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196 results about "2-Hydroxyethyl Methacrylate" patented technology

A hydroxyester compound and a resin monomer used in desensitizing dentin. By applying 2-hydroxyethyl methacrylate locally to sensitive teeth, sensitive areas in the teeth get sealed and block the dentinal tubules at the dentin surface from stimuli that cause pain. This prevents excitation of the tooth nerve and relieves pain caused by tooth hypersensitivity.

Sensor system

A sensor probe suited for implanting into the skin of a person includes a sensor body which may be formed from a polymer which includes 2-hydroxyethyl methacrylate (HEMA). A sensing system is supported by the body. The sensing system exhibits a detectable change when the probe is exposed to the analyte in the fluid. The sensing system may include an enzyme capable of catalyzing a reaction of the analyte to form a reaction product and a dye system which absorbs in the infrared region of the spectrum in response to the reaction product.
Owner:CASE WESTERN RESERVE UNIV

Bone connective prosthesis and method of forming same

The above-discussed and other problems and deficiencies of the prior art are overcome or alleviated by the improved bone connective prosthesis and method of forming the same of the present invention, comprising the addition of at least one biocompatible metal coupling agent to a prosthetic element, and then adding the biocompatible copolymerizer 2-hydroxyethyl methacrylate (“HEMA”) to the PMMA film and / or cement in an amount effective to enhance the cohesion between the prosthetic and the bone cement. In general, a PMMA / HEMA film is applied to the prosthetic element in the presence of a silane coupling agent by dipping, painting, spraying, etc.
Owner:FARO TECH INC

Silicone hydrogels for tissue adhesives and tissue dressing applications

A silicone hydrogel formulation may contains random and / or block copolymers or oligomers or macromers. The silicone copolymer is copolymerized or blended with other polymers or monomers or macromers to obtain final formulation. The silicone hydrogel may contain crosslinking groups to provide a complete or partially crosslinked final structure. The silicone hydrogel formulation may be pre-formed as a film or other structure, or it may be polymerized during application as in the case of an adhesive formulation. A wound dressing comprising a silicone hydrogel formed as a film, either prior to application to a wound or in situ on a wound, which film has gas permeability, moisture permeability, and high water content, wherein said silicone hydrogel is formed from a polymerizable silicone such as a difunctional polydimethylsiloxane methacrylate and crosslinking agents such as N,N-dimethyllacrylamide (DMA), 2-hydroxyethyl methacrylate (HEMA), and trimethylsiloxy silane (TRIS).
Owner:DSM IP ASSETS BV

Balloon catheter comprising pressure sensitive microparticles

The invention provides a solution to the above mentioned problem in that it provides a catheter balloon comprising a flexible coating on its outer surface wherein a plurality of microparticles are contained wherein said coating comprises a material selected from the group consisting of poly(N-vinyl-pirrolidone, poly(N-vinyl-pirrolidone-co-butylacrylate), poly(-vinyl pyridine), polyacrylamides, e.g. poly(N-isopropylacrylamide), poly(amido-amines), poly(ethylene imine), poly(ethylene oxide-block-propylene oxide), poly(ethylene oxide-block-propylene oxide-block-ethylene oxide), poly(styrene-block-isobutylene-block-styrene), poly(hydroxystyrene-block-isobutylene-block-hydroxystyrene), polydialkylsiloxanes, polysaccharides, polyacrylates and polyalkylmethacrylates, e.g. polymethylmethacrylate and poly(2-hydroxyethylmethacrylate) and wherein said microparticles comprise a material selected from the group consisting of polyesters, e.g. poly(lactic acid), poly(lactic-co-glycol acid), poly(glycolic acid), poly(3-hydroxybutyrate), poly(3-hydroxyvalerate), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) and polycaprolactone, polyamides, polysaccharides, polyurethanes, polyalkylmethacrylates and polyacrylates, e.g. polymethylmethacrylate and poly(2-hydroxyethylmethacrylate) and wherein the microparticles comprise a pharmaceutically active compound.
Owner:ENCAPSON

