55results about How to "Magnetically responsive" patented technology

The present invention relates to a magnetic fluorescent double-functional microsphere with core-shell structure and its preparation method. Firstly, said invention uses strong acid and sodium citrate to modify surface of inorganic magnetic nano granules, then uses alkyl orthosilicate as precursor body, and adopts gel-sol process to prepare silicon dioxide magnetic microsphere with core-shell structure, finally utilizes the copolycondensation method of alkyl orthosilicate and silane coupling agent of bonded fluorescein to prepare silicon dixide fluorescent microsphere with magnetism. Said microsphere has magnetic response characteristic, and can send out fluorescence under the excitation of UV-light and visible light.

The invention provides a method for preparing lysozyme molecular imprinting nano particles with magnetic responsiveness and extremely high adsorption capacity. In the method, lysozymes are used as template molecules. The method comprises the following steps of: carrying out template polymerization under the conditions that suitable functional monomers, a cross-linking agent and an initiator and magnetic nano particles the surfaces which are coated with SiO2 and are modified by sulfydryl and acryloyloxy exist; and washing out the template molecules to obtain the lysozyme molecular imprinting nano particles with magnetic responsiveness and high adsorption capacity. The invention also provides a method for preparing the nano particles. The lysozyme molecular imprinting nano particles prepared by adopting the method disclosed by the invention have the characteristics of high adsorption capacity, simpleness for preparation, low cost, strong specific absorption, high physical, chemical stability, capability of being recycled repeatedly and the like.

The present invention belongs to the field of inorganic material technology, and is especially one kind of magnetic metal oxide microsphere in core-shell structure and its preparation process. The microsphere has ferroferric oxide microsphere as the core and metal oxide as the shell. It is prepared through the first hydrothermal process to cover one layer of amorphous carbon onto ferroferric oxide microsphere to form magnetic carbon microsphere Fe3O4@C, the subsequent dispersing microsphere Fe3O4@C in alcohol water solution of pre-hydrolyzed metal alkoxide for adsorbing inorganic oligomer to the surface of the microsphere, and the final calcining in nitrogen atmosphere to obtain the magnetic metal oxide microsphere in core-shell structure. The process is simple and practical, and has adjustable size of the microsphere. The magnetic metal oxide microsphere has important application in separating protein, separating polypeptide and other fields.

The invention relates to a chitosan magnetic nano particle as well as a preparation method and application thereof. The structural formula of the chitosan magnetic nano particle is CTS-Fe3O4NPs, and the particle size is 5-14 nm. The invention also relates to a preparation method and application of the chitosan magnetic nano particle. The chitosan magnetic nano particle provided by the invention has small particle size and large specific surface area and is very easy to be combined with a target object. The speed of removing heavy metal ions in waste water is fast, the extraction rate is high, and the chitosan magnetic nano particle can be reproduced and can be used for removing water-soluble acid dye and phenol substances in waste water. The chitosan magnetic nano particle has particular magnetic responsibility and can be directionally separated through an external magnetic field without centrifugal operation, which is beneficial to simplifying and automating the separation process. The synthetic process is simple and fast, and no toxic substance is used. The entire preparation process and the removal process are easy to operate and consume short time, the efficiency can be improved, and manpower and energy can be saved. The chitosan magnetic nano particle is especially applicable to removing heavy metal ions in waste water.

The invention provides carboxyl magnetic microspheres, a preparation method and an application. The surfaces of mesoporous polymer microspheres are modified with functional groups with a physical adsorption method, carboxyl magnetic microspheres are prepared with an in-situ coprecipitation synthesis method, and magnetic microspheres modified with carboxyl repeatedly is prepared by silica coating,amino modification and carboxyl re-modification. The carboxyl repeatedly modified magnetic microspheres are functional composite microspheres, have the advantages of magnetic responsiveness, high stability, better biological compatibility, uniform particle size, good monodispersity, controllable magnetic content and good batch repeatability, are suitable for large-scale stable preparation in industry, and can be widely applied to the fields of cell separation, immune detection, protein purification, immobilized enzyme, environmental protection and the like.

