43 results about "Atypical hyperplasia" patented technology

The invention relates to the discovery that specific adamantyl or adamantyl group derivatives containing retinoid-related compounds induce apoptosis of cancer cells and therefore may be used for the treatment of cancer, including advanced cancer. Also, the present invention relates to novel adamantyl or adamantyl group derivatives containing retinoid compounds and their usage for treatment and / or prevention of cancer, keratinization disorders, dermatological conditions, and other therapies More specifically, it has been shown that such adamantyl compounds, e.g., 6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, 2-[3-(1-adamantyl)-4-methoxyphenyl]-5-benzimidazole carboxylic acid, and 6-[3-(1-adamantyl)-4,5-methylenedioxyphenyl]-2-naphthoic acid, can be used to treat or prevent cervical cancers and precancers such as cervical dysplasias, including high grade and low grade dysplasias.

The present invention provides methods of identifying a genetic abnormality such as mutation in EGFR or KRAS or ALK which is associated with the management of lung cancer or diagnosing, prognosing or monitoring the treatment of pre-cancerous conditions of the lung, such as bronchial dysplasia or atypical alveolar hyperplasia (AAH), through the detection of at least one volatile organic compound indicative of these states.

The invention relates to application of a Chinese materia medica preparation, in particular to application of a traditional Chinese drug Zengshengping to treating mammary gland tumor. Achievements ofexperimental investigation accidentally disclose that zengshengping has good effect on treating the mammary gland tumor, galactocele, normal hyperplasia of mammary glands and atypical hyperplasia of mammary glands.

The present invention relates to a method to assist in the determination of therapy for a patient suffering from Barrett's oesophagus, especially where first-line therapy has been unsuccessful and when dysplasia has been diagnosed. The method comprises the use of an imaging agent comprising a vector which targets (a) Her2, (b) cMet, (c) guanylyl cyclase or (d) IGF1R. The imaging agent is suitable for radioisotope or optical imaging in vitro or preferably in vivo.

The invention relates to novel application of small molecule metabolites, namely hypoxanthine, 2-ketoisocaproic acid, glutamic acid and aspartic acid, in a serum sample as combined markers in preparation of a kit for distinguishing patients with esophageal squamous carcinoma and esophageal epithelial atypical hyperplasia in subjects. The invention further relates to a kit for detecting patients with esophageal squamous cell carcinoma in subjects. The relative concentration of the combined markers in serum samples from the subjects is detected, the variables P of the combined marker are calculated based on a linear regression equation, and whether the subjects suffer from esophageal squamous cell carcinoma or not is judged based on a determined threshold value. The kit can realize high-sensitivity and high-efficiency detection of several metabolites involved in the invention, and has the advantages of low detection cost and good repeatability. The kit can be applied to clinical auxiliary diagnosis of the esophageal squamous cell carcinoma, has the advantages of high diagnosis sensitivity and capability of effectively distinguishing the esophageal squamous cell carcinoma from precancerous lesions, and has a relatively good application prospect.

The invention discloses a traditional Chinese medicine for treating atrophic gastritis with intestinal metaplasia and atypical hyperplasia, which comprises rhizoma acori tatarinowii, herba pogostemonis, herba eupatorii, longhairy antenoron herb, stringy stonecrop herb, dandelion, fructus forsythia, dried tangerine, herba artemisiae scopariae, herba rabdosiae, scorpio, fructus gardeniae, Indian iphigenia bulb and the like. According to the traditional Chinese medicine disclosed by the invention, the components realize functions of eliminating turbid, removing toxin and activating blood, gastric mucosa inflammation can be eliminated, the blood flow of gastric mucosa is effectively improved, and the glands experiencing atrophy and intestinal metaplasia return to normal so as to reverse precancerous lesions of the gastric cancer.

