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Anticoagulant blood dialysis membrane and preparation method thereof

A technology of hemodialysis and anticoagulation, which is applied in the field of hemodialysis membranes, can solve the problems of complex methods, large consumption of chemical reagents, increase of separation membrane hydrophilicity and anticoagulation performance, so as to improve solubility and anticoagulation blood effect

Inactive Publication Date: 2019-09-27
JIANGSU LISHENG BLOOD PURIFICATION TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The application number in the prior art is 201811316273.1, which discloses a sulfonated dihydroxypropyl chitosan modified polyurethane hemodialysis membrane and its preparation method. A chemical reaction occurs between the modified chitosan and polyurethane, and a covalent bond is used to Connect the two and use the solubility of polyurethane to form a film. This method is relatively complicated, with many chemical reaction steps, and the preparation and purification of raw materials will consume a large amount of chemical reagents; the application number is 201710792954.4, which discloses a polyacrylonitrile-carboxymethyl A chitosan-based composite hemodialysis membrane and a preparation method thereof, wherein the carboxymethyl chitosan mentioned is a water-soluble chitosan, and after blending, the chitosan derivatives will be soluble in water and cannot be used in It exists inside the separation membrane and will not increase the hydrophilicity and anticoagulant performance of the separation membrane. Its anticoagulant performance is mainly obtained by heparin, and the heparin mentioned in this patent is also soluble in water

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] 50g sulfated chitosan (chitosan molecular weight is 100000, the degree of substitution of sulfonic acid group or carboxylic acid group is 0.24, the degree of deacetylation of chitosan is 65%), 150g polysulfone, 60g polyethylene glycol Mix 400g and 740g of dimethylacetamide, heat and stir at 80°C for 24h, and vacuum defoam. The spinneret was used for spinning, the core fluid was deionized water, and the anticoagulant hemodialysis membrane was prepared by the immersion sedimentation method.

[0024] The test performance is as follows:

[0025] The effective membrane area of ​​the modified hemodialyzer is 1.4m 2 . The residual blood cells were 0.72‰, the residual white blood cells were 2.17‰, and the residual platelets were 0.18‰. The water permeability of the hemodialysis membrane is 22.3mL / m 2 / h / mmHg, urea clearance rate is 199.2mL / m 2 / min, the phosphate clearance rate is 175.2mL / m 2 / min, the clearance rate of vitamin B12 was 135.2mL / m 2 / min. The plasma recal...

Embodiment 2

[0027] 70g sulfated chitosan (chitosan molecular weight is 80000, the degree of substitution of sulfonic acid group or carboxylic acid group is 0.34, the degree of deacetylation of chitosan is 75%), 150g polysulfone, 60g polyethylene glycol Mix 400g and 720g of dimethylformamide, heat and stir at 80°C for 24h, and vacuum defoam. The spinneret was used for spinning, the core fluid was deionized water, and the anticoagulant hemodialysis membrane was prepared by the immersion sedimentation method.

[0028] The test performance is as follows:

[0029] The effective membrane area of ​​the modified hemodialyzer is 1.4m 2. The residual blood cells were 0.72‰, the residual white blood cells were 2.17‰, and the residual platelets were 0.18‰. The water permeability of the hemodialysis membrane is 20.3mL / m 2 / h / mmHg, urea clearance rate is 175.2mL / m 2 / min, the phosphate clearance rate is 157.2mL / m 2 / min, the clearance rate of vitamin B12 was 127.2mL / m 2 / min. The plasma recalci...

Embodiment 3

[0031] 70g carboxylated chitosan (chitosan molecular weight is 150,000, the degree of substitution of sulfonic acid group or carboxylic acid group is 0.28, the degree of deacetylation of chitosan is 85%), 210g polyacrylonitrile, 60g polyethylene Mix 400 g of diol and 660 g of dimethylformamide, heat and stir at 120 ° C for 24 h, and vacuum defoam. The spinneret is used for spinning, the core fluid is deionized water, and the anticoagulant hemodialysis membrane is prepared by thermally induced phase separation.

[0032] The test performance is as follows:

[0033] The effective membrane area of ​​the modified hemodialyzer is 1.4m 2 . The residual blood cells were 0.70‰, the residual white blood cells were 2.27‰, and the residual platelets were 0.19‰. The water permeability of the hemodialysis membrane is 19.6mL / m 2 / h / mmHg, urea clearance rate is 173.0mL / m 2 / min, the phosphate clearance rate is 152.2mL / m 2 / min, the clearance rate of vitamin B12 was 120.2mL / m 2 / min. T...

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Abstract

The invention relates to an anticoagulant blood dialysis membrane and a preparation method thereof. A sulfate ester or carboxylic ester chitosan derivative is selected; the sulfate ester or carboxylic ester chitosan derivative is blended with a film-forming polymer; an additive and a solvent are added to prepare a membrane preparing solution, and the membrane preparing solution is used for preparing the blood dialysis membrane. According to the anticoagulant blood dialysis membrane and the preparation method thereof, the oil-soluble chitosan derivative modified by sulfonic acid groups or carboxylic acid groups is blended with the film-forming polymer, the blood dialysis membrane is prepared by using an immersion sedimentation method or thermally induced phase separation method, the chitosan derivative exists in the prepared blood dialysis membrane, which plays a role of improving the hydrophilic and anticoagulant properties of the dialysis membrane. The method has the advantages that the process is simple, the cost is low, and the industrial amplification is easy.

Description

Technical field: [0001] The invention relates to the field of hemodialysis membranes, in particular to an anticoagulant hemodialysis membrane and a preparation method thereof. Background technique: [0002] Chronic renal failure is a global challenge. As of the end of 2010, 2.621 million patients with chronic renal failure have been treated worldwide, of which about 2.029 million received dialysis treatment in 145 countries, and another 592,000 received kidney transplantation. Among the more than 2 million patients receiving dialysis treatment, about 20% are receiving treatment in the United States, 16% are in EU countries, 15% are in Japan, and about 49% of the remaining dialysis patients are distributed in about 120 other countries such as China. In 2011, the number of people on dialysis worldwide was 2.158 million, and it is expected to increase to about 3.8 million by 2020. [0003] China has a population of more than 1.3 billion, and there were about 2 million patients...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/68B01D71/42B01D71/34B01D71/16B01D71/08B01D67/00A61M1/16
CPCA61M1/16B01D67/0018B01D71/08B01D71/16B01D71/34B01D71/42B01D71/68
Inventor 付晓燕于海军
Owner JIANGSU LISHENG BLOOD PURIFICATION TECH CO LTD
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