The invention discloses a method for preparing magnetic super-hydrophobic sponge materials. The method includes steps of carrying out cleaning pretreatment on sponges; preparing modified Fe3O4 solution; preparing polydimethylsiloxane solution; preparing magnetic super-hydrophobic sponges. The method has the advantages that the method is economical, environmentally friendly and simple and is high in efficiency, oil or solvents with the volumes dozens of times the volumes of the magnetic super-hydrophobic sponge materials prepared by the aid of the method can be absorbed by the magnetic super-hydrophobic sponge materials, the magnetic super-hydrophobic sponge materials are excellent in oil or organic solvent and water separating capacity, and the oil or the solvents can be quickly recycled by the aid of the magnetic super-hydrophobic sponge materials; the magnetic super-hydrophobic sponge materials are excellent in compression resistance and can be recycled.

The invention relates to a preparation method of nano magnetic particles for detection and treatment of coronary heart diseases, which comprises the following steps: A, mixing transition layer molecules on the surfaces of magnetic nuclei, wherein the transition layer molecule are compounds which simultaneously contain amino groups, carboxyl groups or hydrosulfide groups and groups capable of reacting with hydroxyl groups; B, on the magnetic nuclei fixed with the transition layer molecules, fixing functional molecules capable of prolonging the residence time of nano particles in blood; and C, on the magnetic nuclei fixed with functional molecules, fixing specific recognition ligands of endothelial progenitor cells or diseased endothelial cells, thus obtaining the nano magnetic particles. The method can be used for preparing magnetic nano particles for early-stage detection and location of diseased endothelial cells of coronary heart diseases, and the detection is sensitive and reliable; the method can be also used for preparing magnetic nano particles for mid-late-stage treatment of coronary heart diseases; and good repairing and treatment effects on coronary heart diseases can be achieved.

The invention provides a preparation method of immobilized lipase. The preparation method is characterized by using amino-functionalized magnetic Fe3O4@C nanoparticles as carriers and immobilizing lipase on the surfaces of the nanoparticles through covalent binding. The method is specifically divided into two methods. The first method is characterized by firstly binding an aldehyde group at one terminal of glutaraldehyde with the amino groups on the surfaces of the amino-functionalized magnetic Fe3O4@C nanoparticles by utilizing nucleophilic reaction and then binding an aldehyde group at the other terminal of glutaraldehyde immobilized on the surfaces of the magnetic Fe3O4@C nanoparticles with the amino groups of lipase. The second method is characterized by converting the amino groups on the surfaces of the magnetic Fe3O4@C nanoparticles to carboxy groups by utilizing succinic anhydride and immobilizing lipase on the surfaces of the Fe3O4@C nanoparticles by utilizing amidation after activation with a mixture of N,N-dicyclohexylcarbodiimide and N-hydroxysuccinimide in a molar ratio of 1:(0.5-2). The preparation method has the beneficial effects that the preparation method is simple and mild; the lipase immobilization amount is large; the immobilized lipase has high enzyme activity and enzyme recovery and good stability, can be simply and conveniently recycled, effectively reduces the real cost of production and has wide application prospect.

The invention discloses a method for preparing a magnetism papermaking sizing agent stabilized by magnetism solid particle emulsification. The method comprises the steps of adding magnetism nanometer solid particles in the particle diameter of 18nm to 50nm into deionized water, carrying out ultrasonic dispersion, adding absolute ethyl alcohol, then adding a silane coupling agent, stirring, standing the solution, cooling the solution to room temperature, obtaining magnetism nanometer solid particles modified by the silane coupling agent, then dispersing the magnetism nanometer solid particles into deionized water, mixing the solution with alkenyl succinic anhydride oil liquid, carrying out high-speed shearing emulsification, and obtaining the magnetism papermaking sizing agent stabilized by the magnetism solid particle emulsification. The magnetism papermaking sizing agent with the stable magnetism solid particle emulsification prepared by the method allows a paper sheet to have water resistance, meanwhile has magnetism, and is high in sizing efficiency, simple in preparation, capable of allowing alkenyl succinic anhydride to be emulsified into Pickering type emulsion with quite high stability without addition of any superficial active agent, little in emulsion emulsifier dosage, high in stability and low in foam, toxicity and cost.

