42results about How to "Improve the linear relationship" patented technology

The invention provides a finished hybrid power automobile torque distribution system and method based on parallel control and relates to the field of hybrid power automobile control. The finished hybrid power automobile torque distribution system based on the parallel control consists of a real system and an artificial system, wherein the real system is responsible for driving of actual running of a real automobile, the artificial system is responsible for real automobile modeling and controller parameter optimization in a real automobile real-time running state and parallel execution. The real system consists of a sensor detection circuit, a signal conditioning circuit, a controller and a liquid crystal display. The artificial system consists of a sensor detecting circuit, a signal conditioning circuit and a computer processing system. The finished hybrid power automobile torque distribution system based on the parallel control is simple in structure, easy to achieve and high in reliability, improves the engine fuel utilization rate, reduces emission and effectively improves the actual running performance and working efficiency of the real automobile within a whole service life.

The invention discloses a full-spectrum transmission plant biochemical parameter nondestructive detection device and a full-spectrum transmission plant biochemical parameter nondestructive detection method, which are used for solving the technical problems of low model applicability, poor anti-jamming capacity, low detection accuracy, less detected parameters and the like in the conventional spectrum nondestructive detection method. The full-spectrum transmission measurement principle is adopted and a plurality of parameters are simultaneously measured in high accuracy; the time-divided double optical path reference measurement principle is adopted to ensure the accuracy of transmittance spectrum signals; the integrated transmission fixture and program controlled adjustable voltage-stabilizing drive light source circuit makes the measurement principle realized in plant leaf transmittance spectrum measurement so as to form the miniature and portable plant biochemical parameter nondestructive detection device; and in a prediction model of the device, an improved expansion multiple scattering correction method is adopted to correct basic lines of leaves due to scattering and optical path length difference due to different leaf thicknesses, the sensitivity of spectrum data to chemical substance concentration is improved, and the anti-jamming capacity of the model is improved.

A current mode dual-slope temperature-to-digital conversion device is disclosed. The conversion device comprises a temperature dependent current source and a reference current source. Firstly, a capacitor is charged by the temperature dependent current source. Next, the capacitor is discharged by the reference current source. The capacitor is coupled to at least one trigger, and the trigger sends out a first digital signal to a logic controller by the voltage of the capacitor. Then, the logic controller sends out a second digital signal to a time-to-digital converter according to the first digital signal. When the capacitor is discharged by the reference current source and before the first digital signal is varied, the converter receives the second digital signal and a clock signal to generate a corresponding digital output value. The present invention achieves the requirement of the high linearity resolution with the dual-slope architecture lest the curvature effect resulted from the time-domain circuit be occurred.

The invention discloses a detection device for detecting thickness of a vacuum vapor plating membrane and a vacuum vapor plating device and aims to solve the problem that in the prior art, production cost is excessively high due to frequent change of a quartz vibrator. The detection device comprises a detection structure and a quartz vibrator, and the detection structure is provided with openings corresponding to the quartz vibrator so that vapor plating molecules can be deposited on the quartz vibrator through the openings; the detection device further comprises filtering layers arranged between the openings and the quartz vibrator.

The invention belongs to the chemical field of medicines, and particularly relates to a method for measuring the contents of 5-soquinolinesulfonic acid methyl ester and 5-isoquinolinesulfonic acid ethyl ester in fasudil hydrochloride through an LC-MSMS (Liquid Chromatography-Tandem Mass Spectrum) method. Through HPLC (High Performance Liquid Chromatography), the problems that 5-soquinolinesulfonicacid methyl ester and 5-isoquinolinesulfonic acid ethyl ester can not be simultaneously measured on a single liquid phase condition, in addition, a moving phase greatly damages a chromatographic column and the chromatographic column is non-durable to cause poor method reproducibility can be solved. The LC-MS method is high in detection sensitivity, two ingredients are simultaneously detected, themethod is good in durability and high in accuracy, analysis time is shortened, and detection efficiency is improved.

A current mode dual-slope temperature-to-digital conversion device is disclosed. The conversion device comprises a temperature dependent current source and a reference current source. Firstly, a capacitor is charged by the temperature dependent current source. Next, the capacitor is discharged by the reference current source. The capacitor is coupled to at least one trigger, and the trigger sends out a first digital signal to a logic controller by the voltage of the capacitor. Then, the logic controller sends out a second digital signal to a time-to-digital converter according to the first digital signal. When the capacitor is discharged by the reference current source and before the first digital signal is varied, the converter receives the second digital signal and a clock signal to generate a corresponding digital output value. The present invention achieves the requirement of the high linearity resolution with the dual-slope architecture lest the curvature effect resulted from the time-domain circuit be occurred.

