The invention provides a Nnintedanib
inclusion compound and preparation and a preparation method thereofof the preparation. The
inclusion compound comprises a main
drug and an inclusion material, wherein the main
drug is Nnintedanib or pharmaceutically acceptable salt in
pharmacy, and the inclusion material is
cyclodextrin or a derivative of cyclodrxtrin. The
inclusion compound can sharply improvethe
drug solubility of a simulated intestinal solution, the probability of the drug being separated out in the intestinal canal is lowered, and accordingly the
bioavailability of the drug is improved. The inclusion compound and the preparation prepared from the inclusion compound and pharmaceutically acceptable ingredients in the
pharmacy can outstandingly improve the
dissolution degree and the
dissolution rate of the drug in the simulated intestinal solution, the
bioavailability of the drug is improved, meanwhile, the inclusion compound and the preparation have good stability, thus the flexibility and compliance of
drug taking of patients are improved, and accordingly the
treatment effect of the drug is improved. In addition, the invention provides a preparation method of the medicinal preparation of the Nnintedanib inclusion compound, no specific equipment is needed, the technology is simple, the production cost is low, and the preparation method is suitable for industrialized production.