546results about How to "Play a therapeutic role" patented technology

The invention relates to a medicine-carrying membrane-covered stent and a preparation method thereof. The medicine-carrying membrane-covered stent is covered with a medicine-carrying low-speed degrading fiber layer with an electrostatic spinning method, and the surface of the medicine-carrying low-speed degrading fiber layer is covered with a medicine-carrying low-speed degrading fiber layer with the electrostatic spinning method. The medicine-carrying membrane-covered stent provided by the invention can be used for treating the malignant stricture of a biliary tract, has the action of mechanical expansion and also has the action of topical therapy. The provided medicine-carrying membrane-covered stent is characterized in that medicine can be slowly released to lesion positions so as to perform the therapy effect. Compared with the common bare stent or the common membrane-covered stent, the medicine-carrying membrane-covered stent is characterized by better solving the problem of the benign and malignant stricture of the biliary tract. In addition, the method also can be used for modifying an esophagus stent, a trachea stent and a cardiovascular stent.

The invention discloses an anti-restenosis digestive tract stent which is characterized in that a main body (1) is formed by connecting a plurality of stent units (2) and an easily-bent connecting part (3), wherein two ends of the connecting part (3) are respectively connected with the corresponding stent unit (2), the main body (1) is of a right circular cylinder structure which is easy to bend or a composite structure which is easy to bend and consists of a cylinder and a cone; and each stent unit (2) is of an integral structure formed by carving a metal pipe material or a structure formed by weaving a silk material, and the connecting part (3) is formed by weaving a metal line material or plastic line material with good flexibility. The anti-restenosis digestive tract stent has better radial supporting strength and better compliance, and ensures that the stent has the advantages of more accuracy of positioning, difficulty in translocation, low restenosis incidence and the like.

This invention involved oncolytic adenovirus mutant with the multiple antitumoral Mec. It belongs to the BME field. The adenovirus mutant Elb-55kDa and Elb-19kDa has missing gene, inserts chimeric promoter composed by the human telomerase reverse transcriptase core sequence and human tumor epidermal growth factor receptor enhancer before the replication required gene Ela codons mEla289R and mEla243R. So the virus can specific proliferate in cancer cell. Oncolytic viruses and mEla protein can exert thire influence. It can also increase the sensitivity of cancer cell to chemoradiation and have no influence to normal cell. It inserts the human h-endostatin gene expression cassette in adenovirus mutant gene group; along the replication of virus in cancer cell to amplificate h-endostatin gene and effective expression in tumor so to restrain neovascularization of tumor so to realize the result of restrain the increase and transformation of cancer cell and apoptotic cell. This new oncolytic adenovirus mutant has good clinical prospect in gene curing so to used in curing many kinds of human tumors.

The present invention relates to a gastrointestinal color ultrasonic contrast medium. It is a Chinese medicine preparation made up by using the Chinese medicinal materials of ark shell 2 portions, corydalis tuber 2 portions, pearl 1 portion, abalone shell, portion and cuttlefish bone 1 portion through the processes of selecting raw material, washing, drying, pulverizing to 100 meshes, uniformly mixing them, sterilizing, filling and capsulizing to obtain the invented finished procuct. The invention has no toxic side effect, can be used for accurately diagnosing various gastrointestinal diseases.

The invention discloses a drug-loaded saccule and a manufacture method thereof. The drug-loaded saccule comprises a saccule with a multivalve structure, wherein a drug-coated crystal layer is adhered to the surface of the saccule, and comprises an active drug and a drug mixture; the content of the active drug in the drug-coated crystal layer is gradually reduced from the surface of the saccule outward, while the content of the drug mixture is gradually increased from the surface of the saccule outward. The manufacture method comprises the following steps: firstly, folding the surface of the saccule; preparing drug-coating solutions with different proportions by using the active drug, the drug mixture and solvent as raw materials; then, sequentially coating the drug-coating solutions to the surface of the saccule according to a decreasing sequence of the content of the active drug, drying and crystallizing to obtain a multi-layer drug-coated crystal layer having the content of the active drug in a gradient descending shape inside-out; and finally, rolling and pressing the saccule to obtain the final drug-loaded saccule. The drug-loaded saccule has an excellent drug-loading performance, strong adhesion soundness and strong washing resistance.

