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Feed additive as well as preparation method, application and corresponding feed thereof
ActiveCN106974113AImprove disease resistanceEnhance digestionFood processingAnimal feeding stuffRadix Rehmanniae PreparataCodonopsis pilosula
The invention provides a feed additive as well as a preparation method, an application and a corresponding feed thereof. The feed additive comprises a compound traditional Chinese medicine and other additives, wherein the compound traditional Chinese medicine comprises codonopsis pilosula, bighead atractylodes rhizome, rhizoma smilacis glabrae, liquorice, radix rehmanniae preparata, radix paeoniae alba, ligusticum wallichii, angelica sinensis, rhizoma atractylodis, mangnolia officinalis, dried tangerine or orange peel, fried endothelium corneum gigeriae galli, hawthorn, fried malt, rhizoma alismatis and carrier. The feed additive provided by the invention has the function of promoting the immunity and production performance of the pig herd in each stage, can be used for fully replacing antibiotics and also can effectively prevent and treat cad pig diseases.
Owner:谢又华
Medicine-carrying membrane-covered stent and preparation method thereof
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH +1
Anti-restenosis digestive tract stent
InactiveCN102335052AMeet the requirements of minimally invasive operationsRelieve painStentsRadiation therapyCylindromaPercent Diameter Stenosis
The invention discloses an anti-restenosis digestive tract stent which is characterized in that a main body (1) is formed by connecting a plurality of stent units (2) and an easily-bent connecting part (3), wherein two ends of the connecting part (3) are respectively connected with the corresponding stent unit (2), the main body (1) is of a right circular cylinder structure which is easy to bend or a composite structure which is easy to bend and consists of a cylinder and a cone; and each stent unit (2) is of an integral structure formed by carving a metal pipe material or a structure formed by weaving a silk material, and the connecting part (3) is formed by weaving a metal line material or plastic line material with good flexibility. The anti-restenosis digestive tract stent has better radial supporting strength and better compliance, and ensures that the stent has the advantages of more accuracy of positioning, difficulty in translocation, low restenosis incidence and the like.
Owner:MICRO TECH (NANJING) CO LTD +2
Tumour-dissolving adenovirus mutant possessing multiple specific anti-tumour mechanism
InactiveCN1884556AGood curative effectPlay a therapeutic roleFermentationGenetic engineeringHuman tumorReverse transcriptase
This invention involved oncolytic adenovirus mutant with the multiple antitumoral Mec. It belongs to the BME field. The adenovirus mutant Elb-55kDa and Elb-19kDa has missing gene, inserts chimeric promoter composed by the human telomerase reverse transcriptase core sequence and human tumor epidermal growth factor receptor enhancer before the replication required gene Ela codons mEla289R and mEla243R. So the virus can specific proliferate in cancer cell. Oncolytic viruses and mEla protein can exert thire influence. It can also increase the sensitivity of cancer cell to chemoradiation and have no influence to normal cell. It inserts the human h-endostatin gene expression cassette in adenovirus mutant gene group; along the replication of virus in cancer cell to amplificate h-endostatin gene and effective expression in tumor so to restrain neovascularization of tumor so to realize the result of restrain the increase and transformation of cancer cell and apoptotic cell. This new oncolytic adenovirus mutant has good clinical prospect in gene curing so to used in curing many kinds of human tumors.
Owner:JIANGSU SHUNTANG BIOENG
Gastrointestinal colour ultrasonic contrast medium
InactiveCN1535730APlay a therapeutic roleClear diagnosisEchographic/ultrasound-imaging preparationsDiseaseCuttlefish
The present invention relates to a gastrointestinal color ultrasonic contrast medium. It is a Chinese medicine preparation made up by using the Chinese medicinal materials of ark shell 2 portions, corydalis tuber 2 portions, pearl 1 portion, abalone shell, portion and cuttlefish bone 1 portion through the processes of selecting raw material, washing, drying, pulverizing to 100 meshes, uniformly mixing them, sterilizing, filling and capsulizing to obtain the invented finished procuct. The invention has no toxic side effect, can be used for accurately diagnosing various gastrointestinal diseases.
