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Application of nintedanib in external preparation drug for treating psoriasis

A technology of nintedanib and topical preparations, which can be applied in drug combinations, medical preparations containing active ingredients, skin diseases, etc., and can solve the problems of nintedanib's activity and use that have not been seen

Inactive Publication Date: 2017-08-11
REYOUNG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report on the activity and use of nintedanib for the treatment of psoriasis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Nintedanib and a suitable base are made into paste-like ointment for external use: 1g of nintedanib, 83g of white petrolatum, 6g of Span, and 10g of propylene glycol, mixed to obtain a cream for external use with a mass content of nintedanib of 1%. . Its properties and appearance are uniform in texture, delicate in appearance, and stable in quality. It has no obvious acute toxic reaction, no irritation, and no local and systemic allergic reactions when applied to the skin.

Embodiment 2

[0023] Nintedanib 3g, white petrolatum 81g, Span 6g, propylene glycol 10g, mixed to obtain a cream for external use with a mass content of nintedanib of 3%. Its properties and appearance are uniform in texture, delicate in appearance, and stable in quality. It has no obvious acute toxic reaction, no irritation, and no local and systemic allergic reactions when applied to the skin.

Embodiment 3

[0025] Nintedanib 9g, white petrolatum 75g, Span 6g, propylene glycol 10g, mixed to obtain a cream for external use with a mass content of nintedanib of 9%. Its properties and appearance are uniform in texture, delicate in appearance, and stable in quality. It has no obvious acute toxic reaction, no irritation, and no local and systemic allergic reactions when applied to the skin.

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PUM

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Abstract

The invention relates to application of nintedanib or its physiologically acceptable salt in an external preparation drug for treating psoriasis. When the nintedanib or its physiologically acceptable salt is used for treating the psoriasis, a mode of locally applying an external preparation is adopted. During local application, the nintedanib or its physiologically acceptable salt can be in the form of a semisolid or liquid preparation containing the nintedanib or its physiologically acceptable salt and at least one physiologically acceptable excipient and / or adjuvant, and the preparation can be an ointment, cream, gel, a solvent agent, an emulsion, a mixed suspension or spray. An experiment shows that the nintedanib has the positive effect on the aspect of nintedanib treatment and can obviously inhibit epithelial mitosis and promote formation of a mouse tail scale epidermis particle layer.

Description

technical field [0001] The present invention relates to the new use of nintedanib or its physiologically acceptable salt for treating psoriasis. Background technique [0002] Psoriasis (Psoriasis) is commonly called as psoriasis, is a kind of chronic inflammatory skin disease, and the course of disease is long, has easy relapse tendency, and some cases almost never heal all one's life. The disease mainly occurs in young and middle-aged people, and has a great impact on the physical health and mental status of patients. The clinical manifestations are mainly erythema and scales, and the disease can occur all over the body. The scalp and the extensor sides of the limbs are more common, and it usually aggravates in winter. The pathological features are hyperproliferative epidermal cells and parakeratosis. [0003] At present, there are many drug treatments for psoriasis, including retinoic acid, anthralin, glucocorticoids, vitamin D3 analogs, tars, and new immunosuppressants....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/496A61P17/06
CPCA61K31/496
Inventor 苗得足胡清文曾丽丽吕帅
Owner REYOUNG PHARMA
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