137results about How to "Reduce hypoxia" patented technology

The transistor characteristics of a MIS transistor provided with a gate insulating film formed to contain oxide with a relative dielectric constant higher than that of silicon oxide are improved. After a high dielectric layer made of hafnium oxide is formed on a main surface of a semiconductor substrate, the main surface of the semiconductor substrate is heat-treated in a non-oxidation atmosphere. Next, an oxygen supplying layer made of hafnium oxide deposited by ALD and having a thickness smaller than that of the high dielectric layer is formed on the high dielectric layer, and a cap layer made of tantalum nitride is formed. Thereafter, the main surface of the semiconductor substrate is heat-treated.

This invention provides aryl and heteroaryl compounds of Formula (I) as described herein, and methods of their preparation. Also provided are pharmaceutical compositions made with the compounds of Formula (I) and methods for making such compositions. The compounds of Formula (I) may activate an erythropoietin receptor and thus, may be useful to induce red blood cell production. The compounds of Formula (I) and compositions including compounds of Formula (I) may be useful in a variety of applications including the management, treatment and / or control of diseases caused at least in part by deficient (or inefficient) EPO production relative to hemoglobin level.

One embodiment of the present invention is to achieve high mobility in a device using an oxide semiconductor and provide a highly reliable display device. An oxide semiconductor layer including a crystal region in which c-axis is aligned in a direction substantially perpendicular to a surface is formed and an oxide insulating layer is formed over and in contact with the oxide semiconductor layer. Oxygen is supplied to the oxide semiconductor layer by third heat treatment. A nitride insulating layer containing hydrogen is formed over the oxide insulating layer and fourth heat treatment is performed, so that hydrogen is supplied at least to an interface between the oxide semiconductor layer and the oxide insulating layer.

A combination of a confocal scanning laser ophthalmoscope and external laser sources is used for microphotocoagulation purposes. An opto-mechanical linkage device and beamsplitter is used to align the pivot point of the Maxwellian view of the scanning laser ophthalmoscope with the pivot point of non-scanning external laser beams. The same pivot point is necessary to minimize wavefront aberrations and to enable precise focussing of a therapeutic laser beam on the retina. An AOM and / or two-dimensional AOD can be inserted in the pathway of the Gaussian therapeutic beam to control intensity and spatial pattern of small and short-duration pulses. The location of the external laser beam on the retina is determined with the help of two synchronized detectors and image processing. One detector is used to localize moving fiducial landmarks of the retina. A second detector is used to locate on the retina the external laser aiming beam. Two different confocal apertures are used. Polarizing the aiming beam is necessary to further reduce unwanted reflections from the anterior corneal surface.

A scintillator single crystal of a specific cerium-doped silicate compound that contains 0.00005 to 0.1 wt % of one or more types of element selected from the group consisting of elements belonging to group 2 of the periodic table based on the total weight of the single crystal.

The invention discloses a micro bio-chip for real-time detection of substances in body fluids, the micro bio-chip is assembled by a circulating microfluidic chip and a film biosensor, parts of the circulating microfluidic chip in turn are connected with each other to form a complete fluid pathway, and the film biosensor includes a working electrode, a counter electrode and a reference electrode; in a testing room of the circulating microfluidic chip, one or more film biosensors are embedded in the manner of series connection, or parallel connection / series connection and parallel connection, so that the surfaces of the embedded film biosensors are always contacted with the body fluid flowing by for real-time detection of the substances in the body fluids.

The scintillator single crystal of the invention comprises a cerium-activated orthosilicate compound represented by the following general formula (1). The scintillator single crystal of the invention exhibits improved scintillation properties by reduced segregation between elements in the crystal ingot.Lm2−(x+y+z)LnxLuyCezSiO5  (1)(Wherein Lm represents at least one element selected from among Sc and Y and lanthanoid elements with lower atomic numbers than Lu, Ln represents at least one element selected from among Sc, Y, B, Al, Ga and In and lanthanoid elements with ion radii intermediate between Lm and Lu, x represents a value of greater than zero and no greater than 0.5, y represents a value of greater than 1 and less than 2, and z represents a value of greater than zero and no greater than 0.1.)

A scintillator single crystal of a specific cerium-doped silicate compound that contains 0.00005 to 0.1 wt % of one or more types of element selected from the group consisting of elements belonging to group 2 of the periodic table based on the total weight of the single crystal.

A single crystal for a scintillator that is a specific single crystal of a cerium-activated orthosilicate compound that comprises 0.00005 to 0.1 wt. %, based on the entire weight of the single crystal, of at least one element selected from a group consisting of elements belonging to Group 13 of the periodic table.

