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52results about How to "No risk of infection" patented technology

Collagen material and its production process

The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amount of time even after application to the body; its production process; and, a medical material on which it is based, examples of which include a artificial tube for nerve, artificial tube for spinal cord, artificial esophagus, artificial trachea, artificial blood vessel, artificial valve or alternative medical membranes such as artificial endocranium, artificial ligaments, artificial tendons, surgical sutures, surgical prostheses, surgical reinforcement, wound protecting materials, artificial skin and artificial cornea, characterized by filling or having inside a substance having biocompatibility that can be degraded and absorbed in the body into a matrix of a non-woven fabric-like multi-element structure of collagen fibers having ultra-fine fibers of collagen as its basic unit.
Owner:TAPIC INT

Vascular occlusion systems and methods

A blood vessel occlusion system and method includes a handheld probe including a power source, the probe being adapted to transmit energy from the power source through a body surface and into a target blood vessel, for example a varicose vein. Further included is a manual or automatic switch mechanism adapted to enable and disable the power source in response to a predetermined level of compression applied, by means of the probe against the target blood vessel. When the blood vessel is compressed sufficiently to collapse and substantially slow or substantially prevent a flow of blood therethrough, the power source is activated and the vessel is cauterized, leaving the blood vessel in a condition that is resistant to recanalization.
Owner:VANDOLAY INC

Recombinant Bacillus subtilis for producing chondroitinase and application thereof

The invention discloses recombinant Bacillus subtilis for producing chondroitinase and application thereof and belongs to the technical field of bioengineering. Chondroitinase of common Proteus origin is heterologously expressed in Bacillus subtilis, signal peptide amyX is selected, 3 strong constitutive promoters and strong RBS (ribosome binding site) of pP43NMK vector itself are utilized, histidine tags are added to facilitate subsequent purification, and expressive enzyme activity of chondroitinase in Bacillus subtilis is improved. Certain basis is laid for efficiently producing chondroitinase from food-grade microbes, and the recombinant Bacillus subtilis is suitable for industrial application.
Owner:JIANGNAN UNIV

Method and Apparatus for Measuring Blood Volume, and Vital Sign Monitor Using the Same

ActiveUS20070167852A1No risk of infectionSuffering of the patient is lessenedCatheterSensorsPeripheral pulsesNormal blood volume
A first member is adapted to measure an electrocardiogram of a patient. A second member is adapted to measure a peripheral pulse wave of the patient. A first calculator calculates a pulse wave propagation time (PWTT) and a heart rate (HR) of the patient based on the electrocardiogram and the peripheral pulse wave. A second calculator calculates a cardiac output (CO) of the patient with an equation of CO=(αK·PWTT+βK)·HR, where α, β and K are coefficients inherent to the patient.
Owner:NIHON KOHDEN CORP

Recombinant aviadenovirus type 4 fiber2 protein as well as preparation method and application thereof

The invention discloses a recombinant fowl adenovirus type 4 (FAdV-4) fiber2 protein as well as a preparation method and application thereof, and belongs to the technical field of gene engineering. The recombinant protein is obtained by removing 274 amino acid residues at the N end of the fowl adenovirus type 4 fiber2 protein and then recombining with the 21-55th amino acid sequence of the fowl adenovirus type 4 hexon protein; and can be used for preparing the avian adenovirus 4-type genetic engineering subunit vaccine. Aiming at the defects of poor solubility and immunogenicity of prokaryoticexpression natural fiber2 protein, the fiber2 protein coding gene is subjected to series modification, and compared with the unmodified fiber2 protein, the recombinant protein has the advantages thatthe gene coding sequence of 274 amino acid residues at the N end of the fiber2 protein is removed, and the gene coding sequences of two important antigen epitopes of the hexon protein are fused; so that the solubility and the immunogenicity are obviously improved, so that the subunit vaccine which is controllable in quality, safe and effective and can prevent highly pathogenic FAdV-4 virus infection can be prepared, and complete protection can be obtained by once immunization.
Owner:YANGTZE UNIVERSITY +1

