The invention discloses a stirred
bioreactor convertible in flow direction and for an
artificial liver. The stirred
bioreactor convertible in flow direction and for the
artificial liver comprises a
bioreactor with a stirring
paddle, wherein microcapsules of hepatic cells are loaded and embedded in the bioreactor. Due to the fact that the
specific gravity of the microcapsules is approximate to the
specific gravity of water, the microcapsules can easily enter a suspension state under stirring function, and accordingly the microcapsules can be fully mixed with liquid under a
continuous perfusion operating condition high in flow speed, and simultaneously
solid-liquid
mass transfer is promoted, and furthermore sufficient
nutrient substance supply and efficient active substance release of the hepatic cells in the microcapsules are guaranteed. Additionally, for avoiding the circumstance that the microcapsules or fragments block a filter screen, which possibly occurs in long time
single pass perfusion, an
electromagnetic valve and a
peristaltic pump are respectively arranged at an inlet end and an outlet end of the bioreactor, conversion of flow directions can be achieved, backlash effects are achieved, a pipeline is prevented from jamming, and
solid and liquid mixing in the bioreactor is kept even. The stirred bioreactor
convertible in flow direction and for the
artificial liver can achieve good
solid and liquid mixing and substance exchange under the conditions that a solid-to-
liquid ratio is large, the
perfusion speed is high and the
cell density is large, effectively avoids a
perfusion dead space and invalid perfusion, and develops cure effects of the artificial liver to the utmost.