79results about How to "Suitable for industrial amplification" patented technology

The invention discloses preparation methods of a sustained-release microcapsule and a sustained-release composite membrane for inhibiting the monilinia fructicola. The preparation method of the sustained-release microcapsule comprises the following steps: the chitosan and the berberine are weighed, the mass ratio between the chitosan and the berberine is 9-11:0.22-0.28, the acetate solution is added, then the chitosan and the berberine are sufficiently swelled to obtain berberine-chitosan solution after stirring for dissolving, standing and air bubble removal, and the berberine-chitosan solution is added in the soybean oil containing span 80, stirred at the constant temperature of 40-50 DEG C and then emulsified for 28-32 min to form a W / O system; the glutaraldehyde solution is added for stirring for 2.5-3.5 hours, and the centrifuging is carried out so that the microcapsule is fully settled; and the preparation liquid on the upper layer is obliquely taken, the obtained microcapsule is washed with petroleum ether for 3-5 times and then dried for 23-25 hours under the vacuum at the temperature of 48-52 DEG C. The invention also provides the preparation method for the sustained-release composite membrane for inhibiting the monilinia fructicola. Both the microcapsule and the composite membrane have the sustained-release effects and have no toxic side effect to the environment and the plants since the berberine is a native compound.

The invention discloses a novel method used for preparing high-purity 4-chloropyrrolo[2,3-d]pyrimidine in industrialization scale. According to the method, ethyl cyanoacetate, bromo-acetal, formamidine acetate, and sodium alcoholate are taken as raw materials; N,N-dimethylformamide, ethyl alcohol, and phosphorus oxychloride are taken as solvents; and 4-chloropyrrolo[2,3-d]pyrimidine is obtained via three-step approach. The process route of the method is simple; time is short; next step feed can be carried out directly without complex purification process of intermediates; no toxic agent is used; the method is safe and reliable, and is low in cost; total yield is higher than 30%; and the purity of obtained products is as high as 99.2%.

The invention discloses a method for synthesizing a molecular sieve membrane, which adopts a mode of crystal seed coating by a crystal seed slurry coating method for the synthesis of the molecular sieve membrane. A sol with a composition similar to that of a synthetic fluid for synthesizing the molecular sieve membrane is prepared, and the sol is mixed with molecular sieve crystals and water according to a certain proportion to prepare a crystal seed slurry; a supporting body is soaked with water, and after the surface of the supporting body is dried in the air, the crystal seed slurry is coated on the surface; when the surface is almost dry, the coating is strickled and dried to obtain a supporting body with a crystal seed layer; finally the molecular sieve membrane is synthesized by a hydrothermal synthesis method. The crystal seed layer prepared by the invention can eliminate possible defects on the supporting body surface, is distributed uniformly, and is not easy to be erased from the supporting body surface, so the synthesized molecular sieve membrane has a continuous and dense surface, excellent separation performance, good repeatability, and is applicable to large-scale production.

The invention provides a catalyst for producing low-carbon mixed alcohol by using synthesis gas. The catalyst comprises copper oxide, zinc oxide, zirconium oxide and auxiliaries, and the general formula of the catalyst is CuaZnbZrcMdNeOx, wherein M refers to at least one of metal elements such as Mn, Ce, Mg, Fe, Co and Ni; N refers to an alkali metal; a is equal to 0.3-4.0; b is equal to 0.5-3.5; c is equal to 1.0-5.0; d is equal to 0.02-0.3; e is equal to 0.01-0.2; and x refers to the sum of number of oxygen atoms needed by all the metal elements in the general formula. The invention also discloses a preparation method and application of the catalyst. The catalyst has high C2<+> alcohol selectivity, high selectivity of isobutyl alcohol and low hydrocarbon selectivity, the water content in the liquid phase product is low, the preparation method is simple and feasible, and industrialization is easily realized.