Oil absorbing fibre and perparing method thereof

The invention relates to a kind of oil-absorbed fiber and its producing method. Its prescription is: 100% polymer monomer, 10-40% of potential gemel agent, 0.1-0.5% solicitation, 0.5-1% dispersant. Moreover the water-like body is 3-4 times more in volume than polymer monomer. The polymer monomer is methacrylate monomer involving butyl methacrylate, the potential gemel agent is 2-hydroxyethyl methacrylate, the solicitation is benzoyl peroxide, and dispersant is poly-vinyl-alcohol. The process is (1) use water-suspending polymerization to produce butyl methacrylate under 70-80 deg.C for blending and polymerizing for 8-10 hours. (2) dissolve the polymer into proper solvent to deploy 20-25% liquid and then insert potential gemal agent and solicitation to polymerize for 3-5 hours under 75-80 deg.C to obtain the original liquid. (3) take off dunking. (4) spin using one of wet or dry method or both, (5) treat with fibre for 10-60 minutes under 120-165 deg.C to obtain the production. The solvent discussed above is one of DMF, DMAC or dimethoxysulfoxide.
Owner:TIANJIN POLYTECHNIC UNIV

Terpolymer dispersants and preparation technique and use thereof

The invention discloses a terpolymer dispersing agent with high dispersion and stability, low preparation cost and environmental protection as well as a preparation process and applications thereof. The terpolymer dispersing agent is prepared through free radical copolymerization of acrylic acid, sodium styrene sulfonate, hydroxypropyl acrylate or 2-hydroxyethyl methacrylate, the number average relative molecular weight of the terpolymer is between 2000 and 40000, and the dispersing agent has advantages of high thermal stability, good water solubility, excellent adaptability to acid and alkali and good dispersion stability, and also has good dispersion effects to calcium carbonate, zinc oxide, barium sulfate, titanium dioxide and pesticide Atrazine water dispersible granules and fipronil water dispersible granule, and can be widely used in the pesticide, pigment, dyestuff, coal water slurry and other industries. In addition, the preparation process has the advantages of simple operation, short cycle, environmental protection and low cost, and is suitable for the industrial scale production.
Owner:SHANGHAI NORMAL UNIVERSITY

Synthesis of biocompatible nanocomposite hydrogels as a local drug delivery system

Nanocomposite biocompatible hydrogels (NCHGs) may be synthesised as model systems for in situ cured local drug delivery devices for treatment of inter alia periodontal infections. The composite includes the following components: nanoparticles (NPs), a matrix gel, and chlorhexidine (CHX) or other antibacterial drug. The NPs were obtained by free radical initiated copolymerization of the monomers, 2-hydroxyethyl methacrylate (HEMA) and polyethyleneglycol dimethacrylate (PEGDMA), in aqueous solution. The same monomers were used to prepare crosslinked matrices by photopolymerization. NCHGs were obtained by mixing NPs, monomers, and drug in an aqueous solution then crosslinked by photopolymerization.
Owner:BAKO JOZSEF +6

Transparent bacterial cellulose nanocomposite hydrogels

A transparent polymeric nanocomposite hydrogel is provided, wherein the polymeric nanocomposite hydrogel is made from a water insoluble polymer, i.e. poly(2-hydroxyethyl methacrylate) (PHEMA) or / and crosslinked PHEMA and a water insoluble nanofiber, i.e., bacterial cellulose (BC). Disclosed is a synthetic route for polymeric nanocomposites hydrogels. The preferred polymeric nanocompositions are produced through free radical polymerization of HEMA monomer in the presence of bacterial cellulose with an assistance of ultrasound to enhance the mixing of bacterial cellulose, initiator, and the monomers. The polymeric nanocomposite hydrogel is then formed by immersion of the dry polymeric nanocomposite in water. Disclosed is a high transmittance polymer nanocomposite hydrogel with a preferred BC loading less than 0.1%, water content of about 40% in weight, good mechanical integrity and strength. The disclosed polymer nanocomposite hydrogel and compositions pertain to hydrogel applications, particularly contact lenses and optic components for biosensor.
Owner:AXCELON BIOPOLYMERS COPRORATION

Means and method for the preparation of sealings in oil and gas wells

PCT No. PCT / NO96 / 00255 Sec. 371 Date Apr. 23, 1998 Sec. 102(e) Date Apr. 23, 1998 PCT Filed Oct. 25, 1996 PCT Pub. No. WO97 / 15746 PCT Pub. Date May 1, 1997Agent and method for establishing different types of zone sealings particularly in oil wells and gas wells, wherein the zone to be sealed is supplied with a composition comprising: monomers, an initiator for heat-induced production of free radicals, a pot life extending inhibitor for stabilization of free radicals, and optionally other additives. The composition is subjected to radical polymerization induced by heat in the well zone and at a temperature of 5-120 DEG C., and establishes a cured mass, particularly at temperatures in the range of 65-100 DEG C. The composition is supplied with an at least partly unsaturated prepolymer selected from the group consisting of polyester and epoxy vinylester, including one or more vinyl-containing co-monomers selected from the group consisting of styrene, vinyltoluene, 2-hydroxyethyl-methacrylate and 2-hydroxypropyl-methacrylate. The prepolymer is present in a quantity of 15-75 weight parts and the vinyl-containing co-monomers are added in a quantity of 75-15 weight parts. The composition is particularly suited for low temperature applications.
Owner:WELLCEM

