54 results about "Helicobacter pylori infection" patented technology

A rapid, non-invasive breath-test method and device for diagnosing the presence or absence of H. pylori in a subject without administration of isotopic tracers is described. The device consists of a highly sensitive colorimetric ammonia sensor placed in contact with sampled subject breath. The sensor is measured using appropriate reflection spectroscopy instrumentation. The breath-test method consists of measuring a basal ammonia level with the device, administering non-isotopic urea and continuing measurement of the ammonia content in a plurality of consecutive breaths. Diagnostic differences in breath ammonia are identified between H. pylori infected and uninfected individuals.

The invention provides an intragastric floating tablet for periplaneta americana. The intragastric floating tablet is a tablet prepared from periplaneta americana powder or periplaneta americana extracting solution as an active ingredient and an auxiliary material, wherein the weight ratio of the active ingredient to the auxiliary material is 1:(1-30), preferably 1:(2-20), and more preferably 1:19. The intragastric tablet can stay longer in stomach, can well treat helicobacter pylori infection gastritis, peptic ulcer and gastric cancer, and has a wide market prospect.

The invention relates to an application of bacillus coagulans in preparing preparations for preventing and treating helicobacter pylori infection, and in particular relates to an application in preventing or eradicating gastric or duodenal helicobacter pylori infection.

PCT No. PCT / SE96 / 01428 Sec. 371 Date May 7, 1998 Sec. 102(e) Date May 7, 1998 PCT Filed Nov. 6, 1996 PCT Pub. No. WO97 / 17612 PCT Pub. Date May 15, 1997A method for identification of an infant being particularly susceptible to sudden infant death syndrome (SIDS) comprises the determination of an Helicobacter pylori infection in the infant's mother, particularly by detection of antibodies to H. pylori of the IgG type, in a blood sample drawn from the infant's mother or by determination of carbon dioxide formed from urea in the air exhaled from the infant's mother upon oral administration of a challenge dose of urea. Also disclosed is the use of an antibiotic effective against H. pylori for the manufacture of a medicament for administration to mothers and other persons infected by H. pylori and coming into close bodily contact with infants below two years of age, and a method of prevention of SIDS by administration of that antibiotic.

A composition used as health-care food or medicine for preventing and treating the digestive ulcer and chronic gastritis caused by pylorospirobacillus contains the vegetative lactobacillus LP-Onlly (CGMCC No.1258) and its metabolic product, and the extracts of 5 Chinese-medicinal materials including liquorice root, white peony root, astragalus root, etc.

The invention discloses a system for detecting Helicobacter pylori. The system comprises a laser output unit, a frequency locking unit, a detection unit, an air channel control unit and a display unit. The output wavelength of a semiconductor laser is adjusted by a laser temperature controller and a laser current controller, output laser is divided by a fiber splitter to form two beams, one beam of laser is input to the frequency locking unit to stabilize the wavelength in an absorption peak position, the other beam of laser enters the detection unit, the detection unit is provided with a white cell device in order to effectively increase the length of a light path and improve the detection sensitivity, a signal obtained by the detection unit is transmitted to the display unit, and an alarm gives an alarm when the <13>CO2 concentration of the display unit exceeds a preset concentration value in order to fast detect the existence of Helicobacter pylori in the stomach of a patient. The system effectively improves the detection sensitivity, allows the real-time detection sensitivity to be in ppm magnitude, greatly shortens the detection cycle, improves the detection accuracy, increases the stability, reduces the detection cost, and effectively meets application demands of medical detection.

The invention relates to a method for extracting and purifying Pinostrobin from medicinal plants, and a pharmaceutical preparation and application thereof. The invention particularly discloses a method for extracting and purifying Pinostrobin from medicinal plants, and a pharmaceutical preparation and application thereof in preparing medicines for treating gastroenteropathy, and belongs to the field of life sciences. The method comprises the following steps: extracting medicinal plants with 70-95% ethanol homogenate; and after the extract is concentrated to a certain volume, standing to precipitate, removing a supernatant, dissolving the obtained precipitate with an organic solvent, separating by gel-resin column chromatography, crystallizing and recrystallizing to obtain the Pinostrobin monomer of which the purity is higher than 90%. The Pinostrobin monomer in which different excipients can be added is prepared into any common pharmaceutical formulation. The pharmaceutical preparation has obvious biological activity on peptic ulcer, gastritis, stomachache, gastric evacuation (gasterectasis), alimentary tract tumors and the like caused by Helicobacter pylori infection, and has thecharacteristic of no toxic or side effect.

