Ordered mesoporous organosilica hollow sphere prepared by one-step method and preparation method thereof

Abstract

The invention relates to an ordered mesoporous organic silicon oxide hollow ball prepared through a one-step method and a preparation method of the ordered mesoporous organic silicon oxide hollow ball. The prepared ordered mesoporous organic silicon oxide hollow ball has good spherical morphology. The ball grain size ranges from 50 nm to 100 nm. The ball grain size distribution is uniform. The ordered mesoporous organic silicon oxide hollow ball is high in monodispersity, strength and dispersibility. A spherical shell comprises ordered radial mesoporous ducts. The preparation method is simple and easy to implement and can be easily conducted in an industrial mode. The ordered mesoporous organic silicon oxide hollow ball can be prepared through one step without sacrificial template or postprocessing. The fastest preparation process lasts for only 0.25 h. By means of the structure, reaction molecules or medicine molecules can conveniently enter and leave the ordered mesoporous organic silicon oxide hollow ball, and the ordered mesoporous organic silicon oxide hollow ball has good application prospects in the fields of medicine slow release, release control, medical imaging, catalysis and the like.

Description

technical field [0001] The invention relates to the field of organic-inorganic composite materials, in particular to organic silicon oxide hollow spheres with ordered mesoporous channels and a preparation method thereof. Background technique [0002] Mesoporous silica spheres combine the dual advantages of mesoporous and spherical shapes, and their application research in the fields of catalysis, batteries, and biomedicine has attracted widespread attention, especially as an anticancer drug delivery system, which has become a new generation of Cancer drug carrier. However, due to the inherent inorganic characteristics of mesoporous silica spheres, compared with other organic supports, mesoporous silica spheres have lower biocompatibility and biosafety. Therefore, the organofunctionalization of silicon oxide—that is, the introduction of organic functional groups into the surface or pore walls of mesoporous molecular sieves to form organic-inorganic hybrid porous materials ca...

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Problems solved by technology

This method utilizes the hydrolysis of 1,2-bis(trimethoxysilyl)ethane silicon source to introduce C-C bonds into the inorganic silica framework, but because the etching process of this patent requires tetraethyl orthosilicate (RO) 4 Si is the silicon source, and the silicon source of this structure makes inorganic SiO exist in the product 2 structure, due to the existence of Si-O-Si bonds, the loading amount of organic groups in the prepared silica skeleton is limited, and the loading amount of organic groups in the skeleton will directly affect the adsorption, catalysis and drug absorption of organosilica. Slow release and controlled release performance, so increasing the loading of organic groups in the organosilica framework is also a technical problem to be solved urgently

At the same time, because the patent needs to synthesize silica spheres with a solid structure first, and then etch again to obtain mesoporous silica products with an egg yolk-eggshell structure, compared with the direct generation of core-shell or hollow silica spheres in one step. method, complex process, long production cycle, high energy consumption, which seriously hinders its industrialization process

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