Hydrogel networks having living cells encapsulated therein

The present invention is directed to a hydrogel network comprised of a physically cross-linked polymer and a chemically cross-linked polymer or physically entangled copolymer containing living cells, such as chondrocytes, encapsulated therein. In a preferred aspect, the physically cross-linked polymer is selected from the group consisting of thermally gelling polysaccharides and proteins, such as agarose or gelatin, and the chemically cross-linked or physically entangled polymer is synthesized from a water-soluble vinyl monomer, either as a homopolymer or copolymer, such as polyethylene glycol diacrylate (“PEG-DA”) and 2-hydroxyethyl methacrylate (“HEMA”).
Owner:UNIVERSITY OF KANSAS

Water-soluble crylic acid resin and preparation method thereof

The invention discloses a waterborne acrylic resin and the preparation method, which aims to provide a waterborne acrylic resin and the preparation method which can not only keep the performance of organic solvent type acrylic resins, but also have friendly environmental protection property. The invention comprises the following matters of mass portion: 1 to 2 of acrylic, 15 to 29 of methyl methacrylate, 18 to 22 of butyl acrylate, 3 to 7 of styrene, 3 to 7 of 2-hydroxyethyl methacrylate, 0.25 to 0.65 of mercaptoethanol, 0.3 to 0.7 of azobisisobutyronitrile, 3 to 5 of isopropanol, 15 to 20 of ethanol, 2.5 to 8.75 of monoethanolamine and 25 to 31.5 of water.
Owner:浙江英科水墨材料有限公司

Polyacrylate, pressure-sensitive adhesive and preparation method

The invention relates to polyacrylate. Polyacrylate is synthesized from raw materials in percentage by mass as follows: 10%-30% of a hard monomer, 15%-40% of a soft monomer, 1%-5% of a functional monomer, 0.5%-2% of a special monomer and 40%-50% of a solvent, wherein the hard monomer comprises one or more of methyl acrylate, methyl methacrylate, vinyl acetate, acrylonitrile and isobornyl methacrylate; the soft monomer comprises one or more of ethyl acrylate, n-butyl acrylate, 2-ethylhexyl acrylate and n-propyl acrylate; the functional monomer comprises one or more of hydroxyethyl acrylate, acrylic acid, methacrylic acid, hydroxypropyl acrylate and 2-hydroxyethyl methacrylate; the special monomer comprises one or more of methacrylamido ethyl ethylene urea, hydroxyethyl methacrylate phosphate and glycidyl methacrylate. A pressure-sensitive adhesive has good high-temperature-resistant adhesive property, does no squeeze out, has no residue, has low cost and can be applied to masking tapesused in capacitor taping in the electronics industry as well as certain high-temperature-resistant adhesive tapes.
Owner:CYBRID TECHNOLOGIES INC

Preservative Removal from Eye Drops

ActiveUS20170224531A1Reduce or eliminate further drug uptakeOrganic active ingredientsSemi-permeable membranesPreservativeMicroparticle
A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.
Owner:UNIV OF FLORIDA RES FOUNDATION INC

Ambient Temperature Curable Hydrophilic PU Oligomer, Method for Synthesizing the same and Surface Treatment Method of using the same

InactiveUS20080194723A1Increase double-bond concentrationHigh densityImpression capsSynthetic resin layered productsUltravioletWater resistant
An ambient temperature curable hydrophilic PU oligomer includes a PU pre-polymer having a hydrophilic center group and a curable terminated group. The ambient temperature curable hydrophilic PU oligomer includes the moisture-curable hydrophilic PU oligomer such as isocyanate-terminated PU pre-polymer and free-radical curable hydrophlic PU oligomer. The isocyanate-terminated PU pre-polymer is synthesized by mixing at least one multi-isocyanate, at least one polyol and one or more diol monomer with hydrophilic group. The acrylate-terminated PU oligomer is synthesized by adding 2-hydroxyethyl methacrylate (HEMA) into the isocyanate-terminated hydrophilic PU pre-polymer. Either acrylate- or isocyanate-terminated PU oligomer can be applied on a textile or a glass surface with a thin-layer coating technology. The curing reactions of these hydrophilic thin-layer coatings are carried out with moisture or UV-radiation, respectively, at ambient temperature. These moisture-cured or UV-radiation cured hydrophilic PU coating has water-resistant properties and the hydrophilic characters remain unchanged.
Owner:TAMKANG UNIVERSITY