The invention relates to a preparation method for extracting a fluorescent graphene quantum dot material from coffee-ground solid waste. According to the preparation method, the coffee-ground solid waste which is low in price and easy to obtain is selected as a carbon source, and a large number of water-soluble graphene quantum dots can be obtained through a simple hydrothermal process. The synthesized quantum dots can be stably dispersed in water, are light yellow under low concentration and are brown under high concentration (that is, the higher the concentration is, the darker the color is). The particle size of the obtained graphene quantum dots ranges from 3 nm to 7 nm, the surfaces of the graphene quantum dots are provided with a large number of carboxyl groups and amino groups, subsequent surface functionalization is facilitated, multi-purpose application can be brought, and meanwhile the excellent fluorescent property is exerted. The synthesized quantum dot material shows the attractive application prospect in the high and new technical fields such as environmental protection, bionanotechnology, new energy resources and nanometer devices, and the synthesizing method is simple, environmentally friendly, rapid, low in energy consumption and suitable for industry expanding.

The invention provides a novel preparation method of an afatinib compound. Raw materials and reagents used in the preparation method have the advantages of low cost, stable chemical property and convenience in long-term storage and the content of an impurity cis-isomer in the prepared afatinib compound is very low.

The invention relates to an ordered mesoporous organic silicon oxide hollow ball prepared through a one-step method and a preparation method of the ordered mesoporous organic silicon oxide hollow ball. The prepared ordered mesoporous organic silicon oxide hollow ball has good spherical morphology. The ball grain size ranges from 50 nm to 100 nm. The ball grain size distribution is uniform. The ordered mesoporous organic silicon oxide hollow ball is high in monodispersity, strength and dispersibility. A spherical shell comprises ordered radial mesoporous ducts. The preparation method is simple and easy to implement and can be easily conducted in an industrial mode. The ordered mesoporous organic silicon oxide hollow ball can be prepared through one step without sacrificial template or postprocessing. The fastest preparation process lasts for only 0.25 h. By means of the structure, reaction molecules or medicine molecules can conveniently enter and leave the ordered mesoporous organic silicon oxide hollow ball, and the ordered mesoporous organic silicon oxide hollow ball has good application prospects in the fields of medicine slow release, release control, medical imaging, catalysis and the like.

The invention provides a catalyst used in preparation of acrylic acid through one-step oxidation of propylene and a preparation method thereof, which relates to a catalyst and a preparation method thereof. A basic general formula of the catalyst is Mo1VaTebNbcAeBfO / yZ, wherein Mo is molybdenum, V is vanadium, Te is tellurium, Nb is niobium, A is at least one selected from the group consisting of phosphorus, boron, iron, tungsten and the like, B is at least one selected from the group consisting of potassium, cerium, caesium and the like, Z is SiO2 or Al2O3, a, b, c, d, e, f and y respectively represent mol ratios of every element, a is in a range of 0.2 to 0.6, b is in a range of 0.1 to 0.6, c is in a range of 0.01 to 0.2, d is in a range of 0.01 to 0.2, e is in a range of 0 to 0.05, f is in a range of 0 to 0.08, and y is in a range of 0 to 3. When the catalyst is applied to preparation of acrylic acid through one-step oxidation of propylene, the conversion rate of propylene is 78 to 92%, and selectivity of acrylic acid is 79 to 90%. The catalyst prepared by using the method has high activity, good selectivity and stable performance.

The invention relates to the field of pharmaceutical chemistry technology, and more specifically relates to an anticarcinogen 10-Propargyl-10-deazaaminopterin (Pralatrexate) and synthesis of an intermediate thereof. The invention has the advantages of simple operation, low contents of related impurities, easiness in purification of intermediate, thereby avoiding purification mode of column chromatography, and the invention can be applied to large scale production of Pralatrexate bulk drug as well as preparation and purification method of important intermediates.

A nano-molybdenum-based sulfur-tolerant methanation catalyst takes metal Mo as the main active component.A second active component metal M1 and an additive metal M2 are added on the basis of the main active component, and the catalyst is prepared from, by mass, 5%-55% of M, 2%-50% of M1, 0.2%-20% of M2 and the balance oxygen atoms.The nano-molybdenum-based sulfur-tolerant methanation catalyst has the advantages of being simple in preparation, high in sulfur-tolerant capacity, high in methanation activity, good in stability and free of carbon deposition.

