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Medical composition for promotion of skin regeneration

A composition and technology of chitosan derivatives, which are applied in skin diseases, drug combinations, medical preparations with non-active ingredients, etc., can solve the problem of difficulty in ensuring epithelialization of wounds, postoperative bandage replacement and treatment pain or re-obstacles, It takes time and other issues to achieve the effect of improving wound healing activity, preventing infection of the affected area, and promoting epithelialization

Inactive Publication Date: 2008-05-07
NETECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the case of extensive burns, the range of skin that can be harvested for autologous skin transplantation is limited, and it is difficult to ensure the amount necessary for epithelialization of the entire wound.
Moreover, the suturing or stapler for firmly fixing the transplanted tissue to the subcutaneous tissue not only takes time, but also entails the pain of postoperative bandage replacement or the risk of further hindrance, causing great harm to patients and physicians. burden

Method used

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  • Medical composition for promotion of skin regeneration
  • Medical composition for promotion of skin regeneration
  • Medical composition for promotion of skin regeneration

Examples

Experimental program
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Effect test

Embodiment

[0092] Hereinafter, the present invention will be described in detail using specific examples, but the scope of the present invention is not limited to these specific examples.

Synthetic example 1

[0094] Synthesis of Photocrosslinkable Chitosan Derivatives (PRC)

[0095] According to the method described in WO00 / 27889, PRC having UV-reactive functional groups and sugar chains introduced into the chitosan backbone was synthesized. Specifically, an azide (p-azido group) was introduced into the amino group of shrimp-derived chitosan (manufactured by Yaizu Fisheries Industry Co., Ltd.) with a molecular weight of 800 to 1000 kDa and a degree of deacetylation of 85 through a condensation reaction. Benzoic Acid) and Lactose (Lactobionic Acid). By introducing lactose, it is soluble at pH in the neutral range, and the substitution degrees of p-azidobenzoic acid and lactobionic acid were confirmed to be about 2.5% and 5.0%, respectively.

[0096] In addition, the same derivatives can also be synthesized when chitosan raw materials derived from crab shells and cuttlefish cartilage are used.

Synthetic example 2

[0098] Synthesis of Light (Visible Light) Curable Chitosan Derivatives (VL-RC)

[0099] According to the method described in Journal of Polymer Science: Polymer Chemistry Edition, Vol.20, 1419-1432 (1982), methyl-4-[2-(4-formylphenyl)ethenyl] represented by the following formula was synthesized Pyridine mesylate (FPP).

[0100]

[0101] Specifically, a methanol (8.3 ml) solution of γ-picoline (3.07 g, 33 mmol) was added to dimethyl sulfate (4.16 g, 33 mmol) under ice-cooling. After the solution was left standing at room temperature for 1 hour, terephthalaldehyde (13.4 g, 100 mmol) was added and heated to dissolve. Then piperidine (0.47ml) was added and refluxed for 5 hours. The precipitate was filtered off while hot. The hot filtrate was combined with a mixed solvent of ethanol (50 ml) and acetone (16.7 ml), and left at room temperature overnight. The yellow precipitate was separated by filtration, washed with ethanol and acetone, and dried under reduced pressure to obt...

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Abstract

The present invention provides a medical composition which, in autotransplantation which is the only method that can induce the epithelialization even in a widespread full-thickness skin defect, enables the fixation of an autotransplantation skin graft in a simple manner and can increase the efficiency of epithelialization to promote the regeneration of the skin. A medical composition comprises a photocrosslinkable chitosan derivative and an amino acid and / or a saccharide. The amino acid is preferably an essential amino acid, and the saccharide is preferably a neutral saccharide selected from glucose, galactose, mannose and fucose.

Description

technical field [0001] The present invention relates to a medical composition capable of promoting skin regeneration, which contains photocrosslinkable chitosan derivatives, sugars such as glucose, and / or amino acids such as glycine. Background technique [0002] The skin originally has a self-repair function. For mild trauma such as simple trauma, the skin can be regenerated through self-repair function. , it is difficult to completely repair (Non-Patent Document 1). [0003] The mechanism of wound healing proceeds in the following order, (1) recognition of the injury site consisting of inflammatory cells, then connective tissue cells, and epidermal cells, (2) contraction of the wound site, and (3) granulation and epithelial The relevant cells, various factors, cytokines, secretions, etc. in each stage have been clarified. [0004] The research on skin wound healing by artificial skin repair involves the modification of wound coating materials for the purpose of temporary...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61K9/06A61K31/198A61K31/405A61K31/4172A61K31/7004A61K47/36A61P17/02
CPCA61K31/7004A61K31/198A61K31/4172A61L27/60A61K31/405A61L27/20A61P17/00A61P17/02C08L5/08A61K9/06
Inventor 金谷泰宏清住哲郎冈田芳明斋藤大藏石原雅之由良洋文三泽义知
Owner NETECH
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