Owner:张福东
Drug-loaded saccule and manufacture method thereof
InactiveCN106075703AFacilitated releasePromote absorptionBalloon catheterMedical devicesDrugs solutionSaccule
The invention discloses a drug-loaded saccule and a manufacture method thereof. The drug-loaded saccule comprises a saccule with a multivalve structure, wherein a drug-coated crystal layer is adhered to the surface of the saccule, and comprises an active drug and a drug mixture; the content of the active drug in the drug-coated crystal layer is gradually reduced from the surface of the saccule outward, while the content of the drug mixture is gradually increased from the surface of the saccule outward. The manufacture method comprises the following steps: firstly, folding the surface of the saccule; preparing drug-coating solutions with different proportions by using the active drug, the drug mixture and solvent as raw materials; then, sequentially coating the drug-coating solutions to the surface of the saccule according to a decreasing sequence of the content of the active drug, drying and crystallizing to obtain a multi-layer drug-coated crystal layer having the content of the active drug in a gradient descending shape inside-out; and finally, rolling and pressing the saccule to obtain the final drug-loaded saccule. The drug-loaded saccule has an excellent drug-loading performance, strong adhesion soundness and strong washing resistance.
Owner:HANGZHOU WEIQIANG MEDICAL TECH CO LTD
Intelligent cerebral stroke drug carrier for ROS (reactive oxygen species) response and preparation method of drug carrier
InactiveCN106267149AImprove solubilityStrong drug encapsulation abilityPeptide/protein ingredientsPharmaceutical non-active ingredientsMedicineGraft reaction
The invention discloses an intelligent cerebral stroke drug carrier for ROS (reactive oxygen species) response and a preparation method of the drug carrier. The carrier is a nano vesicle, hydrophobic boric acid ester is grafted to hydrophilic glucan framework to form amphiphilic block copolymers, the amphiphilic block copolymers serve as carrier materials to prepare the nano vesicle, and the nano vesicle encapsulates neuroprotective agents NR2B9C. The preparation method includes the steps: performing covalent grafting for the boric acid ester and glucan; preparing a nano vesicle carrier by grafting reaction carrier materials in an automatically filling manner; encapsulating the neuroprotective agents NR2B9C in the nano vesicle carrier. The weight ratio of the boric acid ester and the glucan is 10: (5-25), the carrier easily responds degradation of ROS mediation, so that drugs rapidly release at cerebral ischemia lesion positions, and release in non-lesion areas is decreased, so that the neuroprotective agents are more safely and effectively transmitted in intracerebral target areas.
Owner:NANJING MEDICAL UNIV
Probiotics microcapsule preparation and preparation method thereof
ActiveCN105567669APlay a role in health carePlay a therapeutic roleBacteriaMetabolism disorderHigh activityGenus Lactobacillus
The invention relates to a probiotics microcapsule preparation and a preparation method thereof. The microcapsule preparation comprises a capsule material and a wall material. The wall material is composed of soybean oil and Span 80. The capsule material contains enterococcus faecium and lactobacillus casei. Before the fermentation, the microbes are embedded in the microcapsules. Low density microbial cells are wrapped in the capsule material, and then fermentation is carried out to obtain higher bacterium concentration and cell activity. Through simple separation, a dual lactobacillus microcapsule preparation containing high density enterococcus faecium and lactobacillus casei can be obtained directly. The preparation method has the advantages that the microbes are embedded before fermentation, two different lactobacillus cells are embedded into a same microcapsule at the same time, the intergrowth of different microbial cells is realized, the synergetic effect can be generated; due to the pre-fermentation embedding technology, two microbial cells can proliferate for another time, and thus higher activities can be obtained more easily.
Owner:魏永刚
Chinese foot-soaking powder
InactiveCN1742994ANo side effectsPlay a role in healingPowder deliveryDermatological disorderDiseaseClematis
The present invention discloses a Chinese medicine foot-soaking powder for external application. It is made up by using 15 Chinese medicinal materials of clematis root, star jasmine stem, chaenomeles fruit, dried ginger, aconite accessory tuber, cinnamon twig and others as raw material, pulverizing them to obtain the invented medicine powder. When it is used, the medicine power is added into hot water to soak foot. It has the effect for curing general diseases and building up body.