This invention relates to a method for synthesizing 2-amino-4, 6-dichloro-5-formylaminopyrimidine. The method adopts low-cost malonate and guanidine hydrochloride as the starting materials to synthesize 2-amino-4, 6-dichloro-5-formylaminopyrimidine with high efficiency. The method has such advantages as simple process and easy operation.

The invention relates to a Chinese yam soluble dietary fiber and a preparation method thereof. The preparation method comprises the following steps: (1) smashing Chinese yam, and adding water for leaching to obtain a leaching liquor; (2) adding a compound enzyme into the leaching liquor obtained in the step (1), performing enzymatic hydrolysis, performing solid-liquid separation, and collecting supernatant; (3) concentrating and drying the supernatant prepared in the step (2) to obtain the Chinese yam soluble dietary fiber. Based on 100 percent by mass of the Chinese yam used in the step (1), the compound enzyme used in the step (1) is prepared from the following components in percentage by mass: 0.1 to 0.5 percent of papain, 0.2 to 0.8 percent of neutral protease 0.4 to 1.0 percent of glucoamylase, 0.3 to 0.8 percent of cellulose enzyme, and 0.1 to 0.3 percent of hemicellulose. The prepared Chinese yam soluble dietary fiber is 30 percent or more in purity, is 7.5 percent or more in yield, and has high solubility.

The invention relates to a three-dimensional oxidized graphene frame film and a preparing method and application thereof. Particularly, the invention discloses a three-dimensional oxidized graphene frame film used for sea water desalination, the frame film comprises an oxidized graphene film layer modified by p-phenyl diisocyanate (PDI) and an optional porous alumina tubular carrier used for loading the oxidized graphene film layer modified by p-phenyl diisocyanate (PDI), and the porous alumina tubular carrier is modified by PDI. The invention further discloses the preparing method and application of the frame film. The frame film has the advantages that the preparation process is simple, the thickness and the interlayer spacing are controllable, and the frame film is uniform and dense, high in stability in water and excellent in sea water desalination performance and can greatly promote development of the sea water desalination technology.

A method for synthesizing a type A molecular sieve membrane by evacuation and crystal coating method, the steps are: 1) introduce a layer of uniformly dispersed molecular sieve crystal seeds on the base membrane by using a vacuum pump to evacuate or compress with a compressor, and the evacuation or compression pressure is 0.0010 -0.0500Mpa, the dipping time is 30-300S, the concentration of the dipping solution is 1-20g / l, and the grain size is 0.20-10μm. 2) Synthesize A-type molecular sieve membrane by hydrothermal synthesis method and microwave synthesis method, and the solution composition of synthetic A-type molecular sieve membrane is: aNa2O:bAl2O3:5SiO2:cH2O, where a=(20-100), b=(0.5-5 ), c=(500-4000); hydrothermal or microwave synthesis, the temperature of hydrothermal synthesis is 323-373K, and the synthesis time is 2-60h; the temperature of microwave synthesis is 323-373K, and the synthesis time is 30-120min. The molecular sieve membrane synthesized by the method of the invention has good separation performance and high repeatability, and is suitable for industrial amplification.

The invention discloses an environment-friendly asphalt mixture additive and a preparation method thereof. The environment-friendly asphalt mixture additive is prepared from, by weight, 55%-90% of powdery solids, 7%-20% of polyethylene, 1%-5% of a fluorocarbon surfactant, 1%-10% of Kaloamine and 1%-10% of alkyl glycoside. The preparation method comprises the following steps that the powdery materials, polyethylene, the fluorocarbon surfactant, Kaloamine and alkyl glycoside are put into a screw extruder in proportion, mixed to be uniform and extruded to obtain a finished product, and then the asphalt mixture additive is obtained. According to the asphalt mixture additive, the powdery solids generated after thermal extraction treatment of oily sludge can be fully reused and can be put into asphalt mixture production by replacing ore powder, environmental pollution is reduced, the cost is reduced, the rutting deformation resistance of the asphalt mixture is improved, and the service life of a pavement can be prolonged.