The invention discloses a thermally induced voltage material and application thereof, belonging to the technical field of transverse thermoelectric materials and devices. A (Ca / Sr) 3Co4O9 or (Ca / Na) xCoO2 (x=0. 52-0.8) thin film is selected as thermally induced voltage material in the present invention. As the thermal field or the thermal fluid induce voltage material of the invention has high signal response rate and does not need to establish heat balance, the response time is fast, and the signal repeatability and the linear relationship are good; the temperature gradient of the thermally induced voltage thin film is converted into a larger thermoelectric voltage signal by directly using heat source or thermal field heating, which has no time term, strong anti-interference ability, no power supply driving, no refrigeration and amplification, and can be used to fabricate some sensitive and fast thermally induced voltage detection devices. The temperature and thermoelectric potentialare perpendicular to each other, and can modulate dimension and direction independently. It is easy to fabricate arrays to detect transient thermal field or heat flux. Compared with the current devices, the material has great breakthrough and advantages, and can be used in the industrial and military fields of pulse or continuous thermal signal detection, transient thermal field and thermal fluiddetection.

The invention relates to the technical field of electronic circuits and discloses a voltage-controlled ring oscillator with high linearity. The voltage-controlled ring oscillator comprises a time delay module, a voltage-to-current conversion circuit and a current mirror, wherein the time delay module is used for generating oscillation signals; the voltage-to-current conversion circuit is used for converting control voltage to driving current; the current mirror is used for mirroring the driving current to the time delay module as the working current of the time delay module; the voltage-to-current conversion circuit is a linear voltage-to-current conversion circuit to enable the frequency of the oscillation signals and the control voltage to present a linear relation; and the time delay unit in the time delay module adopts an output common-mode voltage self-stabilization technology to obtain stable output common-mode level. The voltage-controlled ring oscillator disclosed by the invention has the advantages of high linearity and stable output common-mode voltage.

The invention discloses a moving coil type actuator for the active suspension of an engine. The moving coil type actuator comprises an end cover, two leaf springs, a permanent magnet, a pushing rod, acoil, a coil bracket, an outer keeper, an inner keeper, a fixed-distance tube, and a fastening sleeve, the outer keeper is arranged on the outer side of the inner keeper, the inner keeper and the outer keeper are mounted on the end cover, a groove is formed in the outer side face of the inner keeper, the permanent magnet is fixedly mounted in the groove of the inner keeper, the fixed-distance tube is mounted between the two leaf springs, and the two leaf springs are connected with the top end and the bottom end of the fixed-distance tube; and the coil is arranged between the outer keeper andthe inner keeper, the coil is connected with the coil bracket, and the coil bracket is fixed on the fixed-distance tube through the fastening sleeve. The moving coil type actuator can effectively solve the problem of excessive mass of a rotor, the response speed of the actuator to the control signal in the actuating process and the stiffness linearity within the excitation amplitude range of the engine are improved, the heat emission capacity of a shell of the actuator is improved, and the service life of the shell of the actuator is prolonged.

The invention provides a spectral calibration method for a crop nitrogen sensor. The method is characterized by comprising the following steps: 1) respectively calibrating the irradiance of an up light sensor and the radiance of a down light sensor by using a standard detector, i.e., in virtue of the up light sensor and the standard detector, synchronously measuring the irradiance of the waveband r of sun light and fitting a linear relation between the output DN_Up(r) of the up light sensor and the output EB(r) of the standard detector so as to realize calibration of the optical radiance of the up light sensor as shown in a formula (3) which is described in the specification; etc. The up light sensor is in good linear relation with the irradiance of sun light, the down light sensor is in good linear relation with the radiance, and linear relativity reaches 99%. The calibration method based on radiation can greatly improve measurement precision and stability of the crop nitrogen sensor compared with a calibration method based on a standard gray scale plate.