Owner:夏景祁
Instant donkey-hide gelatin cake piece for strengthening congenital qi, resisting fatigue, lengthening life, controlling hyperglycemia, hypertension and hyperlipidemia, balancing and resisting sugar, and preparation method thereof
InactiveCN102150777AEnhance immune functionFit for consumptionFood preparationAcute hyperglycaemiaSecondary hyperlipidemia
The invention relates to an instant donkey-hide gelatin cake piece for strengthening congenital qi, resisting fatigue, lengthening life, controlling hyperglycemia, hypertension and hyperlipidemia, balancing and resisting sugar, and a preparation method thereof. The instant donkey-hide gelatin cake piece is low in cost and convenient for processing, and comprises the following components: 750g of donkey-hide gelatin powder, 1000g of black sesame, 500g of walnut kernels, 250g of seedless red jujube pieces, 500g of sunflower seed kernels, 200g of crystal sugar, 1000ml of rice wine, 400ml of A well water (which is water from A well in ancient Dong A county), 250g of barbary wolfberry fruit kernels, 150g of dried longan pulp, 100g of protein powder and 750g of arabinose.
Owner:王以盘
Chinese medicinal health-care cigarette
InactiveCN102217797AHave character traitsNo discomfortTobacco treatmentCigar manufactureSide effectHigh volume manufacturing
The invention relates to a Chinese medicinal health-care cigarette. The Chinese medicinal health-care cigarette is prepared by the steps of: screening perilla leaves, whole plantain herb, mint leaves, liquorice, fiveleaf gynostemma herb leaves, and viscid germander herb leaves and flowers to remove impurities, then cleaning, airing and cutting up; mixing the cut up active ingredients in proportion, blending uniformly, putting in a piece of cigarette paper, and rolling into a cigarette. By using the Chinese herbal medicine ingredients, the Chinese medicinal health-care cigarette disclosed by the invention can be used as a common cigarette; besides, the Chinese medicinal health-care cigarette has the peculiarities of the common cigarette, so that the cigarette does not make a smoker unconformable. The Chinese medicinal health-care cigarette disclosed by the invention has no toxic or side effects to a smoker and surrounding crowd, and has health-care, prevention and treatment functions for lungs, stomachs, livers, kidneys, and other organs of the smoker and the surrounding crowd; the Chinese medicinal health-care cigarette is prepared by using the Chinese herbal medicine ingredients which are rich in sources and low in cost, so that the cigarette is suitable for volume production.
Owner:赵龙山
Special biological disease-resistant vermin-proof culture medium for flowers and preparation method thereof
The invention relates to a special biological disease-resistant vermin-proof culture medium for flowers and a preparation method thereof. The special biological disease-resistant vermin-proof culture medium for flowers is prepared from smoke dross, furfural residue, microbial fermentation inoculum, superphosphate, trichoderma microbial inoculum, bacillus microbial inoculum and expanded perlite. The preparation method comprises the following steps: compounding smoke dross, furfural residue, microbial fermentation inoculum and superphosphate; after the mixture is decomposed, sterilizing, adding trichoderma microbial inoculum and bacillus microbial inoculum with disease-resistant function; and after composting for some time, adding the expanded perlite. Abundant active trichoderma and bacillus and metabolites thereof contained in the culture medium provided by the invention have obvious inhibiting action on flower diseases; and the smoke residue and resolvents thereof have the action of expelling and killing vermins which are easily generated in the medium. When being used for planting flowers, the special culture medium for flowers can protect the environment, and is beneficial to human health.
Owner:SHANDONG GUANGDA FERTILIZER INDAL TECHCO
Attention switching training device for infantile autism treatment
ActiveCN104888332AStrengthen the ability to switch "attention"Alleviate symptoms of indifference to external informationDiagnostic recording/measuringSensorsInfantile autismPhysical medicine and rehabilitation
An attention switching training device for infantile autism treatment comprises different types of stimulus signal generating modules, and further comprises a signal switching trigger circuit used for driving stimulus signals to be switched and an output signal switching circuit used for executing stimulus signal switching. The attention switching training device for infantile autism treatment has the advantages that the attention of a brain to the stimulus signals can be effectively drawn, and the attention point of the brain can be continuously switched between different information channels; the stimulation of attention drawing and attention switching is repeatedly conducted on a patient, so that the transmission efficacy of neural pathways is interfered and influenced through the plasticity of cranial nerves, and the attention to outside information and the capacity of attention switching of the patient are strengthened. The attention switching training device can be used for treating infantile autism.