The amount of water and hydrogen contained in an oxide semiconductor film is reduced, and oxygen is supplied sufficiently from a base film to the oxide semiconductor film in order to reduce oxygen deficiencies. A stacked base film is formed, a first heat treatment is performed, an oxide semiconductor film is formed over and in contact with the stacked base film, and a second heat treatment is performed. In the stacked base film, a first base film and a second base film are stacked in this order. The first base film is an insulating oxide film from which oxygen is released by heating. The second base film is an insulating metal oxide film. An oxygen diffusion coefficient of the second base film is smaller than that of the first base film.

The invention discloses a water quality improver for aquaculture. The water quality improver is prepared from the following components in percentage by mass: 30 percent to 40 percent of a microorganism strain, 20 percent to 30 percent of a plant mixture, 5 percent to 10 percent of a biological growth accelerant, 2 percent to 5 percent of an amino acid, 0.1 percent to 0.5 percent of chitosan and the balance of water; the microorganism strain disclosed by the invention is prepared from the following components: rhodopseudomonas palustris, bacillus subtilis, denitrifying bacteria, bacillus licheniformis, candida utilis, enterococcus faecalis, enterococcus faecium, bacillus laterosporus, denitrifying bacteria, photosynthetic bacteria and lactic acid bacteria; the water quality improver disclosed by the invention has a long acting time and is convenient to use; when the water quality improver is used for adjusting the water quality, the water quality improver also can be used for accelerating photosynthesis of alga to generate oxygen for alleviating a hypoxia phenomenon of fishes. The water quality improver has the advantages of high bacterium content, strong activity and small utilization dosage.

The invention provides a preparation method of Cu2MoS4 nano-enzyme, and the method comprises the following steps: mixing cuprous oxide, an organic carbon source, an inorganic molybdenum source and anorganic sulfur source in an organic solvent, and carrying out high-temperature calcination to obtain the hollow Cu2MoS4 nano-enzyme. Compared with the prior art, the Cu2MoS4 nano-enzyme prepared by the invention has catalase activity and greatly relieves tumor hypoxia, and meanwhile, the nano-enzyme also has peroxidase activity and can consume glutathione overexpressed in a tumor, so that an antioxidant defense system of the tumor is destroyed, and the chemokinetic treatment efficiency is enhanced; two pairs of redox couples exist, the redox couples can react with hydrogen peroxide to generatehigh-toxicity hydroxyl radicals, a remarkable chemical and dynamic curative effect is achieved, meanwhile, the nano-enzyme has strong absorption in the whole near-infrared area, and photo-thermal therapy can be achieved; and under laser excitation, superoxide anion free radicals can be generated and used for photodynamic therapy.

A single crystal for a scintillator that is a specific single crystal of a cerium-activated orthosilicate compound that comprises 0.00005 to 0.1 wt. %, based on the entire weight of the single crystal, of at least one element selected from a group consisting of elements belonging to Group 13 of the periodic table.

The invention discloses a comprehensive prevention and control technology of a corn waterlogging disaster, wherein soil ridging or compartment ridging regulation and control are utilized. The comprehensive prevention and control technology comprises the following steps: sowing in a wide and narrow row spacing manner during corn sowing, carrying out intertillage ridging or ditching during the five-leaf stage of corn, ditching in wide rows of corn and ridging in narrow rods of corn, or ditching in wide rows on the two sides of a compartment consisting of four or six rows, additionally applying nitrogen-oxygen mixed fertilizer instantly after the corn waterlogging disaster occurs, and spraying spermidine chemical modifier on leaf surfaces at the same time, wherein spraying is carried out once in the morning and night for 2-3 days continuously; other steps are the same as that during normal management, corn is harvested until bracts of corn clusters are dried up, corn grain milk lines disappear, and a black layer appears, namely when grains are completely and physiologically matured. According to the comprehensive prevention and control technology, through comprehensive precontrol advantages of prevention in advance and remedy after the disaster, the root oxygen deficiency after waterlogging can be effectively reduced and retarded, accumulated toxic effect of hazardous substances of soil is reduced, and the root growth and absorption capacity is strengthened, so that the symplastic growth of overground part and root system is promoted, and the yield is improved.

The invention discloses a porphyrin-based metal organic framework nano-carrier with a sonodynamic combined starvation therapy anti-tumor function and a preparation method of the porphyrin-based metal organic framework nano-carrier. The preparation method comprises the following steps: dissolving a porphyrin-based ligand and metal salt in a solvent, and heating to obtain porphyrin-based metal organic framework particles; and dispersing the porphyrin-based metal organic framework particles into water, adding high-valence metal acid or high-valence metal salt and a reducing agent, and mixing with a cell membrane and glucose oxidase to obtain the cell membrane modified porphyrin-based metal organic framework nano-carrier loaded with the metal nanoparticles and the glucose oxidase. The nano-carrier can enhance the accumulation at the tumor site and improve the tumor targeted hunger treatment effect; and meanwhile, tumor hypoxia is relieved, sonodynamic reaction substrates are increased, and the sonodynamic effect is improved. The preparation process is simple and controllable, the material source is wide, and scale amplification can be realized; and in vivo, good stability and tumor sonodynamic and hunger treatment combined treatment effect are achieved, and good application prospects are achieved in the field of tumor treatment.