Separable hydrogel microneedle loaded with recombinant human fibronectin as well as preparation method and application of separable hydrogel microneedle

The invention relates to a separable hydrogel microneedle loaded with recombinant human fibronectin and a preparation method and application thereof, the separable hydrogel microneedle loaded with recombinant human fibronectin comprises a microneedle substrate and a microneedle tip separably attached to the microneedle substrate, the microneedle tip is formed by crosslinking and curing a hydrogel precursor solution through UV initiation, and the hydrogel precursor solution comprises a hydrogel material, a carrier delivery protein, a photoinitiator and an aqueous medium; the delivery protein is recombinant human fibronectin obtained through genetic engineering. A hydrogel material, carrier delivery protein, a photoinitiator and an aqueous medium are subjected to UV-induced crosslinking curing to obtain the separable microneedle tip, the microneedle tip can be retained in a body after application, and a carrier drug embedded in the microneedle tip is released to surrounding tissues through diffusion. And retention and slow release of functional drugs are realized.
Owner:BEOGENE BIOTECH GUANGZHOU

Method for producing biodegradable plastic from activated sludge

The invention relates to the technical field of environmental biology, in particular to a method for producing biodegradable plastics (polyhydroxy paraffinic acid ester (PHA)) by using activated sludge. The method comprises the following steps: in a sequencing batch reactor, using the activated sludge as a strain, adding a mineral salt culture solution containing volatile fatty acid into the sequencing batch reactor by adopting a dynamic substrate feeding mode, and cultivating the activated sludge with storage power of the polyhydroxy paraffinic acid ester under oxic zone condition; transferring the activated sludge with the storage power of the polyhydroxy paraffinic acid ester discharged by the sequencing batch reactor to another reactor, and simultaneously feeding the mineral salt culture solution containing the volatile fatty acid into the another reactor, and making the polyhydroxy paraffinic acid ester stored in bacterial cells in the activated sludge saturated through oxic zone reaction; and extracting the polyhydroxy paraffinic acid ester by the sludge containing the polyhydroxy paraffinic acid ester entering the downstream technology. The method provides possibility for producing a novel environment-friendly material with low cost.
Owner:RES CENT FOR ECO ENVIRONMENTAL SCI THE CHINESE ACAD OF SCI

Method for manufacturing material for repairing human tissue by adopting autologous fingernails

InactiveCN107335094APromote absorptionThe recovery process is fast and goodTissue regenerationProsthesisTissue repairBiological materials
The invention provides a method for manufacturing a material for repairing the human tissue by adopting autologous fingernails. The method mainly comprises the following steps: washing the autologous fingernails to be clean, carrying out disinfecting and sterilizing on the washed autologous fingernails, dehydrating the fingernails until the water content is less than 50%, immersing the dehydrated fingernails into liquid nitrogen, grinding the fingernails by adopting a grinder until the particle diameter is less than 5000 [mu] m, and screening the particles by adopting a sieve so that matrix and powder are separated, wherein the powder can be used as the material for repairing the human tissue. The powder biological material manufactured by adopting the method provided by the invention is rich in collagen, collagen is the important substance for maintaining the human tissue structure, the powder biological material is manufactured by adopting the autologous fingernails, so as to be easily absorbed by the human body, the host immune response can not be caused, further, the danger of rejection or infection is avoided, in addition, the acquisition source is simple, so that the material can be used as the most ideal material for human tissue repair or tissue transplantation, or other purposes.
Owner:薛培贤