The invention discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis. The composition adopts the following 18 components for compatibility: largehead atractylodes rhizome, orange fruit, nutgrass galingale rhizome, dangshen, coptis root, medicinal evodia fruit, almonds, sharpleaf galangal fruit, radix astragali, turmeric root tuber, medicated leaven, raw hawthorn, morinda root, weeping forsythia capsule, radix bupleuri, honeysuckle, akebia stem and white paeony root. The composition has obvious treatment effects on chronic gastritis, intestinal metaplasia accompanied by atrophic gastritis and atypical hyperplasia. The composition has the following pharmacological characteristics that the composition invigorates the spleen and supplements qi, harmonizes the liver and spleen, regulates qi and dissipates dampness, removes stasis to stop pains, softens hardness to break stones, nourishes and relaxes the liver, nourishes yin with sour and sweet herbs and can adjust the functions of pylorus, prevent backflow of bile and promote damaged tissue healing and gastric mucosa regeneration. The composition makes up for the deficiency of single traditional Chinese medicine preparations, solves the problems that the Western medicines fail to solve and toxic and side effects and has short course of treatment and low side effects.

The invention discloses a Shenzhu pharmaceutical composition for treating atrophic gastritis. The pharmaceutical composition comprises the following raw materials in parts by weight: 10-20 parts of codonopsis pilosula, 8-12 parts of largehead atractylodes rhizome, 8-12 parts of baical skullcap root, 13-17 parts of danshen root, 25-35 parts of coix seed, 8-12 parts of hairyvein agrimonia herb and bud, 12-18 parts of spreading hedyotis herb, 13-17 parts of barbed skullcap herb, 13-17 parts of Mongolian dandelion herb, 8-12 parts of Chinese waxgourd semen, 8-12 parts of curcuma zedoary and 9-11 parts of bitter orange. The invention also discloses an application of the Shenzhu pharmaceutical composition for treating atrophic gastritis in preparation of medicines for treating atrophic gastritis, intestinal metaplasia and atypical hyperplasia. The Shenzhu pharmaceutical composition disclosed by the invention has the effects of replenishing qi to invigorate the spleen, removing heat and dampness, and detoxifying and activating blood circulation, can reverse and prevent gastric mucosa carcinogenesis, and can be used for treating atrophic gastritis, intestinal metaplasia and atypical hyperplasia which are caused by weakness of spleen and stomach and damp-heat syndromes.

The invention discloses an application of a Chinese medicine composition in preparation of a medicine for treating the atypical hyperplasia of the gastric mucosa. The medicine is formed by combining Chinese medicines such as radix astragali, glossy privet fruit, and the like. The Chinese medicine composition has the efficacy of supplementing qi and nourishing yin, spleen kidney nourishing and eliminating stagnation activate meridians, is tangential to pathogenesis and is clinically used for treating the disease to obtain a better effect. The invention has rational proportion and small adverse reaction of the medicine, and can be used by patients for a long time.

The invention discloses a Chinese medicine composition for performing postoperation cooperative treatment on mammary intraepithelial neoplasia. The Chinese medicine composition is prepared from Chinese angelica, white paeony roots, radix bupleuri, poria cocos, fried bighead atractylodes rhizome, green tangerine peels, dried tangerine peels, nutgrass galingale rhizome, szechwan Chinaberry fruits, pinellia ternate, rhizoma arisaematis, semen brassicae, snake gourd fruits, tangerine seeds, figwort roots, raw oyster shells, big fritillaria, spina gleditsiae, selfheal, weeping forsythiae capsule, Indian iphigenia bulbs, seaweed, sea-tent, rhizoma curculiginis and herba epimedii in a certain weight proportion, and has functions of promoting blood circulation and arresting pain, tretching liver to smooth qi, softening hard lump and dissipating stagnation and tuning up qi blood; and after the Chinese medicine composition can effectively treat the mammary intraepithelial neoplasia in a cooperative mode, common epithelium hyperplasia of a mammary duct is delayed and changed into atypical hyperplasia, preinvasive carcinoma and infiltrating carcinoma.