In formation of a gate insulating film made of a high dielectric constant metal silicate, atomic layer deposition (ALD) is performed by setting exposure time to a precursor containing a metal or the like to saturation time of a deposition rate by a surface adsorption reaction and by setting exposure time to an oxidizing agent to time required for a composition of a metal oxide film to reach 97% or more of a stoichiometric value.

The invention discloses an oxygen-producing hydrogel and a preparation method and application thereof. The oxygen-producing hydrogel comprises photosynthetic microalgae and biodegradable hydrogel, andby wrapping the photosynthetic microalgae with the hydrogel good in biocompatibility, the oxygen-producing hydrogel is formed; the photosynthetic microalgae in the hydrogel performs oxygen producingby means of photolysis of water, the local oxygen yield is increased so as to improve the anoxic microenvironment of the location, and then the curative effect of treatment of hypoxic diseases is enhanced. Due to protection of the gel, the photosynthetic microalgae can keep the oxygen activity in the body for a long time, and the requirements of long-time repeated oxygen supply for the hypoxic diseases are met.

The invention provides a pawpaw seed germination accelerating method. The method specifically includes steps of disinfection treatment, ventilation seed soaking, constant-temperature germination accelerating and seeding. By disinfecting and soaking seeds, germination rate of the seeds is increased and can be increased by 6-8%, and germination period is shortened by 1-2 days; pawpaws planted by the method are fresh and tender in quality, good in taste and high in nutritional value, the method is simple to operate, planting cost is lowered, economic benefit is increased, and the method is suitable for large-scale production and popularization.

The invention discloses a blood maintenance liquid, a preparation method and application thereof. The blood maintenance liquid is an aqueous solution comprising 88.85-90.00mmol / L of sodium citrate, 15.10-16.20mmol / L of citric acid, 136.50-146.60mmol / L of waterless glucose, 14.00-14.31mmol / L of sodium dihydrogen phosphate (NaH2PO4.H2O), 5.30-5.58mmol / L of adenine and 2.20-3.00mmol / L of L-arginine, wherein the pH value of the aqueous solution is 5.5. According to the invention, a case that the blood maintenance liquid is only used for maintaining the oxygen carrying function of erythrocytes is fundamentally changed, and new functions of hemangiectasis and local blood amount increase are endowed to stored blood, so the vasodilation activity is improved, the tissue perfusion flow is increased and the tissue blood and oxygen supply is increased during blood transfusion, thereby the blood maintenance liquid of the invention, which allows the clinical blood transfusion security and validity to be improved, is a revolution of the blood preservation and the blood quality control.

The invention provides a platinum@polydopamine-dihydroporphin nano composite material. The surface of platinum is coated with polydopamine to form a core-shell structure, and dihydroporphin is loadedas a photosensitizer. The composite material has low toxicity, significant biocompatibility and good biodegradability, and can be used as a photothermal therapy reagent and a photodynamic therapy reagent. Besides, Pt can assist in the photodynamic therapy process, relieve the problem of oxygen deficit of a tumor part and finally achieve the PTT-PDT synergistic treatment effect. The invention alsodiscloses a preparation method and application of the composite material.

The invention discloses a biological composite oxygen producer, which is prepared from the following raw materials by weight: 1.5-3 parts of a chemical oxygen producer, 1 part of a biological agent, 0.1-0.2 parts of sodium citrate and 0.6-1 part of an adhesive. The chemical oxygen producer is prepared by mixing anhydrous sodium carbonate and hydrogen peroxide in the mass ratio of 5: 3, and adding sodium chloride in the mixing process. The biological agent is a mixed powder of one or two of Bacillus subtilis N9-1-35 and Bacillus subtilis B7348 at an arbitrary ratio. The invention also discloses a preparation method of the biological composite oxygen producer. The biological composite oxygen producer provided by the invention effectively combines the biological agent with the chemical oxygen producer, so that the biological agent and oxygen producer can reach the bottom of the pond at the same time; the oxygen producer releases oxygen to increase the dissolved oxygen at the bottom, and the biological agent can decompose harmful materials at the bottom, degrade ammonia content and play a role in regulating water quality and balancing the microecology of the water, so as to fundamentally ease the problem of pond hypoxia.

The invention discloses a preparation method of a bimetallic nano-enzyme composite material with an anti-tumor effect. The invention belongs to the field of biomedical materials, and particularly relates to the preparation method of the bimetallic nano-enzyme composite material with the anti-tumor effect. The invention aims to solve the problems that an existing tumor treatment material has a poor treatment effect and single intelligent nano-enzyme research is rare. The preparation method comprises the following steps of: 1, synthesizing a nanoparticle material; and 2, modifying the nano material. The preparation method disclosed by the invention is used for preparing the bimetallic nano-enzyme composite material with the anti-tumor effect.

