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Preparation method of bimetallic nano-enzyme composite material with anti-tumor effect

A technology of bimetallic nano and composite materials, which is applied in the field of preparation of bimetallic nanozyme composite materials, can solve the problems of single intelligent nanozyme scarcity and poor therapeutic effect, and achieve improved hydrophilicity, excellent morphology, and stable tumor diagnosis and the effect of treatment

Active Publication Date: 2021-09-17
HARBIN ENG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention provides a method for preparing a bimetallic nanoenzyme composite material with anti-tumor effect in order to solve the problem that the existing tumor treatment materials have poor therapeutic effect and the research on single intelligent nanozyme is rare.

Method used

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  • Preparation method of bimetallic nano-enzyme composite material with anti-tumor effect
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  • Preparation method of bimetallic nano-enzyme composite material with anti-tumor effect

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specific Embodiment approach 1

[0046] Specific embodiment one: a kind of preparation method of the bimetallic nano-enzyme composite material with anti-tumor effect of the present embodiment is specifically carried out according to the following steps:

[0047] 1. Synthetic nanoparticle materials:

[0048] ①Add copper source and iron source to the solvent to obtain mixed solution A;

[0049] ②. Pour the mixed solution A into a three-necked flask, vacuumize, stir magnetically at a stirring rate of 200r / min-400r / min, and raise the reaction temperature from room temperature at a heating rate of 3°C / min-10°C / min Raise to 90°C-120°C, and react for 20min-60min under the condition of 90°C-120°C to obtain mixed solution B;

[0050] ③. Inject nitrogen gas into the mixed solution B, and raise the reaction temperature from 90°C to 120°C to 250°C to 290°C at a heating rate of 3°C / min to 10°C / min. Under the condition of reaction for 20min ~ 60min, after the reaction is completed, cool down to room temperature, then sta...

specific Embodiment approach 2

[0064] Embodiment 2: This embodiment is different from Embodiment 1 in that: the copper source described in step ① is copper acetylacetonate, the iron source is iron acetylacetonate; the solvent is tetraethylene glycol. Other steps and parameters are the same as those in the first embodiment.

specific Embodiment approach 3

[0065]Specific embodiment three: the difference between this embodiment and specific embodiment one or two is that the mass ratio of copper source and iron source described in step 1. is 1: (0.5~2), and the mass ratio of copper source and iron source The mass ratio of the total mass to the solvent is 1:(50-80). Other steps and parameters are the same as those in Embodiment 1 or 2.

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Abstract

The invention discloses a preparation method of a bimetallic nano-enzyme composite material with an anti-tumor effect. The invention belongs to the field of biomedical materials, and particularly relates to the preparation method of the bimetallic nano-enzyme composite material with the anti-tumor effect. The invention aims to solve the problems that an existing tumor treatment material has a poor treatment effect and single intelligent nano-enzyme research is rare. The preparation method comprises the following steps of: 1, synthesizing a nanoparticle material; and 2, modifying the nano material. The preparation method disclosed by the invention is used for preparing the bimetallic nano-enzyme composite material with the anti-tumor effect.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a preparation method of a bimetallic nano-enzyme composite material with anti-tumor effect. Background technique [0002] Malignant tumors are considered to be one of the main causes of human tumor death, and highly efficient and safe multi-task therapeutic nanoplatforms are needed. As an emerging strategy for intelligent tumor treatment, catalytically active nanomaterials called "nanozymes" have attracted great attention. big interest. Nanozyme, as a new type of artificial material, benefits from the continuous development and mutual integration of nanotechnology and biotechnology. high stability. At present, nanozymes with peroxidase (Peroxidase, POD), catalase (Catalase, CAT), superoxide dismutase, oxidase and glutathione peroxidase (Glutathione peroxidase, GPx) activities has been reported. Antagonizing or regulating the tumor microenvironment (Tumor microe...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/04A61K49/18A61K41/00A61K33/34A61K47/58A61K47/60A61K47/69A61P35/00B82Y5/00B82Y40/00C01G49/00
CPCA61K41/0052A61K49/186A61K49/1854A61K49/049A61K47/60A61K47/58A61K47/6935A61K47/6933A61K33/34A61P35/00C01G49/0018B82Y40/00B82Y5/00C01P2002/72C01P2004/04C01P2004/51C01P2004/64C01P2002/85A61K2300/00
Inventor 丁鹤杨飘萍贺飞盖世丽杨丹李思怡
Owner HARBIN ENG UNIV
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