The invention relates to a method for preparing 4-propargyl azetidine-2-ketone and / or 4-dialkenyl azetidine-2-ketone. The method can conveniently and efficiently obtain the 4-propargyl azetidine-2-ketone and / or 4-dialkenyl azetidine-2-ketone by taking simple cheap 4-acyloxy-azetidine-2-ketone and propargyl alogenated compound as starting materials. The method has the advantages of convenience and easy operation.

The invention discloses a method for synthesizing a PHI-type molecular sieve membrane on the surface of an α-Al2O3 support body. In the method, the support body pretreatment and the preparation of a seed crystal synthesis solution are carried out first, and then the crystal seed is introduced, and then the membrane is synthesized and washed and dried. The PHI type molecular sieve membrane is obtained; the preparation of the seed crystal synthesis solution is to configure alkali, silicon source, aluminum source and deionized water according to the molar ratio of Na2O, K2O, SiO2, Al2O3 and H2O, a1, b1, c1, 1 and d1, The source of alkali is Na2O and K2O, a1=1.5-2.5, b1=0.2-0.5, c1=4-8, d1=80-108; the molecular sieve membrane synthesized by the present invention has perfect crystal form, compact structure and good permeability, The synthesis process has high repeatability, the membrane has a long service life, and is suitable for industrial scale-up.

The invention discloses a molecular sieve composite membrane which is a multichannel molecular sieve composite membrane formed by molecular sieve polycrystal membranes, which are the same kind as the molecular sieve particles constituting the support body, on the internal surface of a porous multichannel composite support body formed by 40-90 wt% of molecular sieve particles (the particle sizes are 0.1-5 m) and 10-60 wt% of organic macromolecules or organic macromolecule mixture. The preparation method comprises the following steps: (1) adding sodium aluminate to distilled water, sufficiently stirring to form an aluminum solution, dissolving sodium hydroxide in the distilled water, defecating, adding a silicon source, heating and stirring to form a silicon solution, adding the aluminum solution into the silicon solution, and stirring to prepare reaction liquor for synthesizing the molecular sieve membrane; (2) and pouring the reaction liquor into a high pressure reactor, directly and perpendicularly inserting the organic macromolecular / molecular sieve composite support body into the reaction liquor to carry out the hydrothermal synthesis, cooling after crystallizing, washing with distilled water to be neutral, and drying to obtain the molecular sieve composite membrane. The invention has the advantages of simple operation, high repetitiveness of membrane formation and favorable performance, and is suitable for industrial magnification.

The invention discloses a cocoa polyphenol extraction and enrichment preparation method which comprises the following steps: (1) crushing a cocoa raw material; (2) soaking the crushed cocoa raw material by using an ethanol-water solution as an extracting solution, heating to 70-85 DEG C, carrying out extraction, and removing ethanol in an extracting solution after the extraction is finished; (3) standing and filtering the extracting solution, diluting a filtrate with water, and centrifuging to remove insoluble substances in the filtrate to obtain sample loading liquid; (4) loading the sample loading liquid onto pretreated macroporous resin, eluting the macroporous resin by adopting a gradient method, and collecting an eluent; and (5) carrying out drying treatment on the eluent to obtain enriched cocoa polyphenol. By adopting the cocoa polyphenol extraction and enrichment preparation method, higher recovery rate and content of polyphenol can be obtained at the same time, the operation process is simple, a solvent can be recycled, the environment is little polluted, the raw material cost is low, the separation process is efficient, and the cocoa polyphenol extraction and enrichment preparation method is suitable for industrial product in a large scale.