Owner:徐志强
Sinkiang-arnebia-root-containing skin-care traditional Chinese medicine composition, sinkiang-arnebia-root-containing skin-care cream and preparation method of sinkiang-arnebia-root-containing skin-care traditional Chinese medicine composition and sinkiang-arnebia-root-containing skin-care cream
ActiveCN104857073APromotes self-healingEnhanced barrier functionCosmetic preparationsAerosol deliverySelf-healingRosmarinus
The invention relates to sinkiang-arnebia-root-containing skin-care traditional Chinese medicine composition and a preparation method thereof. Effective components of the sinkiang-arnebia-root-containing skin-care traditional Chinese medicine composition are prepared from raw materials in parts by weight as follows: 30-70 parts of sinkiang arnebia roots, 15-45 parts of boswellia serrate, 5-15 parts of liquorice and 1-10 parts of rosemary leaves. The preparation method is characterized in that a method of stir-frying traditional Chinese medicines with honey is adopted, dissolution of effective substances is promoted, the effective preservation life of extracts is prolonged, besides, meadowfoam seed oil is taken as a solvent and performs a synergistic anti-oxidation function along with the rosemary leaves added to the meadowfoam seed oil. The invention further provides sinkiang-arnebia-root-containing skin-care cream. The sinkiang-arnebia-root-containing skin-care cream is mainly prepared from raw materials as follows: the traditional Chinese medicine composition, maize germ oil, beewax, cocoa seed butter, natural tocopherol, avocado oil, lavender essential oil, mango seed butter, lanolin and prinsepia utilis royle oil. The sinkiang-arnebia-root-containing skin-care cream is environment-friendly and safe and can effectively promote self-healing of the skin of infants and improve the skin barrier function.
Owner:GUANGZHOU XIAOMIFENG BIOTECH CO LTD
Traditional Chinese medicine composition for treating blue ear diseases and preparation method thereof
InactiveCN101700301ALow toxicityLow costAnthropod material medical ingredientsAntiviralsHoneysuckleToxic material
The invention provides a traditional Chinese medicine composition for treating blue ear diseases and a preparation method thereof. The traditional Chinese medicine composition comprises 5-10 parts of mulberry leaf, 5-10 parts of chrysanthemum, 5-10 parts of platycodon grandiflorus, 5-10 parts of weeping forsythiae, 2-6 parts of almond, 2-6 parts of muscardine silkworm, 2-6 parts of tangerine peel, 5-9 parts of Chinese ephedra, 10-20 parts of honeysuckle, 10-20 parts of radix isatidis, 2-6 parts of liquorice, 2-6 parts of baikal skullcap root and 2-6 parts of herba schizonepetae. The preparation method comprises the following steps: after the traditional Chinese medicines are soaked in water according to the ratio, decocting twice, combining filtrate, and concentrating until the relative density is 1.0-1.2. The traditional Chinese medicine composition clears away heat and toxic materials, resolves phlegm, ventilates and smoothes lung, strengthens the anti-adversity ability of organism, combines supplement, nourishing and treating and effectively treats the blue ear diseases. The preparation method is simple and is suitable for the requirements of large-scale industrial production.
Owner:TIANJIN SHENGJI GRP CO LTD
Focusing ultrasonic cavitation treatment instrument with ultrasonic focusing positioning function
The invention relates to a focusing ultrasonic cavitation treatment instrument which is used for treating tumor, thrombolysis, ischemic myocardium and disease of prostate based on the cavitation effect of the ultrasonic contrast agent microvesicle. The focusing ultrasonic cavitation treatment instrument comprises a main control machine, two combined treatment probes, and a B ultrasonic machine with an ultrasonic focusing ultrasonic cavitation treatment instrument function. The focusing ultrasonic cavitation treatment instrument is mainly used for the partial area of the focus, and carries out non-invasive treatment on the tumor based on the cavitation effect of the microvesicle. The microvesicle can greatly improve the cavitation effect, so that the ultrasonic focusing positioning radiation with low power can be precisely carried out in the partial area of the focus, and the cavitation effect of the microvesicle within the vessel just can be activated within the partial area, and the capillaries in the tumor can be subject to embolism and damage, so as to achieve the purpose of 'starving' the tumor. The threshold for generating the cavitation is not met by the ultrasonic energy at the periphery of the focusing area, so that the cavitation effect is not generated, so that the path where the ultrasonic wave passes or the ambient tissue can not be damaged; and the functions of the common tissue and organs are protected.