Implantable left ventricular assisting system

The invention discloses an implantable left ventricular assisting system which comprises an in-vivo module and an in-vitro module. No transmission lines exist between the in-vivo module and the in-vitro module. The in-vitro module comprises a strong current power supply unit, a power supply end power converting unit, a resonant transformation unit, a primary side coil of a loosely coupled transformer, a power supply end weak current power supply unit, a power supply end controller, a switch tube drive unit, an optical coupler isolating unit, a current sampling unit, a power supply end signal conditioning unit, a protecting unit, a battery state display module and a demodulator for receiving battery state information. The in-vivo module comprises an auxiliary side coil of the loosely coupled transformer, a receiving end resonant transformation unit, a receiving end power conversion unit, a receiving end controller, a battery charging management module, a battery, a modulator and a blood pump. The implantable left ventricular assisting system is simple and compact in structure, small in size and lightweight, and subcutaneous wire holes of a patient can be avoided.
Owner:HANGTIANTAIXIN TECH CO LTD

Heparin precursor synthase and application thereof

The invention discloses a heparin precursor synthase and application thereof and belongs to the technical field of bioengineering. Heparin precursor synthases KfiC and KfiA from escherichia coli K5 are modified in three ways in bacillus subtilis, i.e., the two synthases are directly fused; the two synthases are connected through a flexible linker; and key areas in the KfiC and KfiA replace a key area of a PmHS synthase from pasteurella multocida to obtain three novel heparin precursor synthases, and the results that the yield of heparin precursors is improved and the molecular weight of the heparin precursors is reduced are realized. The invention lays a foundation for efficiently producing and preparing the heparin precursors from food grade microorganisms, and the heparin precursor synthase is suitable for industrial production and application.
Owner:JIANGNAN UNIV

Multifunctional absorbable artificial lamina

The invention discloses a multifunctional absorbable artificial lamina comprising a lamina body. The lamina body is composed of a base body, an outer fixing piece and an inner fixing piece. The base body is of an arched structure, and the outer fixing piece and the inner fixing piece are arranged on two sides of the base body respectively. Autogenous bone fragments can be implanted above the base body. An upper margin and a lower margin are arranged at two ends of the base body respectively and are arc-shaped protrusions respectively. A first arc-shaped groove and a second arc-shaped groove are formed in the lower surface of the upper margin and the upper surface of the lower margin respectively. The second arc-shaped groove of the upper surface of the lower margin of a previous lamina body can be in seamless joint with the first arc-shaped groove of the lower surface of the upper margin of a next lamina body. A plurality of suture holes used for suturing are symmetrically formed in one sides, close to the base body, of the outer fixing piece and the inner fixing piece respectively. The multifunctional absorbable artificial lamina is proper in physical performance and mechanical strength, and can be widely applied to injury repairing of various structures such as rear sides, rear lateral sides and outer lateral sides of cervical vertebras, thoracic vertebras, lumbar vertebras and caudal vertebras.
Owner:陈哲

Hospital wastewater comprehensive treatment device with zero sludge discharge and treatment method thereof

The invention discloses a hospital wastewater comprehensive treatment device with zero sludge discharge and a treatment method thereof. The device is composed of a chlorine dioxide disinfection tank,a three-grid septic tank, an adjusting tank, a closed ultraviolet sterilizer, a multistage bio-chemical tank and a chlorine dioxide disinfection tank which are sequentially connected in series, and further comprises a waste gas treatment module; a cutting pump is arranged in the adjusting tank; the waste gas treatment module is composed of plasma equipment and activated carbon adsorption equipment; wherein the multi-stage biochemical tank is formed by connecting a multi-stage unit A, a multi-stage unit O and a precipitation unit in series, part of sludge at a sludge outlet of a precipitation unit flows back to the front section of the multi-stage unit A through a sludge return pump and a sludge return pipe, and the rest sludge is discharged to the water inlet section of the three-grid septic tank as residual sludge; by adopting the treatment method disclosed by the invention, the effluent quality is superior to the standard of Discharge Standard of Water Pollutants for Medical Organization (GB18466-2016), the treatment method has the advantages that residual sludge, grid slag and the like are not generated, and the risk of bacterial infection of aerosol, sludge, grid slag, waste gas and the like is avoided.
Owner:HUAQI ENVIRONMENT PROTECTION SCI & TECH

Chondroitinase ABC producing recombinant yeast strain and structuring and applying methods thereof