The invention discloses a preparation method of polyimide with a fluorine-silicon modified main chain. The preparation method sequentially comprises the following steps: (A) reacting perfluoroalkyl glycol with toluene diisocynate at room temperature for 8-16 hours, so as to obtain perfluoroalkyl glycol isocyanate; (B) sequentially dissolving perfluoroalkyl glycol isocyanate and aromatic dianhydride into an organic solvent, heating to 50-80 DEG C in the presence of nitrogen, and stirring for 4-6 hours, so as to obtain polyimide with a fluorine-containing main chain; and (C) sequentially adding silicon-containing diamine and aromatic dianhydride into a polyimide solution with the fluorine-containing main chain, reacting at the room temperature for 4-8 hours in the presence of nitrogen so as to obtain a prepolymer of polyimide with a main chain containing fluorine-silicon polyimide, coating, and baking, so as to obtain a polyimide material with the fluorine-silicon modified main chain. A fluorine-silicon modified polyimide membrane prepared by virtue of the preparation method has good hydrophobicity, translucency, film-forming property and adhesion property; furthermore, an operation method is simple and is applicable to industrial expansion.

The invention belongs to the field of medicine impurities, and particularly relates to a delafloxacin impurity IV and a product refining method. A proper analysis method is selected through optimization to detect related stubborn impurities of a product. The specific structure of related impurities is separated, detected and confirmed. Finally, synthesis and process routes are optimized, impurities are controlled within a safe range, a basis is provided for product process amplification, stability, quality, pharmacology and toxicology and clinical research, and the method has important significance in reducing the safety risk of drug impurities.

The invention belongs to the technical field of nanocomposite, and particularly relates to a bubble dispersion method for preparing graphene / epoxy resin composite materials. The method includes the steps that gas of proper pressure and flow is guided to a premixed material of graphene / epoxy resin, clustering of graphene is scattered through graphene particles, generated in the bubble generation and floating processes, in a volume expansion tensioning resin base body, and stretching of the graphene particles is promoted. Under the situation that dispersing agents are not used, the graphene is evenly dispersed in epoxy resin through relative motion of bubble wall films in the bubble generation, growing and breaking processes by means of a physical method, the dispersion process is simple in technology and convenient to control, the dispersion effect is good, popularization of the technology is achieved easily, and the graphene / epoxy resin composite materials excellent in performance can be obtained. The method is less in energy consumption, low in cost and free of pollution, factory mass production is achieved easily, and chemical properties of the obtained composite materials is obviously promoted.

The invention discloses a preparation method of main chain fluorine silicon modified polyimide. The steps of the method are as follows: A. react perfluoroalkyl diol with toluene diisocyanate at room temperature for 8-16 hours to obtain perfluorinated polyimide Diol isocyanate; B Dissolve perfluorodiol isocyanate and aromatic tetraacid dianhydride in an organic solvent in sequence, heat to 50‑80°C and stir for 4~6 h under a nitrogen atmosphere to obtain a polyimide containing fluorine in the main chain. Amine; C. Add silicon-containing diamine and aromatic tetra-acid dianhydride to the polyimide solution containing fluorine in the main chain in sequence, and react at room temperature for 4~8 h under nitrogen atmosphere to obtain the fluorine-containing silicon polyimide in the main chain. The prepolymer of the coating film is baked to obtain the main chain fluorosilicon modified polyimide material. The fluorine-silicon modified polyimide film prepared by the method of the invention has good water repellency, light transmittance, film-forming property and adhesion performance, and the operation method of the invention is simple, and is suitable for industrial scale-up.

The invention belongs to the technical field of energy utilization, and provides a method for making an oil product taking methane as a raw material. The method comprises the following steps that (1)the raw material methane serves as virgin gas of reforming reaction after being decontaminated, purified and compressed through a purification compression system; (2) the virgin gas enters into a reforming reaction system and is translated into synthesis gas; (3) the synthesis gas enters a Fischer-Tropsch synthesis system for reaction to generate a Fischer-Tropsch synthesis product; (4) the obtained Fischer-Tropsch synthesis product is subjected to gas-liquid separation in a separation system to obtain a hydrocarbon product, a gas product and synthetic water respectively; (5) the hydrocarbon product enters a hydrocarbon product hydroisomerization system for hydrogenation and quality improvement to obtain the oil product not containing sulfur, nitrogen and arene; and the balance of pressureand material flow between a reforming reactor and a Fischer-Tropsch synthesis reactor is controlled through a pressure flow coupling control system. The method fully develops and utilizes potential value of the methane to achieve that the methane is translated into the oil product.