The present invention relates to a chicken vitellus antibody (anti-HPTxIgY) with antibody activity for resisting pyloric helicobacterium cytotoxin, its preparation method and application in the preparation of medicine and health-care product for curing related diseases resulted from pyloric helicobacterium infection and preparation for detecting these related diseases. The above-mentioned antibody is undergone the process of IgY purity checking treatment. PAGE electrophoressi can be used for detecting purified vitallus antibody purity. Only one electrophoretic band is produced in the electrophoresis, and an UV spectrophotometer is used for determination so as to calculate the albumen concentration (mg / ml) which is (1.45XOD 280nm-0.74XOD 260nm)X dilute multiple. The above-mentioned method is as follows: preparing pyloric helicobacterium cytotoxin antigen, immunizing health hen with said antigen, collecting egg and extracting anti-HPTxIgY from the egg.

The invention discloses a desert cistanche coffee beverage composition, relating to a health-care beverage composition suitable for long-term consumption, and belonging to the field of food health care. The desert cistanche coffee beverage composition is characterized by comprising the following raw materials in proportion by weight: 8-15% of desert cistanche extract, 10-25% of coffee powder, 5-35% of fresh milk, 4-5% of non-dairy creamer, 0.5-1% of oligosaccharide, 4-12% of cocoa powder, 5-8% of cane sugar and 4-56.5% of oats. The desert cistanche coffee beverage composition has the beneficial effects that the desert cistanche coffee beverage composition is rich in multi-amino acids, microelements, high-content beta-glucan and vitamins, has high nutritional value, and is mellow in flavor, smooth and unctuous in mouthfeeling, and sweet and dense in aroma; and the desert cistanche extract can activate immune system, increase the weight of immune organs, prevent and treat intestinal cancer, reduce occurrence of intestinal cancer, protect the normal intestinal epidermis cells, reduce helicobacter pylori infection in intestinal tract, and integrate the efficacies of warming and invigorating kidney-Yang, and therefore, the desert cistanche coffee beverage composition is of a novel nutritional health-care beverage.

The invention provides a protein chip for typing detection on helicobacter pylori infection. The protein chip comprises a basement membrane and antigens which are respectively dotted on the basement membrane in the form of dot matrix, wherein the antigens include three types, i.e. CagA (cytotoxin-associated gene) antigens, VacA (Vacuolating cytotoxin A) antigens and Ure (ureaplasma urealyticum) antigens. Due to the fact that the detection antigens used by the protein chip are three single proteins, i.e. Ure, CagA and VacA, specific IgG antibodies for the three antigens in the blood serum of a patient can be detected at the same time, I-type infection or II-type infection can be judged, and clinic treatment is better facilitated; furthermore, the protein chip has the advantages of high detection sensitivity, quick, simple and convenient detection, instant readability, small using amount of antigen and the like.

The present invention discloses a novel application of rifamycin-nitroimidazole coupling molecule and belongs to the field of medicinal chemistry. The rifamycin-nitroimidazole coupling molecule shows high activity to drug-resistant strains in the treatment of undistinguishable Clostridium, Helicobacter pylori infection related diseases, not only has antibacterial resistant activity to the rifamycin single drug-resistance bacteria and metronidazole single drug-resistance bacteria, but also has antibacterial activity against rifamycin resistant and metronidazole double drug-resistance bacteria; and the activity of the coupling molecule is superior to that of the composition of rifampicin and metronidazole in the molar ratio of 1:1.

