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62 results about "Mammary tumor" patented technology

A mammary tumor is a neoplasm originating in the mammary gland. It is a common finding in older female dogs and cats that are not spayed, but they are found in other animals as well. The mammary glands in dogs and cats are associated with their nipples and extend from the underside of the chest to the groin on both sides of the midline. There are many differences between mammary tumors in animals and breast cancer in humans, including tumor type, malignancy, and treatment options. The prevalence in dogs is about three times that of women. In dogs, mammary tumors are the second most common tumor (after skin tumors) over all and the most common tumor in female dogs with a reported incidence of 3.4%. Multiple studies have documented that spaying female dogs when young greatly decreases their risk of developing mammary neoplasia when aged. Compared with female dogs left intact, those spayed before puberty have 0.5% of the risk, those spayed after one estrous cycle have 8.0% of the risk, and dogs spayed after two estrous cycles have 26.0% of the risk of developing mammary neoplasia later in life. Overall, unspayed female dogs have a seven times greater risk of developing mammary neoplasia than do those that are spayed. While the benefit of spaying decreases with each estrous cycle, some benefit has been demonstrated in female dogs even up to 9 years of age. There is a much lower risk (about 1 percent) in male dogs and a risk in cats about half that of dogs.

Prospective identification and characterization of breast cancer stem cells

Human breast tumors contain hetrogeneous cancer cells. using an animal xenograft model in which human breast cancer cells were grown in immunocompromised mice we found that only a small minority of breast cancer cells had capacity to form new tumors. The ability to form new tumors was not a slochastic property, rather certain populations of cancer cells were depleted for the ability to form new tumors, while other populations were enriched for the ability to form new tumors. Tumorigenic cells could be distinguished from non-tumorigenic cancer cells based on surface marker expression. We prospectively identified and isolated the tumorigenic cells as CD4430CD24−/lowLINEAGE A few as 100 cells from this population were able to form tumors the animal xenograft model, while tens of thousands of cells from non-tumorigenic populations failed to form tumors. The tumorigenic cells could be serially passaged, each time generating new tumors containing and expanded numbers of CD44+CD24 Lineage tumorigenic cells as well as phenotypically mixed populations of non-tumorigenic cancer cells. This is reminiscent of the ability of normal stem cells to self-renew and differentiate. The expression of potential therapeutic targets also differed between the tumorigenic and non-tumorigenic populations. Notch activation promoted the survival of the tumorigenic cells, and a blocking antibody against Notch 4 induced tumorigenic breast cancer cells to undergo apoptosis.
Owner:RGT UNIV OF MICHIGAN

Traditional Chinese medicinal composition for treating breast cancer and preparation method thereof

The invention discloses a traditional Chinese medicinal composition for treating breast cancer. In the traditional Chinese medicinal composition, the oral medicament is prepared from white peony root, pilose asiabell root, astragalus root, angelica, rhizoma drynariae, spica prunellae, radix gentianae, lithosperm root, rhizoma atractylodis macrocephalae, gamboges, scorpion, Tuckahoe, lumbricus, Chinese sage herb, fructus psoraleae, frankincense, nutgrass galingale rhizome and rhizoma paridis; and the external medicine is prepared from arisaema tuber, red sage root, prepared kusnezoff monkshood root, dahurian patrinia herb, suberect spatholobus stem, giant typhonium rhizome, frankincense, myrrh, szechuan lovage rhizome, mongolian dandelion herb, dahurian angelica, scorpion and ginger. The traditional Chinese medicinal composition has the advantages of strong targeting property with direct access to affected parts, low cost and the like, and is convenient for administration and manufacture. The traditional Chinese medicinal composition has the beneficial effects that traditional Chinese medicinal materials with different medicine properties are scientifically combined so as to reach ideal and safe therapeutic effect; by adopting oral and external administration modes, antitumor function can be realized, mammary tumor cells are eliminated and bone metastasis is inhibited, thus improving symptoms of a patient maximally, enhancing life quality and prolonging life; and the composition has low cost and is convenient to use, thus creating higher social value and higher economic benefit.
Owner:潘国芬

Use of miR-100 inhibitor in cancer metastasis reduction

The invention relates to a use of an miR-100 inhibitor in cancer metastasis reduction, and concretely relates to a use of a reagent for determining the miR-100 expression level in the preparation of breast cancer diagnosis reagents, and a use of the miR-100 inhibitor, and a use of the miR-100 inhibitor or an miR-100 antagonist in the preparation of medicines for treating breast cancer. Up-regulation of miR-100 in in-vivo tumor related macrophages and in-vitro induced M2 type macrophages is induced by tumor micro-environment. In in-vivo test, the microRNA antagonist knocks down the expression of the miR-100 in mouse mammary gland tumor tissues, and a case that in-situ tumor growth has no statistic difference, the quantity of lung metastasis tubercles is obviously down-regulated and the mammary gland tumor metastasis is inhibited in an experiment group of the miR-100 down-regulation in the tumor related macrophages is found.
Owner:THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI

