32 results about "Palmoxiric Acid" patented technology

Disclosed are: surface-treated calcium carbonate which can impart a high viscosity and high thixotropic properties to a paste-like resin composition when added to the composition and can impart good mechanical properties and good adhesion properties to a cured product of the paste-like resin composition; and a paste-like resin composition containing the surface-treated calcium carbonate. The surface-treated calcium carbonate is produced by treating the surface of calcium carbonate with a surface-treating agent comprising a sodium salt or a potassium salt of a fatty acid, is characterized in that the sum total of PW and SW (PW + SW) is 90 or more and the ratio of PW to SW (PW / SW) falls within the range from 0.30 to 1.1 inclusive (wherein PW represents the content (wt%) of the sodium salt or the potassium salt of palmitic acid in the surface-treating agent in terms of acid content; and SW represents the content (wt%) of the sodium salt or the potassium salt of stearic acid in the surface-treating agent in terms of acid content), and is also characterized in that SA2 falls within the range from 15 to 48 inclusive and the ratio of FA to SA2 (FA / SA2) falls within the range from 0.095 to 0.135 inclusive (wherein SA2 represents the BET specific surface area (m2 / g) of the surface-treated calcium carbonate; and FA represents the amount of the sodium salt or the potassium salt of the fatty acid to be used for the treatment in terms of acid content relative to 100 parts by weight of calcium carbonate).

A powder injection of a donepezil semi palmoxiric acid salt, a composition containing the same and a preparation method therefor. The powder injection contains donepezil semi palmoxiric acid salt crystals, and the average grain size of the crystals ranges from 0.5 μm to 100 μm.

The invention belongs to the field of feed processing and particularly provides ruminant animal fat powder. The ruminant animal fat powder is prepared by matching hexadecanoic acid, high-melting-point palm oil, soybean concentrated phospholipids and the like as main fat raw materials with a carrier. The ruminant animal fat powder has no influence on normal physiological activity of microflora in ruminant animal rumen, can pass through the rumen, can be converted into an absorbed form under the actions of chemistry and enzyme in abomasums and duodenum of a digestion system and is digested, absorbed and utilized by small intestine. The product prepared by a formula and a processing technique of the invention is favorable in flowing property and can be mixed to the feed by adopting corresponding dosage stirring according to the requirement of animal nutrition; and the product is convenient and practical and is convenient for storage and transportation.

The invention discloses a solid cefprozi lipid nanoparticle preparation and a preparation method thereof. Cefprozi, palmitic acid and glycerol tristearate are dissolved in an organic solvent to form an oil phase; and with a water solution of polyoxyethylene 40 stearate as water phase, the cefprozi is entrapped in a solid lipid nanoparticle to obtain the solid cefprozi lipid nanoparticle preparation by adopting a mixed emulsifying and high-pressure uniformly-emulsifying combined method. The solid lipid nanoparticle preparation provided by the invention has the advantages of high drug loading amount, uniformity in grain size, long reservation time of a medicament in blood circulation and better slowly-releasing and controlled-release effects; and the quality of a preparation product is improved and toxic or side effects are reduced. In addition, equipment used by a preparation method is simple, easy for operation and suitable for industrial large-scale production.

The invention belongs to the technical field of medicine, and specifically relates to a paclitaxel palmitate liposome and a preparation method thereof, wherein paclitaxel palmitate is obtained by esterifying palmitic acid and the 2' hydroxyl of paclitaxel, and belongs to the pro-paclitaxel liposome medicine. The prodrug fundamentally changes the problem of poor fat solubility of paclitaxel, and substantially solves the problem of poor druggability of paclitaxel nano-preparations. Aiming at the special physical and chemical properties of paclitaxel palmitate, the present invention has carried out matching research on the composition of the prescription and the preparation process, and developed a polyoxyethylene castor oil-free, safe, stable quality and simple preparation process in the true sense. Paclitaxel palmitate liposomes have laid a solid foundation for the further research and application of paclitaxel in the field of anti-tumor.

The invention provides a method for preparing vitamin A palmitate by enzyme catalysis, and relates to a synthesis method of vitamin A palmitate. The method comprises the following steps of (1) dissolving the vitamin A palmitate and low-grade fatty alcohol palmitate into an organic solvent, and adding lipase; (2) performing vacuum pumping from a condenser, performing enzyme catalysis ester exchange reaction, and separating out a reaction byproduct of low-grade fatty alcohol acetate and an organic solvent through a rectifying column; (3) removing lipase from reaction material liquid, adding an adsorbent for adsorbing remained low-grade fatty alcohol palmitate, and filtering out the vitamin A palmitate solution; and (4) performing organic solvent reduced pressure evaporation to obtain the vitamin A palmitate. The oxidation cannot easily occur; meanwhile, the enzyme catalysis ester exchange is used during the reaction; the reaction conditions are mild; the side reactions can be effectively inhibited; the operation is simple; the reaction yield is high; and the product quality is high.

The invention discloses a method for synthesizing 1-(6-nitrobenzimidazolyl)ethyl palmitate on line under the catalysis of lipase. The method comprises the steps of with 6-nitro-benzimidazole and vinyl palmitate which are in the molar ratio of 1:(1-8) as raw materials, 0.5-1.0g of lipase Lipozyme TLIM as a catalyst and a DMSO solvent as a reaction solvent, uniformly filling a reaction channel of a microfluidic channel reactor with the lipase Lipozyme TLIM, wherein the internal diameter of the reaction channel of the microfluidic channel reactor is 0.8-2.4mm, and the reaction channel is 0.5-1.0m long; and continuously introducing the raw materials and the reaction solvent to the reaction channel to carry out Markovnikov addition reaction, controlling the reaction temperature at 40-55 DEG C and the reaction time at 20-35 minutes, collecting a reaction solution on line, and carrying out conventional treatment on the reaction solution to obtain 1-(6-nitrobenzimidazolyl)ethyl palmitate. The method has the advantages of short reaction time, high selectivity and high yield.

Provided is a method for preparing 1,3-dioleoyl-2-palmitoylglycerol in a subcritical system, comprising the following steps: (1) preparation of raw materials: selecting, as a raw material A, lard having a cholesterol content of less than 0.05% by mass, or selecting, as raw material A, restructured palm oil having an sn-2 palmitic acid content of not less than 60% by mass; and, selecting as a raw material B, at least one of oleic acid and an oleic acid ester; and (2) subcritical enzyme-catalyzed transesterification: in a subcritical system, enabling raw materials A and B to undergo selective enzymatic transesterification in a reaction solvent under the catalysis of lipase to obtain 1,3-dioleoyl-2-palmitoylglycerol. With a rapid reaction rate, high selectivity, minimal enzyme usage, and no solvent residue, this method is readily adapted to large-scale continuous production.