filtration, and drying to obtain 180 g of natural vitamin E succinate monoester with a purity of 93.6% and a melting point of 71-73°C.

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PUM

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Abstract

The present invention relates to a preparation method of natural vitamin E succinic acid monoester, and is characterized by that it used natural vitamin E and succinic anhydride according to a certain proportion and dissolves them in reaction medium petroleum ether, uses tertiary amine as catalyst, its reaction temp. is 30-70 deg.C, and its reaction time is 2-6 hr., after reaction it uses dilute acid and distilled water to wash it to neutrality, them makes it stand still and laminate, removes its lower layer and makes it recrystallize, its recrystallization temp. is -5-10 deg.c, them adopts the processes of suction filtering and drying so as to obtain the invented product natural vitamin E succinic acid monoester, its content is greater than 95.0%. It is simple in synthesis process, and is suitable for industrial production.

Description

Technical field: [0001] The invention relates to a method for preparing natural vitamin E succinate monoesters, in particular to a method for preparing vitamin E succinate monoesters at low temperature and using tertiary amines as catalysts, ether compounds as solvents, and belongs to the technical field of chemical engineering. Background technique: [0002] Natural vitamin E has important nutritional health and pharmaceutical value, and the safety of long-term use is far better than synthetic vitamin E. However, natural vitamin E is a free form, which is insoluble in water, easily oxidized, and unstable, which hinders its application in medicines and cosmetics. Therefore, free vitamin E is often converted into other ester derivatives, and vitamin E succinate monoester is one of them. It not only has the physiological activity of free vitamin E, but also has excellent chemical stability, and thus has a wider range of uses. Therefore, the synthesis of vitamin E succinate monoeste...

Claims

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Application Information

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IPC IPC(8): C07D311/72
Inventor 赵亚平
Owner SHANGHAI JIAO TONG UNIV
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