147results about How to "Produce toxic side effects" patented technology

The invention relates to a new method for preparing an antibiotic bioactive coating material on the surface of titanium alloy and magnesium alloy by ultrasonic-microarc oxidation composite technology, which can be used for obtaining a biological coating material which is compact at the bottom layer and is porous at the surface layer, wherein Ca, P and Ag contained in the coating can improve the bioactivity and the corrosion resistance of magnesium and titanium, and reduce bacterial infection caused by implantation. The invention can meet the requirements of bearing bones of human beings for mechanical properties of implanted materials, and can overcome disadvantages of the traditional surface modification method for biologic materials. In the coating composite material, the coating thickness of titanium alloy is 50-85 mu m, the surface hole diameter is 4-25 mu m, the porosity is 20-30%, and the bonding strength between the coating and the matrix is 23-40 MPa. The coating thickness of magnesium alloy is 16-22 mu m, the surface hole diameter is 5-28 mu m, the porosity is 21-30%, and the bonding strength between the coating and the matrix is 8-20 MPa.

The invention relates to a completely degradable polymer medicine elution stent and a preparation method thereof. The stent is prepared from the following steps: 1) processing and forming a degradable polymer material into a pipe; 2) subjecting the pipe to laser engraving to form a stent substrate; 3) polishing the surface of the degradable polymer stent substrate and removing processing defects on the surface of the stent; and 4) forming a medicine carrier coating on the surface of the degradable polymer stent substrate. In the invention, a novel light source is used for implementing the laser engraving of the pipe and the processing defects on the surface of the stent is polished by using a polishing technique, so the obtained stent has high structural stability and can has high mechanical supporting performance; and compared with the conventional method, the method has obvious advantages, the prepared stent has high biocompatibility, can effectively treat diseases such as intravascular stenosis and thrombus, has high positive remodeling effect on blood vessels and can effectively prevent a restenosis in later implanting period of the stent.

The present invention discloses a compound scutellaria injection for curing infectious diseases in livestock and poultry, characterized in that the injection is prepared from the following raw materials with the weight portions: 10 to 50 portions of scutellaria, 30 to 100 portions of radix bupleuri, 30 to 100 portions of honeysuckle, 30 to 100 portions of cordate houttuynia, 30 to 100 portions of dyers woad root, 30 to 100 portions of Daqing leaf, 10 to 15 portions of tween 80 and 10 to 15 of benzyl alcohol; and the water for injection is appropriately confected to 1,000. The present invention is a pure Chinese medicine injection with quick effect, high curing effect, rare recurrence after cure and no drug resistance of bacteria. The present invention with no side effect on livestock and poultry and safe use has the curing rate of virus and bacterial infectious diseases in poultry up to 95 percent and of toxic epidemic diseases and bacterial diseases in other livestock up to 82 percent.

The invention provides a preparation method of a magnesium surface ultrasonic micro-arc oxidation-HF-silane coupling agent multistage compound bioactive coating, relates to a method for preparing a pure magnesium bioactive coating composite material, and aims to solve the problems of low bonding strength and poor biocompatibility of a coating and a base in a bioactive coating composite material. The method comprises the following steps: 1, roughly grinding and cleaning a pure magnesium sample; 2, preparing an Na2SiO3 electrolyte A and a KOH electrolyte B, mixing the two electrolytes, and adding KF to obtain a micro-arc oxidation electrolyte; 3, regulating parameters of micro-arc oxidation equipment, and performing micro-arc oxidation on the sample to prepare a coating composite material; and 4, sequentially soaking the rinsed coating composite material in an HF solution and a silane coupling agent, thus completing preparation of the bioactive coating. According to the invention, the bonding strength of the coating and the base in the obtained bioactive coating is high; and meanwhile, magnesium fluoride and magnesium silicate in the oxidation layer ensure favorable biocompatibility.

The invention discloses a compound preservative for chilled meat, which consists of the following raw materials in weight content: 0.005 to 0.05 percent of nisin, 0.005 to 0.5 percent of vitamin C, 0.01 to 0.2 percent of versenate, 0.01 to 0.5 percent of citric acid, and the balance being water. The compound preservative can effectively delay the spoilage of chilled pork and furthest maintain the freshness of the pork.