The invention discloses a preparation method of a porous TiO2 / NaPSS composite sensitive material and a product thereof. The preparation method specifically comprises the steps of firstly, uniformly coating polystyrene microspheres and a titanium tetrachloride aqueous solution on a cleaned interdigital electrode through a spin-coating method, and drying; secondly, putting the dried electrode into adichloromethane solution, ultrasonically dissolving the polystyrene microspheres, and performing solution driving to obtain an interdigital electrode with a porous TiO2 film; and finally, coating theinterdigital electrode with the porous TiO2 film with a sodium polystyrenesulfonate solution added with sodium carboxymethyl cellulose by adopting an impregnation method to obtain the porous TiO2 / NaPSS composite sensitive material. The prepared material has the advantages of reduced impedance value and humidity hysteresis difference, enhanced linear relationship, accelerated response speed and greatly improved repetitive stability, and can have wide application prospects in the aspect of humidity sensors.

The invention discloses a glutathione reductase detection reagent kit which is prepared from the following components: a first reagent and a second reagent. The first reagent is prepared from the components of a phosphate buffer solution, EDTA-NA2, ascorbic acid oxidase, potassium ferricyanide, a preservative and oxidized glutathione. The second reagent is prepared from the components of a trimethylamine methane buffer solution, EGTA, a preservative and reduced coenzyme. The first reagent and the second reagent are both liquid and can be stored for 12 months at 2-8 DEG C environment. Potassiumferricyanide can oxidize hemoglobin to produce stable hemiglobincyanide, and the influence of detection results is reduced. The second reagent adopts EGTA, the linear relationship between the detection results and the change rate of absorbance is can be improved, and adopting of two-point calibration is convenient. The invention further discloses application using the glutathione reductase detection reagent kit. The application comprises the steps that the first reagent and the second reagent are added into a sample solution separately and put into a biochemical analyzer for incubating, the absorbance is read and the change rate of absorbance delta A1 is calculated, and then the glutathione reductase activity of a sample is calculated.

The invention belongs to the technical field of analytical chemistry, and particularly relates to a method for detecting phospholipid in protein powder by the aid of liquid chromatography-mass spectrometry technologies. The method includes individually preparing gradient-concentration working standard solution of phosphatidyl ethanolamine (PE), phosphatidyl serine (PS) and phosphatidyl inositol (PI), detecting the working standard solution by the aid of the HPLC-MS / MS (high-performance liquid chromatography-mass spectrometry / mass spectrometry) technologies and plotting standard working curves;ultrasonically extracting, centrifuging and filtering to-be-detected samples by solvents to obtain test solution, detecting the test solution according to the HPLC-MS / MS technologies and substitutingresults into the standard working curves to obtain the concentration of the phosphatidyl ethanolamine, the concentration of the phosphatidyl serine and the concentration of the phosphatidyl inositolin the to-be-detected samples. The concentration is used as horizontal coordinates of the standard working curves, and peak areas are used as vertical coordinates of the standard working curves. HPLCsystem conditions include that C4 chromatographic columns or chromatographic columns with the performance identical to the performance of the C4 chromatographic columns are used as stationary phase. The method has the advantage that the technical shortcoming of deficiency of methods for quantitatively detecting the contents of PE, PS and PI in existing protein powder at present can be overcome bythe aid of the method.

The invention provides a method for improving sensitivity and linearity of a latex reagent, and belongs to the field of medical test. The method comprises the following steps: step (1), preparing a solution A: the solution A includes a monoclonal antibody connected to a latex microsphere for an antigen to be tested; step (2), preparation a solution B: the solution B includes phenylalanine, lysineand vitamin C; and step (3), mixing the solution A obtained in step (1) and the solution B obtained in step (2) to obtain a solution C, wherein the solution C is used for detecting the antigen to be tested. The invention further provides a preparation method of a detection kit, wherein a certain amount of the solution B is added to a reagent R2, and the addition of the solution B not only improvesthe sensitivity of the detection, but also can obviously improve the linear relationship of the detection; and the addition of the solution B is unexpectedly found to improve the stability of the reagent R2, and the stability of the reagent R2 is still relatively high under the condition that a preservative does not need to be added.

The invention discloses a gas chromatography method for detecting C18 fatty acid isomers in grease. A high-polarity ionic liquid gas chromatographic column with the specifications of 200 m*0.25 mm*0.20 mu m is used for detecting the C18 fatty acid isomers in the grease. By means of the method, the separation degree of C18:1 and C18:2 isomers is improved and C18:3 isomers are effectively separated. According to the established C18 fatty acid isomer method, the RSD (relative standard deviation) of the within-day precision is controlled in the range of 0.83%-4.30%, the RSD of the day to day precision is controlled in the range of 1.53%-3.90%, and the quantitative analysis requirements are met. According to the established C18 fatty acid isomer method, the detection limit ranges from 0.009 mg / L to 0.075 mg / L, and the minimum determination limit ranges from 0.028 mg / L to 0.225 mg / L, and the detection limit and the determination limit of C18 cis-trans-isomers are remarkably reduced.