The invention provides a freeze-dried dexlansoprazole composition powder injection for injection and a preparation method thereof. The powder injection comprises the active components consisting of dexlansoprazole and arginine, and meglumine and / or excipients like mannitol. The preparation method comprises the following steps: dissolving raw and adjuvant materials with water; adding a proper amount of a sodium hydroxide solution to allow a solution obtained in the previous step to be clear; then adding active carbon for decoloring; carrying out active carbon removal and then adjusting a pH value; and successively carrying out filtering with a filter membrane, split charging and freeze-drying. The powder injection is clinically applied to treatment of diseases like gastric ulcer, duodenal ulcer, erosive gastro-oesophageal reflux disease, helicobacter pylori infection and Zollinger-Ellison syndrome. The freeze-dried dexlansoprazole composition powder injection for injection provided by the invention overcomes the problem of poor redissolvability of dexlansoprazole, has stable quality and good redissolvability and improves medication security.

The present invention provides a fluorescent sensor for detecting respiratory ammonia. A curcumin derivative (BFCUR) having a large steric hindrance and electrospun nanofibers (ENF) having a high porosity and a high specific surface area are compounded. The BFCUR with large steric hindrance is used as a sensing fluorophore, so that aggregation caused by pi-pi accumulation is effectively avoided; and the ENF with high porosity and high specific surface area can improve the sensitivity of the sensor. The sensor provided by the invention shows excellent performance in detection of respiratory ammonia, has ultralow detection limit, wider ammonia gas concentration response range and short response time, is slightly interfered by carbon dioxide and water vapor, and is high in cycling stability and light stability and good in recoverability. The sensor disclosed by the invention is successfully applied to respiratory ammonia detection of patients with chronic kidney diseases and helicobacter pylori infection, is high in sensitivity and reliable in detection result, and has important significance in clinical practice.

The invention belongs to the technical field of immunochromatographic diagnosis of in vitro diagnosis reagents, and particularly relates to a fluorescent immunochromatographic reagent kit for detecting a human helicobacter pylori antibody and a preparation method of the reagent kit. The reagent kit comprises a support, a blotting membrane fixed on the support, a water absorption pad fixed at one end of the blotting membrane, and a combining pad fixed at the other end of the blotting membrane, wherein a sample pad is fixed at the other end of the combining pad; a blood filter membrane is fixedat the other end of the sample pad; a detection line coated with a Caga A, urease and cell vacuolating cytotoxin recombinant antigen mixture and a control line coated with sheep anti-mouse IgG (immunoglobulin G) are arranged on the blotting membrane; and a mouse anti-human IgG fluorescent emulsion microsphere is sprayed onto the combining pad. The reagent kit achieves quick and sensitive quantitative detection of the helicobacter pylori antibody by a fluorescent immunochromatographic method through an indirect method principle and fluorescent characteristics of the fluorescent emulsion microsphere.

The present invention discloses a stomach helicobacter pylori infection pathological diagnosis support system and method. The system comprises: an image data obtaining unit configured to obtain normalstomach section images and pathological section images of a confirmed stomach helicobacter pylori infection case as input image data; an image data marking unit configured to perform marking for theinput image data; an image database construction unit configured to perform classification and arrangement for the marked image data provided by the image data marking unit and construct a pathology image database; a convolutional neural network (CNN) construction unit configured to construct a CNN model; and a CNN model training unit configured to obtain an ideal CNN model. The stomach helicobacter pylori infection pathological diagnosis support system and method can achieve accurate, efficient and intelligent section reading to assist in the clinical pathological diagnosis work of the stomach helicobacter pylori infection so as to improve the accuracy, the working efficiency and the work persistent state.

The invention relates to reagent used for diagnosing helicobacter pylori infection and preparation method thereof and kit thereof; wherein the reagent contains 0.3-0.5ml of CO2 absorbent, 2-3ml of organic solvent, 0.7-2ml of emulsifier and 0.01-0.038g of scintillator. The reagent used for diagnosing helicobacter pylori infection, preparation method thereof and kit thereof are applied, CO2 absorption and scintillation measurement on all the required substances are merged, thus reducing operation step and being more convenient for doctor to use. Further more, under the same experiment condition, DPM value can be above 30% higher than that of the existing assay kit; the reagent has positive effect for judging weak positive close to critical value appeared in clinic, sensitivity of measurement method can be improved, and false negative is reduced; usage amount of reagent is reduced by about 30%, thus being beneficial to reducing production cost and reducing adverse effect on environment; and use is safer.

