The invention provides a high efficiency livestock and poultry nutrition replenisher and a preparation method thereof, and the nutrition replenisher contains various vitamins, amino acids and electrolyte. Simultaneously, the multi-stage premixing process is adopted by the high efficiency livestock and poultry nutrition replenisher, so that the high mixing uniformity of ultra-trace elements can beensured; and furthermore, sanguinarine is introduced into drinking water nutrition replenisher and is processed by peridium treatment, and emulsification treatment is carried out on liposoluble vitamins, so that good water-solubility can be guaranteed. The high efficiency livestock and poultry nutrition replenisher has comprehensive nutrition, leads all nutrient components to be supplemented witheach other, can effectively prevent deficiency of the vitamins and the amino acids, maintains electrolyte balance, regulates the metabolism of organism, improves the feed conversion rate and the anti-stress capability, stimulates the immune function, reduces the occurrence of diseases, and has remarkable economic and social benefits as well as broad market prospect.