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Super-paramagnetic targeting dual-drug sustained-release carrier material and preparation method thereof

A superparamagnetic, slow-release carrier technology, applied in the field of medical materials, can solve the problems of drug toxicity and side effects, anticancer drugs can not recognize normal cells and tumor cells, etc., and achieve the effect of easy degradation

Inactive Publication Date: 2016-08-31
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In addition, since most anticancer drugs cannot recognize normal cells and tumor cells, the drugs have serious side effects

Method used

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  • Super-paramagnetic targeting dual-drug sustained-release carrier material and preparation method thereof
  • Super-paramagnetic targeting dual-drug sustained-release carrier material and preparation method thereof
  • Super-paramagnetic targeting dual-drug sustained-release carrier material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] A superparamagnetic targeted dual-drug slow-release carrier material is prepared by the following method:

[0033] (1) 0.54g iron salt FeCl 3 ·6H 2 O, the urea of ​​1.68g sodium citrate, 0.36g joins in the water of 40mL, stirs and dissolves at room temperature;

[0034] (2) Add 0.3g polyacrylamide to the solution obtained in step (1). After the particles in the solution are dissolved, transfer it to the reaction kettle and react at 200°C for 12 hours. The product is washed, filtered and dried to obtain super smooth Magnetic Fe 3 o 4 hollow microspheres;

[0035] (3) Take 30mg Fe 3 o 4 Disperse the hollow microspheres in 30mL of water, add 150mL of ethanol, 3.5mL of ammonia water, and 0.4g of surfactant CTAB, stir at room temperature for 2h, then add 500μL of TEOS (tetraethylorthosilicate), and stir at room temperature 5h, the obtained product was washed, filtered, and dried to obtain superparamagnetic Fe embedded in silica 3 o 4 hollow microspheres;

[0036] (...

Embodiment 2

[0039] A superparamagnetic targeted dual-drug slow-release carrier material is prepared by the following method:

[0040] (1) 0.54g iron salt FeCl 3 ·6H 2 O, the urea of ​​1.68g sodium citrate, 0.36g joins in the water of 40mL, stirs and dissolves at room temperature;

[0041] (2) Add 0.3g polyacrylamide to the solution obtained in step (1). After the particles in the solution are dissolved, transfer it to the reaction kettle and react at 200°C for 12 hours. The product is washed, filtered and dried to obtain super smooth Magnetic Fe 3 o 4 hollow microspheres;

[0042] (3) Take 30mg Fe 3 o 4 Disperse the hollow microspheres in 30mL of water, add 150mL of ethanol, 3.5mL of ammonia water, and 0.3g of surfactant CTAB, stir at room temperature for 2h, then add 375μL of TEOS (tetraethylorthosilicate), and stir at room temperature 5h, the obtained product was washed, filtered, and dried to obtain superparamagnetic Fe embedded in silica 3 o 4 hollow microspheres;

[0043] (...

Embodiment 3

[0046] A superparamagnetic targeted dual-drug slow-release carrier material is prepared by the following method:

[0047] (1) 0.45g iron salt FeCl 3 ·6H 2 O, the urea of ​​1.68g sodium citrate, 0.36g joins in the water of 40mL, stirs and dissolves at room temperature;

[0048] (2) Add 0.3g polyacrylamide to the solution obtained in step (1). After the particles in the solution are dissolved, transfer it to the reaction kettle and react at 200°C for 12 hours. The product is washed, filtered and dried to obtain super smooth Magnetic Fe 3 o 4 hollow microspheres;

[0049] (3) Take 30mg Fe 3 o 4 Disperse the hollow microspheres in 30mL of water, add 150mL of ethanol, 3.5mL of ammonia water, and 0.4g of surfactant CTAB, stir at room temperature for 2h, then add 500μL of TEOS (tetraethylorthosilicate), and stir at room temperature 5h, the obtained product was washed, filtered, and dried to obtain superparamagnetic Fe embedded in silica 3 o 4 hollow microspheres;

[0050] (...

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Abstract

Belonging to the field of medical materials, the invention in particular relates to a super-paramagnetic targeting dual-drug sustained-release carrier material and a preparation method thereof. The inner shell of the carrier material is super-paramagnetic Fe3O4 hollow microspheres, and the outer shell is mesoporous silica, the inner shell is accumulated by Fe3O4 nanoparticles and has a thickness of 5-50nm, and the accumulation holes formed between the Fe3O4 nanoparticles are mesopores. The outer shell is formed by hydrolysis of a silicon source, and the mesoporous aperture of the mesoporous silica is 2-4nm. The super-paramagnetic Fe3O4 hollow microspheres of the inner shell involved in the invention can load hydrophobic drug, and the outer shell mesoporous silica can load hydrophilic drugs, and the drugs are released through the mesopores of the inner shell and the outer shell. Therefore, the super-paramagnetic targeting dual-drug sustained-release carrier material provided by the invention can load two different drugs, and under the orientation action of a magnetic field, can realize targeted sustained-release of dual drugs so as to achieve the purpose of synergy therapy of dual drugs.

Description

technical field [0001] The invention belongs to the field of medical materials, and in particular relates to a superparamagnetic targeted double-drug slow-release carrier material and a preparation method thereof. Background technique [0002] Cancer has always been a threat to human health, especially after entering the 21st century, due to environmental pollution and ecological destruction, the human cancer rate has increased linearly. Therefore, how to treat cancer has attracted increasing attention. In the past two decades, the application of nanotechnology in the field of biomedicine, especially in the treatment of cancer, has developed rapidly. Chemotherapy is one of the main ways to treat cancer. However, in the process of treating cancer with chemical drugs, due to the diffusibility of the drug itself, most of the drugs are released before reaching the lesion, and the amount of drug actually reaching the lesion is very small, which seriously reduces the efficiency ...

Claims

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Application Information

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IPC IPC(8): A61K47/48A61K41/00A61P35/00
CPCA61K41/00
Inventor 阳晓宇刘欢别亚琦范思宇庞淇瑞王永王洪恩苏宝连
Owner WUHAN UNIV OF TECH
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