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Combination of containing Lactobobacillus plantarum

A technology of Lactobacillus plantarum and composition, applied in the field of composition containing Lactobacillus plantarum, can solve the problems of occurrence of pseudomembranous enteritis, affecting the effect of treatment, affecting the antibacterial efficacy, etc.

Active Publication Date: 2005-08-31
SHANGHAI JIAODA ONLLY CO LTD
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AI Technical Summary

Problems solved by technology

Although the current triple therapy regimen can increase the eradication rate of HP to more than 80%, the incidence of side effects is about more than 30%, including nausea, vomiting, diarrhea, headache, poor appetite, fungal infection, and even pseudomembranous infection. Enteritis, etc., to a large extent affected the effect of treatment
Secondly, HP can develop resistance to antibacterial drugs during treatment, which greatly affects the antibacterial efficacy.
[0004] At present, based on the mechanisms of Chinese herbal medicines such as clearing away heat and removing dampness, nourishing the stomach and invigorating the spleen, regulating qi and neutralizing, reducing inflammation and relieving pain, a variety of traditional Chinese medicine preparations have been developed in my country to prevent and assist the treatment of Helicobacter pylori infection, such as ZL1171952, "Anti-Helicobacter pylori traditional Chinese medicine "Preparations" mainly use the antibacterial and anti-inflammatory effects of Coptis chinensis, Scutellaria baicalensis and Phellodendron Phellodendri, and these traditional Chinese medicine preparations are generally taken in large doses, and due to the possible toxic and side effects of traditional Chinese medicine raw materials, it is not suitable for long-term use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Embodiment 1: Microscopic examination of bacterial strains

[0018] Under sterile conditions, Lactobacillus plantarum LP-Onlly was picked with an inoculation ring, spread on a glass slide, prepared and stained with Gram, and observed the morphology of the bacteria under a microscope.

Embodiment 2

[0019] Embodiment 2: MRS plate purification separation

[0020] Under sterile conditions, pick Lactobacillus plantarum LP-Onlly with an inoculation loop, streak on the MRS plate, place the plate in an incubator at 37°C for 72 hours, and select a single colony for microscopic examination to achieve pure strain isolation.

Embodiment 3

[0021] Embodiment 3: strain fermentation

[0022] Pick two loops of Lactobacillus plantarum LP-Onlly from the slope with an inoculation loop into 50ml MRS liquid medium, culture at 37°C for 24 hours, then insert 5% inoculum into 50ml MRS liquid medium, and culture at 37°C After 72 hours, the fermentation broth of Lactobacillus plantarum LP-Onlly was obtained.

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PUM

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Abstract

A composition used as health-care food or medicine for preventing and treating the digestive ulcer and chronic gastritis caused by pylorospirobacillus contains the vegetative lactobacillus LP-Onlly (CGMCC No.1258) and its metabolic product, and the extracts of 5 Chinese-medicinal materials including liquorice root, white peony root, astragalus root, etc.

Description

technical field [0001] The invention relates to a composition containing Lactobacillus plantarum. The Lactobacillus plantarum LP-Onlly used is CGMCC NO.1258, and its 16S rRNA gene GeneBank (NCBI) sequence accession number is AY590777. The composition contains Lactobacillus plantarum LP-Onlly live bacteria and / or dead bacteria and metabolites thereof, and also contains one or more Chinese herbal medicine extracts, such as licorice, dandelion, Codonopsis pilosula, Radix Paeoniae Alba, Radix Astragali and the like. The composition is suitable for long-term consumption as food or medicine, and is mainly used for the prevention and / or auxiliary treatment of diseases such as peptic ulcer and chronic gastritis caused by Helicobacter pylori infection. Background technique [0002] Helicobacter pylori (HP) is a helical, Gram-negative, microaerophilic bacterium that can grow and reproduce in the low pH environment of the human stomach. It is associated with peptic ulcer disease, chro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P1/04A61P31/04
Inventor 范小兵杭晓敏沙大年张和春王劲松杨国周丛
Owner SHANGHAI JIAODA ONLLY CO LTD
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