The invention relates to a probiotics microcapsule preparation and a preparation method thereof. The microcapsule preparation comprises a capsule material and a wall material. The wall material is composed of soybean oil and Span 80. The capsule material contains enterococcus faecium and lactobacillus casei. Before the fermentation, the microbes are embedded in the microcapsules. Low density microbial cells are wrapped in the capsule material, and then fermentation is carried out to obtain higher bacterium concentration and cell activity. Through simple separation, a dual lactobacillus microcapsule preparation containing high density enterococcus faecium and lactobacillus casei can be obtained directly. The preparation method has the advantages that the microbes are embedded before fermentation, two different lactobacillus cells are embedded into a same microcapsule at the same time, the intergrowth of different microbial cells is realized, the synergetic effect can be generated; due to the pre-fermentation embedding technology, two microbial cells can proliferate for another time, and thus higher activities can be obtained more easily.

The present invention discloses a Chinese medicine foot-soaking powder for external application. It is made up by using 15 Chinese medicinal materials of clematis root, star jasmine stem, chaenomeles fruit, dried ginger, aconite accessory tuber, cinnamon twig and others as raw material, pulverizing them to obtain the invented medicine powder. When it is used, the medicine power is added into hot water to soak foot. It has the effect for curing general diseases and building up body.

The invention relates to an instant donkey-hide gelatin cake piece for strengthening congenital qi, resisting fatigue, lengthening life, controlling hyperglycemia, hypertension and hyperlipidemia, balancing and resisting sugar, and a preparation method thereof. The instant donkey-hide gelatin cake piece is low in cost and convenient for processing, and comprises the following components: 750g of donkey-hide gelatin powder, 1000g of black sesame, 500g of walnut kernels, 250g of seedless red jujube pieces, 500g of sunflower seed kernels, 200g of crystal sugar, 1000ml of rice wine, 400ml of A well water (which is water from A well in ancient Dong A county), 250g of barbary wolfberry fruit kernels, 150g of dried longan pulp, 100g of protein powder and 750g of arabinose.

The invention relates to a Chinese medicinal health-care cigarette. The Chinese medicinal health-care cigarette is prepared by the steps of: screening perilla leaves, whole plantain herb, mint leaves, liquorice, fiveleaf gynostemma herb leaves, and viscid germander herb leaves and flowers to remove impurities, then cleaning, airing and cutting up; mixing the cut up active ingredients in proportion, blending uniformly, putting in a piece of cigarette paper, and rolling into a cigarette. By using the Chinese herbal medicine ingredients, the Chinese medicinal health-care cigarette disclosed by the invention can be used as a common cigarette; besides, the Chinese medicinal health-care cigarette has the peculiarities of the common cigarette, so that the cigarette does not make a smoker unconformable. The Chinese medicinal health-care cigarette disclosed by the invention has no toxic or side effects to a smoker and surrounding crowd, and has health-care, prevention and treatment functions for lungs, stomachs, livers, kidneys, and other organs of the smoker and the surrounding crowd; the Chinese medicinal health-care cigarette is prepared by using the Chinese herbal medicine ingredients which are rich in sources and low in cost, so that the cigarette is suitable for volume production.

The invention relates to sinkiang-arnebia-root-containing skin-care traditional Chinese medicine composition and a preparation method thereof. Effective components of the sinkiang-arnebia-root-containing skin-care traditional Chinese medicine composition are prepared from raw materials in parts by weight as follows: 30-70 parts of sinkiang arnebia roots, 15-45 parts of boswellia serrate, 5-15 parts of liquorice and 1-10 parts of rosemary leaves. The preparation method is characterized in that a method of stir-frying traditional Chinese medicines with honey is adopted, dissolution of effective substances is promoted, the effective preservation life of extracts is prolonged, besides, meadowfoam seed oil is taken as a solvent and performs a synergistic anti-oxidation function along with the rosemary leaves added to the meadowfoam seed oil. The invention further provides sinkiang-arnebia-root-containing skin-care cream. The sinkiang-arnebia-root-containing skin-care cream is mainly prepared from raw materials as follows: the traditional Chinese medicine composition, maize germ oil, beewax, cocoa seed butter, natural tocopherol, avocado oil, lavender essential oil, mango seed butter, lanolin and prinsepia utilis royle oil. The sinkiang-arnebia-root-containing skin-care cream is environment-friendly and safe and can effectively promote self-healing of the skin of infants and improve the skin barrier function.

