Application of irisin in the preparation of medicines for the prevention and treatment of severe acute pancreatitis

A technology of acute pancreatitis and irisin, applied in the field of medicine, can solve the problem of lack of irisin and other problems, and achieve the effects of preventing multiple organ failure syndrome, inhibiting severe disease and protecting local organs

Active Publication Date: 2021-10-22
崇好科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no report on the application of irisin in severe acute pancreatitis

Method used

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  • Application of irisin in the preparation of medicines for the prevention and treatment of severe acute pancreatitis
  • Application of irisin in the preparation of medicines for the prevention and treatment of severe acute pancreatitis
  • Application of irisin in the preparation of medicines for the prevention and treatment of severe acute pancreatitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1: 100 micrograms of irisin were dissolved in 10 milliliters of physiological saline to prepare 10 ug / ml injection.

[0021] Take this injection as an example to study the effect of irisin on severe acute pancreatitis.

[0022] Animal experiment.

[0023] 1. Experimental animals: 20-25g male C57BL / 6J mice were randomly divided into 4 groups, 6 in each group:

[0024] Normal control group (Sham);

[0025] Severe acute pancreatitis control group: mice were intraperitoneally injected with 8% L-arginine 4g / kg (Vehicle);

[0026] Severe acute pancreatitis high-dose irisin treatment group: mice were intraperitoneally injected with 8% L-arginine 4g / kg, and then given 250 μg / kg irisin (H-Irisin) 2 hours later.

[0027] Severe acute pancreatitis low-dose irisin treatment group: mice were intraperitoneally injected with 8% L-arginine 4g / kg, and then given 50ug / kg irisin (L-Irisin) 2 hours later.

[0028] II: Severe acute pancreatitis model establishment: Vehicle mice ...

Embodiment

[0041] Example: 100 micrograms of irisin were dissolved in 5 milliliters of physiological saline to prepare a 20 ug / ml injection.

[0042] Take this injection as an example to study the effect of irisin on severe acute pancreatitis.

[0043] Animal experiment.

[0044]1. Experimental animals: 20-25g male C57BL / 6J mice were randomly divided into 4 groups, 6 in each group:

[0045] Normal control group (Sham);

[0046] Severe acute pancreatitis control group: mice were intraperitoneally injected with 8% L-arginine 4g / kg (Vehicle);

[0047] Severe acute pancreatitis high-dose irisin treatment group: mice were intraperitoneally injected with 8% L-arginine 4g / kg, and then given 250 μg / kg irisin (H-Irisin) 2 hours later.

[0048] Severe acute pancreatitis low-dose irisin treatment group: mice were intraperitoneally injected with 8% L-arginine 4g / kg, and then given 50ug / kg irisin (L-Irisin) 2 hours later.

[0049] II: Severe acute pancreatitis model establishment: Vehicle mice we...

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PUM

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Abstract

The invention belongs to the field of medicine, and specifically discloses the application of irisin in the prevention and treatment of severe acute pancreatitis. In mice with severe acute pancreatitis, intravenous injection of exogenous irisin can significantly improve the function of the pancreas and alleviate the symptoms of severe acute pancreatitis. Endoplasmic reticulum stress in pancreatic cells can reduce pancreatic tissue damage and cell death, indicating that irisin can significantly improve severe acute pancreatitis; apply irisin to drug development, and inject intravenously when acute pancreatitis is diagnosed in the emergency department to block and prevent pancreas In the case of inflammation, the local inflammatory response progresses to systemic inflammatory response syndrome or reduces the effect of chain expansion of systemic inflammatory response syndrome, thereby inhibiting the severity of pancreatitis, protecting local organs and preventing the occurrence of multiple organ failure syndrome; The invention provides a brand-new choice and thought for the current prevention and treatment of severe acute pancreatitis.

Description

technical field [0001] The invention relates to the field of medicine, in particular to the application of irisin in medicines for preventing and treating severe acute pancreatitis. Background technique [0002] Acute pancreatitis (Acute Pancreatitis, AP) is a common acute abdomen in clinical practice, and 20%-25% of the patients are clinically severe, with local or systemic complications, multiple organ failure, and even life-threatening. Severe acute pancreatitis (Severe Acute Pancreatitis, SAP). The etiology of SAP is complex, and its pathogenesis has not yet been fully clarified. According to the World Health Organization, SAP will become the number one cause of death in pancreatic diseases by 2020. After nearly 30 years of research, the treatment effect of severe acute pancreatitis in my country has been significantly improved, and the treatment viewpoint has also reached a consensus in principle, that is, individualized treatment plans for different etiologies and dif...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/39A61P1/18
CPCA61K38/39A61P1/18
Inventor 吴荣谦任一凡吕毅
Owner 崇好科技有限公司
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