The invention discloses a preparation method and a using method of a magnetic response aminated cellulose-based heavy metal adsorption material. The preparation method comprises the following steps: S1, crushing cellulose and dissolving the crushed cellulose in an alkali urea solution under stirring state to obtain a transparent cellulose solution; S2, adding an animation reagent and a superparamagnetic material into the cellulose solution, uniformly mixing, then adding a cross-linking agent and grafting the animation reagent to a cellulose chain to obtain modified cellulose; and S3, converting the modified cellulose from liquid state into solid state by adjusting reaction temperature and pH value of a modified cellulose system to obtain the magnetic response aminated cellulose-based heavymetal adsorption material. The magnetic response aminated cellulose-based heavy metal adsorption material prepared by the method has high amino density and magnetic response, is capable of rapidly carrying out solid-liquid separation in an externally-applied magnetic field, has a good effect of removing various heavy metals in water, has good regeneration property, and can be applied to the fieldof treatment of wastewater with heavy metals.

The invention discloses a structure and a preparation method for magnetic sliver-flower nano-particles. The structure takes magnetic nano-particles (Fe3O4) as the core and takes a silicon dioxide shell layer (SiO2) as a multi-functional layer. By formaldehyde reduction, flower-shaped sliver shells similar to needle points rapidly grow. The preparation method comprises the following steps: wrapping surfaces of 100-6000 nano Fe3O4 magnetic nanoparticles with an SiO2 layer and improving dispersion of magnetic nano-particles and providing position points of sliver seed growth; utilizing a chemical electroplating method with the assistance of ultrasonic wave to grow the surfaces of the Fe3O4@SiO2 magnetic particles with uniform and dense sliver particles as seeds for growth of flower-shaped sliver shells; finally, utilizing formaldehyde as a reduction agent and ammonium hydroxide as a catalyst to rapidly reduce magnetic sliver-flower nano-particles on the ultrasonic condition. The invention further discloses a magnetic SERS substrate prepared by the above method. The magnetic SERS substrate is made from magnetic sliver-flower nano-particles and is good in dispersion, high in magnetic induction, stable in structure and great in heart and can be directly used for SERS detection of small molecule pollutants, pesticide residuals and illegal additives of food.

The method for preparing polymer magnetic medicine-loaded particle by utilizing the process using supercritical CO2 to resist solvent mainly includes the following steps: firstly, adding magnetic powder into polymer solution containing medicine, uniformly dispersing said magnetic powder, placing them into reaction still, then injecting CO2 into reaction still according to a certain flow rate, making the solute undergo the supercritical CO2 reversed-phase extraction process, be crystallized, precipitated and separated out, continuously introducing CO2 to clean residual organic solvent to obtain the polymer particle containing medicine and magnetic powder.

The invention discloses high-strength magnetic responsiveness double-network hydrogel based on Fe3O4 nanoparticles and a preparation method thereof. The hydrogel is formed by introducing Fe3O4 nanoparticles into double-network (DN) hydrogel, and the hydrogel utilizes carboxyl groups on molecular chains of natural anionic polysaccharide pectin and trivalent iron ions to form coordination complexesto construct a first network, and a covalently crosslinked polyacrylamide network is taken as a second network. The hydrogel can achieve a tensile strength of 1.20+ / -0.07 MPa, a tensile strain of 1600+ / -232 percent, and an elastic modulus of 1.10 MPa+ / -0.08 MPa by adjusting the content of Fe3O4. More importantly, the hydrogel not only has good mechanical properties, but also has good magnetic responsiveness, can achieve different degrees of bending under an external magnetic field, and can be applied to the field of soft brakes.