Owner:黄品同 +1
Vascular optical fiber guide wire
InactiveCN106512232APlay a therapeutic rolePlay a diagnostic roleLight therapyTreatment needHydrophilic coating
The invention relates to a vascular optical fiber guide wire. The vascular optical fiber guide wire comprises at least one optical fiber core wire, a wire winding layer and a hydrophilic coating capable of improving body fluid compatibility and reducing resistance, wherein the optical fiber core wire is arranged at an axial position of the optical fiber guide wire; the wire winding layer is composed of at least one winding wire or winding piece which coats and surrounds the optical fiber core wire; and the hydrophilic coating is painted on the periphery of the wire winding layer. The vascular optical fiber guide wire can enter an artery blood vessel of a human body to arrive at a predetermined position, and lead light into and / or out of a lesion part to realize photodynamic therapy for in-vivo tumors and the like, so as to satisfy the diagnosis and treatment needs in biological, medical fields and the like.
Owner:尚华
Nasal cavity drop for treating diabetes and preparation method thereof
InactiveCN101601646BAvoid painAvoid inconveniencePeptide/protein ingredientsMetabolism disorderDiabetes mellitusCalcium biphosphate
The invention discloses a nasal cavity drop for treating diabetes and a preparation method. The nasal cavity drop comprises solvent and accessories, and is characterized in that the solvent contains a compound of calcium phosphate nano particles and exenatide, the weight ratio of the calcium phosphate nano particles to the exenatide in the compound is 1-10:0.1-10, and the content of the exenatidein the solvent is 0.01 to 0.5 milligram per milliliter. The preparation method for the nasal cavity drop comprises the following steps: mixing aqueous solutions of calcium salt, phosphate, citrate and exenatide to form the compound of the calcium phosphate nano particles and the exenatide, adding the accessories which are frequently used for aqueous agent into the mixture, detecting and adjustingthe pH of the solution, and finally forming the nasal cavity drop, wherein the weight ratio of the calcium phosphate nano particles to the exenatide in the compound is 1-10:0.1-10, and the content ofthe diluted exenatide in the solvent is 0.01 to 0.5 milligram per milliliter.
Owner:南京凯瑞尔纳米生物技术有限公司
Traditional Chinese medicine composition for treating mycoplasmal pneumonia of swine and preparation method thereof
The invention provides a traditional Chinese medicine composition for treating mycoplasmal pneumonia of swine and a preparation method thereof. The composition is made from the following materials: 5-12 parts of balloonflower root, 5-12 parts of white swallowwort, 5-12 parts of radix asteris, 5-12 parts of white mulberry bark, 3-8 parts of birthwort fruit, 3-8 parts of tuber stemona root, 3-8 parts of perilla fruit, 5-12 parts of scutellaria root, 3-8 parts of apricot kernel, 3-8 parts of wind-weed rhizome, 3-8 parts of red sage root, 3-8 parts of angelica, 3-8 parts of zedoary, 1-7 parts of dried tangerine peel and 1-5 parts of licorice. The preparation method comprises the following steps: proportionally adding water to the traditional Chinese medicines for soaking, decocting for three times, taking filtrate, keeping standing, condensing to relative density of 1.0-1.2, and obtaining the traditional Chinese medicine composition. The traditional Chinese medicine composition is of low toxicity, can effectively treat mycoplasmal pneumonia of swine, enhance adversity resistance ability of the body at the same time, has simple preparation method, and is suitable for the needs of large-scale industrial production.
