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New application of achyranthes for preparing medicines for preventing and/or treating gastric precancerous lesion and gastric cancer

A technique for precancerous lesions and Achyranthes, which is applied in the field of medicine, can solve the problems of no application of gastric precancerous lesions, and the prevention and treatment of gastric mucosal precancerous lesions, etc., and achieves the effect that the extraction method is simple and feasible.

Inactive Publication Date: 2010-10-20
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no literature records or officially published research reports on the use of Achyranthes bidentata for the prevention and treatment of gastric mucosal precancerous lesions in domestic and foreign literature.
[0006] 2. Achyranthes bidentata is widely used clinically, but its application in the prevention and / or treatment of gastric precancerous lesions has not been seen
So far, there is no report on the clinical application of Achyranthes bidentata alone or the compound with Achyranthes bidentata as the main component in the treatment of gastric precancerous lesions in any drug route related preparations

Method used

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  • New application of achyranthes for preparing medicines for preventing and/or treating gastric precancerous lesion and gastric cancer
  • New application of achyranthes for preparing medicines for preventing and/or treating gastric precancerous lesion and gastric cancer
  • New application of achyranthes for preparing medicines for preventing and/or treating gastric precancerous lesion and gastric cancer

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Experimental program
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Embodiment Construction

[0023] 1. Preparation method of Achyranthes bidentata

[0024] Take 1000 grams of Achyranthes bidentata decoction pieces and add 50% ethanol, reflux and extract four times, each time adding ethanol amount is respectively 4000, 3000, 3000, 3000ml and reflux for 1 hour. Soak for 8-12 hours before the first reflux, combine the four reflux liquids, filter, remove insoluble matter, recover ethanol under reduced pressure, concentrate until there is no alcohol smell, add water to dilute to 2500ml, refrigerate for more than 24 hours, filter, and clear liquid Concentrate to 1000ml.

[0025] 2. Animal experiment methods

[0026] The SD rats were randomly divided into 4 groups, namely: ① normal group; ② model group (10 mg / kg aristolochic acid caused benign hyperplasia of gastric mucosa → precancerous lesions of gastric mucosa → gastric malignant tumor model); ③ Achyranthes bidentata 1g / kg group; ④ Achyranthes bidentata 2g / kg group. ⑤Achyranthes bidentata 4g / kg group. Except for the c...

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Abstract

The invention relates to a new application of achyranthes for preparing medicines for preventing and / or treating gastric precancerous lesion and gastric cancer, belonging to the field of medicines. The invention aims to provide a new application of radix achyranthis bidentatae in the medicines for preventing and / or treating gastric precancerous lesion and preventing and treating gastric malignant tumors. Active portion of achyranthes are prepared by adopting an organic solvent extraction method. The animal experiment proves that achyranthes can obviously inhibit the atypical hyperplasia of gastric mucosa cells, inhibit the precancerous lesion and prevent the occurrence of gastric malignant tumors, which are not reported and applied in traditional researches and clinics, thus the invention has uniqueness and novelty. The achyranthes has wide resources and simple and convenient extraction methods and can be prepared into various dosage forms. Gastric cancer is one of common malignant tumors in China, the morbidity of the gastric cancer in China ranks first among all tumors so as to demand large medicines in clinic. Thus, the invention has very strong practicability and has very wide application prospects in the aspects of preventing and / or treating gastric mucosa precancerous lesion and the occurrence of gastric malignant tumors.

Description

1. Technical field [0001] The invention belongs to the field of medicine. 2. Background technology [0002] Achyranthes bidentata is the dried root of Achyranthes bidentata B1, a perennial herb of the family Amaranthaceae. It has the effects of promoting blood circulation and removing blood stasis, nourishing liver and kidney, strengthening muscles and bones, diuresis and treating stranguria, and drawing blood downward. Achyranthes bidentata is a commonly used traditional Chinese medicine for expelling wind and dampness, promoting blood circulation and removing blood stasis, and treating gynecological diseases. It is clinically used for irregular menstruation, dysmenorrhea, amenorrhea, postpartum stasis abdominal pain, bruises, waist and knee pain, lower limb weakness, Hematuria, dysuria, urethral astringent pain embolism. In recent years, new progress has been made in the study of its pharmacological effects, and it is believed that it has antiviral, immune regulation, an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/21A61K8/97A23L1/30A61P1/04A61P35/00A61Q19/00A61K125/00A23L33/105
Inventor 梁爱华李春英
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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