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Nano fiber composite hemodialysis membrane with directional toxin removing passage and preparation thereof

A nanofiber membrane and hemodialysis technology, which is applied in the field of composite dialysis membrane and its preparation, can solve the problems of toxicity and incompatible carbon nanotubes, and achieve high protein adsorption resistance, low hemolysis rate, and inhibition of platelet adhesion. Effect

Active Publication Date: 2019-04-19
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the incompatibility between inorganic carbon nanotubes and organic polymer matrix and the potential toxicity of carbon nanotubes have become two major problems that need to be solved urgently in the field of hemodialysis.

Method used

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  • Nano fiber composite hemodialysis membrane with directional toxin removing passage and preparation thereof
  • Nano fiber composite hemodialysis membrane with directional toxin removing passage and preparation thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0034] (1) Dissolve 250 mg of dopamine in 500 mL of tris buffer solution (10 mmol / L), add 500 mg of carbon nanotubes, adjust the pH of the solution to 8.5 after ultrasonic dispersion, stir and react at room temperature for 12 h, and filter The polydopamine-adhered carbon nanotubes were obtained by washing with 0.02mol / L hydrochloric acid and ultrapure water, respectively, and drying.

[0035] (2) The polydopamine-adhered carbon nanotubes were ultrasonically dispersed in ultrapure water at a concentration of 1.0 mg / mL, 500 mg of heparin sodium was added, and the reaction was stirred at room temperature for 24 h, filtered, washed with ultrapure water, and dried to obtain heparin functionalization. of carbon nanotubes.

[0036](3) Dissolve polyacrylonitrile with a weight-average molecular weight of 120,000 in N,N-dimethylformamide for 8 hours at a temperature of 50°C to prepare a solution with a mass fraction of 8%, at an ambient humidity of 45%, and an ambient temperature of 30°...

Embodiment 2

[0040] (1) Dissolve 250mg of dopamine in 500mL tris buffer solution (10mmol / L), add 500mg of carbon nanotubes, adjust the pH value of the solution to 8.5 after ultrasonic dispersion, stir and react at room temperature for 12h, and filter Washing with 0.02 mol / L hydrochloric acid and ultrapure water respectively and drying to obtain polydopamine-adhered carbon nanotubes.

[0041] (2) Ultrasonic dispersion of polydopamine-adhered carbon nanotubes in ultrapure water at a concentration of 1.0 mg / mL, adding 500 mg of heparin sodium and stirring at room temperature for 24 hours, filtered, washed with ultrapure water, and dried to obtain heparin functionalization of carbon nanotubes.

[0042] (3) Dissolve polyacrylonitrile with a weight-average molecular weight of 120,000 in N,N-dimethylformamide for 8 hours at a temperature of 50°C to prepare a solution with a mass fraction of 8%, at an ambient humidity of 45%, and an ambient temperature of 30°C , the voltage is 24kV, the spinning ...

Embodiment 3

[0046] (1) Dissolve 250mg of dopamine in 500mL tris buffer solution (10mmol / L), add 500mg of carbon nanotubes, adjust the pH value of the solution to 8.5 after ultrasonic dispersion, stir and react at room temperature for 12h, and filter Washing with 0.02 mol / L hydrochloric acid and ultrapure water respectively and drying to obtain polydopamine-adhered carbon nanotubes.

[0047] (2) Ultrasonic dispersion of polydopamine-adhered carbon nanotubes in ultrapure water at a concentration of 1.0 mg / mL, adding 500 mg of heparin sodium and stirring at room temperature for 24 hours, filtered, washed with ultrapure water, and dried to obtain heparin functionalization of carbon nanotubes.

[0048] (3) Dissolve polyacrylonitrile with a weight-average molecular weight of 120,000 in N,N-dimethylformamide for 8 hours at a temperature of 50°C to prepare a solution with a mass fraction of 8%, at an ambient humidity of 45%, and an ambient temperature of 30°C , the voltage is 24kV, the spinning ...

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Abstract

The invention relates to a nano fiber composite hemodialysis membrane with a directional toxin removing passage and preparation thereof. A cortex of the hemodialysis membrane is a polyving akohol separation layer with a heparin functionalization carbon nanotube, and a supporting layer is a polyacrylonitrile nano fiber membrane. According to the hemodialysis membrane, the directional nano passage is provided for toxins by a nano clearance which is formed in the part between the heparin functionalization carbon nanotube and polyving akohol substrate in the cortex, and under the premise that macromolecular protein selectivity is not sacrificed, the composite hemodialysis membrane has the advantages of efficient micro and medium molecular toxin removing rate and excellent blood compatibility.

Description

technical field [0001] The invention belongs to the field of composite material dialysis membrane and its preparation, in particular to a nanofiber composite hemodialysis membrane containing directional toxin removal channels and its preparation. Background technique [0002] According to statistics, millions of people worldwide suffer from kidney disease, and kidney failure has become one of the diseases that endanger human health. Acute and chronic renal failure can lead to an increase in toxins in the human body, which in turn can cause adverse reactions in the body and even uremia. Hemodialysis is considered the most feasible and effective clinical alternative therapy and has been used for more than 50 years. In the dialyzer, the dialysis membrane separates the blood and the dialysate, the small and medium molecular toxins in the blood are removed by the diffusion and convection of the dialysis membrane, and the macromolecular plasma proteins necessary for the human bod...

Claims

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Application Information

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IPC IPC(8): B01D69/12B01D71/02B01D71/42B01D67/00
CPCB01D67/0079B01D69/12B01D71/021B01D71/42B01D2323/39
Inventor 王雪芬于旭峰朱雅东张同辉李霈云沈克
Owner DONGHUA UNIV
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