Owner:天津诺康动物药业有限公司
Traditional Chinese medicine for treating diabetic nephropathy and preparation method thereof
ActiveCN103316101AProtect kidney structureReduce urine proteinMetabolism disorderUrinary disorderDose dependenceUrine
The invention provides a traditional Chinese medicine for treating diabetic nephropathy and a preparation method thereof. The traditional Chinese medicine for treating diabetic nephropathy is prepared from the following traditional Chinese medicinal materials by weight: 6 to 15 parts of common fenugreek seed, 6 to 15 parts of milkvetch root, 3 to 8 parts of epimedium herb, 3 to 8 parts of malaytea scurfpea fruit, 3 to 8 parts of Asiatic cornelian cherry fruit, 1 to 5 parts of rhubarb root and rhizome, 3 to 8 parts of Chinese cassia tree and 2 to 6 parts of coptis. The invention further discloses the preparation method for the traditional Chinese medicine. According to the invention, renal tubulointerstitial fibrosis is dose-dependently inhibited through reduction of urine protein of rats with diabetic nephropathy, so a certain treatment effect is exerted on type 1 diabetic nephropathy and the treatment effect is equal to that of a benazepril hydrochloride tablet but better than that of a kidney-qi-tonifying pill. The traditional Chinese medicine also exerts a certain treatment effect on rats with type 2 diabetic nephropathy through approaches like protection of a kidney structure, reduction of the content of urine protein and improvement of in-vivo lipid metabolism disorder.
Owner:WUHAN JIANHENG PHARMA
Drug-loaded mesoporous-silica-reinforced dental binder and preparation method thereof
InactiveCN103655207APorousAct as a bondAntibacterial agentsImpression capsMesoporous silicaDrug release
The invention relates to a drug-loaded mesoporous-silica-reinforced dental binder and a preparation method thereof. The binder comprises following components by weight: 40-60% of a resin component, 35-50% of a dilution component, 2-10% of an acid monomer, 0.2-0.5% of a photoinitiator, 0.1-0.3% of a promoter, a trace amount of a polymerization inhibitor and 1-10% of mesoporous silica. The binder has high strength and drug releasing property, and therefore the binder is advantaged by loading and performing controlled releasing of antibacterial agents, anti-inflammatory drugs, hemostatics, etc.. The binder not only has a binding function, but also has certain functions of treating and preventing bacterial infection, and can be used as a dentine binder in clinic.
Owner:SHANGHAI NAT ENG RES CENT FORNANOTECH
Dendrobium officinale fat-reducing and blood pressure-lowering tea
InactiveCN103749771AActivating receptorsSolve the problem of resistancePre-extraction tea treatmentMetabolism disorderAcute hyperglycaemiaSide effect
The invention discloses fat-reducing and blood pressure-lowering tea prepared by taking dendrobium officinale as a main raw material, matching with thirteen Chinese herbal medicines such as rhizoma anemarrhenae, scutellaria baicalensis, mangnolia officinalis, amomum tsao-ko, white paeony root, uncaria, semen cassiae, chrysanthemum, oriental wormwood, the root of kudzu vine, green tea, selfheal and licorice roots northwest origin and drying, grinding and bagging the medicines. The tea has good effects of reducing fat and lowering blood pressure, does not have a toxic or side effect, is suitable for the crowd suffering from hyperlipidemia, hypertension and hyperglycemia, particularly suitable to serve as a daily drink for the old and has the health-care effect of prevention and treatment.
Owner:GUANGXI JIANBAO SHIHU
Pregelatinized and re-pelleted composite brown rice
InactiveCN102652548ANutrition, Green and Environmental ProtectionNutritional diversityFood preparationCorn flourSemen
The invention discloses pregelatinized and re-pelleted composite brown rice which is prepared from the following raw materials in parts by weight: 10-120 parts of coarse rice powder, 8-15 parts of corn starch, 5-10 parts of black soya bean powder, 3-8 parts of purslane lyophilized powder, 3-5 parts of semen sesami nigrum powder, 3-5 parts of lotus leaf powder, 3-5 parts of lotus seed powder, 3-5 parts of Lycium barbarum L powder, 3-5 parts of buckwheat powder and 3-5 parts of lily root flour. The pregelatinized and re-pelleted composite brown rice is prepared by adopting double-screw extruding re-pelleting technology and processes such as gelatinization, extruding and re-pelleting on the raw materials which are rich in nutrition, the nutrition rice has the same shape as the common rice, a rice product with the same steaming performance and method as the common rice can be achieved, the process is green, environment-friendly, flexible in operation, efficient in production and low in fault rate, and the prepared composite brown rice has more complete nutrition and finer taste than the common brown rice.
