Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Methods for treating fibrosis

A technology for fibrosis and pulmonary fibrosis, which is used in pharmaceutical formulations, medical preparations containing active ingredients, respiratory diseases, etc.

Inactive Publication Date: 2019-03-15
CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
View PDF2 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, attempts to develop clinically effective fibrosis treatments have been unsuccessful and there is still a need to find a cure for fibrosis

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods for treating fibrosis
  • Methods for treating fibrosis
  • Methods for treating fibrosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0062] Some of the methods used below can be found in SONTAKE et al., "Hsp90 regulation of fibroblast activation in pulmonary fibrosis" (2017) JCI Insight, Vol. 2, Issue 4, Entry e91454. > (incorporated herein by reference in its entirety).

[0063] Identification of naltrexone as a candidate therapeutic agent for idiopathic pulmonary fibrosis (IPF) using a computational approach. We used a previously published transcriptome dataset (GSE53845) recorded from lung biopsies of 40 IPF patients and 8 healthy controls. An IPF disease signature was created based on the mRNA expression data and a linear model was fitted for each gene to estimate the effect of IPF disease status and gene expression change (log2 fold change) in diseased versus normal control samples. The IPF gene signature was queried in the LINCS database, a resource with a large number of expression profiles. This database is a catalog of gene expression profiles collected from human cells subjected to chemical and ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Some embodiments of the invention include methods for treating an animal for fibrosis comprising one or more administrations of one or more compositions comprising one or more opioid receptor inhibitors. Other embodiments of the invention further include other fibrosis treatments. Still other embodiments of the invention include methods for treating a human for idiopathic pulmonary fibrosis, comprising administering one or more compositions comprising naltrexone and optionally administering one or more compositions comprising pirfenidone, nintedanib, or both. Additional embodiments of the invention are also discussed herein.

Description

[0001] Cross References to Related Applications [0002] This application claims the benefit of US Provisional Application 62 / 362,169, filed July 14, 2016, which is hereby incorporated by reference in its entirety. Background technique [0003] Fibrosis is the formation of excess fibrous connective tissue. In certain instances, fibrosis results in the accumulation of extracellular matrix proteins. [0004] Several compounds are known to treat fibrosis, but their treatment is inadequate. For example, pirfenidone and nintedanib are newly FDA-approved drugs for the treatment of idiopathic pulmonary fibrosis. However, pirfenidone had no effect on respiratory symptoms. Neither pirfenidone nor nintedanib had any effect on mortality. Thus, attempts to develop clinically effective fibrosis treatments have been unsuccessful, and a cure for fibrosis remains to be found. [0005] Certain embodiments of the present invention address one or more of the above-mentioned deficiencies. F...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395
CPCA61K45/06A61K31/4418A61K31/485A61K31/496A61P11/00A61K31/405A61K31/439A61K31/4412A61K2300/00
Inventor A·G·杰格S·K·马达拉
Owner CHILDRENS HOSPITAL MEDICAL CENT CINCINNATI
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com