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A heparin-like modified polyvinyl alcohol hydrogel thin-layer nanocomposite hemodialysis membrane and its preparation method

A polyvinyl alcohol and nano-composite technology, applied in dialysis systems, semi-permeable membrane separation, chemical instruments and methods, etc., can solve the problem of low non-specific adsorption of various proteins, the ability to resist protein pollution needs to be improved, and the removal of middle molecules needs to be solved. Improvement and other issues, to achieve excellent biocompatibility, high permeability, low protein adsorption effect

Inactive Publication Date: 2018-04-20
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The membrane prepared according to the patent description has the characteristics of permanent hydrophilicity, protein contamination resistance and excellent blood compatibility, but its effect on dialysis efficiency needs to be improved
Patent CN201210590594.7 reports a preparation method of polyethersulfone hollow fiber membrane modified by heparin-like polyurethane blending. According to the patent description, the prepared membrane has strong anticoagulant function, but its anti-protein pollution ability needs to be improved
Patent CN201410425668.0 reports a highly antifouling polyethersulfone blood purifier and its The preparation method, the modified membrane prepared according to the patent description has low non-specific adsorption of various proteins, but its removal of middle molecules needs to be improved

Method used

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  • A heparin-like modified polyvinyl alcohol hydrogel thin-layer nanocomposite hemodialysis membrane and its preparation method

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Embodiment 1

[0032] Dissolve polyacrylonitrile (PAN) in N,N-dimethylformamide to prepare 8wt% uniform clear and transparent solution, and prepare PAN nanofiber membrane through electrospinning technology. The electrospinning parameters are as follows: voltage 20KV; Propelling rate: 16μL / min; receiving distance: 15cm. Add 10g of PVA to 250ml of absolute ethanol, add 1g of sodium hydrogen, and then add 1g of propane sultone, react at 80°C for 12h, filter and dry to sulfonated PVA (s-PVA), the mass ratio s - Add PVA / PVA=1:4 into ultrapure water to prepare a 2wt% coating solution, stir evenly at 60°C for 4 hours to obtain a clear and transparent solution, adjust the pH to 1, add 220 μL of glutaraldehyde, and Under the condition of 25 degrees Celsius, after crosslinking for about 18 minutes, it is coated on the PAN nanofiber membrane, and the coated membrane is placed in a watch glass, sealed at room temperature for 12 hours, soaked in deionized water and stored to obtain heparin-like modificat...

Embodiment 2

[0034] Dissolve polyacrylonitrile (PAN) in N,N-dimethylformamide to prepare 8wt% uniform clear and transparent solution, and prepare PAN nanofiber membrane through electrospinning technology. The electrospinning parameters are as follows: voltage 20KV; Propelling rate: 16μL / min; receiving distance: 15cm. Add 10g of PVA to 250ml of absolute ethanol, add 1g of sodium hydrogen, and then add 1g of propane sultone, react at 80°C for 12h, filter and dry to sulfonated PVA (s-PVA), the mass ratio s - Add PVA / PVA=1:3 into ultrapure water to make a 2wt% coating solution, stir evenly at 60°C for 4 hours to obtain a clear and transparent solution, adjust pH=1, add 220 μL of glutaraldehyde, Under the condition of 25 degrees Celsius, after crosslinking for about 19 minutes, it is coated on the PAN nanofiber membrane. The coated membrane is put into a watch glass, sealed at room temperature for 12 hours, soaked in deionized water and stored to obtain heparin-like modification. Highly antifo...

Embodiment 3

[0036] Dissolve polyacrylonitrile (PAN) in N,N-dimethylformamide to prepare 8wt% uniform clear and transparent solution, and prepare PAN nanofiber membrane through electrospinning technology. The electrospinning parameters are as follows: voltage 20KV; Propelling rate: 16μl / min; receiving distance: 15cm. Add 10g of PVA to 250ml of absolute ethanol, add 1g of sodium hydrogen, and then add 1g of propane sultone, react at 80°C for 12h, filter and dry to sulfonated PVA (s-PVA), the mass ratio s - Add PVA / PVA=1:2 into ultrapure water to make a 2wt% coating solution, stir evenly at 60°C for 4 hours to obtain a clear and transparent solution, adjust pH=1, add 220 μL of glutaraldehyde, Under the condition of 25 degrees Celsius, after crosslinking for about 19.5 minutes, it is coated on the PAN nanofiber membrane. A highly antifouling, anticoagulant polyvinyl alcohol hydrogel thin-layer nanocomposite hemodialysis membrane, the pore diameter of the surface cortex is 11nm, and the thick...

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Abstract

The invention relates to a heparinoid-modified polyvinyl alcohol hydrogel thin nano-compound hematodialysis film and a preparation method thereof. A heparinoid hydrogel skin layer is arranged as an outer layer of a thin nano-compound hematodialysis film and a porous supporting layer with nano-pores communicated with each other is arranged as an inner layer of the thin nano-compound hematodialysis film. The preparation method comprises the following steps: performing electrostatic spinning on a PAN solution, thereby acquiring a nanometer fiber as the supporting layer of a compound film; adding sodium-hydrogen into the PVA solution, and then adding 1,3-propane sultone, reacting for 8-24h at 40-80 DEG C, filtering and drying, thereby acquiring s-PVA; mixing s-PVA with PVA, adding a solvent, adjusting pH, adding a cross-linking agent, coating on the supporting layer after cross-linking, and sealing at room temperature, thereby acquiring the heparinoid-modified polyvinyl alcohol hydrogel thin nano-compound hematodialysis film. The preparation method provided by the invention is simple in reaction process and is easily performed. The prepared thin nano-compound hematodialysis film has the characteristics of permanent hydrophily, low protein adsorbability and excellent biocompatibility.

Description

technical field [0001] The invention belongs to the field of biological materials and their preparation, in particular to a heparin-like modified polyvinyl alcohol hydrogel thin-layer nanocomposite hemodialysis membrane and a preparation method thereof. Background technique [0002] The hemodialysis membrane uses the principle of a semi-permeable membrane, with the help of the solute gradient, osmotic gradient and water pressure gradient on both sides of the membrane, to remove toxins and excess water in the body, while replenishing the substances needed in the body and maintaining electrolytes and acids. The purpose of alkali balance. [0003] With the aggravation of the aging society, the increase of patients with diabetes and hypertension, the number of patients with chronic renal failure is on the rise, and the demand for hemodialyzers continues to increase. In the hemodialysis system, the core component that plays the role of separation is the hemodialysis membrane (re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/82B01D67/00B01D69/02B01D69/12B01D71/38A61M1/16
CPCA61M1/16B01D67/0006B01D67/0011B01D67/0013B01D69/02B01D69/12B01D69/125B01D71/38B01D71/82B01D2325/02B01D2325/04B01D2325/24
Inventor 王雪芬朱雅东于旭峰程诚王文婷华韦康邓莉王敏
Owner DONGHUA UNIV
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