The invention discloses a human body helicobacter pylori infection diagnosing system built on the basis of fuel cells and a method for detecting the content of ammonia in human respiratory gas. The human body helicobacter pylori infection diagnosing system comprises oral urea preparations and a fuel cell type ammonia detecting device. The human body helicobacter pylori infection diagnosing system and the method have the advantages that the human expiratory gas is led into the fuel cell type ammonia detecting device after human bodies administer the oral urea preparations, current signals which indicate that oxidation and reduction reaction is carried out on the ammonia in the human respiratory gas in fuel cell systems are detected, accordingly, the content of the ammonia in the human respiratory gas can be quickly and accurately obtained, the helicobacter pylori infection degrees can be sensitively, quickly and specifically detected, toxic and side effects and service limitation can be reduced to a great extent as compared with an existing diagnosing method, and the detection time can be greatly shortened as compared with the exiting diagnosing method.

The invention discloses a carbon nanosphere preparation as well as a preparation method and an anti-helicobacter pylori infection experiment method thereof. The carbon nanosphere preparation is prepared by mixing carbon nanospheres and dispersion liquid; the concentration of the carbon nanosphere preparation is 0.1 percent to 1.0 percent; the dispersion liquid is de-ionized water and the grain diameter of not less than 95 percent of the carbon nanospheres is 5nm to 30nm. The carbon nanosphere preparation has the advantages of low cost, easiness for manufacturing, good stability, high safety and good anti-helicobacter pylori infection effect. The preparation method of the carbon nanosphere preparation has the characteristics of easiness of implementation, simple process and convenience for operation. The anti-helicobacter pylori infection experiment method of the carbon nanosphere preparation has the characteristics of convenience for implementation, scientificity and rationality. The carbon nanosphere preparation disclosed by the invention can be developed as a new drug for treating helicobacter pylori infection, so that a new idea is provided for developing anti-helicobacter pylori infection medicines and a new strategy is provided for prevention and treatment of anti-helicobacter pylori infection.

The invention discloses a system for diagnosing helicobacter pylori infection of a human body based on a spectrophotometer and a method for detecting the content of ammonia gas in expired gas of a person. The system comprises an expired gas diagnostic kit and the spectrophotometer. The interior of the expired gas diagnostic kit is provided with three reagent pools which are respectively provided with a urea electuary, an ammonia capturing agent and a color developing agent. The method for detecting the content of ammonia gas in the expired gas of a person comprises the following steps: collecting the expired gas of the person; absorbing and immobilizing ammonia gas in the expired gas by using the ammonia capturing agent; and determining the content of the immobilized ammonia gas by using the spectrophotometer. The detection system and method can accurately and rapidly detect the content of ammonia gas in the expired gas of a person, so accurate high-efficiency diagnosis of helicobacter pylori infection of the person can be realized; moreover, the detection system and method reduce production cost for reagents, eliminate the hidden trouble of toxic and side effect of conventional reagents and can be promoted and applied.

The invention provides a capsule preparation for treating epigastralgia. The capsule preparation is prepared from, by mass, 30 parts of fructus aurantii immaturus, 50 parts of ark shells and 10 parts of white peppers; 10 parts by mass of fourstamen stephania roots are added in the capsule preparation for treating stomach antrum erosion, 10 parts by mass of radix et rhizome rhei processed with wine is added in the capsule preparation for treating the epigastralgia with helicobacter pylori infection, and 10 parts by mass of fruit of cinnamomum camphora (L.) Presl. is added in the capsule preparation for treating severe abdominal pain. A preparation method comprises the steps that all the medicine materials in the formula are selected, dried, crushed and then mixed according to the mass proportion of the formula, the uniformly mixed medicine powder is filled in capsules, each capsule is filled with 0.5 g of the medicine powder, and then the capsule preparation is obtained. The capsule preparation is prepared from the natural medicine materials, has the advantages of being safe, non-toxic, free of side effects, convenient to take and obvious in effect and is suitable for patients suffering from diseases such as superficial gastritis, bile reflux gastritis, a gastric and duodenal ulcer and the helicobacter pylori infection.

