Eureka AIR delivers breakthrough ideas for toughest innovation challenges, trusted by R&D personnel around the world.

Sulfonated dihydroxypropyl chitosan modified polyurethane (SDHPCS-PU) hemodialysis membrane and preparation method thereof

A technology of sulfonated dihydroxypropyl chitosan and hemodialysis, which is applied in the field of biomedical materials, can solve the problems of blood compatibility that needs to be further improved, and achieve excellent blood compatibility, mild and controllable conditions, and easy industrialization effect

Active Publication Date: 2019-02-12
CENT SOUTH UNIV
View PDF4 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technology improves the hemocompatibility of polyurethane by covalently grafting citric acid on both ends of the polyurethane main chain, and then selectively grafting chitosan structure on the citric acid, but its hemocompatibility needs to be further improved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Sulfonated dihydroxypropyl chitosan modified polyurethane (SDHPCS-PU) hemodialysis membrane and preparation method thereof
  • Sulfonated dihydroxypropyl chitosan modified polyurethane (SDHPCS-PU) hemodialysis membrane and preparation method thereof
  • Sulfonated dihydroxypropyl chitosan modified polyurethane (SDHPCS-PU) hemodialysis membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Put 18% of sulfonated dihydroxypropyl chitosan modified polyurethane and 82% of N,N-dimethylformamide into the dissolution kettle with thermometer, stirrer and reflux condensing device, control the temperature at 80°C, and stir 15h; after the dissolution is complete, let it stand for 20h to complete the defoaming and obtain the membrane liquid;

[0027] Open the nitrogen valve, control the pressure of the raw material kettle to 0.08MPa, filter the spinning membrane liquid, pump the core liquid into the inner hole of the spinneret through the metering pump and extrude it, control the flow rate of the core liquid to 1.2mL / min, and the flow rate of the core liquid After stabilization, start spinning; the membrane liquid is pressed into the annulus of the spinneret and extruded, the spinning speed is controlled at 1.5mL / min, and the primary spun fiber is extruded 25cm in the air and then cooled in a coagulation water bath at a temperature of 30°C Cured, then passed through ...

Embodiment 2

[0029] Add 15% of sulfonated dihydroxypropyl chitosan modified polyurethane and 85% of N,N-dimethylformamide into a dissolution kettle equipped with a thermometer, agitator and reflux condensing device, control the temperature at 80°C, and stir 20h; after the dissolution is complete, let it stand for 20h to complete the defoaming and obtain the membrane liquid;

[0030] Open the nitrogen valve, control the pressure of the raw material kettle to 0.08MPa, filter the spinning membrane liquid, pump the core liquid into the inner hole of the spinneret through the metering pump and extrude it, control the flow rate of the core liquid to 1.2mL / min, and the flow rate of the core liquid After stabilization, start spinning; the membrane liquid is pressed into the annulus of the spinneret and extruded, the spinning speed is controlled at 1.5mL / min, and the primary spun fiber is extruded 25cm in the air and then cooled in a coagulation water bath at a temperature of 30°C Cured, then passe...

Embodiment 3

[0032] Put 17% of sulfonated dihydroxypropyl chitosan modified polyurethane and 83% of N,N-dimethylformamide into the dissolution kettle with thermometer, stirrer and reflux condensing device, control the temperature at 85°C, and stir 20h; after the dissolution is complete, let it stand for 20h to complete the defoaming and obtain the membrane liquid;

[0033] Open the nitrogen valve, control the pressure of the raw material kettle to 0.08 MPa, filter the spinning membrane liquid, pump the core liquid into the inner hole of the spinneret through the metering pump and extrude it, control the flow rate of the core liquid to 1.3mL / min, and the flow rate of the core liquid After stabilization, start spinning; the membrane liquid is pressed into the annulus of the spinneret and extruded, the spinning speed is controlled at 1.5mL / min, and the primary spun fiber is extruded 25cm in the air and then cooled in a coagulation water bath at a temperature of 30°C Cured, then passed through...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
The inside diameter ofaaaaaaaaaa
Wall thicknessaaaaaaaaaa
Login to View More

Abstract

The invention relates to a sulfonated dihydroxypropyl chitosan modified polyurethane (SDHPCS-PU) hemodialysis membrane and a preparation method thereof. The preparation method comprises the steps of adding 10-20% of SDHPCS-PU and 80-90% of a solvent into a dissolving kettle, controlling the temperature to be 70-90 DEG C, and stirring for 2-20 h; after the materials are completely dissolved, standing for 10-20 h for completing defoaming so as to obtain membrane liquid; after that, adopting a dry-wet spinning method to prepare the SDHPCS-PU hemodialysis membrane. The preparation method providedby the invention has the characteristic that the high-performance hemodialysis membrane is prepared by utilizing the good physical and chemical properties and blood compatibility of the SDHPCS-PU. Themembrane production process provided by the invention is simple and easy to operate.

Description

technical field [0001] The invention belongs to the field of biomedical materials, in particular to a sulfonated dihydroxypropyl chitosan modified polyurethane hemodialysis membrane and a preparation method thereof. Background technique [0002] Polyurethane is a blood-contact material with great application potential. However, microthrombosis and microembolism will still occur when unmodified polyurethane comes into contact with blood, which limits the application of polyurethane as a blood contact material in clinical treatment. The invention aims to solve the deficiencies of the existing polyurethane hemodialysis membrane in anticoagulation, and provides a modified polyurethane hemodialysis membrane with good blood compatibility and a preparation method thereof. [0003] At present, the conventional methods for preparing hemocompatible polyurethane hemodialysis membranes are blending modification, bulk modification and surface modification of polyurethane materials with ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): B01D71/82B01D67/00
CPCB01D67/0006B01D71/82
Inventor 邱运仁王灿
Owner CENT SOUTH UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com