A multi-element mixed
refrigerant suitable for cryogenic regions of -130 to -180 DEG C comprises five groups of substances: 1) the combination of at least two of
nitrogen,
argon,
neon or
alkyl; 2)
tetrafluoromethane and
methane or the combination thereof; 3) trifluoromethane, ethane,
ethylene and
fluoromethane or the combination of at least two thereof; 4) perfluoropropane,
difluoromethane,
propane, propylene and
hexafluoropropylene or or the combination of at least two thereof; 5) 1,1,1,2,2-perfluoropropane, 1,1,1,2,3,3,3-heptafluoropropane, perfluoro-n-
butane, 1,1,2,2-tetrafluoropropane, 1,1,1,2,3,3-hexafluoropropane, 1,1,1,3,3-perfluoropropane, 1,1,1,2,2,3,3,4,4-nonafluorobutane, 1,1,1,2,2,3,3-sevofluorobutane, 1,1,1,2,2,4,4,4-perfluorobutane, 1,1,2,3-perfluoropropane, 1,1,2,2,3-perfluoropropane, 1,1,1,2,3,4,4,4-perfluorobutane and 1,1,1,2,2,3,3,4-perfluorobutane or the combination of at least two thereof. The multi-element mixed
refrigerant can achieve
refrigeration of -130 to -180 DEG C safely and efficiently, the
greenhouse effect is low and no
ozone layer is destroyed.