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Traditional Chinese medicine granules for reversing precancerous lesions of chronic atrophic gastritis and preparation method thereof

A technology of atrophic gastritis and traditional Chinese medicine granules, applied in the field of traditional Chinese medicine, can solve problems such as adverse reactions, dysplasia without reversal effect, and influence on curative effect

Inactive Publication Date: 2014-09-17
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, it is believed that the eradication of H. Intestinal metaplasia or dysplasia developed without reversal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Its preparation steps are as follows:

[0022] (1) Take 2 parts of lily and 2 parts of agrimony, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time and decoct for 1.5 hours respectively, discard the medicinal residues, concentrate the filtrate, and add 95 Adjust the alcohol content to 80% with % ethanol, stir well, let it stand at room temperature for 12 hours, obtain the filtrate at low temperature, reduce the pressure, recover the ethanol until it has no alcohol smell, and obtain the alcohol precipitation paste A;

[0023] (2) Take 1 portion of black herb, add 7 times the amount of 60% ethanol for the first time, and add 8 times the amount of 60% ethanol for the second time to reflux for 2 hours respectively, discard the dregs, put the filtrate at low temperature and reduce pressure, and recover the ethanol to nothing Alcoholic taste, obtain Alcohol Shen Qing Cream B;

[0024] (3) Take 1 part of black herb and 1 p...

Embodiment 2

[0028] Its preparation steps are as follows:

[0029](1) Take 3 parts of lily and 3 parts of agrimony, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time and decoct for 1.5 hours respectively, discard the medicinal residues, concentrate the filtrate, and add 95 Adjust the alcohol content to 80% with % ethanol, stir well, let it stand at room temperature for 12 hours, obtain the filtrate at low temperature, reduce the pressure, recover the ethanol until it has no alcohol smell, and obtain the alcohol precipitation paste A;

[0030] (2) Take 2 parts of black herb, add 7 times the amount of 60% ethanol for the first time, and add 8 times the amount of 60% ethanol for the second time to reflux for 2 hours respectively, discard the dregs, put the filtrate at low temperature and reduce pressure, and recover the ethanol to nothing Alcoholic taste, obtain Alcohol Shen Qing Cream B;

[0031] (3) Take 2 parts of black herb and 2 par...

Embodiment 3

[0035] Its preparation steps are as follows:

[0036] (1) Take 4 parts of lily and 4 parts of agrimony, add 10 times the amount of water for the first time, add 8 times the amount of water for the second time and decoct for 1.5 hours respectively, discard the medicinal residues, concentrate the filtrate, and add 95 Adjust the alcohol content to 80% with % ethanol, stir well, let it stand at room temperature for 12 hours, obtain the filtrate at low temperature, reduce the pressure, recover the ethanol until it has no alcohol smell, and obtain the alcohol precipitation paste A;

[0037] (2) Take 2 parts of black herb, add 7 times the amount of 60% ethanol for the first time, and add 8 times the amount of 60% ethanol for the second time to reflux for 2 hours respectively, discard the dregs, put the filtrate at low temperature and reduce pressure, and recover the ethanol to nothing Alcoholic taste, obtain Alcohol Shen Qing Cream B;

[0038] (3) Take 2 parts of black herb and 2 pa...

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PUM

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Abstract

The invention provides traditional Chinese medicine granules for reversing precancerous lesions of chronic atrophic gastritis. The traditional Chinese medicine granules are prepared from Lilium brownii, agrimonia pilosa ledeb, lindera aggregata or dandelion; the Lilium brownii and the agrimonia pilosa ledeb are decocted with water, the obtained decoction is concentrated and filtered, and then an alcohol precipitation extract A is extracted; the lindera aggregata and the dandelion are precipitated with alcohol and filtered to obtain an alcohol precipitation extract B; the extract A and the extract B are blended, spray-dried and pelletized to obtain the granules. Clinical observation verifies that the traditional Chinese medicine granules are capable of improving the clinical symptoms of a patient suffering the precancerous lesions of the chronic atrophic gastritis, reversing the existing intestinal metaplasia or atypical hyperplasia lesion and reducing the odds of turning to gastric cancer; animal experiments indicate that the traditional Chinese medicine granules are capable of relieving the gastric mucous atrophy lesions of rats and reducing the incidence rate of the intestinal metaplasia and the atypical hyperplasia lesion; the traditional Chinese medicine granules are capable of increasing the content of the serum pepsinogen of rats suffering the precancerous lesions of the gastric cancer, reducing the expression of the gastric mucosa Bc1-2 gene of the rats suffering the precancerous lesions of the gastric cancer and increasing the expression of Bax gene, and further have an inhibition effect on helicobacter pylori infection of the gastric tissue of the rats.

Description

[0001] 1. Technical field [0002] The invention relates to a traditional Chinese medicine granule for reversing precancerous lesions of chronic atrophic gastritis and a preparation method thereof. The medicine of the present invention belongs to the technical field of traditional Chinese medicine. 2. Background technology [0003] Gastric cancer is a common malignant tumor of the digestive tract, leading to poor quality of life, poor prognosis, and high mortality. Therefore, the prevention of this disease has attracted much attention. Chronic atrophic gastritis is recognized as a precancerous disease of the stomach. Its pathological features are gastric mucosal epithelium and gland atrophy, mucosal thinning, and muscularis mucosa thickening. The cancerous rate is about 2.55% to 7.46%. The process is intestinal metaplasia and dysplasia of the gastric mucosa and the proliferation and spread of cancer cells. Therefore, reducing the incidence of gastric cancer by reversing int...

Claims

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Application Information

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IPC IPC(8): A61K36/8967A61P1/04A61P35/00
Inventor 彭海燕
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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