The invention relates to a focusing ultrasonic cavitation treatment instrument which is used for treating tumor, thrombolysis, ischemic myocardium and disease of prostate based on the cavitation effect of the ultrasonic contrast agent microvesicle. The focusing ultrasonic cavitation treatment instrument comprises a main control machine, two combined treatment probes, and a B ultrasonic machine with an ultrasonic focusing ultrasonic cavitation treatment instrument function. The focusing ultrasonic cavitation treatment instrument is mainly used for the partial area of the focus, and carries out non-invasive treatment on the tumor based on the cavitation effect of the microvesicle. The microvesicle can greatly improve the cavitation effect, so that the ultrasonic focusing positioning radiation with low power can be precisely carried out in the partial area of the focus, and the cavitation effect of the microvesicle within the vessel just can be activated within the partial area, and the capillaries in the tumor can be subject to embolism and damage, so as to achieve the purpose of 'starving' the tumor. The threshold for generating the cavitation is not met by the ultrasonic energy at the periphery of the focusing area, so that the cavitation effect is not generated, so that the path where the ultrasonic wave passes or the ambient tissue can not be damaged; and the functions of the common tissue and organs are protected.

The invention relates to a drug-loaded mesoporous-silica-reinforced dental binder and a preparation method thereof. The binder comprises following components by weight: 40-60% of a resin component, 35-50% of a dilution component, 2-10% of an acid monomer, 0.2-0.5% of a photoinitiator, 0.1-0.3% of a promoter, a trace amount of a polymerization inhibitor and 1-10% of mesoporous silica. The binder has high strength and drug releasing property, and therefore the binder is advantaged by loading and performing controlled releasing of antibacterial agents, anti-inflammatory drugs, hemostatics, etc.. The binder not only has a binding function, but also has certain functions of treating and preventing bacterial infection, and can be used as a dentine binder in clinic.

The invention discloses fat-reducing and blood pressure-lowering tea prepared by taking dendrobium officinale as a main raw material, matching with thirteen Chinese herbal medicines such as rhizoma anemarrhenae, scutellaria baicalensis, mangnolia officinalis, amomum tsao-ko, white paeony root, uncaria, semen cassiae, chrysanthemum, oriental wormwood, the root of kudzu vine, green tea, selfheal and licorice roots northwest origin and drying, grinding and bagging the medicines. The tea has good effects of reducing fat and lowering blood pressure, does not have a toxic or side effect, is suitable for the crowd suffering from hyperlipidemia, hypertension and hyperglycemia, particularly suitable to serve as a daily drink for the old and has the health-care effect of prevention and treatment.

The invention provides a calcium alginate-graphene oxide nanofiber and a preparation method and a drug-carrying calcium alginate-graphene oxide nanofiber and relates to the technical field of nanofibers. The preparation method of the calcium alginate-graphene oxide nanofiber comprises the following step: carrying out microfluidics spinning on a mixed solution of calcium alginate and graphene oxideand a calcium chloride solution, thereby obtaining the calcium alginate-graphene oxide nanofiber. The technical problem that a sudden drug release phenomenon is caused as a conventional calcium alginate nanofiber is good in hygroscopicity and low in mechanical strength is alleviated. By adopting the preparation method provided by the invention, the graphene oxide is put into raw materials, so that the calcium alginate-graphene oxide nanofiber has hydrogen bond interactions with oxygen-containing groups on a graphene oxide sheet and hydroxyl in calcium alginate molecules, the hydrogen bond function of the calcium alginate and water molecules is weakened, the swelling velocity of the calcium alginate is reduced, and the sudden drug release phenomenon can be prevented.