The invention provides traditional Chinese medicine granules for reversing precancerous lesions of chronic atrophic gastritis. The traditional Chinese medicine granules are prepared from Lilium brownii, agrimonia pilosa ledeb, lindera aggregata or dandelion; the Lilium brownii and the agrimonia pilosa ledeb are decocted with water, the obtained decoction is concentrated and filtered, and then an alcohol precipitation extract A is extracted; the lindera aggregata and the dandelion are precipitated with alcohol and filtered to obtain an alcohol precipitation extract B; the extract A and the extract B are blended, spray-dried and pelletized to obtain the granules. Clinical observation verifies that the traditional Chinese medicine granules are capable of improving the clinical symptoms of a patient suffering the precancerous lesions of the chronic atrophic gastritis, reversing the existing intestinal metaplasia or atypical hyperplasia lesion and reducing the odds of turning to gastric cancer; animal experiments indicate that the traditional Chinese medicine granules are capable of relieving the gastric mucous atrophy lesions of rats and reducing the incidence rate of the intestinal metaplasia and the atypical hyperplasia lesion; the traditional Chinese medicine granules are capable of increasing the content of the serum pepsinogen of rats suffering the precancerous lesions of the gastric cancer, reducing the expression of the gastric mucosa Bc1-2 gene of the rats suffering the precancerous lesions of the gastric cancer and increasing the expression of Bax gene, and further have an inhibition effect on helicobacter pylori infection of the gastric tissue of the rats.

The invention relates to a new application of achyranthes for preparing medicines for preventing and / or treating gastric precancerous lesion and gastric cancer, belonging to the field of medicines. The invention aims to provide a new application of radix achyranthis bidentatae in the medicines for preventing and / or treating gastric precancerous lesion and preventing and treating gastric malignant tumors. Active portion of achyranthes are prepared by adopting an organic solvent extraction method. The animal experiment proves that achyranthes can obviously inhibit the atypical hyperplasia of gastric mucosa cells, inhibit the precancerous lesion and prevent the occurrence of gastric malignant tumors, which are not reported and applied in traditional researches and clinics, thus the invention has uniqueness and novelty. The achyranthes has wide resources and simple and convenient extraction methods and can be prepared into various dosage forms. Gastric cancer is one of common malignant tumors in China, the morbidity of the gastric cancer in China ranks first among all tumors so as to demand large medicines in clinic. Thus, the invention has very strong practicability and has very wide application prospects in the aspects of preventing and / or treating gastric mucosa precancerous lesion and the occurrence of gastric malignant tumors.

The present invention relates to Psoralca corylifolia and new application of its fat-soluble portion in medicine. They have obvious action for resisting helicobacter pylori (Hp), and can be used for curing the diseases of gastritis and peptide gastric ulcer, etc. resulted from helicobacter pylori infection, in particular, they are good therapeutic effect for curing active gastritis, gastric erosion, gastric ulcer and duodenal ulcer, and have the action for curing and preventing the diseases of gastric lymph tissue (MALT) lymphoma and early gastric cancer, moderate intestinal glands metaplasia or atypical hyperplasia.

The present invention relates to a method to assist in the determination of therapy for a patient suffering from Barrett's oesophagus, especially where first-line therapy has been unsuccessful and when dysplasia has been diagnosed. The method comprises the use of an imaging agent comprising a vector which targets (a) Her2, (b) cMet, (c) guanylyl cyclase or (d) IGF1R. The imaging agent is suitable for radioisotope or optical imaging in vitro or preferably in vivo.

The present invention provides, inter alia, methods of predicting the risk of a subject having Barrett's Esophagus to develop a more severe condition, such as, e.g., low-grade dysplasia (LGD), high-grade dysplasia (HGD) and esophageal adenocarcinoma (EAC), methods for supporting the diagnosis of dysplasia or esophageal adenocarcinoma (EAC) in a subject having Barrett's Esophagus. Also provided are kits to implement such methods.

The invention provides a preparation method of a plaster used for treating mammary gland hyperplasia and an application thereof. The preparation method of the plaster used for treating mammary gland hyperplasia comprises the steps of preparing substrate, mixing an aqueous phase comprising glycerol and the like and an oil phase comprising glycerin monostearate and the like to obtain the substrate, preparing concentrated extract comprising 18 traditional Chinese medicines, and finally arranging the traditional Chinese medicine paste on the substrate of a disposable air permeable adhesive material which does not cause skin allergy easily. The plaster is applied on the acupoints of double breasts, the shenque point or the lesions of the patient and is suitable for the patient with mammary gland hyperplasia, early breast fibroadenoma, fibrosis, atypical hyperplasia and postoperative recrudescence or complication of mammary gland hyperplasia of breast fibroadenoma. The traditional Chinese medicine plaster can be applied alone or cooperatively with related Chinese patent medicines or traditional Chinese medicines, and the patient can use the plaster conveniently and has fewer side effects.