The invention discloses a composite emulsifier having magnetic-responsive performance and belongs to the technical field of colloid and interface chemistry. The emulsifier includes commercial nano Fe3O4 particles, which are not subjected to any modification, and enzyme; original particle size of the nano Fe3O4 particles is 20-200 nm, and application concentration, on the basis of a water phase, is0.05-5.0%; the lipases are protein enzymes and nucleic acid enzymes, and application concentration, on the basis of the water phase, is 0-20 mg / ml. An emulsion stabilized by the composite emulsifierbelongs to Pickering emulsion, wherein the composite emulsifier and the emulsion stabilized thereby have magnetic-responsive performance; at room temperature, as the emulsion passes through an area having certain magnetic field intensity, the composite emulsifier can leave from the interface of the Pickering emulsion and can be gathered, thus demulsifying the emulsion, but the composite emulsifierstill has interface activity; by homogenizing the separated system, the stable Pickering emulsion can be produced again.

The invention discloses a magnetic nano-chitosan loaded sheath bacteria composite biological adsorbent and a preparation method thereof, and belongs to the technical field of bio-adsorbent preparation. The preparation method comprises the following steps: (1) preparing magnetic nanoparticles; (2) adding the magnetic nanoparticles into a chitosan solution to prepare magnetic nano-chitosan microspheres; (3) loading sheath bacteria on the magnetic nano-chitosan microspheres. The composite biological adsorbent loaded with sheath bacteria can load the sheath bacteria, has a good Cr(VI) treatment effect, carries multiple active groups, has the characteristics of magnetic responsiveness as well as large specific surface area, porosity, narrow particle size distribution and the like of nanoparticles, and can move and separate rapidly under the action of an external magnetic field to realize the advantages of easiness in recycling, renewability and the like.

The invention provides a clathrate compound of cyclodextrin / Fe3O4 magnetic nano compound and ibuprofen, prepared by adopting the following steps of: adding a cyclodextrin / Fe3O4 magnetic nano compound into ibuprofen ethanol solution in the weight ratio of (0.2-20): 1, and carrying out ultrasonic processing for 2-4 hours; washing products with secondary distilled water, separating by adopting a permanent magnet, and carrying out vacuum drying to obtain the clathrate compound. The cyclodextrin / Fe3O4 magnetic nano compound realizes targeting delivery on a medicine by simultaneously utilizing clathration characteristic of cyclodextrin and magnetic performance of a Fe3O4 magnetic nano particle; the ibuprofen is clathrated by the Fe3O4 magnetic nano compound, adverse effect of the medicine is reduced, peculiar and odour smells of the medicine are covered, solubility, bioavailability and stability are all improved, the clathrate compound can be used for targeting medicine delivery under the action of an external magnetic field, and curative effect of the medicine can be played to the utmost extent.

The invention provides a sulfobutyl ether-beta-cyclodextrin / Fe3O4 magnetic nano particle composite (SBE-beta-CD / Fe3O4MNP), which is prepared by modifying sulfobutyl ether-beta-cyclodextrin with citric acid to introduce carboxyl onto the sulfobutyl ether-beta-cyclodextrin, and subjecting the sulfobutyl ether-beta-cyclodextrin with the carboxyl to dehydration condensation together with Arabic gum modified amino-containing Fe3O4 magnetic nano particles. Characterization by X-ray diffraction (XRD), transmission electron microscope (TEM), dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FTIR) and thermogravimetric analysis (TGA) methods proves the Fe3O4 magnetic nano particles are grafted with sulfobutyl ether-beta-cyclodextrin. The composite can be used as a potential medicinal carrier. The invention also provides the inclusion compound of the composite and ibuprofen, which has high solubility and high biocompatibility and can be used in preparation of ibuprofen targeted medicines.