The invention belongs to the field of targeted drug slow-release carrier materials, and particularly relates to a biological responsiveness targeted double-drug slow-release carrier material and a preparation method thereof. The biological responsiveness targeted double-drug slow-release carrier material is prepared from double-shell biological responsiveness nanometer microspheres; an inner shell of the material is prepared from nanometer microspheres formed by aggregating amphiphilic polymers; an outer shell of the material is mesoporous silica; the diameter of the inner shell is 160nm to 800nm; the mesoporous diameter of the mesoporous silica of the outer shell is 2 to 4nm. The amphiphilic polymer nanometer microspheres of the inner shell can provide load loci for a hydrophobic drug, and the mesoporous silica of the outer shell can provide load loci for a hydrophilic drug; hence, the biological responsiveness targeted double-drug slow-release carrier material can load two different drugs and realize slow release of the double drugs, so as to achieve the aim of double-drug synergy therapy.

The invention relates to a Chinese medicinal infusion solution for treating bovine mastitis. The Chinese medicinal infusion solution comprises the following components in parts by weight: 1 to 10 parts of dark plum extract, 1 to 10 parts of wild jujube seed extract, 1 to 10 parts of houttuynia herb extract, 5 to 30 parts of absolute alcohol, and 10 to 50 parts of purified water. The infusion solution has high response speed, no toxic or side effect, no medicament residue, convenience in use, saving of culture cost, simplified operation and high bioavailability, and is a Chinese medicinal infusion solution for according with a safe veterinary medicament, ensuring the safety requirement of animal-derived food and treating the bovine mastitis.

The invention belongs to the field of medicines and particularly relates to a traditional Chinese medicine preparation for treating colon cancer and a preparation method of the traditional Chinese medicine preparation. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 30-60 parts of patrinia, 10-30 parts of sculellaria barbata, 20-40 parts of cowherb seeds, 15-25 parts of rhizoma sparganii, 5-15 parts of tribulus terrestris, 10-30 parts of dogwood, 10-30 parts of gallnut, 20-40 parts of angelica sinensis, 5-15 parts of elderberry, 20-40 parts of salviae miltiorrhizae, 10-30 parts of immature bitter oranges, 5-15 parts of oldenlandia diffusa, 5-15 parts of pseudo-ginseng flowers, 10-30 parts of semen armeniacae amarae and 5-15 parts of elecampane. The invention provides a safe and effective traditional Chinese medicine composition for treating colon cancer with a simple and convenient preparation process. The traditional Chinese medicine composition is remarkable in effect of treating colon cancer which is not easy to relapse after cure, and the total effective rate reaches over 92%.

The invention relates to the technical field of medicinal chemistry, particularly discloses a small-molecule inhibitor of Mdm<X> / Mdm<2>, and also relates to a preparation method of the small-molecule inhibitor of Mdm<X> / Mdm<2>. The small-molecule inhibitor compound can inhibit the interaction of Mdm<X> protein and p53 protein and also can inhibit the interaction of Mdm<2> protein and p53 protein, has antiproliferative activity on cancer cells, and cannot generate toxic and side effects on patients. The small-molecule inhibitor compound can be combined with other therapies for use.

The invention discloses a traditional Chinese medicine foot reflexology bag with an auxiliary therapy effect and a making method of the traditional Chinese medicine foot reflexology bag. The traditional Chinese medicine foot reflexology bag comprises raw materials as follows: caulis polygoni multiflori, herba lycopodii, radix ligustici sinensis, rhizoma atractylodis, ligusticum wallichii, rhizomaet radix notopterygii, radix saposhnikoviae, folium artemisiae argyi, cortex phellodendri chinensis, radix scutellariae, radix sophorae flavescentis, herba pogostemonis, herba menthae, fructus cnidii,fructus kochiae, pericarpium zanthoxyli, flos carthami, radix paeoniae rubra, radix astragali, cortex dictamni, rhizoma zingiberis, cassia twig, radix angelicae pubescentis, radix polygalae, semen persicae, herba asari, herba schizonepetae, radix achyranthis bidentatae, radix salviae miltiorrhizae, cortex moutan radices, cortex albiziae, radix angelicae sinensis and folium isatidis. The traditional Chinese medicine foot reflexology bag is reasonable in composition, safe and convenient to use and stable and reliable in quality, the medicine acts on the whole human body through the feet closelyrelated to the whole human body to realize the disease treatment and healthcare effects, and the traditional Chinese medicine foot reflexology bag does not require oral administration, cannot producetoxic or side effect on the human body after long-term use and has functions of treating and preventing cold, headache, insomnia, rheumatism, skin diseases, tinea pedis, foot itching, dermatophytosis, foot odor and the like.