The invention discloses a chondroitinase ABC producing recombinant yeast strain and application thereof and belongs to the technical field of bioengineering. According to the chondroitinase ABC producing recombinant yeast strain, chondroitinase ABC from Proteus vulgaris ATCC33420 is subjected to heterogeneous expression, and with pPIC9K carriers and through induction of methanol, secretory expression of the chondroitinase ABC in pichia pastoris GS115 can be achieve; by means of a designed chondroitinase ABC-enzymatic membrane reactor, efficient and continuous production of small-molecular chondroitin sulfate can be achieved, the chondroitinase ABC can be recycled and reutilized, and the production cost can be greatly reduced. By taking food-grade yeast as host strains, the chondroitinase ABC producing recombinant yeast strain can be safe and reliable, provide effective references for industrialized and green production of small-molecular chondroitin sulfate A, B and C, and meanwhile, save energy, reduce emission and achieve significant economic and social benefits.
Owner:CHANGSHU INSTITUTE OF TECHNOLOGY

Quality control material for detecting respiratory tract pathogen nucleic acid and preparation method thereof

The invention provides a quality control material for detecting respiratory pathogen nucleic acid. The quality control material comprises any one or more of the following respiratory pathogens: coronavirus, influenza virus, adenovirus, mycoplasma pneumoniae, streptococcus pneumoniae, rhinovirus or / and legionella pneumophila. A full-length genome sequence of the coronavirus is divided into six target fragments, and the length of each fragment ranges from 4000 bp to 5500 bp. The quality control material disclosed by the invention covers all detection target sequences (or target spots) of the coronavirus, the coverage is wide, the detection target spots are comprehensive, and the phenomenon of missing detection is avoided. The quality control material provided by the invention contains main respiratory tract infection pathogens, has a wide coverage range, and has more accurate detection targets by taking a real virus sample and a slow virus sample as raw materials. According to the coronavirus quality control material prepared by the invention, a target gene sequence is integrated into a host genome through a lentiviral vector, an autonomously replicated gene is knocked out in the preparation process, and the coronavirus quality control material has a self-inactivation capability, so that the recombinant lentivirus cannot be replicated in a target cell and infects other cells.
Owner:GUANGZHOU BDS BIOLOGICAL TECH CO LTD

Power plant remote comprehensive monitoring system and method

The invention provides a power plant remote integrated monitoring system and method, and the system comprises a plurality of monitoring units which are disposed in different power plants, and are used for obtaining the internal data of the power plants, an internet-of-things platform connected with the monitoring units through a network and used for acquiring internal data of the power plans and analyzing and processing the internal data to form an analysis report, a main monitoring center communicated with the Internet of Things platform through a network and used for acquiring an analysis report and displaying, monitoring and early warning the analysis report, a mobile monitoring terminal communicated with the Internet of Things platform through a wireless network and used for acquiring an analysis report and performing display, monitoring and early warning, and an electric power company dispatching system interface connected with the monitoring units through a network and used for receiving the internal data transmitted by each power plant. The problems that data transmission of a remote data monitoring system is unstable, front-line workers cannot receive fault information in time, and a data transmission network needs safety guarantee due to decentralized power plants are solved.
Owner:HENAN BCCY IND

A kind of recombinant Bacillus subtilis with high chondroitin production and its application

The invention discloses a recombinant bacillus subtilis for highly producing chondroitin and application of the recombinant bacillus subtilis, belonging to the technical field of bioengineering. By optimizing synthetic routes of the recombinant bacillus subtilis for producing the chondroitin, namely carrying out coexpression on key enzyme genes in a UDP-GlcUA route and a UDP-GlcNAc route, the yield of the chondroitin is increased. The recombinant bacillus subtilis provided by the invention can meet the requirements of medical and health services and food safety, and the endotoxin and pathogenic infection risks are avoided; the accumulation of the chondroitin can be maximum, namely 6.06g / L, and the molecular weight is 78.64KD. According to the research of the invention, a new strategy is provided for the high production of the chondroitin, on one hand, the recombinant bacillus subtilis can be applied to other glycosaminoglycans, and on the other hand, a foundation is laid for the industrial large-scale production of the chondroitin.
Owner:JIANGNAN UNIV