The invention discloses a magnetic black phosphorus microbubble and the application of the magnetic black phosphorus microbubble in preparation of an ultrasonic diagnostic reagent and a medicine for treating breast cancer. A preparation method of the magnetic black phosphorus microbubble comprises the following steps: adding reaction raw materials into a solvent for dissolving; wherein the reaction raw materials comprise distearoyl phosphatidylcholine, distearoyl phosphatidylethanolamine-polyethylene glycol, distearoyl phosphatidylethanolamine-polyethylene glycol-biotin and stearic acid modified polyethyleneimine, the stearic acid modified polyethyleneimine is obtained by grafting stearic acid on low-molecular-weight polyethyleneimine, volatilizing the solvent to form a film from the reaction raw material, adding a biological buffer reagent, heating at 50-70 DEG C to form phospholipid, oscillating in a perfluoropropane atmosphere to prepare biotinylated cationic microbubbles, adding black phosphorus nanosheets for incubation, and then adding streptavidin magnetic beads. The prepared magnetic black phosphorus microbubble can carry black phosphorus in an active targeting manner, and has the effects of ultrasonic diagnosis and tumor treatment.

The invention discloses a preparation method of a magnetic covalent organic framework molecularly imprinted polymer for separating anthocyanin. The invention belongs to the field of molecularly imprinted polymers. The invention aims to solve the technical problem of low selectivity of the traditional separation filler for anthocyanin separation in the prior art. The method disclosed by the invention comprises the following steps: 1, synthesizing aminated magnetic nano Fe3O4-NH2; and 2, synthesizing seven magnetic covalent organic framework molecularly imprinted materials (MCMIPs) with C3G as atemplate molecule through a room-temperature synthesis method. The MCMIPs provided by the invention have magnetic responsiveness, high adsorption performance and excellent specificity, and are suitable for rapidly and purposefully fishing C3G from a complex sample matrix. According to the separation medium, the anthocyanin separation and purification steps are simplified, the separation and purification time is shortened, and the separation and purification efficiency is greatly improved.

The invention provides magnetic copper (II) chelating ferroferric oxide @carbon nanoparticles and a preparation method thereof, and a method for immobilizing laccase. The preparation method comprisesthe steps of firstly preparing hydroxyl / carboxyl functionalized magnetic Fe3O4@C nanoparticles by a hydrothermal method, then performing coordination adsorption on Cu2+ ions to obtain magnetic Cu(II)chelating Fe3O4@C nanoparticles, and finally through the coordination effects of laccase histidine residues and Cu(II), preparing magnetic Cu(II) chelating Fe3O4@C nanoparticle immobilized laccase which is high in stability, high in activity and reusable. Compared with the prior art, the prepared magnetic Cu(II) chelating Fe3O4@C nanoparticle immobilized laccase is simple to operate, economic andenvironmentally-friendly; and the enzyme loading quantity is high, immobilized laccase is high in catalytic activity and high in stability, can be simply cycled and reused, and has great application prospects, and actual production cost can be effectively reduced.

The invention discloses a preparation method of magnetic immobilized lipase capable of being used in organic media. A magnetic Fe3O4 / P(St-AA) nanosphere or a magnetic Fe3O4 / PS-CH3Cl nanosphere is used as a carrier, and the lipase is fixed on the surface of the magnetic Fe3O4 / P(St-AA) nanosphere or the magnetic Fe3O4 / PS-CH3Cl nanosphere through covalent binding. The method is simple and moderate, the carrier content of the lipase is high, and the magnetic immobilized lipase has the advantages of high recovery rate, good stability and wide application prospect and can be widely used in the organic media.

The invention provides a magnetic nano material and a preparation method and application thereof. The magnetic nano-material comprises a magnetic core, a silicon dioxide shell and an amphiphilic organic group grafted outside the silicon dioxide shell. The magnetic nano material has the advantages of being uniform in particle size, magnetic responsive, amphiphilic, non-toxic, environmentally friendly and low in production cost; no by-product is generated in the preparation process, the oil-water interfacial tension can be remarkably reduced, and the method has a good application prospect in the field of oil-water emulsion separation.