Silicone-hydrogel compound for soft contact lens and soft contact lens produced using the compound

The present invention relates to a silicone hydrogel composition for a soft contact lens and a soft contact lens using the same which comprises silicone N,O-bis(trimethylsilyl)acrylamide monomer and 2-hydroxyethyl methacrylate added with water soluble N-vinyl-2-pyrrolidone or N,N-dimethylacrylamide monoer to improve hydrophilic property and a cross-linking agent such as ethylene glyx>l dimethacrylate or divinyl benzene to provide a hydrophilic property, high water content rate, high oxygen permeability, good elongation and optical transmission.
Owner:BESKON KO +1

Flame-retardant block copolymer containing nitrogen and phosphorus and preparation method thereof

The invention discloses a flame-retardant block copolymer containing nitrogen and phosphorus and a preparation method thereof and relates to a block copolymer. The flame-retardant block copolymer containing nitrogen and phosphorus is PMOEPm-b-PDMAEMAn. The preparation method comprises the steps of dissolving 2-hydroxyethyl methacrylate phosphate, cumyl dithiobenzoate and azobisisobutyronitrile in a solvent, carrying out freeze thawing and degassing until unfreezing is realized and no bubbles come out, carrying out polymerization reaction under the protection of inert gas, quenching with liquid nitrogen to stop the reaction, precipitating and drying to obtain a product which is a PMOEPm macromolecular chain transfer agent; dissolving the PMOEPm macromolecular chain transfer agent, dimethylaminoethyl methacrylate and azobisisobutyronitrile in the solvent, carrying out freeze thawing and degassing, carrying out polymerization reaction under the protection of inert gas, quenching with liquid nitrogen to stop the reaction and repeatedly precipitating with ethanol used as a precipitant to obtain the target product, namely, flame-retardant block copolymer containing nitrogen and phosphorus (PMOEPm-b-PDMAEMAn). The flame-retardant block copolymer containing nitrogen and phosphorus can be used in preparation of halogen-free flame retardant and self-assemble micelles.
Owner:XIAMEN UNIV

High-performance water-soluble acrylic resin and preparation method thereof

The invention relates to high-performance water-soluble acrylic resin, which is characterized in that the high-performance water-soluble acrylic resin is prepared by using the following raw materials in parts by weight: 2-5 parts of 2-hydroxyethyl methacrylate, 1-3 parts of hydroxyethylacrylate, 5-8 parts of methyl methacrylate, 3-4 parts of 2-ethylhexyl methacrylate, 6-9 parts of n-butyl acrylate, 3-6 parts of ethyl acrylate, 1-2 parts of acrylic acid, 2-5 parts of tertiary carboxylic glycidyl ester, 1-3 parts of hexafluorobutyl methacrylate, 0.08-0.4 part of initiator, 1-2 parts of neutralizer, 0.01-0.02 part of defoaming agent, 8-15 parts of isopropanol and 10-50 parts of deionized water. By adding two modifiers, i.e. the tertiary carboxylic glycidyl ester and the hexafluorobutyl methacrylate in raw materials for conventional water-soluble acrylic resin, the prepared water-soluble acrylic resin has high alkali resistance and high boiling water resistance, the gloss of products coated with the water-soluble acrylic resin is good and the needs of people are met.
Owner:江阴恒兴涂料有限公司