The invention provides traditional Chinese medicine granules for reversing precancerous lesions of chronic atrophic gastritis. The traditional Chinese medicine granules are prepared from Lilium brownii, agrimonia pilosa ledeb, lindera aggregata or dandelion; the Lilium brownii and the agrimonia pilosa ledeb are decocted with water, the obtained decoction is concentrated and filtered, and then an alcohol precipitation extract A is extracted; the lindera aggregata and the dandelion are precipitated with alcohol and filtered to obtain an alcohol precipitation extract B; the extract A and the extract B are blended, spray-dried and pelletized to obtain the granules. Clinical observation verifies that the traditional Chinese medicine granules are capable of improving the clinical symptoms of a patient suffering the precancerous lesions of the chronic atrophic gastritis, reversing the existing intestinal metaplasia or atypical hyperplasia lesion and reducing the odds of turning to gastric cancer; animal experiments indicate that the traditional Chinese medicine granules are capable of relieving the gastric mucous atrophy lesions of rats and reducing the incidence rate of the intestinal metaplasia and the atypical hyperplasia lesion; the traditional Chinese medicine granules are capable of increasing the content of the serum pepsinogen of rats suffering the precancerous lesions of the gastric cancer, reducing the expression of the gastric mucosa Bc1-2 gene of the rats suffering the precancerous lesions of the gastric cancer and increasing the expression of Bax gene, and further have an inhibition effect on helicobacter pylori infection of the gastric tissue of the rats.

The invention provides a traditional Chinese medicine for treating chronic gastritis. The traditional Chinese medicine is prepared from the following components in parts by weight: 10 to 20 parts of rhizoma pinelliae, 10 to 30 parts of radix scutellariae, 20 to 38 parts of radix codonopsis, 15 to 30 parts of herba taraxaci, 6 to 17 parts of radix bupleuri, 6 to 18 parts of liquorice root, 5 to 10parts of dried ginger, 15 to 50 parts of calcined cuttle bone, 15 to 30 parts of herba hedyotidis diffusae and 10 to 23 parts of fructus jujubae. The traditional Chinese medicine for treating chronicatrophic gastritis, provided by the invention, can be used for improving gastric ulcer symptoms through regulating brain and stomach autonomic nerve parasecretion, so as to protect gastric mucosa; andthrough reducing the content of carbon monoxide, oxidative damages are resisted, inflammatory response is inhibited, the gastric mucosa is protected and helicobacter pylori infection is inhibited.

The present invention relates to a new method for the diagnosis of Helicobacter pylori infection. In particular, the present invention relates to novel non-invasive methods for detecting the presence in biological samples of H. pylori antigens or metabolites produced by said bacteria using biosensor-based measurements. The present invention also relates to the use of a biosensor comprising a Helicobacter pylori-specific antibody or an antigen-binding fragment thereof immobilized thereon and a biomolecule-repelling polymer that prevents non-specific binding. The invention also relates to detection kits used in the method.

Methods are for the preparation and medicinal use of pharmaceutical formulations for the treatment of bacterial infection and / or duodenal ulcer disease.

The invention relates to the technical field of biological medicines, in particular relates to application of a GSDMD inhibitor in preparation of a medicine for treating helicobacter pylori infection,and aims to solve the problem that a death signalling pathway of neutrophile granulocyte after helicobacter pylori infection, in particular change of pyroptosis molecular mechanism, is unclear in theprior art. After the signalling pathway is definite, the condition that stomach helicobacter pylori infection can be treated by utilization of the GSDMD inhibitor can be prompted; the pyroptosis process of the neutrophile granulocyte infiltrated at the infection part is inhibited; therefore, the clinical existing antibacterial medicine combined therapy is replaced; and generation of the medicinetolerance is reduced.