The invention discloses a magnetic field response type spherical microcapsulate with a multi-stage structure and a preparation method thereof, and relates to a stimulation response type composite material and the preparation method thereof. The preparation method provided by the invention adopts two assembling steps: firstly, a shell structure magnetic polymer nanosphere with ferroferric oxide folded inside is prepared under the action of surface-active agent, and a nano microsphere shell is enabled to have certain functions through molecular designing; and secondly, secondary assembling is performed under the interaction of resolvent and functional groups of the magnetic polymer microsphere shell as well as the combined action of oil-water boundary polarity difference so as to obtain the magnetic field response type spherical microcapsulate with the multi-stage structure. The spherical microcapsulate provided by the invention is formed by congregation of a plurality of magnetic nanospheres, disassembly is achieved through an additional alternating magnetic field, and the magnetic field response type spherical microcapsulate with the multi-stage structure and the preparation method are hopeful to be used well on fields such as emulsion stabilization, micro-reactor and the like.

The invention discloses an anti-counterfeiting adhesive tape with magnetic response and biodegradation functions as well as a preparation method and an application of the anti-counterfeiting adhesive tape. One of a chitosan / polyacrylamide double-cross-linked network, a sodium alginate / polyacrylamide double-cross-linked network, a chitosan / polyacrylic acid double-cross-linked network and a sodium alginate / polyacrylic acid double-cross-linked network is formed on the surface of the base material film, wherein the network formed by chitosan or sodium alginate has biodegradability; meanwhile, Fe3O4 particles with magnetism are introduced into the four double-crosslinking networks, so that the modified base material film with excellent magnetic response and biodegradation functions is obtained, and therefore, the anti-counterfeiting adhesive tape prepared by adopting the modified base material film also has the magnetic response and biodegradation functions. According to the method, the whole operation steps are simple, and implementation feasibility is high; The modification process of the substrate film is carried out in a water-phase environment, so that environmental pollution is avoided.

The invention belongs to the technical field of papermaking, and discloses a papermaking surface sizing agent emulsified by magnetic composite particles and a preparation method thereof. The preparation method disclosed by the invention comprises the following steps: (1), dispersing ferroferric oxide nano solid particles wrapped by silicon dioxide in water, uniformly stirring to obtain suspension, and adjusting the pH value of the suspension, thereby obtaining the suspension of the magnetic composite particles; (2), adding alkyl ketene dimer into a reaction kettle, adding polyvinyl alcohol again, heating till the additives become liquid, and stirring with heat preservation, thereby obtaining sizing oil and liquid of the modified alkyl ketene dimer; and (3), heating the suspension of the magnetic composite particles by water bathing, adding the sizing oil and liquid of the modified alkyl ketene dimer, mixing, and emulsifying with heat preservation, thereby obtaining the papermaking surface sizing agent emulsified by the magnetic composite particles. The papermaking surface sizing agent disclosed by the invention is steady in emulsion and high in sizing efficiency and can endow paper with the water-resisting property and the magnetism; a surface active agent is unnecessary to add in the method; the use amount of an emulsifier is low; the method disclosed by the invention is low in cost and pollution and short in maturing time.

The invention relates to a magnetic DNA fluorescent probe and a preparation method thereof. The probe adopts a magnetic core-shell quantum dot CdTe / MNs nano particle as an energy donor for emitting fluorescence, and the CdTe / MNs nano particle is connected with a single chain 3'-NH2-DNA to form CdTe / MNs-DNA; the probe adopts nano nickel oxide as an energy receptor for absorbing fluorescence, and the nano nickel oxide is connected with a single chain 5'-NH2-DNA to form nNiO-DNA; and the single chain 5'-NH2-DNA and the single chain 3'-NH2-DNA are complementary, and the CdTe / MNs-DNA and the nNiO-DNA are hybridized to form the probe. The preparation method comprises the following steps: 1, preparing the magnetic nano particle MNs; 2, preparing CdTe fluorescent quantum dot solution; 3, preparing CdTe / MNs primary solution; 4, preparing CdTe / MNs-DNA solution; 5, purifying the CdTe / MNs-DNA solution; 6, preparing nNiO; 7, preparing nNiO-DNA solution; 8, preparing the DNA fluorescent probe; and 9, purifying the DNA fluorescent probe.