Owner:ANHUI LV ZHEN FANG AGRI SCI & TECH
Calcium alginate-graphene oxide nanofiber and preparation method and drug-carrying calcium alginate-graphene oxide nanofiber
ActiveCN109468708AReduced release rateAvoid burst phenomenonAlginate artificial filamentsPharmaceutical non-active ingredientsOxygenDrug release
The invention provides a calcium alginate-graphene oxide nanofiber and a preparation method and a drug-carrying calcium alginate-graphene oxide nanofiber and relates to the technical field of nanofibers. The preparation method of the calcium alginate-graphene oxide nanofiber comprises the following step: carrying out microfluidics spinning on a mixed solution of calcium alginate and graphene oxideand a calcium chloride solution, thereby obtaining the calcium alginate-graphene oxide nanofiber. The technical problem that a sudden drug release phenomenon is caused as a conventional calcium alginate nanofiber is good in hygroscopicity and low in mechanical strength is alleviated. By adopting the preparation method provided by the invention, the graphene oxide is put into raw materials, so that the calcium alginate-graphene oxide nanofiber has hydrogen bond interactions with oxygen-containing groups on a graphene oxide sheet and hydroxyl in calcium alginate molecules, the hydrogen bond function of the calcium alginate and water molecules is weakened, the swelling velocity of the calcium alginate is reduced, and the sudden drug release phenomenon can be prevented.
Owner:WUYI UNIV
Solid preparation of clopidogrel free alkali and preparation process thereof
InactiveCN101766577AImprove securityImprove stabilityOrganic active ingredientsPill deliveryMANNITOL/SORBITOLHydrolysate
The invention relates to a solid preparation of clopidogrel free alkali and a preparation process thereof. The solid preparation uses the clopidogrel free alkali as the principal agent, and is mixed with anhydrous lactose, microcrystalline cellulose, mannitol, hydroxy propyl cellulose, part of pregelatinized starch, fumed silica and magnesium stearate which are used as auxiliary materials. The method uses the wet granulation to prepare. The solid preparation of the invention solves the problem of clopidogrel hydrolysates during the production of the solid preparation of the clopidogrel free alkal, and the safety and the stability of the solid preparation of the clopidogrel free alkali are improved, and the solid preparation of the clopidogrel free alkali can be more effective to have the therapeutic effect.
Owner:JBC PHARMLAB +1
High-temperature and high-humidity resistant saccharomyces boulardii and application thereof
The invention discloses high-temperature and high-humidity resistant saccharomyces boulardii and application thereof, and belongs to the field of microorganisms. The preservation number of the high-temperature and high-humidity resistant saccharomyces boulardii disclosed by the invention is CGMCC No.10381; the multiplication rate and maximal biomass (namely final density of thallus) of saccharomyces boulardii strains are significantly higher than those of similar saccharomyces cerevisiae strains; the saccharomyces boulardii has high heat-resistant and moisture-resistant capacities; the saccharomyces boulardii disclosed by the invention can be used as a feed additive; and relatively high activity is stored in the high-temperature and high-humidity treatment processes. According to a saccharomyces boulardii capsule, daily gain, immune organ index, disease resistance, oxidation resistance and immune globulin of broiler chicken can be improved; the saccharomyces boulardii is free of a toxic or side effect on beasts and birds, wide in source and low in price, and can be used as a feed additive instead of antibiotics.