The invention relates to a solid preparation of clopidogrel free alkali and a preparation process thereof. The solid preparation uses the clopidogrel free alkali as the principal agent, and is mixed with anhydrous lactose, microcrystalline cellulose, mannitol, hydroxy propyl cellulose, part of pregelatinized starch, fumed silica and magnesium stearate which are used as auxiliary materials. The method uses the wet granulation to prepare. The solid preparation of the invention solves the problem of clopidogrel hydrolysates during the production of the solid preparation of the clopidogrel free alkal, and the safety and the stability of the solid preparation of the clopidogrel free alkali are improved, and the solid preparation of the clopidogrel free alkali can be more effective to have the therapeutic effect.

The invention discloses high-temperature and high-humidity resistant saccharomyces boulardii and application thereof, and belongs to the field of microorganisms. The preservation number of the high-temperature and high-humidity resistant saccharomyces boulardii disclosed by the invention is CGMCC No.10381; the multiplication rate and maximal biomass (namely final density of thallus) of saccharomyces boulardii strains are significantly higher than those of similar saccharomyces cerevisiae strains; the saccharomyces boulardii has high heat-resistant and moisture-resistant capacities; the saccharomyces boulardii disclosed by the invention can be used as a feed additive; and relatively high activity is stored in the high-temperature and high-humidity treatment processes. According to a saccharomyces boulardii capsule, daily gain, immune organ index, disease resistance, oxidation resistance and immune globulin of broiler chicken can be improved; the saccharomyces boulardii is free of a toxic or side effect on beasts and birds, wide in source and low in price, and can be used as a feed additive instead of antibiotics.

The invention belongs to the field of cigarette preparing technology, and particularly relates to a method for preparing an improved cigarette with agilawood type special-grade taste. Agallochum leaves, branches and husks are adopted for preparing agilawood filaments, dehydration is carried out until the water weight percentage is 25-35 percent, the agallochum leaves, branches and husks are cut into the agilawood filaments with the width of 1+/-0.1 mm, a tobacco shred alcoholization mode is adopted to process the agilawood filaments at first, then tobacco shreds and the agilawood filaments are evenly mixed according to the weight ratio of 1:0.053-0.667, tobacco shred alcoholization biological agents are added for processing according to 0.5-2 percent of the weight of the whole firmaments, the whole firmaments are dehydrated until 11 percent of water is left, standing is carried out for 3-4 hours, and the cigarette rolling procedure is to be conducted. The process is simple, cost can be greatly reduced, fishy smell during burning and smoking is eliminated, fragrance of cigarettes is more pure and mild, the breaking rate during preparing can be reduced, and the therapeutical effect of the agallochum leaves on diseases of respiratory system is fully utilized.

Disclosed is a Chinese traditional medicine ointment for curing burn disease and a preparing method; the medicine is composed of the following Chinese traditional medicine materials by weight ratio: 112.5-337.5 parts of Garden Burnet Root, 37.5- 112.5 parts of radix scutellariae, 37.5-112.5 parts of Bark of Chinese Corktree, 12.5-37.5 parts of rhubarb, 12.5-37.5 parts of folium ilicis chinensis, 12.5-37.5 parts of lotus leaf, 12.5-37.5 parts of lithospermum, 12.5-37.5 parts of yellowweed, 12.5-37.5 parts of glabrous sarcandra herb, 7.5-22.5 parts of coptis root, 5-15 parts of borneol, and 450-1350 parts of benne oil and 48.6-145.8 parts of beeswax. With functions of clearing away heat and toxic material, reducing swelling and alleviating pain, promoting Blood circulation to remove Blood stasis, reducing inflammation and clearing away purulence, removing the rotten and drawing the poison, and generating muscle and skin, the medicine ointment has the advantages that the production technique is simple, the quality index can be controlled easily, the cost is low, and the use is security; the medicine is applied to patients with skin burn, and can have effects on resisting bacterium, diminishing inflammation and alleviating pain, and has accurate curative effect.