Hydrogel dressing and preparation method thereof

ActiveCN104841008APromote degradationCcelerated regenerationAbsorbent padsBandagesVitamin CCarrageenan
The invention provides a hydrogel dressing and a preparation method thereof. The dressing is prepared from a sea-buckthorn extract, a Chinese atractylode rhizome extract, hyaluronic acid, polylysin, polyhydroxyethyl methacrylate, carrageenan, 2-hydroxyethyl methacrylate, vitamin C, polyvinyl alcohol, calcium chloride, borax, ammonium dihydrogen phosphate, glycerinum, mannose and deionized water. The preparation method comprises the following steps: firstly preparing the sea-buckthorn extract and the Chinese atractylode rhizome extract, respectively, adding such components as hyaluronic acid, polylysin, polyhydroxyethyl methacrylate, carrageenan, 2-hydroxyethyl methacrylate and ammonium dihydrogen phosphate to 1 / 2 parts by weight of ionized water to obtain a mixed liquid I, next, adding such components as vitamin C, polyvinyl alcohol, calcium chloride, borax, glycerinum and mannose to the rest parts by weight of deionized water to obtain a mixed liquid II, and finally, mixing the sea-buckthorn extract, the Chinese atractylode rhizome extract, the mixed liquid I and the mixed liquid II, namely performing a thermal reaction, thereby obtaining the hydrogel dressing. The hydrogel dressing is capable of promoting the healing of a wound, and lasting in antibacterial effect and low in production cost.
Owner:南京竹海生物科技有限公司

Environment-friendly nontoxic glue

The invention discloses environment-friendly nontoxic glue. The environment-friendly nontoxic glue comprises, by weight, 60-160 parts of polyester, 30-40 parts of butylene glycol acrylate, 40-60 parts of trimethylolpropane, 10-30 parts of butanediol, 20-40 parts of metoxyphenol, 8-12 parts of acetone, 9-12 parts of acrylamide, 10-28 parts of styrene, 6-24 parts of ethyl alcohol, 2-6 parts of xylene, 20-30 parts of poly(isobutyl ester), 10-30 parts of aluminum hydroxide, 24-48 parts of phosphotriester, 12-18 parts of antimonous oxide, 100-160 parts of 2-hydroxyethyl methacrylate, 80-100 parts of methyl methacrylate, 20-60 parts of lauryl methacrylate, 12-16 parts of styrene, 150-200 parts of butyl methacrylate, 20-40 parts of methacrylic acid, 8-16 parts of dehydroacetic acid and 20-40 parts of butanol. According to the environment-friendly nontoxic glue, manufacturing is easy, adopted and selected production raw materials are nontoxic, the using effect of the glue is good, environmental friendliness is achieved, a tough coating can be formed, and lasting water repellency and antistatic performance are achieved.
Owner:启东寅昶精密铸造有限公司

Carbon Cord For Reinforced Rubber Products and the Products

A treated carbon fiber tensile cord for use in power transmission belts, hose, tires or other reinforced rubber products and the resulting product, which includes carbon fibers which are coated with a polymeric layer deposited and polymerized at atmospheric pressure in a plasma assisted chemical vapor deposition process. A suitable polymeric layer is compatible with the intended matrix which the cord will reinforce. For a rubber belt, the coating is compatible with the rubber composition of the belt body or an adhesion gum or adhesive such as RFL which surrounds the cord. For RFL / rubber systems and cast polyurethane elastomers, a suitable polymer is the APP reaction product of a vinyl carboxylic acid or an ester or amide thereof. Suitable carboxylic acids include acrylic acid and methacrylic acid. Various esters and amides of vinyl carboxylic acid are also suitable, such as 2-hydroxyethyl methacrylate, N-isobutoxymethyl acrylamide, and N-hydroxyethyl acrylamide.
Owner:THE GATES CORP

Suturable Hybrid Superporous Hydrogel Keratoprosthesis for Cornea

The present invention features a hybrid superporous hydrogel scaffold for cornea regeneration and a method for producing the same. The hybrid hydrogel is composed of a superporous poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) copolymer mixed with collagen. The hybrid scaffold can be used as a suturable hybrid corneal implant or keratoprosthesis.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS

Triblock copolymer with high biocompatibility and preparation method and application thereof

InactiveCN106397727AAdjustable permeabilityAdjustable physical propertiesDiagnosticsSurgeryPolymer sciencePolypropylene glycol
The invention discloses a triblock copolymer with high biocompatibility. A general formula of the triblock copolymer is A-b-B-b-C, wherein A, B and C are of block structures, B is a block chain extender, A represents a soft segment material with high hydrophily and is a block formed by at least one of polyethylene glycol, polypropylene glycol and polyether amine; B represents a rigid hard segment material with high hydrophobicity and is a block formed by at least one of polycarbonate and polymethyl methacrylate; C represents a flexible polymer and is a block formed by at least one of polydimethylsiloxane and poly(2-hydroxyethyl methacrylate). A permeable membrane prepared from the triblock copolymer has highly-controlled micromolecule permeability, good water resistance and heat resistance, and adjustable hydrophily and biocompatibility.
Owner:MICRO TECH MEDICAL HANGZHOU CO LTD