Herba taraxaci essence cream and method for preparing same

The invention relates to herba taraxaci essence cream and a method for preparing the same. By the aid of the herba taraxaci essence cream and the method, the problems of long preparation time and high loss of nutritional components of existing herba taraxaci preparations can be solved. The herba taraxaci essence cream comprises, by weight, 60%-70% of radix taraxaci, 15%-25% of syringa reticulata and the balance radix astragali. The method includes firstly, selecting materials; secondly, cooking the materials; thirdly, extracting primary pulp; fourthly, concentrating the primary pulp and then filling containers with the primary pulp. The herba taraxaci essence cream and the method have the advantages that the method is simple and is low in cost, convenient to implement, short in processing time and free of loss of nutritional components and trace elements; the radix taraxaci, the syringa reticulata and the radix astragali which are purely natural plants are mixed with one another to obtain radix et caulis acanthopanacis senticosi essence cream, and the herba taraxaci essence cream is made of natural raw materials, is free of toxic and side effects and convenient to take and can be used as a daily healthcare product; effects of clearing heat, removing toxicity, easing pain, resolving lump, removing dampness, treating stranguria and relieving fatigue can be realized by the herba taraxaci essence cream; obvious effects can be realized by the herba taraxaci essence cream for symptoms of mammary tumor, sore throats, gynecological inflammation, swollen sore throats, urinary tract infection and the like.
Owner:陈春祥

Chinese medicinal herb for treating breast neoplasms

The invention discloses a Chinese medicinal herb for treating breast neoplasms, which consists of medicaments for external use and medicaments for oral administration. In the Chinese medicinal herb, the medicaments for external use are taken as main materials while the medicaments for oral administration are taken as subsidiary materials; the medicaments for external use are prepared by grinding and mixing the following 18 Chinese medicinal herbs: 1 to 10g of brimstone, 1 to 10g of red orpiment, 1 to 10g of yellow lead, 2 to 15g of marble, 1 to 10g of galalith, 1 to 10g of rhizoma drynariae, 1 to 10g of liquoric root, 1 to 10g of peristrophe baphica, 1 to 10g of leonurus heterophyllus, 2 to 15g of Chinese fevervine herb, 2 to 15g of rhynohophylla, 1 to 10g of memorialis hirta, 2 to 15g of long-stalked kadsura root, 1 to 10g of paniculate swallowwort root, 1 to 10g of cynanchum amplexicaule, 1 to 10g of Chinese forgetmenot root, 1 to 10g of cotton rose hibiscus leaf and 1 to 10g of grain husk leaf; and the medicaments for oral administration are prepared by decocting 2 to 15g of Chinese angelica, 1 to 10g of akebia stem, 2 to 15g of astragalus, 2 to 15g of October clematis stem, 3 to 20g of root of straight ladybell, 3 to 20g of apricot-leaved adenophora root, 1 to 10g of swordlike atractylodes rhizome, 1 to 6g of ricepaperplant pith and 2 to 15g of liquoric root in water. The suppression powder for the breast neoplasms of the invention has the characteristics of short treatment period, good treatment effect, no side effect and relapse prevention, and simultaneously, patients have no pain during treatment, and the treatment cost is low.
Owner:赖建明

Application of metadherin (MTDH) gene vaccine in preparation of breast cancer cell growth inhibitor

The invention belongs to the field of biotechnologies, and relates to a gene vaccine capable of inhibiting cancer cell growth. The gene vaccine can express a cell membrane surface protein metadherin (MTDH) and thus being named as a MTDH gene vaccine. The MTDH gene vaccine is utilized for immunization in an oral way. The MTDH gene vaccine can activate an immune response of CD8+ cytotoxic T cells on breast cancer cells 4T1 expressing MTDH antigens. The MTDH gene vaccine can inhibit breast cancer cell growth and pulmonary metastasis. Through being combined with adriamycin, the MTDH gene vaccine can improve adriamycin effects of inhibiting breast cancer cell growth and pulmonary metastasis, and prolong a life of a mouse loaded with cancer. More significantly, the MTDH gene vaccine does not produce obvious damages on main organs of a human body. Therefore, the MTDH gene vaccine provides a novel approach for improvement of the existing breast cancer treatment method.
Owner:上海宜诺迪生物科技有限公司
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