The invention discloses a
citric acid-
chitosan-modified anticoagulation
polyurethane blood
dialysis membrane and a preparation method thereof. The membrane is of a hollow fibrous structure, and the inner surface and outer surface are dense cortical
layers, and the middle is a porous supporting layer, so that the blood
dialysis membrane is high in permeability and separating property and
antibacterial property; the inner
diameter is 160 to 250mu m; the
membrane thickness is 30 to 50 mu m, and the
ultrafiltration coefficient is 7.0 to 60 ml / m<2>.h.mmHg;
citric acid-
chitosan-modified anticoagulation
polyurethane is taken as membrane materials, and in membrane solution, the percentage
mass content of the modified anticoagulation
polyurethane is 15 to 30%, and the percentage
mass content of a
solvent is 70 to 85%, and the blood
dialysis membrane is prepared by using a nonsolvent induced phase
separation method. The preparation process of the dialysis membrane is simple and easy to control, and the prepared membrane has good
anticoagulant activity,
biocompatibility and
antibacterial property, and the clearance rates of
urea, beta2-microglobulin and
albumin are respectively 55 to 80%, 48 to 60%, and 2.5 to 9%, and the rate of resisting
pathogenic escherichia coli is 99%.