In formation of a gate insulating film made of a high dielectric constant metal silicate, atomic layer deposition (ALD) is performed by setting exposure time to a precursor containing a metal or the like to saturation time of a deposition rate by a surface adsorption reaction and by setting exposure time to an oxidizing agent to time required for a composition of a metal oxide film to reach 97% or more of a stoichiometric value.

The invention discloses a car child anti-lock alarm, which belongs to car supplies. A kind of car anti-lock alarm for children mainly includes: CPU control center, human body sensor, alarm, temperature sensor, described CPU control center is used for processing the data of each sensor; Described human body sensor is used for getting off and pressing When the car door is locked, detect whether there is anyone in the car. If there is someone, the alarm will alarm, the double flashing lights will flash, and the lock is unsuccessful; the temperature sensor is used to detect the temperature inside the car when there are people in the car. When the temperature is higher than the set value At the same time, the four groups of car windows open 5 cm openings at the same time, and at the same time the alarm sounds, the double flashing lights flash, and the remote control key worn by the car owner emits an alarm sound. The invention has the beneficial effects of effectively reducing the accidents of children being locked in the car and resulting in death due to exposure to the sun or lack of oxygen.

The invention provides a nano-particle for mediating cascade reaction, and a preparation method thereof. The nano-particle provided by the invention comprises a core particle and a wrapping layer wrapping the core particle; the core comprises a metal-organic framework MIL-100 and dihydroporphin e6 loaded on the metal-organic framework MIL-100; and the wrapping layer is a hyaluronic acid layer. Bymeans of the nano-particle in the invention, cascade reaction at a tumour site can be realized; synergistic combination therapy of chemical kinetics and optical dynamics is realized; and thus, the better therapeutic effect of tumour is achieved.

The invention discloses a river penetrating process. The river penetrating process comprises the following steps that S1, pre-construction is carried out; S2, a working well is excavated; S3, equipment is installed; S4, hoisting is carried out; and S5, a pipe is jacked. The S4 comprises the following steps that S4-1, a pipe jacking machine is hoisted; S4-2, the pipe is hoisted; and S4-3, annular top iron is hoisted. The S5 comprises the following steps that S5-1, the pipe is pushed; and S5-2, detection and deviation rectification are realized. According to the river penetrating process, the problem of difficulty in deviation rectification is solved, and the river penetrating process has the advantage of being capable of correcting deviation during the construction and after completion of the construction.

Formulations and methods are provided for improving the function, i.e. clinical outcome, of solid organ transplants. Lung transplantation is of particular interest. In the methods of the invention, a nanoparticle formulation comprising an effective dose of an iron chelator active agent in nanoparticle form, including without limitation, deferoxamine (DFO), deferasirox (DFX), and deferiprone (DFP), etc. suspended in a carrier compatible with the tissue of interest, is topically applied to the surface of tissues at the site of anastomosis. The nanoparticles are comprised of the active agent and a pharmaceutically acceptable stabilizer.

The invention provides a magnetic octahedral platinum-doped gold nano-shell. According to the octahedral platinum-doped gold nano-shell, a metal organic framework material is taken as a template, andthe surface of the octahedral platinum-doped gold nano-shell is modified by an amido bond magnetic protein gadolinium complex. The invention further provides a preparation method and application of the magnetic octahedral platinum-doped gold nano-shell. The synthesized gold nano-shell takes the MOFs material as the template, the method is rapid, simple, convenient, stable and reliable, productionis easy to expand, the better photothermal conversion efficiency is achieved, redundant hydrogen peroxide in a tumor microenvironment can be catalyzed by platinum nano-particles to generate oxygen soas to relieve the hypoxic condition of tumors, and therefore, the spatial and time resolution of CT imaging is promoted, and more accurate imaging is conducted on hypoxic tumors; and the property is stable, good dispersity and biocompatibility are achieved, and the used raw materials are easy to obtain and low in price.

The invention discloses a pair of contact lenses with a water and oxygen channel. An inwards recessed tear channel with the width of 0.5-1.0mm is formed in the inner surface of the periphery of an optical region in the center of each lens; and small vent holes with the diameters of 0.5-1.5mm are formed in the tear channel. The pair of the contact lenses has the advantages that the small vent holes and the tear channel are combined to form a micro tear circulation system, so that the oxygen permeation and flexibility of the lens are ensured and the cornea anoxia is relieved; and the oxygen permeability of the lens can reach 15-20 times that of a pair of general hydrogel contact lenses and is 3-5 times that of a silicone hydrogel lens, so that the lens can be worn for continuous 3-5 days.