Bacteriostatic benzoic acid type enteric sustained-release acidifier and preparation method thereof

Abstract

The invention relates to a bacteriostatic benzoic acid type enteric sustained-release acidifier and a preparation method thereof. The bacteriostatic benzoic acid type enteric sustained-release acidifier is prepared from the following materials by weight percent: 10-60% of benzoic acid, 5-10% of lactic acid, 5-15% of fumaric acid, 5-10% of silica, 5-10% of microcrystalline cellulose and / or corn starch, 5-10% of beta-cyclodextrin and / or maltodextrin, and 10-40% of stearic acid and / or palmitic acid or acrylic resin. The preparation method comprises the following steps: S1: carrying out pretreatment on benzoic acid; S2: carrying out solid-liquid mixing; S3: carrying out solid-solid mixing; S4: tabletting and granulating; S5: carrying out three-stage screening; S6: preparing a coating material;S7: coating; S8: atomizing the coating material, and spraying into a coating machine for coating; after the coating is completed, discharging the material into an automatic screening machine, and screening to obtain the finished product. The product prepared by the method can be released in sections in the gastrointestinal tract, so that the benzoic acid is prevented from being completely absorbed by the anterior segment of the digestive tract, and the acidification range is effectively expanded; furthermore, the preparation process is simple to operate, the degree of automation is high, andthe production cost can be greatly reduced.

Description

technical field [0001] The invention relates to the field of feed additives, in particular to a bacteriostatic benzoic acid type intestinal slow-release acidifier and a preparation method thereof. Background technique [0002] Benzoic acid is a broad-spectrum antibacterial agent, and its antibacterial effect is better than that of general organic acidifiers. Added in animal feed, it can inhibit harmful bacteria, increase the diversity of intestinal flora, and reduce ammonia emissions. Most of the benzoic acid on the market is untreated pure benzoic acid. Untreated pure benzoic acid is easily absorbed by the intestinal wall, and only a small amount of benzoic acid enters the intestinal tract. The absorbed benzoic acid quickly enters the blood and causes an increase in blood sugar concentration, which interacts with sugars in the ration, resulting in satiety and pauses in eating due to the blood sugar effect. On the other hand, the ionization constant of benzoic acid is 4.2....

AI Technical Summary

Problems solved by technology

Its advantage is that it can form a certain protection against the acidifier and avoid the reaction between the acidifier and the feed. However, the production input cost of this method is large, the operation process is complicated, and the cysts are easy to aggregate, resulting in encapsulation failure, resulting in high addition costs, and cannot be used. Widespread use

[0004] Defects in the prior art: 1. Benzoic acid is easily absorbed by the intestinal wall, and is in an ion state under the intestinal environment, causing animals to stop feeding; Benzoic acid has a pungent smell and poor palatability; in practical applications, the addition amount is high

2. Existing coated slow-release technology: the disadvantage of using the embedding technology is that part of the acid is exposed outside, and it is easy to react with other raw materials in the feed, affecting the potency of the nutritional elements in the compound feed; the acidifier mainly acts on digestion. The front part of the tract, can not reach the intestinal tract, the effect is low

Made into micropills or microcapsules, this method has high production input costs, complex operation process, easy aggregation of encapsulated substances, resulting in encapsulation failure, resulting in high addition cost, and cannot be widely used

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