The invention relates to a hydroxyl acid oligomer-containing self-penetrating pressure sensitive adhesive and application thereof, comprising high hydrophilicity component polymer with relative molecular mass, selected from N-vinyl pyrrolidone with relative molecular mass from 100 thousand to 2000 thousand and its alkyl substituted homopolymer of derivative and copolymer, etc. accounting for 30% to 70%, further comprising lactic acid, oligomers of hydroxyl acids of hydroxyacetic acid accounting for 10% to 40% with polymerization degree from 2 to 8 and short chained polylol with relative molecular mass 300 or below and amine and their mixture and water. The invention has features of hydroscopicity and elasticity of aquagel, further greater pressure sensitive adhesive property which can be applied independently or combined with medicament, surface active agent, electrolyte, penetration enhancer or various inorganic and organic additives for pressure sensitive adhesive, for medicament percutaneous absorption preparation system and treatment of skin diseases, hairdressing, skin protection.