Active artificial cornea and preparation method thereof

Abstract

The invention discloses an active artificial cornea and a preparation method thereof. The artificial cornea has a one-piece synthetic high-molecular polymer hydrogel structure containing gradient components, and is prepared from a biological inactive central optical part and a biological active peripheral part. According to the preparation method, a substrate, which is optically transparent in the center and has gradient hydrogel properties at the periphery, of the artificial cornea is prepared; the central parts (inner face and outer face) of the substrate of the artificial cornea are coated with polyvinylidene fluoride, tetrafluoromethane and heptafluoropropane by using a nano-coating technology and are then subjected to plasma treatment, so that inert surfaces are formed; after that, collagen grafting as well as small molecule peptide and growth factor induced activation are carried out on the periphery of the substrate, so that the biological activity and tissue engineering of the substrate are realized; finally, the active artificial cornea which is excellent in center optical properties, good in peripheral biocompatibility, simple in structure and convenient for operation and can stably exist for a long time without prolapsing can be obtained. Perforated hole structures are made at the periphery of the artificial cornea, so that the artificial cornea is facilitated to be closely jointed with the eyes of a patient.

Description

technical field [0001] The present invention relates to ophthalmic medical apparatus and supplies, in particular to an active artificial cornea and a preparation method thereof. Background technique [0002] Corneal disease is currently the main cause of blindness in the world, accounting for the second leading cause of blindness in ophthalmology. There are 32.37 million patients with corneal disease in my country, and the number of blind patients has reached more than 4 million. With the increase of trauma, chemical injury, infection and other patients, the number of blind patients increases by more than 100,000 every year. The best treatment for corneal disease is a corneal transplant, and in the vast majority of these patients, vision can be restored with a corneal transplant. However, due to the severe shortage of donor corneal materials, only about 5,000 patients can undergo corneal transplantation each year, accounting for only 2% of the actual cases requiring surgery...

AI Technical Summary

Problems solved by technology

Moreover, some patients may experience complications such as conjunctival flap leakage, corneal anterior stroma thinning and dissolution, and even artificial corneal discharge.

(2) The MICOF artificial cornea produced in Russia has a certain effect on chemical injury of the eye, but there are problems such as complicated surgical methods and many complications; (3) self-developed improved polyethylene glycol based on the Chirila Pros artificial cornea Methyl acrylate-polymethyl methacrylate integrated artificial cornea, which is still in the stage of animal testing

[0024] Many artificial corneal materials, due to the use of polymer materials, metals or inorganic materials, lead to insufficient biocompatibility, immune reactions, etc., causing inflammation, corneal dissolution, and prolapse of the artificial cornea. The fundamental reason is that artificial materials cannot interact with the host. Cornea produces ideal biological healing

[0025] (2) Maintain the optical transparency and biological inertness of the center of the artificial cornea (fitting the pupil): some materials overcome the lack of biocompatibility and can fit closely with the human eye. However, due to cell growth and newborn The growth of blood vessels, or the adhesion and deposition of other substances in the eye, causes the formation of anterior and posterior membranes, so that the central part of the corneal material will gradually lose optical transparency after a period of time, and cannot maintain the best visual function, resulting in the failure of the artificial corneal material

[0027] (1) The existing patents seldom take into account the biocompatibility of the artificial cornea periphery, use less active ingredients that can promote the growth of peripheral corneal cells, and do not consider the use of gradient hydrogel as the corneal peripheral material importance;

[0028] (2) Most artificial corneas adopt an integrated design, and the central optical part is also compounded with hydrogel components, which can easily cause some cells and new blood vessels to grow in, or the adhesion and deposition of other substances in the eye, resulting in the anterior and posterior membranes. form, gradually lose their transparency;

[0029] (3) In the existing artificial cornea patents, the central part of the designed cornea is not biologically inert.

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