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Traditional Chinese medicine for treating diabetic nephropathy and preparation method thereof

A technology of diabetic nephropathy and traditional Chinese medicine, applied in the direction of medical formula, urinary system diseases, medical preparations containing active ingredients, etc., can solve the problem of no specific treatment for diabetic nephropathy, achieve the improvement of lipid metabolism disorder in the body, protect the structure of the kidney, reduce the Effect of urine protein content

Active Publication Date: 2013-09-25
WUHAN JIANHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] There is no specific treatment for diabetic nephropathy

Method used

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  • Traditional Chinese medicine for treating diabetic nephropathy and preparation method thereof
  • Traditional Chinese medicine for treating diabetic nephropathy and preparation method thereof
  • Traditional Chinese medicine for treating diabetic nephropathy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A traditional Chinese medicine for treating spleen and kidney yang deficiency, which is made of the following Chinese medicinal materials in the weight ratio: 9 parts of fenugreek, 9 parts of astragalus, 5 parts of epimedium, 5 parts of psoralen, 4 parts of dogwood, cinnamon 4 parts, 3 parts of coptis, 2 parts of rhubarb.

[0030] The preparation method is as follows: take the Chinese medicinal materials according to the weight ratio, add astragalus by weight to 8 times of water to extract 3 times, each time for 1 hour, collect the extract and concentrate it to a clear paste with a relative density of 1.1; Add 6 times of 60% ethanol to reflux and extract twice, each time for 1 hour, collect the extract and concentrate it to a clear paste with a relative density of 1.1; Fenugreek, Epimedium, Psoralen, Cornus officinalis, and cinnamon are first weighed Add 8 times of water to extract three times, each time for 1 hour, collect the extract and concentrate to a clear paste w...

Embodiment 2

[0035] Example 2 Study on the therapeutic effect of the present invention on rats with type 1 diabetic nephropathy

[0036] 1. Test substance, reference substance, reagent

[0037] 1.1 Test product: the drug of Example 1, specification: 12g / bag; traits: this product is brown granular. Use an appropriate amount of double distilled water to prepare the concentration required for the experiment, and use it now.

[0038] 1.2 Reference substance 1: benazepril hydrochloride tablets. Source: Beijing Novartis Pharmaceutical Co., Ltd. Specifications: 10mg*14 tablets / box.

[0039] Control substance 2: Jin Kui Shen Qi Wan. Source: Beijing Tongrentang Co., Ltd. Tongrentang Pharmaceutical Factory. Specifications: 360 capsules / bottle.

[0040] Take Benazepril Hydrochloride Tablets and Jinkuishenqi Pills and prepare them with appropriate amount of double-distilled water to the concentration required for the experiment, and prepare them for immediate use.

[0041] 1.3 Reagents: STZ (st...

Embodiment 3

[0115] Example 3 The present invention's research on the therapeutic effect of type 2 diabetic nephropathy rats 1, test article, reference substance, solvent, reagent

[0116] 1.1 Test product: the drug of Example 1, specification: 12g / bag; traits: this product is brown granular. Use an appropriate amount of double distilled water to prepare the concentration required for the experiment, and use it now.

[0117] 1.2 Reference substance 1: benazepril hydrochloride tablets. Source: Beijing Novartis Pharmaceutical Co., Ltd. Specifications: 10mg*14 tablets / box.

[0118] Control substance 2: Jin Kui Shen Qi Wan. Source: Beijing Tongrentang Co., Ltd. Tongrentang Pharmaceutical Factory. Specifications: 360 capsules / bottle.

[0119] Take Benazepril Hydrochloride Tablets and Jinkuishenqi Pills and prepare them with appropriate amount of double-distilled water to the concentration required for the experiment, and prepare them for immediate use.

[0120] 1.3 Reagents: STZ (streptoz...

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Abstract

The invention provides a traditional Chinese medicine for treating diabetic nephropathy and a preparation method thereof. The traditional Chinese medicine for treating diabetic nephropathy is prepared from the following traditional Chinese medicinal materials by weight: 6 to 15 parts of common fenugreek seed, 6 to 15 parts of milkvetch root, 3 to 8 parts of epimedium herb, 3 to 8 parts of malaytea scurfpea fruit, 3 to 8 parts of Asiatic cornelian cherry fruit, 1 to 5 parts of rhubarb root and rhizome, 3 to 8 parts of Chinese cassia tree and 2 to 6 parts of coptis. The invention further discloses the preparation method for the traditional Chinese medicine. According to the invention, renal tubulointerstitial fibrosis is dose-dependently inhibited through reduction of urine protein of rats with diabetic nephropathy, so a certain treatment effect is exerted on type 1 diabetic nephropathy and the treatment effect is equal to that of a benazepril hydrochloride tablet but better than that of a kidney-qi-tonifying pill. The traditional Chinese medicine also exerts a certain treatment effect on rats with type 2 diabetic nephropathy through approaches like protection of a kidney structure, reduction of the content of urine protein and improvement of in-vivo lipid metabolism disorder.

Description

technical field [0001] The invention relates to a traditional Chinese medicine, in particular to a traditional Chinese medicine for treating diabetic nephropathy and a preparation method thereof. Background technique [0002] Diabetic nephropathy (DN) is one of the common and serious chronic complications of diabetes, and it is also the main cause of death in diabetic patients. Diabetes lasts for 10 to 20 years, and the incidence of DN is 30% to 50%. Both type 1 diabetes and type 2 diabetes have symptoms of hyperglycemia, which can lead to serious health-threatening complications including ketoacidosis, kidney failure, heart disease, stroke, and blindness. Type 2 diabetes is often related to obesity and age. It is mainly due to insulin resistance in the body. Under normal insulin levels, muscle or fat cells cannot produce normal physiological responses, which is a relative deficiency of insulin. Type 1 diabetes often develops in teenagers and is also known as juvenile diab...

Claims

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Application Information

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IPC IPC(8): A61K36/718A61P13/12A61P3/10
Inventor 张琼光陆付耳向明熊富良丁英平胡准王晓天卫飞宗震
Owner WUHAN JIANHENG PHARMA
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