Flexible conductive silver paste and manufacturing method

The invention belongs to the field of fine chemicals, and particularly discloses a flexible conductive silver paste and a manufacturing method. The mass percentage of each component of the flexible conductive silver paste is as follows: 30 to 60% of silver nanowires, 1 to 5% of 2-hydroxyethyl methacrylate phosphate, 18 to 30% of a solvent, 15 to 30% of polyurethane resin, 5 to 10% of polyvinyl butyral, 0.5 to 2% of a defoamer and 0.5 to 5% of a curing agent. According to the flexible conductive silver paste, through adding of the 2-hydroxyethyl methacrylate phosphate, due to hydrogen bonding effects generated between hydroxyl groups on 2-hydroxyethyl methacrylate phosphate molecules and the silver nanowires and the polyurethane resin, the stability of the silver nanowires in organic resin is improved, and the flexible conductive silver paste with excellent adhesion and bending resistance performance is obtained. Through adjusting the using amounts of the 2-hydroxyethyl methacrylate phosphate, the silver nanowires and the polyurethane resin, the obtained flexible conductive silver paste has excellent adhesion and bending resistance performance.
Owner:广州市昌鹏实业有限公司

Anionic polyurethane modified polyacrylate emulsion with crosslinked core-shell structure and preparation method of anionic polyurethane modified polyacrylate emulsion

ActiveCN109162123AImprove stabilityModerate film forming speedDyeing processPolyester(Hydroxyethyl)methacrylate
The invention relates to the field of printing adhesives, in particular to anionic polyurethane modified polyacrylate emulsion with a crosslinked core-shell structure and a preparation method of the anionic polyurethane modified polyacrylate emulsion. The method comprises the following steps: polyester diol, hydroxyl terminated polybutadiene, isophorone diisocyanate, dimethylolpropionic acid, trimethylolpropane monoallyl ether, 1,4-butanediol, polyethylene glycol methyl ether and 2-hydroxyethyl methacrylate are subjected to a reaction with a polyurethane catalyst, and a PU active prepolymer isobtained; the PU active prepolymer, part of a polyacrylate monomer, part of an emulsifier, triethylamine and water are mixed, and PUm active prepolymer emulsion is prepared; the remaining polyacrylate monomer, the remaining emulsifier and water are mixed, stirred and emulsified, part of an initiator is added for pre-polymerization, and then the PUm active prepolymer emulsion and the remaining initiator are added for polymerization. An adhesive film formed by the polyurethane modified polyacrylate emulsion has better water resistance, acid resistance and low temperature flexibility.
Owner:WUHAN TEXTILE UNIV +1

Suturable hybrid superporous hydrogel keratoprosthesis for cornea

The present invention features a superporous hydrogel scaffold for corneal regeneration or replacement and a method for producing the same. The superporous hydrogel is composed of a poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) copolymer mixed with collagen. The scaffold can be used as a suturable hybrid corneal implant or keratoprosthesis.
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS

Implantable enzyme-based monitoring system having improved longevity due to improved exterior surfaces

An implantable enzyme-based monitoring system suitable for long term in vivo use to measure the concentration of prescribed substances such as glucose is provided. In one embodiment, the implantable enzyme-based monitoring system includes at least one sensor assembly, an outer membrane surrounding the sensor assembly and having a window therein, and a polymeric window cover affixed to the outer membrane and covering the window. Preferably, the outer membrane of the monitoring system is silicone and the window cover is a polymer of 2-hydroxyethyl methacrylate (HEMA), N,N,-dimethylaminoethyl methacrylate (DMAEMA) and methacrylic acid (MA). Also provided herein is an implantable enzyme-based monitoring system having at least one sensor assembly, an outer membrane surrounding the sensor assembly and a coating affixed to the exterior surface of the outer membrane, wherein the coating resists blood coagulation and protein binding to the exterior surface of the outer membrane. Preferably, the coating is polyethylene glycol (PEG) and heparin in an 80:20 molar ratio. Finally, provided herein is a method of coating the exterior surface of the outer membrane of an implantable enzyme-based monitoring system comprising the steps of forming hydroxyl groups on the silicone surface by plasma etching; reacting the silicone surface with amino functionalized silane, thereby forming amino groups on the silicone surface; simultaneously, covalently binding polyethylene glycol (PEG) and heparin to the amino groups; and ionically binding heparin to the monitoring system surface.
Owner:ALFRED E MANN FOUND FOR SCI RES
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