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Bacteria cellulose hemodialysis membrane

A technology of bacterial cellulose and hemodialysis, which is applied in the field of hemodialysis membranes, can solve the problems affecting the accuracy and reliability of the test data of the mechanical properties of the membrane, uneven microstructure of the regenerated membrane, rough process, etc., and achieve excellent mechanical strength, excellent Biocompatibility, fast dissolution effect

Inactive Publication Date: 2013-02-27
NANJING UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, its film-making method is through glass rod coating or casting method. The process is relatively rough, and the microstructure of the obtained regenerated film is uneven, which affects the accuracy and reliability of the test data of the mechanical properties of the film. In addition, , the maximum concentration of bacterial cellulose solution in this invention is only about 1.5% (wt%), which is far lower than the maximum concentration of 3.0% (wt%) in this patent, and the low-concentration solution is easy to cause shrinkage and wrinkling of the membrane during the film-making process

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0041] combine figure 1 , prepare bacterial cellulose membrane hemodialysis membrane of the present invention, comprise the following steps:

[0042] The first step, bacterial cellulose pretreatment: take a certain amount of bacterial cellulose powder and pass through a 150-mesh sieve, soak the sieved powder in 3% NaOH solution, stir at room temperature for 3 hours, vacuum filter, and use Repeatedly wash with deionized water until the washing liquid is neutral, then soak it in absolute ethanol for 3 times, keep for 3 hours each time, and finally put it into a vacuum drying oven for drying at a drying temperature of 80°C until the powder has a constant weight;

[0043] The second step, the preparation of LiCl / DMAC dissolution system: put a certain mass of analytically pure LiCl particles into a blast drying oven, dry at 80°C for 24 hours, and mix the dried LiCl powder with a certain amount of DMAC solvent And stirred at room temperature, prepared into a LiCl / DMAC solution with...

Embodiment 2

[0053] combine figure 1 , prepare bacterial cellulose membrane hemodialysis membrane of the present invention, comprise the following steps:

[0054] The first step, bacterial cellulose pretreatment: take a certain amount of bacterial cellulose powder and pass through a 150-mesh sieve, soak the sieved powder in 6% NaOH solution, stir at room temperature for 3 hours, vacuum filter, and use Repeated washing with deionized water until the washing solution is neutral, then soaking in absolute ethanol for 4 times, each time for 3 hours, and finally put it into a vacuum drying oven for drying at a drying temperature of 80°C until the powder has a constant weight;

[0055] The second step, the preparation of LiCl / DMAC solution system: put a certain mass of analytically pure LiCl particles into a blast drying oven, dry at 110°C for 24 hours, and mix the dried LiCl powder with a certain amount of DMAC solvent and stirred at room temperature, and prepared into a LiCl / DMAC solution with...

Embodiment 3

[0065] combine figure 1 , prepare bacterial cellulose membrane hemodialysis membrane of the present invention, comprise the following steps:

[0066] The first step, bacterial cellulose pretreatment: take a certain amount of bacterial cellulose powder and pass through a 150-mesh sieve, soak the sieved powder in 6% NaOH solution, stir at room temperature for 3 hours, vacuum filter, and use Wash with deionized water repeatedly until the washing liquid is neutral, then soak in absolute ethanol for 5 times, each time for 3 hours, and finally put it into a vacuum drying oven for drying at a drying temperature of 80°C until the powder has a constant weight;

[0067] The second step, the preparation of LiCl / DMAC solution system: put a certain mass of analytically pure LiCl particles into a blast drying oven, dry at 130°C for 24 hours, and mix the dried LiCl powder with a certain amount of DMAC solvent And stirred at room temperature, prepared into a LiCl / DMAC solution with a concent...

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Abstract

The invention discloses a bacteria cellulose hemodialysis membrane and a preparation method of the bacteria cellulose hemodialysis membrane. The preparation method comprises the following steps of activating bacteria cellulose powder by a NaOH (sodium hydroxide) solution, then dissolving the bacteria cellulose powder in a LiCl / DMAC (lithium chloride / N, N-dimethylacetamide) solvent system under a heating condition, cooling the dissolving system, standing and scraping the membrane; slowly immersing a membrane scraping plate in a coagulating bath, standing, and taking the membrane scraping plate out of the coagulating bath after the membrane strips from the membrane scraping plate so as to obtain the bacteria cellulose regeneration membrane for hemodialysis. Bacteria cellulose is used as raw material, the regeneration cellulose membrane is prepared by an immersing, precipitating and phase conversion method, and then the regeneration cellulose membrane can be used as a novel hemodialysis membrane for treating acute and chronic renal failure. Compared with the traditional hemodialysis membrane, the bacteria cellulose hemodialysis membrane has the advantages that the chemical purity is high, the biocompatibility is high, the mechanical strength is high, the water ultrafiltering rate is high, the simple, environment-friendly, moderate and controllable effects are realized in the preparation process, and the bacteria cellulose hemodialysis membrane is suitable for the industrial production of the hemodialysis membranes with different requirements.

Description

1. Technical field [0001] The invention relates to the technical field of hemodialysis membranes, in particular to a bacterial cellulose hemodialysis membrane. 2. Background technology [0002] Hemodialysis is to remove harmful substances in the body through mechanisms such as diffusion, convection, ultrafiltration, and adsorption. It is the main measure for the treatment of acute and chronic renal failure. The performance of hemodialysis membrane determines the effect of dialysis treatment. Hemodialysis membranes mainly include regenerated cellulose hemodialysis membranes, modified cellulose hemodialysis membranes, artificial synthetic hemodialysis membranes, etc. Among them, regenerated cellulose hemodialysis membrane has the advantages of low price, high hydrophilicity, high mechanical strength, good pollution resistance, and strong ability to remove small molecule toxins. It is the earliest studied and most widely used type of hemodialysis membrane. At present, the most...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D71/10A61M1/16
Inventor 孙东平杨加志黄洋刘广梅朱春林
Owner NANJING UNIV OF SCI & TECH
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