Preparation method of nano magnetic particles for detection and treatment of coronary heart diseases
A technology of nano-magnetic particles and coronary heart disease, which is applied in preparations for in vivo experiments, cardiovascular system diseases, medical preparations of non-active ingredients, etc., can solve the problem of affecting the effect of vascular stenting and difficult to confirm the endothelial cell layer , vascular endothelial cell layer damage, etc., to achieve the effects of prolonging the detection and treatment time, increasing the intensity of magnetic response imaging, and improving sensitivity and reliability
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Embodiment 1
[0037] A method for preparing magnetic nanoparticles for detection and treatment of coronary heart disease, comprising the following steps:
[0038] A. Immobilizing transition layer molecules on the surface of the magnetic core, which is a compound containing amino, carboxyl or mercapto groups and groups capable of reacting with hydroxyl groups.
[0039] The magnetic core in this example has a particle size between 5nm and is paramagnetic, and its composition is γ-Fe 2 o 3 particles, the transition layer molecule is dopamine.
[0040] The specific method of fixing the transition layer molecules on the surface of the magnetic core in step A of this example is: uniformly disperse the magnetic core in the aqueous solution system of the transition layer molecules, the mass ratio of the magnetic core to the transition layer molecules is 1:0.05, and the fixation time is 0.5h , magnetically separated and washed with deionized water.
[0041] B. Then immobilize functional molecules...
Embodiment 2-30
[0048] The preparation method of embodiment 2-30 is all identical with the operation of embodiment 1 method, and difference is only: the magnetic core that A, each embodiment selects for use, the mass ratio of transition layer molecule, magnetic nucleus / transition layer molecule and fixed time; B, Mass ratio of functional molecular species and magnetic core / functional molecule / EDC / NHS immobilized transition layer molecules; C, ligand species specifically recognized by endothelial progenitor cells and magnetic core / specificity of immobilized functional molecules The mass ratio of the recognition ligand / EDC / NHS was correspondingly replaced with the species, mass ratio, and time listed in Table 1 below (for ease of comparison, the data of Example 1 are also listed in the table).
[0049] Table 1: The fixed time of the material type, material ratio and transition layer molecule that each step of embodiment 1-30 selects
[0050]
[0051]
[0052]
[0053]
[0054] (Note...
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