The invention relates to the field of medicine. The internal disinfectant is used as medicine and can be used for oral administration, respiratory aerosol inhalation and intravenous injection. The clinical application of the present invention is a new idea of ​​the treatment plan for diseases caused by pathogenic microorganisms; the main component of the internal disinfectant is a specific concentration of pure chlorine dioxide solution, and the internal disinfectant corresponding to the external disinfectant, It can be used alone or in combination with other drugs. Inhalation of internal disinfectant respiratory aerosol can treat or assist treatment including but not limited to rhinitis, pharyngitis, pneumonia, pneumoconiosis, tuberculosis, etc.; and as a respiratory health care for urban residents with severe air pollution , expel through sputum, clean the lungs of smoke and dust; oral disinfectants can treat stomach problems including but not limited to halitosis and Helicobacter pylori infection.

The invention relates to a traditional Chinese medicine for treating atrophic gastritis. The medicine is characterized by being prepared from the following raw materials: rhizoma zingiberis, codonopsis pilosula, poria cocos, rhizoma corydalis, panax notoginseng, cuttlebone, radix pseudostellariae, endothelium corneum gigeriae galli, coix seeds, dandelion, selfheal, garden burnet, rhizoma cimicifugae, oysters, turtle shells, ginseng, watermelon seeds, medicated leaven, eclipta, Indian iphigenia bulbs and pumpkin seeds. The medicine is used for treating the atrophic gastritis caused by helicobacter pylori infection, a poor dietary habit, genetic factors, superficial gastritis development and the like, accompanied with symptoms such as a stomach swelling pain, heart burn, vomiting, haematemesis, dyspepsia, fecal abnormality and anemia, protects a stomach mucous membrane, improves intestinal epidermic metaplasia and therefore achieves the purposes of alleviation and curing through warming the middle-jiao, dispelling cold, strengthening the spleen and the stomach, promoting blood circulation, dissipating blood stasis, tonifying qi, promoting production of body fluid, nourishing yin and clearing away heat in company with astringency, hemostasis, swelling diminishing and stasis removal. The medicine is a pure traditional Chinese medicine preparation, is free from chemical ingredients and any hormone, has no side effect, is convenient to take, easy to absorb and low in price and takes effect quickly.

The present invention relates to a haw stone composite beverage. The haw stone composite beverage comprises the following components in parts by weight: 18-22 parts of blueberry juice, 18-22 parts ofmulberry juice, 16-25 parts of cherry juice, 1.5-2.5 parts of a haw stone extract and 35-40 parts of deionized water. The present invention also relates to a preparation method of the composite beverage. Firstly, a certain amount of the blueberry juice, mulberry juice, cherry juice, haw stone extract and deionized water are taken respectively to be mixed to prepare a mixed solution; then the mixedsolution is kept for a certain period of time at a 15-20 DEG C environment; then after the mixed solution is kept for a certain period of time, the mixed solution is bottled; and finally, the bottledmixed solution is placed in a sterilization kettle at 100-105 DEG C for sterilization to obtain composite fruit juice. The composite beverage prepared by using the above components and method has a very good inhibitory effect on helicobacter pylori infection, can also effectively eliminate symptoms of thirst, stomach discomfort, etc. after drinking wine, also has effects on protecting the liver and stomach, and improving immunity, is also relatively good in mouthfeel and suitable for people of different ages to use, and can be widely applied in the technical field of beverage preparation.

The invention discloses a formula and a making method of a diet for preventing Helicobacter pylori infection. The formula comprises 100-200g of noodle, 20-30g of lean meat, 20-30g of soybean, 5-10g of apricot kernel, 5-10g of Sinopodophyllum hexandrum, 5-10g of Sapindus mukurossi Gaertn, 5-10g of dry ginger, 3-5g of garlic, 3-5g of mint, 3-5g of cinnamon and other cereals, and vegetables as raw materials. The making method comprises the following steps: cleaning all the cereals and the vegetables, immersing, juicing, and boiling noodles by using the obtained juice. The diet has a unique prevention effect on the Helicobacter pylori infection, and has the advantages of non-toxicity, no side effects, wide food sources, simple making and low cost.