The invention relates to a single photon detector and a high-voltage quick adjusting circuit thereof. The high-voltage rapid adjustment circuit comprises: a high voltage circuit, a reference voltage circuit, an operational amplifier wherein the output end of the high-voltage circuit is used for outputting a set voltage; the output end of the reference voltage circuit is used for generating a reference voltage; and the in-phase input end of the operational amplifier is connected with the output end of the reference voltage circuit, the output end of the operational amplifier is connected with the control end of a switching tube, the input end of the switching tube is connected with the output end of the high-voltage circuit, the output end of the switching tube is used for being connected with the cathode of the single photon detection diode, and a capacitor is connected between the output end of the operational amplifier and the cathode of the single photon detection diode in parallel.The single photon detector and the high-voltage quick adjusting circuit thereof can prevent the breakdown of the photodiode, avoid the problems of ringing and oscillation and improve the stability ofthe circuit.

The invention provides a glutathione reductase determination kit, and a preparation method and applications thereof, and relates to the technical field of biochemical reagent determination. The kit includes a reagent R1 and a reagent R2; the reagent R1 includes a phosphate buffer solution, ascorbic acid oxidase, pyruvate oxidase, potassium ferrocyanide, oxidized glutathione, MgCl2, FAD, a preservative and a surfactant; and the reagent R2 includes a glycine buffer solution, NADPH, the preservative and a protective agent. Through the adding of EGTA and dithiothreitol in the reagents, the linearrange of the kit can be enlarged, and the stability of the kit can be enhanced. The preparation method and applications of the kit are also provided; and the kit can accurately determine glutathione reductase.

The invention provides a finished hybrid power automobile torque distribution system and method based on parallel control and relates to the field of hybrid power automobile control. The finished hybrid power automobile torque distribution system based on the parallel control consists of a real system and an artificial system, wherein the real system is responsible for driving of actual running of a real automobile, the artificial system is responsible for real automobile modeling and controller parameter optimization in a real automobile real-time running state and parallel execution. The real system consists of a sensor detection circuit, a signal conditioning circuit, a controller and a liquid crystal display. The artificial system consists of a sensor detecting circuit, a signal conditioning circuit and a computer processing system. The finished hybrid power automobile torque distribution system based on the parallel control is simple in structure, easy to achieve and high in reliability, improves the engine fuel utilization rate, reduces emission and effectively improves the actual running performance and working efficiency of the real automobile within a whole service life.

The invention discloses a preparation method of dissolved oxygen fluorescent sensing film. The preparation method comprises following steps: 1, preparation of a 0.018mol / L tris(2,2'-bipyridine)ruthenium dichloride [Ru(bpy)3Cl2] ethanol solution; 2, preparation of a high molecular polymer solution; 3, synthesis of silicon dioxide nanometer particles; 4, raw material mixing; and 5, fluorescent filmcoating.

The invention provides a microelectrode sensor for detecting staphylococcus aureus as well as a preparation method and an application method of the microelectrode sensor. The microelectrode sensor is a three-electrode system sensor, a counter electrode of the microelectrode sensor is a platinum wire electrode, a reference electrode of the microelectrode sensor is an Ag / AgCl electrode, and a working electrode of the microelectrode sensor is a silver microelectrode modified by chitosan, catechol and a staphylococcus aureus aptamer. The microelectrode sensor disclosed by the invention is constructed on the basis of a microelectrode with a micro-nano structure on the surface, double media (Fc-Ru < 3 + >), chitosan and catechol. The working electrode of the microelectrode sensor can specifically capture staphylococcus aureus. In the CV test process of the microelectrode sensor, CI <-> in bacteria can leak to the surface of the working electrode under the action of local high field intensity, and when CI <-> ions exist, the cathode reduction peak of the working electrode between 0 and-0.1 V can be specifically enhanced, so that a linear relation between bacterial concentration increase and current signal enhancement is established; the purpose of specifically detecting bacteria is achieved.

