Preparation method of nano magnetic particles for detection and treatment of coronary heart diseases
A technology of nano-magnetic particles and coronary heart disease, which is applied in preparations for in vivo experiments, cardiovascular system diseases, medical preparations with non-active ingredients, etc., can solve the problem of affecting the effect of vascular stenting treatment and the damage of vascular endothelial cell layer , It is difficult to confirm the endothelial cell layer and other problems, to achieve the effect of prolonging the detection and treatment time, improving the intensity of magnetic response imaging, and improving the sensitivity and reliability
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Embodiment 1
[0037] A method for preparing magnetic nanoparticles for detection and treatment of coronary heart disease, comprising the following steps:
[0038] A. Immobilizing transition layer molecules on the surface of the magnetic core, which is a compound containing amino, carboxyl or mercapto groups and groups capable of reacting with hydroxyl groups.
[0039] The magnetic core in this example has a particle size between 5nm and is paramagnetic, and its composition is γ-Fe 2 o 3 particles, the transition layer molecule is dopamine.
[0040] The specific method of fixing the transition layer molecules on the surface of the magnetic core in step A of this example is: uniformly disperse the magnetic core in the aqueous solution system of the transition layer molecules, the mass ratio of the magnetic core to the transition layer molecules is 1:0.05, and the fixation time is 0.5h , magnetically separated and washed with deionized water.
[0041] B. Then immobilize functional molecules...
Embodiment 2-30
[0048] The preparation method of embodiment 2-30 is all identical with the operation of embodiment 1 method, and difference is only: the magnetic core that A, each embodiment selects for use, the mass ratio of transition layer molecule, magnetic nucleus / transition layer molecule and fixed time; B, Mass ratio of functional molecular species and magnetic core / functional molecule / EDC / NHS immobilized transition layer molecules; C, ligand species specifically recognized by endothelial progenitor cells and magnetic core / specificity of immobilized functional molecules The mass ratio of the recognition ligand / EDC / NHS was correspondingly replaced with the species, mass ratio, and time listed in Table 1 below (for ease of comparison, the data of Example 1 are also listed in the table).
[0049] Table 1: The fixed time of the material type, material ratio and transition layer molecule that each step of embodiment 1-30 selects
[0050]
[0051]
[0052]
[0053]
[0054] (Note...
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