The invention discloses a preparing method and application of a loading type gold catalyst. The method includes the steps of mixing a titanium-containing carrier with a gold precursor solution, conducting thermal treatment after drying to obtain the loading type gold catalyst. The gold precursor comprises chloroauric acid or derivatives thereof, inorganic gold compounds and organic gold compounds.

The invention relates to an ordered mesoporous organic silicon oxide hollow ball prepared through a one-step method and a preparation method of the ordered mesoporous organic silicon oxide hollow ball. The prepared ordered mesoporous organic silicon oxide hollow ball has good spherical morphology. The ball grain size ranges from 50 nm to 100 nm. The ball grain size distribution is uniform. The ordered mesoporous organic silicon oxide hollow ball is high in monodispersity, strength and dispersibility. A spherical shell comprises ordered radial mesoporous ducts. The preparation method is simple and easy to implement and can be easily conducted in an industrial mode. The ordered mesoporous organic silicon oxide hollow ball can be prepared through one step without sacrificial template or postprocessing. The fastest preparation process lasts for only 0.25 h. By means of the structure, reaction molecules or medicine molecules can conveniently enter and leave the ordered mesoporous organic silicon oxide hollow ball, and the ordered mesoporous organic silicon oxide hollow ball has good application prospects in the fields of medicine slow release, release control, medical imaging, catalysis and the like.

The invention belongs to the technical field of COF monomer synthesis, and discloses a preparation method of a phenyl dithiourea compound. The preparation method comprises the following steps: uniformly mixing a phenylenediamine compound, an organic phosphine compound and iodide in an organic solvent, slowly adding trifluoromethanesulfonyl chloride at 0 DEG C under the protection of nitrogen, and reacting at room temperature for 1-4 hours; cooling to 0 DEG C, slowly adding ammonia water, stirring for 5-30 minutes, heating to 50 DEG C, and continuously reacting for 0.5-2 hours; and carrying out centrifugal separation, washing and purifying with an organic solvent for treatment, and carrying out vacuum drying to obtain the phenyl dithiourea compound. According to the preparation method of the phenyl dithiourea compound, one-pot reaction preparation is adopted, the process is mild and easy to control, the purity and yield of the product are high, the substrate universality is high, aftertreatment is simple and rapid, and the product can be prepared on an amplification scale. Due to the advantages, the preparation cost of the phenyl dithiourea compound is remarkably reduced, and the phenyl dithiourea compound has good industrial application value.

The invention discloses a reaction device for preparing mandelic acid compounds. The reaction device comprises a first microchannel heat exchanger, a second microchannel heat exchanger, a first microchannel reactor, a second microchannel reactor, a product collector, a first liquid metering pump, a second liquid metering pump, a third liquid metering pump and a fourth liquid metering pump, whereinan outlet of the first liquid metering pump is connected with a first inlet of the first microchannel heat exchanger, an outlet of the second liquid metering pump is connected with a second inlet ofthe first microchannel heat exchanger, an outlet of the first microchannel heat exchanger is connected with a first inlet of the first microchannel reactor, a second inlet of the first microchannel reactor is connected with an outlet of the second microchannel heat exchanger, an inlet of the second microchannel heat exchanger is connected with an outlet of the third liquid metering pump, an outletof the first microchannel reactor is connected with a first inlet of the second microchannel reactor, a second inlet of the second microchannel reactor is connected with an outlet of the fourth liquid metering pump, and an outlet of the second microchannel reactor is connected with the product collector. The invention further discloses a method for preparing mandelic acid compounds by using the device. The reaction device and the method have the advantages of high efficiency, energy saving and environment protection.