Ethanesulfonic acid nintedanib preparation and application thereof
A technology of nintedanib ethanesulfonate and its application, which is applied in the directions of pill delivery, medical preparations without active ingredients, and medical preparations containing active ingredients, etc.
Inactive Publication Date: 2016-08-31
FOSHAN TENGRUI MEDICINE TECH CO LTD
View PDF2 Cites 7 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
There is currently no preventive method or internationally recognized curative treatment other than lung transplantation
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreExamples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0018] 50 mg of nintedanib ethanesulfonate capsules were prepared by the above method
[0019] Element
Embodiment 2
[0021] 100 mg of nintedanib ethanesulfonate capsules were prepared by the above method
[0022] Element
Embodiment 3
[0024] 150 mg of nintedanib ethanesulfonate capsules were prepared by the above method
[0025] Element
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More
Abstract
The invention discloses an ethanesulfonic acid nintedanib preparation and application thereof. The ethanesulfonic acid nintedanib preparation is prepared from ethanesulfonic acid nintedanib, lactose, microcrystalline cellulose and a pharmaceutically-acceptable carrier, and the ethanesulfonic acid nintedanib preparation with the good flowability, stability and dissolution rate can be obtained, so that the ethanesulfonic acid nintedanib preparation is suitable for large industrial production. The ethanesulfonic acid nintedanib preparation is the pharmaceutical composition for treating IPF, the compatibility is reasonable, medicine can be rapidly released, and the good treatment effect on the disease can be generated.
Description
technical field [0001] The present invention relates to the use of nintedanib ethanesulfonate for preparing medicines, especially for preparing tablets and capsules suitable for oral administration. [0002] Nintedanib esylate, molecular formula: C31H33N5O4·C2H6O3S, molecular weight: 649.76 [0003] It is a third class of new drugs for the treatment of idiopathic pulmonary fibrosis (IPF) and is currently undergoing preclinical research. Background technique [0004] Nintedanib is an oral triple angiokinase inhibitor developed by Boehringer Ingelheim. In October 2014, the FDA approved OFEV® (nintedanib) for the treatment of idiopathic pulmonary fibrosis (IPF). , the first tyrosine kinase inhibitor (TKI) approved for the treatment of IPF. Nintedanib acts on growth factor receptors that have been shown to have potential effects in the pathological mechanism of pulmonary fibrosis, the most important of which are platelet-derived growth factor receptor (PDGFR), fibroblast growt...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/48A61K31/496A61K45/06A61K47/26A61K47/38A61K47/36A61K47/10A61K47/02A61P11/00
CPCA61K31/496A61K9/0056A61K9/2054A61K9/4866A61K45/06
Inventor 王雪峰韩亮
Owner FOSHAN TENGRUI MEDICINE TECH CO LTD
Who we serve
- R&D Engineer
- R&D Manager
- IP Professional
Why Patsnap Eureka
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com