Multi-purpose absorbable artificial lamina

The invention discloses a multifunctional absorbable artificial lamina comprising a lamina body. The lamina body is composed of a base body, an outer fixing piece and an inner fixing piece. The base body is of an arched structure, and the outer fixing piece and the inner fixing piece are arranged on two sides of the base body respectively. Autogenous bone fragments can be implanted above the base body. An upper margin and a lower margin are arranged at two ends of the base body respectively and are arc-shaped protrusions respectively. A first arc-shaped groove and a second arc-shaped groove are formed in the lower surface of the upper margin and the upper surface of the lower margin respectively. The second arc-shaped groove of the upper surface of the lower margin of a previous lamina body can be in seamless joint with the first arc-shaped groove of the lower surface of the upper margin of a next lamina body. A plurality of suture holes used for suturing are symmetrically formed in one sides, close to the base body, of the outer fixing piece and the inner fixing piece respectively. The multifunctional absorbable artificial lamina is proper in physical performance and mechanical strength, and can be widely applied to injury repairing of various structures such as rear sides, rear lateral sides and outer lateral sides of cervical vertebras, thoracic vertebras, lumbar vertebras and caudal vertebras.
Owner:陈哲

Standard liquid for flow-type cytometer

This invention relates to a standard fluid for a flow cytometer is characterized by showing, after staining, almost the same fluorescence intensity and scattered light intensity as those of the cells to be assayed. The present invention aims at providing a standard fluid for a flow cytometer which shows almost the same behaviors as those of the cells to be assayed and can be easily handled without any risk of infection.
Owner:SYSMEX CORP

Non-invasive lip beautifying method

The present invention provides a non-invasive lip beautifying method. The non-invasive lip beautifying method comprises the following steps; step 1, uniformly smearing a penetration enhancer on lips to be beautified, and changing cell arrangement of stratum corneum of lips; step 2, smearing liposome containing pure natural plant toner emulsion on part of lip area to be beautified; and step 3, applying electric pulses or ultrasonic waves on the liposome containing pure natural plant toner emulsion smeared on the lips to be beautified, enabling the pure natural plant toner emulsion to penetrateinto the lip skin, and beautifying the different partitions of the lips with different force. By differentiated stimulation on the lips in partitions, the pure natural plant toner emulsion is fused ina non-invasive mode, and the three-dimensional lip beautifying is achieved. The whole lip beautifying process is non-invasive, free of pain and swelling, and avoids risk of scars.
Owner:王瑾

Osteopathic ankle joint complicated fracture treatment fixer

The invention provides an osteopathic ankle joint complicated fracture treatment fixer. A fracture reduction fixer is formed by combining several kinds of apparatuses with different functions together, is a third fixing manner between an orthopedic internal fixation and external fixation, is integrated with functions of traction, reduction, reverse traction and local fixation and longitudinal pressurization, is used for directly fixing a fracture or a bone dislocation in vitro in a minimally invasive manner, and can achieve the goal of restoring body and limb functions. Compared with external fixation by using apparatuses such as splints and gypsum supports, the fixation in this manner is firm and reliable; compared with internal fixation by using apparatuses such as steel plates and intramedullary nails, the damage is small and the risk of wound infection is avoided.
Owner:特格喜吉嘎拉

Recombinant engineering bacterium for producing 2 '-fucosyllactose as well as construction method and application of recombinant engineering bacterium