The invention discloses an FPC module with balanced deflection stress and an electronic device, and relates to the technical field of electronic circuits. The FPC module comprises a first terminal on which a first circuit is distributed, a second terminal on which a second circuit is distributed, and at least three bridging units connected with the first wiring terminal and the second wiring terminal and arranged side by side; a third circuit is distributed on the bridging units, and the first circuit and the second circuit are connected through the third circuit; and the at least three bridging units are used for forming a polygonal three-dimensional supporting structure through reverse bending and staggering. The FPC is designed to be provided with a plurality of bridging units which can form the three-dimensional supporting structure in a staggered mode, the center of the supporting point is located in the center of the three-dimensional supporting structure, balance of deflection stress of the FPC in all directions is facilitated, the stress of the FPC is weakened to a certain degree, the development difficulty of deflection control can be reduced, the linear relation between the deflection degree and the control parameters is improved, and the reliability and stability of FPC deflection control are ensured.

The invention belongs to the field of medicinal chemistry, and in particular relates to a LC-MSMS method for determining the content of methyl 5-isoquinolinesulfonate and ethyl 5-isoquinolinesulfonate in fasudil hydrochloride. HPLC solves the problem that methyl 5-isoquinolinesulfonate and ethyl 5-isoquinolinesulfonate cannot be simultaneously determined under single liquid phase conditions, and the mobile phase has great damage to the chromatographic column, and the chromatographic column is not durable, resulting in poor method reproducibility . LC‑MS has high detection sensitivity and can detect two components at the same time. The method has good durability, high accuracy, shortens analysis time and improves detection efficiency.

The invention discloses a method for high-precision detection of CEA by molecular imprinting combined with biomolecular Raman silent regional standard SERS technology, which firstly prepares gold-silver core-shell nanoparticles with internal standards and polydopamine-coated gold cores with labeled signals. Shell nanoparticles, and then assemble gold-silver core-shell nanoparticles on a gold plate as a SERS substrate, and prepare a molecularly imprinted layer containing CEA on the SERS substrate to obtain a SERS molecularly imprinted layer that can specifically recognize CEA. The CEA in the solution was specifically captured by CEA molecular imprinting, then the captured CEA was labeled with an antibody-modified SERS probe, and finally SERS detection was performed. The ratio of the signal intensities was used to estimate the concentration of CEA in the solution. The invention can greatly improve the detection efficiency of CEA, and realize high-precision and specific detection of trace amount of CEA.

The invention relates to a SERS system for simultaneously detecting multiple toxic substances, including the following substances A and B: substance A is an anti-fouling magnetic microbead coupled with two or more toxic substance haptens, expressed as MB@P‑hap , MB is a magnetic microbead, P is an antifouling polymer brush, and hap is a hapten of a toxic substance, which is obtained by coupling a toxic substance hapten to a magnetic microbead grafted with an antifouling polymer brush; B substance is two kinds of The above mixture of nanoprobes labeled with monoclonal antibodies of toxic substances, said nanoprobes labeled with monoclonal antibodies of toxic substances is represented as SERS substrate@mAb‑RP, wherein SERS substrate represents a surface-enhanced Raman scattering substrate, and mAb represents a toxic substance monoclonal antibody, RP means Raman probe (Raman Probe). The detection and sensing system constructed by the present invention is implemented in a sample solution based on competitive immunoassay, and has satisfactory detection accuracy and sensitivity, and can be used for detection of trace toxic substances in complex matrices such as food.

The invention relates to the technical field of drug analysis, and specifically discloses a detection method for genotoxic impurities in safinamide mesylate. Described detection method comprises the following steps: prepare need testing solution and reference substance solution; Adopt liquid chromatography-mass spectrometry to detect described need testing solution and described reference substance solution, the chromatographic condition of described liquid chromatography Be: adopt C18 chromatographic column, take the formic acid aqueous solution that volume concentration is 0.1% as mobile phase A, the formic acid methanol solution that volume concentration is 0.1% is mobile phase B, gradient elution; Described mass spectrometry adopts ESI ion source, positive ion detection mode. The detection method provided by the invention has the advantages of simple method, stability, high precision, good reproducibility, etc., can quickly and accurately detect the toxic impurities in the safinamide mesylate bulk drug, and conforms to the guiding principle of ICH M7 .