The invention relates to a method for establishing a mouse model with a hepatic preneoplastic lesion caused by double factors of alcohol and the HBV. The method includes the following steps that firstly, according to an animal, a high-duplication HBV transgenic mouse is copied in the substep of 1.3; secondly, white spirit serves as the reagent; thirdly, the mouse model with the hepatic preneoplastic lesion is prepared, the HBV transgenic mouse is fed with the white spirit every day, continuous gavage is conducted for 16-30 weeks, and a mouse eats and drinks freely during the period; fourthly, after-treatment of the model mouse with the hepatic preneoplastic lesion is conducted, wherein after gavage, weighing is conducted respectively, the mouse is taken and put to death, hepatic tissue is taken out, the hepar is weighed, the hepar index is calculated, and pathological section observation is conducted. The method has the advantages that the animal model is easy to manufacture, low in cost and easy to repeat; the HBV transgenic mouse model induced by alcohol for 22 weeks can be put under a scope so that it can be seen that atypical hyperplasia has large-cell and small-cell changes, the method conforms to the criteria of the hepatic preneoplastic lesion model, and successful model making is displayed and deduced.

The invention belongs to the technical field of experimental models, relates to a medicament for intervening in an inflammation related chemically induced pancreatic cancer animal model, and in particularly relates to application of caerulin in preparing a sensitizing preparation for synergizing dimethylbenzanthracene (DMBA) to induce a pancreatic cancer animal model. According to the application, an effective sensitizing preparation is provided to a medicament DMBA for inducing a C57 wild type mouse pancreatic cancer model, and the prepared animal model is an ideal tool for further studying pancreatic precancerous lesions and pancreatic cancer; by virtue of the synergetic effect of caerulin, the experiment cycle can be shortened, the experiment efficiency can be improved, and the experiment cost can be saved; occurrence and development of multiple steps in the process of intervening in the pancreatic cancer animal model and changes of histology are extremely similar to the developing process of pancreatic cancer of human beings, so that normal pancreas ductal epithelium, atypical hyperplasia of pancreas ductal epithelium, carcinoma in situ of pancreas ductal epithelium and invasive pancreatic cancer in the pancreatic cancer developing process can reappear.

The present invention relates to a method for screening, predicting or prognosing esophageal adenocarcinoma / high grade dysplasia in a subject.

The invention relates to an esophageal squamous epithelium dysplasia image processing method and system and a medium, and the method comprises the steps: dividing a pathological full-slice digital image into a training set and a verification set, and carrying out the preprocessing of the training set and the verification set; dividing the preprocessed image into an ESD specimen image and a living specimen image, layering an ESD specimen, evaluating an EDS layer, and extracting feature values of the ESD specimen image and the biopsy specimen image; carrying out feature grouping and aggregation on the feature values of the images in the training set according to cell nucleuses or tissues, and training an image processing model by adopting the feature values subjected to feature grouping and aggregation to obtain an optimal image processing model; verifying the optimal image processing model by using the feature values of the images in the verification set; and inputting the to-be-detected image into the optimal image processing model to obtain the type of the atypical hyperplasia cells or tissues in the to-be-detected image. The method solves the problem of graphic feature extraction of cell tissues in the absence of precisely marked medical images.