Owner:赤峰四海同心生物科技有限公司
Method for preparing cigarette with agilawood type special-grade taste
The invention belongs to the field of cigarette preparing technology, and particularly relates to a method for preparing an improved cigarette with agilawood type special-grade taste. Agallochum leaves, branches and husks are adopted for preparing agilawood filaments, dehydration is carried out until the water weight percentage is 25-35 percent, the agallochum leaves, branches and husks are cut into the agilawood filaments with the width of 1+ / -0.1 mm, a tobacco shred alcoholization mode is adopted to process the agilawood filaments at first, then tobacco shreds and the agilawood filaments are evenly mixed according to the weight ratio of 1:0.053-0.667, tobacco shred alcoholization biological agents are added for processing according to 0.5-2 percent of the weight of the whole firmaments, the whole firmaments are dehydrated until 11 percent of water is left, standing is carried out for 3-4 hours, and the cigarette rolling procedure is to be conducted. The process is simple, cost can be greatly reduced, fishy smell during burning and smoking is eliminated, fragrance of cigarettes is more pure and mild, the breaking rate during preparing can be reduced, and the therapeutical effect of the agallochum leaves on diseases of respiratory system is fully utilized.
Owner:李贵生
Method for processing convenience food of giantarum
InactiveCN1689443AKeep active ingredientsPlay a therapeutic roleFood preparationGlucomannanConvenience food
The instant konjaku food producing process includes producing konjaku curd with fine konjaku powder and producing instant konjaku food with konjaku curd. The konjaku curd is produced with fine konjaku powder in 90-110 weight portions, wild plant powder, juice or slurry in 2-550 weight portions, animal powder or slurry in 0-150 weight portions, water in 300-5500 weight portions and sodium carbonate in 1-10 weight portions, and through mixing and curing naturally at normal temperature. Compared with available technology, the production process with curing at normal temperature can well maintain glucomannan and other effective components in konjaku for effective dietotherapy and the addition of other plant and animal components makes the instant konjaku food complete in nutritive components.
Owner:雷安乐
Pharmaceutical composition for treating periodontitis, and preparation method and application thereof
ActiveCN102240277ASpecial physical propertiesSensitive to temperatureOrganic active ingredientsAerosol deliveryControlled releaseLiquid state
The invention relates to a pharmaceutical composition for treating periodontitis and a preparation method thereof, wherein the pharmaceutical composition comprises chlorhexidine or derivatives thereof, poloxamer 407, a release speed adjusting agent, a stabilizer and other additives. The pharmaceutical composition has particular physical characteristics; when the temperature reaches the gel point, the composition can undergo phase transition from liquid to semisolid gel; the composition is liquid at the room temperature; after being used, the composition changes into semisolid gel quickly under the human body temperature condition and then is adhered on the surface of periodontal mucosa to release the medicine, thus a therapeutic effect is obtained; the composition has specific controlled-release property, and can achieve a controlled-release effect of 4 to 5 days of sustained medicine release by adjusting types and dosages of the release speed adjusting agents, thereby reducing the medicine using times, and improving the medication compliance of patients; and the composition is good in stability, and convenient to produce, transport and store.
Owner:SHENZHEN SOUTH CHINA PHARMA
Traditional Chinese medicine ointment for treating burn and preparation method thereof
InactiveCN101391039AHeat-clearing and detoxifyingWith swelling and pain reliefHydroxy compound active ingredientsAerosol deliveryCoptisToxic material
Disclosed is a Chinese traditional medicine ointment for curing burn disease and a preparing method; the medicine is composed of the following Chinese traditional medicine materials by weight ratio: 112.5-337.5 parts of Garden Burnet Root, 37.5- 112.5 parts of radix scutellariae, 37.5-112.5 parts of Bark of Chinese Corktree, 12.5-37.5 parts of rhubarb, 12.5-37.5 parts of folium ilicis chinensis, 12.5-37.5 parts of lotus leaf, 12.5-37.5 parts of lithospermum, 12.5-37.5 parts of yellowweed, 12.5-37.5 parts of glabrous sarcandra herb, 7.5-22.5 parts of coptis root, 5-15 parts of borneol, and 450-1350 parts of benne oil and 48.6-145.8 parts of beeswax. With functions of clearing away heat and toxic material, reducing swelling and alleviating pain, promoting Blood circulation to remove Blood stasis, reducing inflammation and clearing away purulence, removing the rotten and drawing the poison, and generating muscle and skin, the medicine ointment has the advantages that the production technique is simple, the quality index can be controlled easily, the cost is low, and the use is security; the medicine is applied to patients with skin burn, and can have effects on resisting bacterium, diminishing inflammation and alleviating pain, and has accurate curative effect.
Owner:湖南恒伟药业股份有限公司
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