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Magnetic fluorescent double functional microballoon with core-shell structure and preparation method thereof

A core-shell structure, dual-function technology, applied in the direction of microsphere preparation, microcapsule preparation, chemical instruments and methods, etc., can solve the problems of magnetic microspheres that are difficult to function, wide particle size distribution, irregular shape of microspheres, etc. Achieve the effects of simple method, simple preparation method and easy-to-obtain raw materials

Inactive Publication Date: 2004-08-25
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This method is simple to operate, but the shape of the prepared microspheres is irregular and the size is mostly on the micron scale or even larger. Another feature is that the particle size distribution is generally very wide, which makes it difficult for the prepared magnetic microspheres to wide range of roles

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1: In a 500mL three-necked bottle, add 5.0g of ferric oxide powder through deionized washing, add 200mL of deionized water, stir and disperse at 600rpm, then add 100mL of nitric acid solution (3.0M), Stir at room temperature for 10 minutes. Then separate with a magnet and wash 3-5 times with deionized water. Stir and disperse the iron ferric oxide slurry obtained after washing in 400mL of sodium citrate solution (0.2M), then separate it with a magnet and wash it with deionized water for 3-5 times, and finally the ferric iron tetroxide obtained is dispersed in 200mL In deionized water, a ferrofluid with a solid content of about 2.0 wt% was prepared.

[0035] In a 25mL single-neck round bottom flask, dissolve 0.0356g of fluorescein FITC with 10mL of absolute ethanol, then add 0.01829g of triethoxyaminopropylsilane (APS), and stir the reaction for 48 hours in the dark to obtain the bonded Silane coupling agent of fluorescent molecule FITC.

[0036] In a 500mL th...

Embodiment 2

[0037] Example 2: In a 500mL three-necked bottle, add 5.0g of ferric oxide powder through deionized washing, add 200mL of deionized water, stir and disperse at 600rpm, then add 100mL of nitric acid solution (3.0M), Stir at room temperature for 5-8 minutes. Then separate with a magnet and wash 3-5 times with deionized water. Stir and disperse the iron ferric oxide slurry obtained after washing in 400mL of sodium citrate solution (0.2M), then separate it with a magnet and wash it with deionized water for 3-5 times, and finally the ferric iron tetroxide obtained is dispersed in 200mL In deionized water, a ferrofluid with a solid content of about 2.0 wt% was prepared.

[0038] In a 25mL single-neck round bottom flask, dissolve 0.0356g of fluorescein FITC with 10mL of absolute ethanol, then add 0.01829g of triethoxyaminopropylsilane (APS), and stir the reaction for 48 hours in the dark to obtain the bonded Silane coupling agent of fluorescent molecule FITC.

[0039] In a 500mL t...

Embodiment 3

[0040] Example 3: In a 500mL three-necked bottle, add 5.0g of ferric oxide powder through deionized washing, add 200mL of deionized water, stir and disperse at 600rpm, then add 100mL of nitric acid solution (3.0M), Stir at room temperature for 10-20 minutes. Then separate with a magnet and wash 3-5 times with deionized water. Stir and disperse the iron ferric oxide slurry obtained after washing in 400mL of sodium citrate solution (0.2M), then separate it with a magnet and wash it with deionized water for 3-5 times, and finally the ferric iron tetroxide obtained is dispersed in 200mL In deionized water, a ferrofluid with a solid content of about 2.0 wt% was prepared.

[0041] In a 25mL single-neck round bottom flask, dissolve 0.0356g of fluorescein FITC with 10mL of absolute ethanol, then add 0.01829g of triethoxyaminopropylsilane (APS), and stir the reaction for 48 hours in the dark to obtain the bonded Silane coupling agent of fluorescent molecule FITC.

[0042] In a 500mL...

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Abstract

The present invention relates to a magnetic fluorescent double-functional microsphere with core-shell structure and its preparation method. Firstly, said invention uses strong acid and sodium citrate to modify surface of inorganic magnetic nano granules, then uses alkyl orthosilicate as precursor body, and adopts gel-sol process to prepare silicon dioxide magnetic microsphere with core-shell structure, finally utilizes the copolycondensation method of alkyl orthosilicate and silane coupling agent of bonded fluorescein to prepare silicon dixide fluorescent microsphere with magnetism. Said microsphere has magnetic response characteristic, and can send out fluorescence under the excitation of UV-light and visible light.

Description

technical field [0001] The invention belongs to the technical field of inorganic materials, and in particular relates to a magnetic fluorescent bifunctional microsphere with a core-shell structure and a preparation method thereof. technical background [0002] Functional microspheres are a class of microspheres with special functions, such as magnetic microspheres, fluorescent microspheres, pH-sensitive microspheres, temperature-sensitive microspheres, and surface-modified microspheres with various Microspheres with functional groups, etc. [0003] Fluorescent microspheres are functional microspheres loaded with fluorescent molecules. In recent years, with the in-depth research on fluorescent probe technology, people have been able to prepare various fluorescent microspheres with particle sizes ranging from nanometer to submicron. ball. Due to the enrichment of fluorescent organic molecules in a single microsphere, fluorescent microspheres have broad application prospects ...

Claims

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Application Information

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IPC IPC(8): B01J13/02B01J13/04C08F8/34C09K11/02C09K11/08
Inventor 邓勇辉杨武利高海峰府寿宽汪长春胡建华沈锡中
Owner FUDAN UNIV
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