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Application of cationic polymer in medicine preparation

A cationic polymer and cationic technology, applied in the field of medicine, can solve the problems of immunosuppression and metabolic disorders, which are difficult to be widely used and lack, and achieve the effects of preventing and treating fatty liver disease, relieving local inflammation, and relieving sepsis

Pending Publication Date: 2022-03-08
SQ BIOPHARMA INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The third category is inflammation inhibitors, such as glucocorticoids. Although they have a strong immunosuppressive effect and can control inflammatory storms, their immunosuppression and metabolic disorders are difficult to be widely used
[0033] However, there is still a lack of a simple, safe and low-cost method for treating the above diseases

Method used

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  • Application of cationic polymer in medicine preparation
  • Application of cationic polymer in medicine preparation
  • Application of cationic polymer in medicine preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] The preparation and new clinical application of the high-molecular cationic polymer described in the present invention include treating, alleviating, and preventing various organ failures caused by intestinal microbial toxins, including liver failure, pneumonia failure, renal failure, and sepsis , Acute pneumonia and severe illness caused by Covid-19 infection. As an example of implementation, it includes amine polymers; its preferred practical application is polystyrene quaternary ammonium salt, cholestyramine (cholestyramine, CAS#11041-12-6, referred to as "polyaniline"), the amine polymer Compounds include repeating units derived from the polymerization of amine monomers and crosslinking monomers, such as polystyrene quaternary ammonium salt ([4-[3-(4-ethylphenyl)butyl]phenyl]-trimethylazanium), which has the molecular formula C 21 h 30 N+, including its various derivative structures, such as modified polyallylamine, copolymer of diethylenetriamine, (C 4 h 10 N 3...

Embodiment 2

[0080] The preparation and new clinical application of the high-molecular cationic polymer described in the present invention include treating, alleviating, and preventing various organ failures caused by intestinal microbial toxins, including liver failure, pneumonia failure, kidney failure, sepsis, Acute pneumonia and severe illness caused by Covid-19 infection. It also includes the treatment of various metabolic diseases, including fatty liver and obesity. As an example of implementation, amine polymers are included. As this preferred application, Colestipol (Colestipol, hydrochloride, Epichlorhydrin-tetraethylenepentamine polymer, CAS No.37296-80-3; Molecular Weight: (225.765) n; Molecular Formula: (C 4 h 10 N 3 ) m (C 3 h 6 O) n ), or similar cation-rich polymers. Its molecular mass (molecular mass) exceeds 1x10 6 g / mol, its molecular structure is as follows:

[0081]

[0082] Therefore, the high-molecular-weight cationic polymer can be used for the treatment...

Embodiment 3

[0085] Colesevelam (Colesevelam) is another high molecular weight cationic polymer, its bile acid binding ability is 7 times that of colestyramine. Based on its structural similarity, oral colesevelam preparations can also reduce endotoxins produced by intestinal cells, reduce endotoxins in the blood, thereby reducing systemic inflammation in the body, relieve liver failure, and various severe diseases, and improve patient outcomes. survival rate; the application can also promote the self-ablation of NASH and liver cirrhosis. The daily dosage can refer to 1-4g, and can be administered with powder or tablet. The specific dose depends on the condition. The molecular formula of colesevelam is C 31 h 67 Cl 3 N 4 O; CAS#: 182815-44-7. International Union of Pure and Applied Chemistry (IUPAC) named: 2-(chloromethyl)oxirane; prop-2-en-1-amine; N-prop-2-enyldecan-1-amine; trimethyl-[6-(prop- 2-enylamino)hexyl]azanium; chloride; hydrochloride.

[0086]

[0087] Where A=Prima...

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Abstract

The invention relates to application of a cationic polymer in preparation of a medicine for preventing or treating diseases caused by toxins generated by intestinal microorganisms or diseases caused by new coronavirus infection. Toxin released by intestinal microorganisms can be neutralized and cleared by oral administration of cationic polymers, and most of these microbial toxins present anionic acidity. By adopting the application, various intestinal microbial toxins entering blood can be reduced; therefore, systemic inflammation, local inflammation, hepatic failure and liver injury, insulin tolerance, fatty liver disease, lung failure, kidney failure, hepatic encephalopathy, septicemia and inflammatory storm, severe illness and the like caused by novel coronavirus infection are relieved; the traditional Chinese medicine composition can also be used for treating ICU patients, reducing systemic inflammation, recovering organ functions and improving the survival rate, and can also be used for preventing or treating chronic inflammation and various metabolic diseases caused by intestinal bacterial toxins, preventing and treating fatty liver diseases, relieving insulin tolerance, relieving diabetes mellitus and relieving obesity.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of a cationic polymer in the preparation of medicines. Background technique [0002] As one of the important organs of the human body, the liver has the functions of synthesis, detoxification, metabolism, secretion, biotransformation and immune defense. When severe damage is caused by various factors (such as viruses, alcohol, drugs, etc.), a large amount of necrosis of liver cells is caused, resulting in serious impairment or decompensation of the above-mentioned functions, and then the coagulation mechanism disorder and jaundice, hepatic encephalopathy, ascites A group of clinical syndromes mainly manifested as liver failure. Symptoms of the disease include extreme fatigue, severe gastrointestinal symptoms (abdominal pain, abdominal distension, nausea, loss of appetite, vomiting), progressive yellowing of skin and mucous membranes, progressive deepening of uri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K31/787A61K38/17A61P31/14A61P31/04A61P29/00A61P1/16A61P11/00A61P13/12A61P25/00A61P1/00A61P3/00A61P3/10A61P3/04A61P5/50A61P39/02
CPCA61K45/06A61K31/787A61K38/1729A61P31/14A61P31/04A61P29/00A61P1/16A61P11/00A61P13/12A61P25/00A61P1/00A61P3/00A61P3/10A61P3/04A61P5/50A61P39/02
Inventor 韩源平
Owner SQ BIOPHARMA INC
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