45 results about "Localised inflammation" patented technology

The present disclosure relates to parenteral nutrition formulations, including ready-to-use parenteral nutrition formulations which are reconstituted from multi-chamber containers and amino acid formulations. More particularly, the present disclosure is directed to formulations comprising butyrate derivatives, specifically arginine butyrate, for use with adult or pediatric patients. The disclosure further provides for methods of reducing or preventing systemic and local inflammation of patients receiving parenteral nutrition, and methods of maintaining or ameliorating their systemic immunity and local immunity, as well as the patients' gut barrier functions.

The invention discloses a non-woven fabric, a production process of the non-woven fabric and baby diapers made of the non-woven fabric, and belongs to the technical field of light industry. The surface of the non-woven fabric is attached with sodium bicarbonates and shikonin. The preparation method includes the following steps that aqueous solutions are modulated, and the aqueous solutions are prepared according to the mass ratio of water, the sodium bicarbonates and the shikonin of (90-110) : (3-5) : 1; atomization and spraying are conducted, and the modulated aqueous solutions are atomized and sprayed onto carded and formed screen cloth; and heat seal, evaporation and forming are conducted. The non-woven fabric can dissolve effective ingredients of inhibiting fungi and eliminating localskin inflammation after being treated with water, thus improving the safety and comfort of the non-woven fabric for baby skin. The sodium bicarbonates and the shikonin can produce a synergistic effect, on one hand, the uric acid in the urine of babies can be neutralized to make the urine be weakly alkaline and avoid the irritation to baby skin, and on the other hand, under the weakly alkaline condition, the shikonin can be dissolved and plays an antibacterial and antiphlogistic role.

Disclosed are means of treatment of cancer by enhancing efficacy of oncolytic virus ability to eradicate tumors through the destruction / inactivation of cancer endothelial cells through immunological means. In one embodiment of the invention, administration of placental endothelial cells generated antitumor endothelial immune responses are used to sensitize tumors to oncolytic viral entry. In another embodiment, oncolytic viruses are utilized to enhance generation of cancer endothelial specific responses by causing localized inflammation in the tumor endothelium, which enhances efficacy of the tumor endothelial targeting vaccine. In another embodiment, the invention teaches the use of replication deficient oncolytic viruses to deliver proteins to tumor cells in an immunogenic manner such that proteins encoded by the oncolytic viruses induce immunity to tumor endothelial cell antigens.

The invention belongs to the field of medicine, and specifically discloses the application of irisin in the prevention and treatment of severe acute pancreatitis. In mice with severe acute pancreatitis, intravenous injection of exogenous irisin can significantly improve the function of the pancreas and alleviate the symptoms of severe acute pancreatitis. Endoplasmic reticulum stress in pancreatic cells can reduce pancreatic tissue damage and cell death, indicating that irisin can significantly improve severe acute pancreatitis; apply irisin to drug development, and inject intravenously when acute pancreatitis is diagnosed in the emergency department to block and prevent pancreas In the case of inflammation, the local inflammatory response progresses to systemic inflammatory response syndrome or reduces the effect of chain expansion of systemic inflammatory response syndrome, thereby inhibiting the severity of pancreatitis, protecting local organs and preventing the occurrence of multiple organ failure syndrome; The invention provides a brand-new choice and thought for the current prevention and treatment of severe acute pancreatitis.

Compositions containing purified collagen biomaterial derived from tissues, for example, insoluble amnion, soluble amnion, soluble chorion of the human placenta, are provided. The collagen compositions can be used to promote wound healing, promote tissue regeneration, prevent or reduce scarring, reduce local inflammation, minimize tissue rejection, promote graft integration. Methods for using the collagen composition as a biomaterial implant for dermal filling, skin grafting, and hair transplantation are also provided.

The invention discloses application of lactic acid and salt thereof. The lactic acid and the salt thereof are applied to preparation of drugs for preventing or treating ethanol-induced gastric mucosal lesion, and the salt is pharmaceutically acceptable salt. The lactic acid can reduce uncontrolled local inflammatory response when gastric mucosa is damaged, and intervene in apoptosis of gastric mucosa cells by down-regulating expression of Bax and Caspase-3 genes; and in addition, the lactic acid can up-regulate the expression of tight junction protein genes such as Occludin, Claudin-1 and Claudin-5 in gastric tissues, and finally, the severity of the ethanol-induced gastric mucosal lesion is remarkably relieved.

The invention belongs to the technical field of traditional Chinese medicine, and specifically relates to a plaster for treating rheumatic bone disease and a preparation method thereof, which is prepared from the following raw materials in parts by weight: 3 parts of angelica, 3 parts of Chuanxiong, 3 parts of frankincense, 3 parts of myrrh, 2 parts of cinnamon sticks, 2 parts of safflower, 2 parts of ground turtle, 2 parts of Clematis, 2 parts of sumac, 3 parts of Achyranthes bidentata, 2 parts of Asarum, 2 parts of Zhicaowu, 2 parts of Zhichuanwu 2 parts, 2 parts of southern star, 2 parts of pinellia, 3 parts of rhubarb, 3 parts of bletilla striata, 2 parts of zhebei, 2 parts of angelica dahurica, 2 parts of nuxychee, 3 parts of turmeric, 10 parts of borneol, 500 parts of sesame oil, the present invention A variety of Chinese herbal medicines are used in combination and comprehensive treatment. The active ingredients of the medicine penetrate into the lesion through the skin, improve the blood circulation of the lesion, promote the subsidence of local inflammation and edema, relieve muscle tension and spasm, and quickly relieve symptoms. It is suitable for various Rheumatic bone diseases such as rheumatism, rheumatoid arthritis, degenerative arthritis, etc. The medicine components are cheap and suitable for industrial production.