The invention discloses a traditional Chinese medicine for treating hyperplastic disease of breast and a preparation method of the traditional Chinese medicine and belongs to the technical field of medicines. The traditional Chinese medicine is prepared from the following components in parts by weight: 1 to 4 parts of vinegar-processed curcuma zedoary, 1 to 4 parts of radix notoginseng, 1 to 6 parts of radix angelicae sinensis, 1 to 6 parts of vinegar-processed rhizoma corydalis, 1 to 6 parts of radix curcumae, 1 to 6 parts of spica prunellae, 1 to 6 parts of bulbus fritillariae thunbergii, 1to 6 parts of pericarpium trichosanthis, 3 to 9 parts of vinegar-processed carapax trionycis, 3 to 8 parts of ecklonia kurome okam, 1 to 4 parts of pericarpium citri reticulatae viride, 1 to 6 parts of radix bupleuri, 1 to 4 parts of fructus aurantii immaturus, 0.02 to 0.5 part of borneolum syntheticum, 1 to 4 parts of herba menthae, 2 to 6 parts of radix astragali, 1 to 4 parts of radix ginseng and 2 to 6 parts of radix asparagi. The invention also discloses a preparation method of the traditional Chinese medicine for treating the hyperplastic disease of breast. The traditional Chinese medicine disclosed by the invention has the main effects of relieving Qi stagnancy in liver to dissipate sorrow, removing and discharging heat from the liver, transforming phlegm and softening hardness, removing food retention and eliminating stagnation, promoting Qi to activate blood, relieving swelling and pain, and strengthening the body resistance and reinforcing Qi and blood, and has an important significance on preventing and treating the hyperplastic disease of breast as well as preventing the hyperplastic disease of breast from being developed into atypical hyperplasia and reverse atypical hyperplasia.

The invention discloses a traditional Chinese medicine Niweikang, which comprises hemsleya amabilis, Lungwortlike lobaria herb, radix astragali, airpotato yam rhizome, herba scutellariae barbatae and endoconcha sepiae. The traditional Chinese medicine is utilized to treat precancerous lesions of gastric cancer, such as superficial gastritis, chronic atrophic gastritis with intestinal metaplasia, atypical hyperplasia and the like and has the advantages of treating both principal and secondary aspect of disease, strengthening body resistance and eliminating evil, being remarkable in efficacy, high in cure rate, free of toxic and side effects, not easy to have a relapse, no drug injury and drug resistance and low in cost and improving immunity of the organism and the like.

The invention discloses a novel application of compound seabuckthorn oil in pharmacy, that is, the compound seabuckthorn oil in preparing drugs for repairing trauma surface after physical therapy of cervical erosion and light to medium degree atypical hyperplasia of cervical intraepithelial neoplasia. Proved by pharmacodynamics test and study, the compound seabuckthorn oil suppository has a certain treatment effect on animal vagina and cervicitis model caused by chemical burn and biological factors infection and on light to medium degree atypical hyperplasia of cervical intraepithelial neoplasia and can present preclinical effectiveness on the therapy of cervical erosion and on light to medium degree atypical hyperplasia of cervical intraepithelial neoplasia.

Carcinogenic iodized oil solution is prepared by dissolving methyl cholanthrene and diethylnitrosamine in iodized oil. Filling the said iodized oil into bronchus of left lung of Wistar rat induces positioned lung scaly cancer. At 3 days after the said iodized oil being filled, hyperplasia is occurred on epithelium mucosae of bronchus. At 5, 6 days, squamous metaplasia is occurred. At 7-9 days, atypical hyperplasia is occurred. At 13-16 days, early invasive carcinoma is occurred. After 22 days, wet ability scaly cancer is formed. The invention can be utilized in researching pathogenesis, new drugs and new therapeutic methods. Advantages of the invention are: inducing lung scaly cancer at specific position, high rate of inducing cancer and high repeatability. The method is easy of operation, economy as a good model for researching lung cancer.

The invention discloses a traditional Chinese medicine composition for treating precancerous lesion chronic atrophic gastritis and a preparation method and application thereof. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 8 to 12 parts of herba eupatorii, 3 to 8 parts of Pu-Erh tea, 8 to 12 parts of rhizoma corydalis, 5 to 10 parts of faeces trogopterori (stir-fried with vinegar), 10 to 15 parts of jasminum grandiflorum, 3 to 8 parts of amomum tsao-ko and 3 to 8 parts of liquorice root. The traditional Chinese medicine composition disclosed by the invention can obviously improve clinical symptoms of chronic atrophic gastritis, reverse intestinal metaplasia or atypical hyperplasia lesions, and reduce the incidence of the gastric cancer caused by chronic atrophic gastritis.

