The invention discloses a circulation aquaculture process and system. The aquaculture system includes a breeding unit, a filtering unit, a biological reaction unit, a degassing unit, a plant cleaning unit, an oxygenation disinfection unit, a water feeding and drainage unit, and an intelligent control unit; the breeding unit, the filtering unit, the biological reaction unit, the degassing unit, the plant cleaning unit, and the oxygenation disinfection unit are successively connected through a pipe of the water feeding and drainage unit to form a circulation system. The beneficial effects of the invention are that the micro-nano bubble aeration technology has a good oxygenation effect, and can improve the biological activity of cells and the breeding density; micro-nano ozone bubbles and ultraviolet light can improve the disinfection effect, can reduce chemicals, and can ensure food safety; water feeding and drainage, temperature control, pH control, oxygenation, disinfection and feeding can be achieved automatically, and labors can be saved; processed waste water can be used for watering or enter to the system to be used; sludge becomes an organic fertilizer, a closed ecological chain is formed, and zero emission, a water saving, energy saving, and environment protection effect can be achieved.