The invention discloses a recombinant engineering bacterium for producing 2 '-fucosyllactose as well as a construction method and application of the recombinant engineering bacterium, and belongs to the technical field of genetic engineering. The invention discloses a recombinant engineering bacterium for producing 2 '-fucosyllactose, the strain name of the recombinant engineering bacterium is KMdeLac24-FL15, the recombinant engineering bacterium is preserved in the China General Microbiological Culture Collection Center on March 21, 2022, the preservation number is CGMCC NO.24549, and the recombinant engineering bacterium is classified and named as Kluyveromyces marxianus. The invention further discloses a preparation method of the recombinant engineering bacterium for producing 2'-fucosyllactose. The strain can efficiently express the 2 '-fucosyllactose and is applied to preparation of the 2'-fucosyllactose. The invention also discloses a recombinant engineering bacterium for producing the 2 '-fucosyllactose and a construction method of the recombinant engineering bacterium, and also discloses application of the recombinant engineering bacterium in preparation of the 2'-fucosyllactose.
Owner:OCEAN UNIV OF CHINA

needle with safety device

The invention relates to a needle (10) having a distal end (11), a proximal end (12) and a stem (13) extending between them, and a tip (14) at its distal end (11). The needle (10) is provided with a safety device (20) arranged to be able to move between a first position in the proximal region of the stem (13) and a second position at the distal end (11) of the stem slide on the trunk (13). The safety device also includes a housing (21, 22) having a proximal opening (23) and a distal opening (24) for passage of the stem of a needle, the tip of the needle when the safety device is in the second position (14) is inside the housing. The device comprises closure means (30) which close the distal opening (24) of the housing when the tip of the needle is located within the housing.
Owner:B BRAUN MEDICAL

Wound imaging device

The invention discloses a wound imaging device which comprises an optical transmitting set. Light emitted by the optical transmitting set is reflected by a wound and then is received by a sensor, a central processing unit carries out coded imaging on the signals received by the sensor, and imaging results are stored in a memorizer and are displayed and output through a displayer. The wound imaging device does not make contact with the wound directly, infection risks do not exist, measuring speed is fast, precision is high, and the wound imaging device is suitable for being popularized and applied in clinical practice.
Owner:QINGDAO ANXIN MEDICAL DEVICES

Cultivation method for twice gonad maturation of micropterus salmoides in one year

The invention relates to the field of aquaculture technology and fishery independent innovation, and discloses a cultivation method for twice gonad maturation of micropterus salmoides within one year, which comprises the steps of parent selection and temporary rearing, culture water temperature reduction in summer, culture water temperature increase in autumn and winter, illumination time adjustment, parent nutrition supplement adjustment, gonad maturation index calculation and the like. The sexual glands of micropterus salmoides are induced to develop out-of-season maturity, and the requirement that out-of-season breeding has serious lack of parents is met. Through a water temperature adjusting technology, a natural illumination simulation technology and a nutrition enrichment technology, the water temperature, illumination and nutrition requirements of seasonal changes in the nature for gonad development of fishes are simulated, the gonads of micropterus salmoides are induced to mature for the second time within one year, and the purpose of providing sufficient parents required by out-of-season breeding is achieved. And support is provided for expanding the micropterus salmoides culture scale and realizing adult fish culture in the current year.
Owner:HUAIYIN TEACHERS COLLEGE

A blood treatment filter

The invention discloses a blood treatment filter. A cylindrical electronic pressurizer is arranged in a bacteria-free room, a blood filtering device which is stretchable and rotatable and can be matched with the pressurizer is disposed on the left side of the cylindrical electronic pressurizer, a rotatable blood storing device which can be matched with the blood filtering device is disposed on the right side of the cylindrical electronic pressurizer, and an automatic sealing machine is disposed at the upper end of the blood storing device; a constant temperature room is disposed on the right side of the bacteria-free room, and the constant temperature room is connected with the bacteria-free room through an elastic door; an automatic conveying belt is disposed below the blood storing device; a sterilization room which is connected with the bacteria-free room through an inclined channel is disposed at the bottom of the bacteria-free room; a numerical control system which can automatically control all parts and are electrically connected with all the parts through numerical programs is disposed on the outer side of the bacteria-free room. By means of the blood treatment filter, blood treatment and filtering can be performed in bacteria-free and full-automatic environments, the working efficiency can be greatly increased, and working strength of doctors can be reduced.
Owner:BEIHUA UNIV
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