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Preparation method of blood dialysis membrane raw material

A dialysis membrane and raw material technology, applied in the field of medical materials, can solve the problems of high retention rate of small molecular proteins and high production cost, and achieve the effect of improving mechanical properties and high corrosion resistance.

Inactive Publication Date: 2018-10-23
漳州龙文琪睿生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The anticoagulant effect of the invention is good, the flexibility is strong, and the retention rate of small molecular proteins is high, but the production cost is relatively high

Method used

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  • Preparation method of blood dialysis membrane raw material
  • Preparation method of blood dialysis membrane raw material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A kind of preparation method of the dialysis membrane that hemodialysis instrument is used comprises the following steps:

[0023] In the sterile room, control the temperature of the reactor at 70°C, add 150 parts by mass of solvent and 120 parts of 50% modified polytetrafluoroethylene into the reactor, turn on the stirrer, and control the stirring speed at 250rpm, slowly 20 parts by mass of polyethylene and 3 parts of silane coupling agent are added to the reactor, and after they are completely dissolved, 2 parts of macromolecular anticoagulant and 12 parts of polylactic acid fiber are slowly Put it into the reaction kettle, and then react for 5 hours, then add 2 parts of reinforcing agent and 8 parts of polyacrylic butyl ester into the reaction, and carry out thermal polymerization reaction for 2 hours, then pour the obtained colloid into the spinning tank In the process, the spinning tank pressure is adjusted to 20 atmospheric pressure for spinning, and the temperatu...

Embodiment 2

[0031] A kind of preparation method of the dialysis membrane that hemodialysis instrument is used comprises the following steps:

[0032]In the sterile room, control the temperature of the reactor at 65°C, add 150 parts by mass of solvent and 110 parts of 55% modified polytetrafluoroethylene into the reactor, turn on the stirrer, and control the stirring speed at 250rpm, slowly 25 parts by mass of polyethylene and 4 parts of silane coupling agent are added to the reactor, and after they are completely dissolved, 1 part of macromolecular anticoagulant and 15 parts of polylactic acid fiber are slowly Put it into the reaction kettle, and then react for 5 hours, then add 3 parts of reinforcing agent and 10 parts of polyacrylamide butyl ester into the reaction, carry out thermal polymerization reaction for 2 hours, and pour the obtained colloid into the spinning tank In the process, adjust the pressure of the spinning tank to spin at 8 atmospheres, wherein the temperature of the dr...

Embodiment 3

[0040] A kind of preparation method of the dialysis membrane that hemodialysis instrument is used comprises the following steps:

[0041] In the sterile room, control the temperature of the reaction kettle at 65°C, add 200 parts by mass of solvent and 100 parts of 50% modified polytetrafluoroethylene into the reaction kettle, turn on the stirrer, and control the stirring speed at 250rpm, slowly 20 parts by mass of polyethylene and 5 parts of silane coupling agent are added to the reactor, and after they are completely dissolved, 0.5 parts of macromolecular anticoagulant and 10 parts of polylactic acid fiber are slowly Put it into the reaction kettle, and then react for 3 hours, then add 5 parts of reinforcing agent and 6 parts of polyacrylamide butyl ester into the reaction, carry out thermal polymerization reaction for 1 hour, and pour the obtained colloid into the spinning tank In the process, adjust the pressure of the spinning tank to spin at 8 atmospheres, in which the te...

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Abstract

The invention belongs to the technical field of medical care material, and particularly relates to a preparation method of a blood dialysis membrane raw material. The blood dialysis membrane raw material is prepared from 100 to 120 parts by mass of 50-60 percent modified polytetrafluoroethylene, 10 to 20 parts by mass of polytetramethylene glycol, 20 to 30 parts by mass of polyethylene, 2 to 5 parts by mass of enhancing agents, 0.5 to 2 parts by mass of macromolecular anticoagulants, 10 to 20 parts by mass of polylactic acid fiber, 6 to 10 parts by mass of polypropylene butyl ester and 100 to200 parts by mass of solvents. The invention provides a preparation method of a dialysis membrane for a blood dialysis instrument. Through the proportioning ratio of various kinds of monomers and thescreening of reaction conditions, the mechanical performance of the dialysis membrane is excellent; in addition, the mechanical performance of the dialysis membrane is effectively improved through theaddition of modified polytetrafluoroethylene; meanwhile, the anti-corrosion performance is very high; the cost is lower than that in the prior art.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to a preparation method of a hemodialysis membrane raw material. Background technique [0002] Hemodialysis is one of the renal replacement therapies for patients with acute and chronic renal failure. Therefore, the development of permeable membranes for hemodialysis is particularly important. [0003] Chinese patent application CN 107930416 A discloses a dialysis membrane for hemodialysis, which relates to the field of medical equipment. The dialysis membrane for hemodialysis of this invention, its raw material comprises by mass parts: its raw material comprises by mass parts: chitosan quaternary ammonium salt 26-33 parts, polylactic acid 107-111 parts, polylactic acid 29-34 parts of ethylene glycol, 0.5-0.8 parts of heparin, 0.10-0.14 parts of ethylenediamine, 0.4-0.7 parts of glycidyl methacrylate, 0.05-0.08 parts of N,N-dicyclohexylcarbodiimide, butyl Di...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/02B01D71/36B01D67/00D01F8/10D01F8/06D01F8/14D01F1/10A61M1/16
CPCA61M1/16B01D67/0006B01D69/02B01D71/36B01D2325/24B01D2325/30D01F1/10D01F8/06D01F8/10D01F8/14
Inventor 周赞虎张鸣青张海艳
Owner 漳州龙文琪睿生物科技有限公司
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