Alginate fiber hematodialysis membrane and preparation method thereof

Abstract

The invention provides an alginate fiber hematodialysis membrane and a preparation method thereof, relating to the field of biological materials. The alginate fiber hematodialysis membrane is a hollow fiber membrane and comprises the following components in parts by weight: 20-35 parts of polyamide, 10-20 parts of alginate fiber, 3-8 parts of a toughening agent, 5-15 parts of polylactic acid and 30-60 parts of a solvent, wherein the average inner diameters of hollow fibers are 100-300 microns, and the wall thicknesses of the hollow fibers are 20-50 microns. According to the preparation method of the alginate fiber hematodialysis membrane, the alginate fiber hematodialysis membrane is prepared by virtue of a dry-wet method preparation process. According to the alginate fiber hematodialysis membrane, the hollow fiber membrane with good biocompatibility and high mechanical strength is prepared by virtue of the characteristic of high biocompatibility of the alginate fiber and the superiorities of the dry-wet method preparation process. By adjusting parameters in the dry-wet method preparation process, particularly the pressures of core liquid and a spinning solution tank, the prepared hollow fiber has large inner diameter and small wall thickness and is beneficial to the elimination of micromolecule toxin and the entrapment of macromolecule protein.

Description

technical field [0001] The invention belongs to the field of biological materials, in particular to a seaweed fiber hemodialysis membrane and a preparation method of the hemodialysis membrane. Background technique [0002] The hemodialysis membrane uses the principle of a semi-permeable membrane to introduce the patient's blood and dialysate into the dialyzer at the same time. The two flow in opposite directions on both sides of the dialysis membrane. , in order to achieve the purpose of removing toxins and excessive water retention in the body, replenishing the substances needed in the body, and maintaining electrolyte and acid-base balance. A dialyzer mainly consists of a support structure and a dialysis membrane. According to the support structure, the shape of the membrane and the mutual configuration relationship, the dialyzers that have appeared successively in history can basically be divided into three types: flat plate type, coil type and hollow fiber type. Among ...

AI Technical Summary

Problems solved by technology

[0005] According to the above-mentioned disclosed technical solutions, the hemodialysis membrane is a polysulfone membrane. In order to improve the hemodialysis membrane, a biocompatible functional polymer is added to the hemodialysis membrane to reduce the complement activation effect, but the actual effect is not good. Moreover, the removal effect of small molecule toxins is general, and the preparation method is dry preparation, and the prepared membrane material has a large pore size, which is easy to cause the loss of blood polymer compounds. Therefore, the effect is not ideal.