Bionic tendon tissue incubator

Abstract

The invention discloses a bionic tendon tissue incubator. The bionic tendon tissue incubator comprises a culture room and a sliding column, wherein the culture room is provided with a liquid inlet hole and a liquid outlet hole; one end of the sliding column extends into the sliding column; the liquid inlet hole and the liquid outlet hole are respectively formed in the side wall of the culture room; the two ends of the culture room are respectively sealed by a first end cover and a second end cover; a guide hole is formed in the first end cover; the sliding column is in clearance fit in the guide hole; a first fixing plate used for fixing a tendon tissue is arranged at one end, extending into the culture room, of the sliding column; a second fixing plate which is used for fixing the tendon tissue and is opposite to the first fixing plate is arranged on the second end cover; a plurality of hanging hooks used for fixing the tendon tissue are respectively arranged on the opposite surfaces of the first fixing plate and the second fixing plate. By the bionic tendon tissue incubator, blood circulation of a body is simulated, and meanwhile, in-vivo physiological stress is simulated; meanwhile, the bionic tendon tissue incubator acts on the tendon tissue, promotes the maturation of the structure and the function of the tendon tissue, and really simulates the bionic culture of the physiological environment movement of the body.

Description

technical field [0001] The invention relates to the field of biological tissue engineering preparation devices, in particular to a tendon tissue bionic culture device. Background technique [0002] Tendon injury is a common injury in clinical practice. The self-repair ability of tendon tissue is limited. The traditional methods of tendon repair mainly include autologous tendon transplantation, allogeneic tendon transplantation and heterogeneous tendon transplantation. However, due to the lack of donor tendon or immune rejection, the repair of damaged tendon is one of the clinical difficulties. In recent years, with the development of biomaterials and clinical medicine, tissue-engineered tendon provides a new feasible way for the repair of defective tendon. [0003] At present, the in vitro culture of tendon tissue usually adopts the method of placing the cultured tendon in a culture chamber and applying stretch stress stimulation to realize the biomimetic culture of tendon ...

AI Technical Summary

Problems solved by technology

Although this static stress can enhance the mechanical strength of tendon tissue by stimulating the proliferation and secretion of seed cells, this static stress is obviously different from the stress load on tendon under physiological conditions, and it is very important for enhancing the mechanical strength of tendon tissue. limited

Moreover, the culture solution in the existing culture room for cultivating tendon tissue is static, which cannot improve the mass transfer and support of the tendon tissue through the slow flow and continuous renewal of the culture solution, and cannot fully understand the whole process of tissue structure maturation. Produce a promotion effect; and the culture medium needs to be opened and replaced after a certain period of time, which is easy to cause pollution

Therefore, the existing tendon tissue culture devices still have certain deficiencies, and cannot form a bionic culture that truly simulates the human physiological exercise environment. How to solve the shortcomings of the existing devices and realize the bionic tendon tissue culture that conforms to the human physiological environment has always been an important issue for tissue engineering tissues. The goal pursued by technicians in the field of in vitro culture

Images