The invention discloses a method for constructing a SERS spectral probe to detect breast cancer marker EGFR phosphorylated tyrosine: a gold plate is used as a substrate, and core-shell structure nanoparticles are used as a substrate for SERS detection to develop high selectivity and high sensitivity A "sandwich" configuration probe molecule to detect the phosphorylation of breast cancer marker EGFR tyrosine. Using the 4‑MB Raman spectrum, the peak position in the Raman silent zone of biomolecules is 2221cm ‑1 The intensity of the SERS spectrum of the marker molecule was used as an internal standard to normalize the intensity of the spectral signal of the marker molecule 4-MBA, which can avoid the influence of the Raman signal in the biomolecular fingerprint region on the quantitative detection, and make the concentration of the EGFR phosphorylated tyrosine solution and the SERS intensity The linear relationship is greatly improved, further improving the detection sensitivity of the SERS spectral probe. 4-MB and 4-MBA are located in the middle layer between the gold core and the silver shell, which ensures that its properties, spatial structure and quantity remain unchanged, thereby ensuring the reliability of the data. The method of the present invention shows great potential in ultrasensitive detection of cancer markers.

The invention relates to a method and a system for positioning dairy cow individuals. The recognition accuracy of the dairy cow individuals is improved, in particular to the recognition accuracy of multiple pedometers within a smaller range. The method comprises the following steps of setting an excitation range by controlling low-frequency field intensity, and continuously sending low-frequency activating signals at a scheduled period within the excitation range; receiving field intensity reference data from at least one pedometer within the excitation range by high-frequency transceiving; recording the current field intensity reference data after low-frequency activating information within the excitation range is received by the pedometers, and activating the high-frequency transceiving of the pedometers so as to send the field intensity reference data; and sending the field intensity reference data and the excitation range to an upper computer server.

The invention relates to a method for measuring the pH value of an aqueous solution based on gold nanorods, and belongs to the technical field of nanomaterials. The method comprises the following steps: (A) continuously monitoring the RGB color space values ​​of the solution after adding the gold nanorod solution and the etching solution to the solution to be tested, corresponding to the red, green and blue color component values ​​respectively, until the etching reaction ends; (B) Convert the GRB color space value into a hue value; (C) plot the hue value against the etching reaction time in the polar coordinate system, and obtain the reversal value of the hue within 400 seconds after the start of etching and the entire etching The maximum reverse value in the process; (D) When the reverse value is less than 38°, the maximum reverse value of the hue value is substituted into the calibration curve to realize the measurement of pH value. In the method provided by the invention, during the measurement process, the quality of the gold nanorods is screened through the inversion value, and unqualified colorimetric probes are eliminated, thereby significantly improving the measurement precision and accuracy.

The invention relates to a method for measuring the pH value of an aqueous solution based on gold nanorods, and belongs to the technical field of nano materials. The method comprises the following steps: (A) adding a gold nanorod solution and an etching solution into a to-be-detected solution, and then continuously monitoring RGB color space values of the solution corresponding to red, green and blue color component values until the etching reaction is finished; (B) converting the GRB color space value into a hue value; (C) mapping the tone value to the etching reaction time in the polar coordinate system to obtain a reverse value of the tone within 400 seconds after the etching is started and a maximum forward rotation value in the whole etching process; and (D) when the reverse rotation value is less than 38 degrees, substituting the maximum forward rotation value of the hue value into the correction curve to realize the measurement of the pH value. According to the method provided by the invention, the quality of the gold nanorod is discriminated through the reversal value in the measurement process, and unqualified colorimetric probes are removed, so that the measurement precision and accuracy are remarkably improved.

The invention relates to the technical field of pharmaceutical analysis, and particularly discloses a method for detecting genotoxic impurities in safinamide mesylate. The detection method comprises the following steps: a test solution and a reference solution are prepared; and the test solution and the reference solution are detected by adopting a liquid chromatography-mass spectrometry method, and the chromatographic conditions of liquid chromatography are as follows: a C18 chromatographic column is adopted, a formic acid aqueous solution with the volume concentration of 0.1% is taken as a mobile phase A, a methanol solution of formic acid with the volume concentration of 0.1% is taken as a mobile phase B, and gradient elution is performed; and the mass spectrum adopts an ESI ion source and a positive ion detection mode. The detection method provided by the invention has the advantages of being simple, convenient, stable, high in precision, good in reproducibility and the like, can be used for rapidly and accurately detecting the toxic impurities in the safinamide mesylate raw material medicine, and accords with the guiding principle of ICH M7.