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Magnetic octahedral platinum-doped gold nano-shell as well as preparation method and application thereof

A gold nanoshell and octahedral technology, which is applied in the field of magnetic octahedral platinum-doped gold nanoshells, and can solve problems such as octahedral platinum-doped gold nanoshells that have not yet been magnetic

Pending Publication Date: 2020-07-03
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

So far, no magnetic octahedral platinum-doped gold nanoshells have been reported.

Method used

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  • Magnetic octahedral platinum-doped gold nano-shell as well as preparation method and application thereof
  • Magnetic octahedral platinum-doped gold nano-shell as well as preparation method and application thereof
  • Magnetic octahedral platinum-doped gold nano-shell as well as preparation method and application thereof

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Embodiment 1

[0094] This embodiment is used to illustrate the preparation method of the magnetic octahedral platinum-doped gold nanoshell of the present invention, comprising the following steps:

[0095] (1) Synthesis of metal-organic frameworks (Pt@MOFs, PtM) doped with platinum nanoparticles:

[0096] A. Preparation of platinum nanoparticles:

[0097] 0.196mmol of platinum chloric acid (H 2 PtCl 6 ·6H 2 O) and the PVP of 444mg are respectively dissolved in the three-neck round bottom flask containing ethylene glycol. The whole system was placed in an oil bath and reacted at 180° C. for 10 minutes. After the reaction, the obtained product was removed by centrifugation for several times, and finally dispersed in dimethylformamide solution (N,N-Dimethylformamide, DMF) to obtain platinum nanoparticles with a concentration of 1 mg / mL for preparation. Use later.

[0098] B. Preparation of metal-organic frameworks (Pt@MOFs, PtM) doped with platinum nanoparticles:

[0099] 8.75mM zirconi...

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Abstract

The invention provides a magnetic octahedral platinum-doped gold nano-shell. According to the octahedral platinum-doped gold nano-shell, a metal organic framework material is taken as a template, andthe surface of the octahedral platinum-doped gold nano-shell is modified by an amido bond magnetic protein gadolinium complex. The invention further provides a preparation method and application of the magnetic octahedral platinum-doped gold nano-shell. The synthesized gold nano-shell takes the MOFs material as the template, the method is rapid, simple, convenient, stable and reliable, productionis easy to expand, the better photothermal conversion efficiency is achieved, redundant hydrogen peroxide in a tumor microenvironment can be catalyzed by platinum nano-particles to generate oxygen soas to relieve the hypoxic condition of tumors, and therefore, the spatial and time resolution of CT imaging is promoted, and more accurate imaging is conducted on hypoxic tumors; and the property is stable, good dispersity and biocompatibility are achieved, and the used raw materials are easy to obtain and low in price.

Description

technical field [0001] The invention belongs to the field of nanomedicine, and in particular relates to a magnetic octahedral platinum-doped gold nanoshell, its preparation method and application. Background technique [0002] In recent years, near-infrared light-induced photothermal therapy has attracted extensive attention from researchers because of its characteristics of non-invasive and minimally invasive treatment of tumors. Photothermal therapy mainly uses a photothermal conversion agent to convert the energy of near-infrared light into heat energy, so that the temperature of tumor or cancerous tissue rises to the effective therapeutic temperature range, and utilizes the difference in temperature tolerance between tumor tissue and normal tissue to achieve killing purpose of tumor cells. Gold nanoshells have been widely used in photothermal therapy and drug delivery systems due to their tunable near-infrared absorption, easy modification, and loose porous structure. ...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/14A61K49/04A61K41/00A61P35/00
CPCA61K49/1869A61K49/143A61K49/04A61K49/0002A61K41/0052A61P35/00
Inventor 杨延莲游青朱凌王琛
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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