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Surface heparinization hemodialysis film and preparation method thereof

A technology of hemodialysis and heparinization, applied in chemical instruments and methods, dialysis systems, semi-permeable membrane separation, etc., can solve the problems of low removal efficiency and poor anti-bacterial pollution ability.

Inactive Publication Date: 2017-02-22
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above materials are mainly negatively charged polymer materials, which have low removal efficiency for macromolecular toxins such as β2-microglobulin and endotoxin, and poor anti-bacterial pollution ability

Method used

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  • Surface heparinization hemodialysis film and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) Preparation of cellulose quaternary ammonium salt

[0029] A 12% NaOH-urea solution was prepared, 0.2g of cellulose was accurately weighed and added to 10g of the above-mentioned NaOH-urea solution, and placed in a refrigerator at -20°C for 2h. After being taken out, it was solid, and after stirring and dissolving vigorously for 10 minutes under the stirring state of a stirring blade, the resulting solution was a cellulose-NaOH-urea solution with a concentration of 2% (based on the mass fraction of cellulose in NaOH-urea). Weigh a certain amount of CHPAC, first prepare it into an aqueous solution with a mass fraction of 40%, add the aqueous solution dropwise to the cellulose-NaOH-urea solution under vigorous stirring, and stir for reaction overnight (12h) at room temperature. After the reaction, the reaction system was transferred to a dialysis bag with a molecular weight cut-off of 8000, and dialyzed with deionized water for 15 times with an interval of more than 3 ho...

Embodiment 2

[0037] (1) Preparation of cellulose quaternary ammonium salt / polyacrylic acid film

[0038] Take 80 mg of the cellulose quaternary ammonium salt obtained in step (1) of Example 1, 120 mg of ionic liquid (BMIM) Cl, and prepare an 8% cellulose quaternary ammonium salt-12% ionic liquid solution (1 ml), and weigh 0.0040 g of Example 1 The polyacrylic acid obtained in step (2) was mixed, stirred at 78°C (1000 r / min) to dissolve, centrifuged at 3000 r / min for 5 minutes to remove bubbles, poured into a mold, placed at 18°C ​​for 2 hours, and 75% ethanol was added to form a film.

[0039] (2) Surface grafted heparin

[0040] Heparin (titer> 160U / mg) was prepared with deionized water to prepare a polyanion solution with a concentration of 3mg / mL, 0.14mol / L NaCl, and a pH of 5.0. Inject the above polyanion solution into the inner cavity of step (1) cellulose quaternary ammonium salt / polyacrylic acid membrane, react at 20°C for 0.5h, wash the inner surface of the membrane with deionized water,...

Embodiment 3

[0042] (1) Preparation of cellulose quaternary ammonium salt / polyacrylic acid film

[0043] Take 160 mg of cellulose quaternary ammonium salt, 200 mg of ionic liquid (BMIM) Cl to prepare a 16% cellulose quaternary ammonium salt-20% ionic liquid solution (1 ml), and weigh 0.0040 g of the polyacrylic acid obtained in step (2) of Example 1 , Mix, stir at 78°C (1000r / min) to dissolve, centrifuge at 3000r / min for 5min to remove bubbles, pour it into a mold, place it at 18°C ​​for 2h, add 75% ethanol to form a film.

[0044] (2) Surface grafted heparin

[0045] Heparin (titer> 160U / mg) was prepared with deionized water to prepare a polyanion solution with a concentration of 4mg / mL, 0.14mol / L NaCl, and a pH of 5.5. Inject the above polyanion solution into the inner cavity of step (1) cellulose quaternary ammonium salt / polyacrylic acid membrane, react at 20°C for 0.5h, wash the inner surface of the membrane with deionized water, and repeat the steps of injecting heparin solution, reaction a...

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Abstract

The invention mainly provides a surface heparinization hemodialysis film and a preparation method thereof. The hemodialysis film is formed by heparin and a high-molecular polymer film in a physical crosslinking mode, wherein the biological compatibility of the high-molecular polymer film is high, and the surface of the high-molecular polymer film carries positive charges. The hemodialysis film is good in biological compatibility; due to the heparin with the firm surface, risks such as whole body heparinization and in-vitro coagulation are avoided, and the safety is high; due to the fact that the outer surface of the film carries the positive charges, a positive charge barrier can be formed, and the phenomenon that external bacteria enter the film is effectively restrained; the positive charges on the inner surface of the film can effectively remove beta 2-microglobulin, endotoxin and other macromolecular toxins, and the synergic treatment effect is achieved.

Description

Technical field [0001] The invention belongs to the fields of membrane surface engineering and biological separation engineering, and provides a novel surface heparinized hemodialysis membrane and a preparation method. Background technique [0002] At present, hemodialysis has been widely used in the treatment of acute and chronic kidney disease, multiple organ failure, severe trauma, infection, systemic inflammatory response syndrome (SIRS), burns, acute pancreatitis, chemical poisoning and other diseases. An important support measure in the treatment of critical illnesses. During the dialysis process, the physical and chemical properties of the dialysis membrane determine the dialysis effect, and the biocompatibility of the dialysis membrane is directly related to the quality of life and survival rate of patients. At present, my country still uses the first and second generation hemodialysis membrane materials in clinical practice. Such hemodialysis membrane materials often n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/82B01D67/00B01D69/02A61M1/16
CPCB01D71/82A61M1/1621B01D67/0006B01D69/02
Inventor 李其彬林霞陈敬华杨子毅于菁张薏刘雨姝沈楷韬
Owner JIANGNAN UNIV
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