The invention discloses a traditional Chinese medicine composition for treatment of cervical cancer and a preparation method thereof and belongs to the technical field of traditional Chinese medicine.The traditional Chinese medicine composition for treatment of cervical cancer is made from Danshen root, amur corktree bark, dried alum, pseudo-ginseng root, rhubarb root or rhizome, dahurian angelica root, argy wormwood leaf, nutgrass galingale rhizome, Mongolian dandelion herb, spreading hedyotis herb, Chinese gentian root, and Chinese angelica root. The preparation method of the traditional Chinese medicine composition comprises washing the twelve medicinal materials with water, drying, mixing, drying at a low temperature, crushing to obtain dry powder, adding honey and tea seed oil, and emulsifying at a low temperature. The traditional Chinese medicine composition herein can be externally applied to the cervix to block the induction of cervical intraepithelial neoplasia and the development of pathological changes, thereby promoting transformation of atypical hyperplasia into normal tissues; no surgery is required, no economic burden is added to a patient, the positive-to-negativeconversion rate of low grade to high grade lesions (CINI, CINII and CINIII) of cervical cancer, and ideal effect for early inversion of carcinoma in situ is achieved.

The invention discloses an application of a Chinese medicine composition in preparation of a medicine for treating the atypical hyperplasia of the gastric mucosa. The medicine is formed by combining Chinese medicines such as radix astragali, glossy privet fruit, and the like. The Chinese medicine composition has the efficacy of supplementing qi and nourishing yin, spleen kidney nourishing and eliminating stagnation activate meridians, is tangential to pathogenesis and is clinically used for treating the disease to obtain a better effect. The invention has rational proportion and small adversereaction of the medicine, and can be used by patients for a long time.

The invention discloses a traditional Chinese medicine composition for treating chronic atrophic gastritis. The composition comprises the following components in percentage by mass: 30-50% of Taibai rice, 10-15% of red ginseng, 20-25% of coix seed, 10-15% of garlic and 10-15% of seabuckthorn oil, wherein the sum of the mass percentages of the components is 100%. The invention further discloses a preparation method of a capsule of the traditional Chinese medicine composition for treating chronic atrophic gastritis. The traditional Chinese medicine composition for treating chronic atrophic gastritis not only can treat atrophic gastritis with intestinal metaplasia and atypical hyperplasia, prevent precancerous lesions, but also can be used as an auxiliary drug for digestive tract tumors.

The invention discloses a traditional Chinese medicine for treating cervical cancer, and a preparation method thereof. Ointment for external application is prepared from the following traditional Chinese medicines: herba scutellariae barbatae, herba patriniae, cyrtomium rhizome, edible tulip, radix rumicis japonici, brucea javanica, fructus polygoni orientalis, common camptotheca fruits, rhizoma curcumae, rhizoma sparganii, Chinese angelica, common dysosmatis rhizome and root, calamine, gallnut, semen coicis, rhizoma alismatis and the like; and if the ointment is externally applied to the cervix, induction of cervical intraepithelial neoplasia etiology and lesion development can be blocked, and atypical hyperplasia is promoted to be converted to normal tissues. By adoption of the traditional Chinese medicine for treating cervical cancer in the invention, an operation is not required; the financial burden of a patient is not increased; within a relatively short period, the positive-to-negative rate of the low and high degree lesions of the cervical cancer (CINI, CINII and CINIII) is high; and the early reversal effect on carcinoma in situ is ideal. The inventor grasps the pathogenesis key of gathering of poison and evil; the traditional Chinese medicine is mainly used for clearing heat, removing toxicity, removing slough, promoting tissue regeneration, dispelling toxin, pullingout toxin, removing necrotic tissue of phagedenoma and promoting blood circulation to remove blood stasis; tonification and purgation in combination and treatment of both symptoms and root causes areachieved; the body resistance is strengthened to eliminate pathogenic factors; therefore, the immune function is adjusted and enhanced; and repairing and healing of local tissues are promoted.